Interfacial interactions between rough mineral particles have garnered considerable attention as they directly determine particle agglomeration and floatability.This study comprehensively investigates the agglomeratio...Interfacial interactions between rough mineral particles have garnered considerable attention as they directly determine particle agglomeration and floatability.This study comprehensively investigates the agglomeration characteristics of siderite particles after argon(Ar)plasma surface modification through settling tests,flocs size measurements,and fractal dimension calculations.Ar plasma surface modification promotes the agglomeration of siderite particles,as evidenced by increased floc size and density.The agglomeration mechanism induced by Ar plasma surface modification is evaluated using a theoretical model combining the surface element integration(SEI)approach,differential geometry,and the composite Simpson's rule.Changes in surface roughness,wettability,and charge are considered in this model.Compared to the unpretreated siderite particles,the energy barrier for interaction of the 30-min Ar plasma-pretreated siderite particles decreases from 2.3×10-^(17)J to 1.6×10^(-17)J.This reduction provides strong evidence for the agglomeration behavior of siderite particles.Furthermore,flotation experiments confirm that Ar plasma surface modification is conducive to the aggregation flotation of siderite.These findings offer crucial insights into particle aggregation and dispersion behaviors,with notable application in mineral flotation.展开更多
In contrast to research on active sites in nanomaterials,lithium tantalate single crystals,known for their exceptional optical properties and long-range ordered lattice structure,present a promising avenue for in-dept...In contrast to research on active sites in nanomaterials,lithium tantalate single crystals,known for their exceptional optical properties and long-range ordered lattice structure,present a promising avenue for in-depth exploration of photocatalytic reaction systems with fewer constraints imposed by surface chemistry.Typically,the isotropy of a specific facet provides a perfect support for studying heteroatom doping.Herein,this work delves into the intrinsic catalytic sites for photocatalytic nitrogen fixation in iron-doped lithium tantalate single crystals.The presence of iron not only modifies the electronic structure of lithium tantalate,improving its light absorption capacity,but also functions as an active site for the nitrogen adsorption and activation.The photocatalytic ammonia production rate of the iron-doped lithium tantalate in pure water is maximum 26.95μg cm^(−2)h^(−1),which is three times higher than that of undoped lithium tantalate.The combination of first-principles simulations with in situ characterizations confirms that iron doping promotes the rate-determining step and changes the pathway of hydrogenation to associative alternating.This study provides a new perspective on in-depth investigation of intrinsic catalytic active sites in photocatalysis and other catalytic processes.展开更多
This paper introduces an advanced and efficient method for distributed drone-based fruit recognition and localization, tailored to satisfy the precision and security requirements of autonomous agricultural operations....This paper introduces an advanced and efficient method for distributed drone-based fruit recognition and localization, tailored to satisfy the precision and security requirements of autonomous agricultural operations. Our method incorporates depth information to ensure precise localization and utilizes a streamlined detection network centered on the RepVGG module. This module replaces the traditional C2f module, enhancing detection performance while maintaining speed. To bolster the detection of small, distant fruits in complex settings, we integrate Selective Kernel Attention (SKAttention) and a specialized small-target detection layer. This adaptation allows the system to manage difficult conditions, such as variable lighting and obstructive foliage. To reinforce security, the tasks of recognition and localization are distributed among multiple drones, enhancing resilience against tampering and data manipulation. This distribution also optimizes resource allocation through collaborative processing. The model remains lightweight and is optimized for rapid and accurate detection, which is essential for real-time applications. Our proposed system, validated with a D435 depth camera, achieves a mean Average Precision (mAP) of 0.943 and a frame rate of 169 FPS, which represents a significant improvement over the baseline by 0.039 percentage points and 25 FPS, respectively. Additionally, the average localization error is reduced to 0.82 cm, highlighting the model’s high precision. These enhancements render our system highly effective for secure, autonomous fruit-picking operations, effectively addressing significant performance and cybersecurity challenges in agriculture. This approach establishes a foundation for reliable, efficient, and secure distributed fruit-picking applications, facilitating the advancement of autonomous systems in contemporary agricultural practices.展开更多
BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social lives.However,these survivors encounter significant challenges during their...BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social lives.However,these survivors encounter significant challenges during their RTW process.Hence,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC survivors.AIM To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW outcomes.METHODS A cross-sectional investigation was adopted in this study.From September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in Chongqing.The investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and FT.To analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were used.RESULTS A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 days.Cox regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further improvement.Elevated levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC survivors.Health professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.展开更多
Trapped-ion systems are one of the leading platforms for quantum information processing, where a key challenge is to scale up system size while maintaining high-fidelity two-qubit operations. A promising approach is t...Trapped-ion systems are one of the leading platforms for quantum information processing, where a key challenge is to scale up system size while maintaining high-fidelity two-qubit operations. A promising approach is to build high-performance modules interconnected via strong coupling. In particular, axial motional modes offer a practical mechanism to couple the ions in a chain, enabling the preparation of Greenberger–Horne–Zeilinger states with up to 24 ions using global operations, as well as high-fidelity two-qubit gates(96.6%–98.0%) in fully connected five-ion chains. Here, we demonstrate two-qubit quantum logic gates in a 5-ion^(40)Ca^(+)chain using axial modes, achieving fidelities exceeding 99% for adjacent pairs and over 98% for arbitrary pairs by carefully tackling dominant error sources. Our results are beneficial to the development of scalable ion-trap quantum processors,quantum simulation and quantum-enhanced metrology.展开更多
BACKGROUND Blood glucose and serum albumin have been associated with cardiovascular disease prognosis,but the impact of admission-blood-glucose-to-albumin ratio(AAR)on adverse outcomes in critical ill coronary artery ...BACKGROUND Blood glucose and serum albumin have been associated with cardiovascular disease prognosis,but the impact of admission-blood-glucose-to-albumin ratio(AAR)on adverse outcomes in critical ill coronary artery disease(CAD)patients was not investigated.METHODS Patients diagnosed with CAD were non-consecutively selected from the MIMIC-IV database and categorized into quartiles based on their AAR.The primary outcome was 1-year mortality,and secondary endpoints were in-hospital mortality,acute kidney injury(AKI),and renal replacement therapy(RRT).A restricted cubic splines model and Cox proportional hazard models assessed the association between AAR and adverse outcomes in CAD patients.Kaplan-Meier survival analysis determined differences in endpoints across subgroups.RESULTS A total of 8360 patients were included.There were 726 patients(8.7%)died in the hospital and 1944 patients(23%)died at 1 year.The incidence of AKI and RRT was 63%and 4.3%,respectively.High AAR was markedly associated with in-hospital mortality(HR=1.587,P=0.003),1-year mortality(HR=1.502,P<0.001),AKI incidence(HR=1.579,P<0.001),and RRT(HR=1.640,P<0.016)in CAD patients in the completely adjusted Cox proportional hazard model.Kaplan-Meier survival analysis noted substantial differences in all endpoints based on AAR quartiles.Stratified analysis and interaction test demonstrated stable correlations between AAR and outcomes.CONCLUSIONS The results highlight that AAR may be a potential indicator for assessing in-hospital mortality,1-year mortality,and adverse renal prognosis in critical CAD patients.展开更多
In the lattice system,when the synthetic flux reaches aπphase along a closed loop under the synthetic gauge field,destructive interference occurs and gives rise to the localization phenomenon.This is known as the Aha...In the lattice system,when the synthetic flux reaches aπphase along a closed loop under the synthetic gauge field,destructive interference occurs and gives rise to the localization phenomenon.This is known as the Aharonov-Bohm(AB)caging effect.It provides a powerful tool for the study of quantum transport and dynamical effects.In the system where lattice sites possess internal structure and the underlying gauge field is non-Abelian,localization can also occur,forming the non-Abelian AB caging.Here,we propose an experimental scheme to synthesize non-Abelian gauge fields with a single trapped ion by coupling multiple internal levels and Fock states in its motion via laser fields.In contrast to the Abelian AB caging,we numerically observe that the non-Abelian AB caging occurs either when the interference matrix is nilpotent,or when the initial state is specifically set.Our experimental scheme broadens the study of localization phenomena and provides a novel tool for the study of non-Abelian physics.展开更多
BACKGROUND Laparoscopic sleeve gastrectomy(LSG)can lead to complete resolution of hypertension in most patients with obesity within one year.However,the preoperative factors related to this resolution are still unclea...BACKGROUND Laparoscopic sleeve gastrectomy(LSG)can lead to complete resolution of hypertension in most patients with obesity within one year.However,the preoperative factors related to this resolution are still unclear.AIM To clarify the impact of relevant factors,particularly perirenal fat,on postoperative hypertension resolution.METHODS In this retrospective single-center study,a total of 138 patients with obesity and hypertension were included,all of whom underwent LSG in the hospital and were followed up for one year.Multivariate logistic regression models were used to identify independent risk factors for postoperative hypertension resolution.Generalized additive models were employed to clarify the nonlinear relationships between these factors and hypertension resolution,and their predictive values were compared using fivefold cross-validation.RESULTS After LSG,107 patients(77.5%)experienced hypertension resolution,while 31 patients(22.5%)did not achieve resolution.Both the preoperative perirenal fat area(PrFA)and perirenal fat thickness were independent risk factors for postoperative hypertension resolution(P<0.001 vs P=0.002).These factors are curvilinearly correlated with the hypertension resolution rate,but PrFA has a better predictive value than perirenal fat thickness dose(area under the curve=0.846 vs 0.809).Compared with those with PrFA≥18 cm2,patients with PrFA<18 cm2 had a higher hypertension resolution rate[87%vs 68.1%;odds ratio(95%confidence interval)=3.513(1.367-9.902),P=0.012].CONCLUSION PrFA is a preoperative predictor of postoperative hypertension resolution.It is curvilinearly associated with the resolution rate,and patients with PrFA<18 cm²have better hypertension resolution outcomes after LSG.展开更多
The linker defect engineering for MOFs is a viable strategy that usually can effectively augment conductivity to further promote charge carrier separation,which is the most excellent conductivity of preserved metal cl...The linker defect engineering for MOFs is a viable strategy that usually can effectively augment conductivity to further promote charge carrier separation,which is the most excellent conductivity of preserved metal clusters.However,the partially missing photosensitive linker often leads to the diminished light utilization efficiency.As we know,in the linker defect engineering,addressing the lack of photosensitivity while maintaining outstanding conductivity is still in its infancy.In this essay,the linkerdefective NH_(2)-MIL-125 was obtained by adding the glacial acetic acid regulator,subsequently,the excellent light-responsive Pt/CQDs with up-conversion effect was in-situ encapsulated into the enlarged pore space of linker-defective NH_(2)-MIL-125.It is excited that the fabricated dual-functional composite ideally integrates photosensitivity and conductivity for photocatalytic hydrogen evolution and NO elimination.The optimal Pt/CQDs@NM-125-4 exhibited very superior photocatalytic hydrogen evolution(28.75mmol/g),it was 11.63 times as that of the initial NH_(2)-MIL-125(2.47 mmol/g)and 1.4 times as that of the defective NM-125-4(20.46 mmol/g).In addition,the excellent photocatalytic NO removal efficiency was 52.12%for Pt/CQDs@NM-125-4,whereas the original NH_(2)-MIL-125 only reached 30%and the defective NM-125-4 achieved 44.96%.The corresponding optical and electrical characterization based on UV-vis,up-conversion photoluminescence(UCPL),and electrochemical impedance spectroscopy(EIS)etc.demonstrated the defect engineering accelerates the charge carriers transfer via enhancing conductivity,and the in-situ confined up-conversion Pt/CQDs promote the visible light response.Our work presents a feasible avenue to integrate photosensitivity and conductivity via in-situ fabricating excellent lightresponsive Pt/CQDs within linker-defective NH_(2)-MIL-125 for further significantly boosting photocatalytic performance.展开更多
A series of optically active copolymers with various feed ratios have been synthesized through helix-sense-selective copolymerization catalyzed by[Rh(norbornadiene)Cl]2-triethylamine.This process involves two proline-...A series of optically active copolymers with various feed ratios have been synthesized through helix-sense-selective copolymerization catalyzed by[Rh(norbornadiene)Cl]2-triethylamine.This process involves two proline-derived acetylene monomers,(S)-N-(4-chlorophenyl)carbamoyl-2-ethynyl pyrrolidine(MCl)and(S)-N-(tert-butoxycarbonyl)-2-ethynyl pyrrolidine,followed by acidic deprotection and neutralization.These copolymers adopt helical conformations with a preferred handedness,as demonstrated by nuclear magnetic resonance spectroscopy and a series of spectroscopic analyses.The chiroptical activity intensity of copolymer has been found to increase with MCl content.Consequently,the enantioseparation capabilities of copolymers containing 95 mol%,90 mol%,and 85 mol%MCl units have been assessed as chiral stationary phases in high-performance liquid chromatography because of their good chiroptical activities.These chiral stationary phases effectively enantioseparate racemic alcohols,sulfoxides,amides,and metal complexes.Notably,the copolymer with 90 mol%MCl shows superior chiral recognition ability,especially for 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol(α=1.19)and 4-methylbenzenesulfinamide(α=1.47).Insights from molecular dynamic simulation and autodock analysis indicate that hydrogen bonding andπ-πstacking interactions between the chiral stationary phases and enantiomers play a key role for successful chiral separation.Our contribution not only demonstrates the importance of hydrogen bonding donor and copolymer chiroptical activity of chiral stationary phases for chiral resolution,but will also provide valuable insights for the future development of novel stationary phases.展开更多
Objective:To improve the efficiency of drug delivery,a mannose vinyl stearate mannose ligand(Man ligand)with active liver-targeting properties was synthesized.Methods:Non-aqueous enzymatic synthesis was used to modify...Objective:To improve the efficiency of drug delivery,a mannose vinyl stearate mannose ligand(Man ligand)with active liver-targeting properties was synthesized.Methods:Non-aqueous enzymatic synthesis was used to modify the structure of mannose.Glycyrrhetinic acid-tanshinone lipid nanoparticles(GT-LN)and liver-targeted glycyrrhetinic acid-tanshinone mannose-modified lipid nanoparticles(GT-MLN)were prepared.The physicochemical properties and release profiles of both formulations were evaluated,and their pharmacokinetic behavior and tissue distribution were investigated.Results:The average particle sizes of GT-LN and GT-MLN were 190.20±1.35 and 204.83±3.86 nm,respectively,with corresponding surface Zeta potentials of-28.0±1.68 and-30.24±2.10 mV.The drug release profile of GT-LN conformed to the Higuchi equation,whereas that of GT-MLN followed both the first-order kinetic and RitgerePeppas equations.Both formulations significantly enhanced the gastrointestinal stability of the drug.In vivo studies in mice demonstrated that hepatic GA and TSN concentrations in both groups were significantly higher than those in the original drug suspension group(P=.01).Notably,the concentrations in the GT-MLN group were significantly higher compared to the GTLN group(P=.01).Conclusion:Man ligand was formed via the linkage of vinyl stearate with the hydroxyl group at C-6 in mannose.The Manligand endowed these lipid nanoparticles with obvious active liver-targeting properties.Our results provide an efficient and stable route of drug delivery to the liver with improved drug availability.展开更多
Rational design of catalytic interfaces at the atomic level is crucial for enhancing electrocatalytic CO_(2)reduction.In this study,a Zeolite imidazolate frameworks-8 derived catalyst is developed,featuring atomically...Rational design of catalytic interfaces at the atomic level is crucial for enhancing electrocatalytic CO_(2)reduction.In this study,a Zeolite imidazolate frameworks-8 derived catalyst is developed,featuring atomically dispersed Ni–Zn dual-atom sites(NiZnN_(6))coexisting with Ni_(3)ZnC_(0.7) nanoparticles on nitrogen-doped carbon nanotubes.Strong interaction between the NiZnN_(6) moieties and Ni_(3)ZnC_(0.7) nanoparticle induces charge redistribution,enhancing the electron-donating ability of Ni active sites.Simultaneously,the dual-atom configuration creates an asymmetric electronic environment,where interfacial electronic coupling facilitates partial electron transfer from Zn to Ni,leading to electron enrichment at the Ni center.Consequently,Ni sites preferentially donate electrons to active CO_(2)molecules,lowering the ^(*)COOH formation energy,while Zn sites promote ^(*)CO desorption,thus achieving high CO selectivity(99.6%@-0.7V vs.Reversible Hydrogen Electrode(RHE)).The in-depth investigation in this work provides guidance for establishing the relationship between structure and electrocatalytic activity,holding significant implications for fundamental research on the CO_(2)reduction mechanism.展开更多
By combining with an improved model on engraving process,a two-phase flow interior ballistic model has been proposed to accurately predict the flow and energy conversion behaviors of pyrotechnic actuators.Using comput...By combining with an improved model on engraving process,a two-phase flow interior ballistic model has been proposed to accurately predict the flow and energy conversion behaviors of pyrotechnic actuators.Using computational fluid dynamics(CFD),the two-phase flow and piston engraving characteristics of a pyrotechnic actuator are investigated.Initially,the current model was utilized to examine the intricate,multi-dimensional flow,and energy conversion characteristics of the propellant grains and combustion gas within the pyrotechnic actuator chamber.It was discovered that the combustion gas on the wall's constant transition from potential to kinetic energy,along with the combined effect of the propellant motion,are what create the pressure oscillation within the chamber.Additionally,a numerical analysis was conducted to determine the impact of various parameters on the pressure oscillation and piston motion,including pyrotechnic charge,pyrotechnic particle size,and chamber structural dimension.The findings show that decreasing the pyrotechnic charge will lower the terminal velocity,while increasing and decreasing the pyrotechnic particle size will reduce the pressure oscillation in the chamber.The pyrotechnic particle size has minimal bearing on the terminal velocity.The results of this investigation offer a trustworthy forecasting instrument for comprehending and creating pyrotechnic actuator designs.展开更多
Perovskite solar cells (PSCs) exhibit significant development potential in the last decade due to their high efficiency and low manufacturing cost, with power conversion efficiencies (PCE) as high as 26.1 %. However, ...Perovskite solar cells (PSCs) exhibit significant development potential in the last decade due to their high efficiency and low manufacturing cost, with power conversion efficiencies (PCE) as high as 26.1 %. However, several problems still limit PSCs' performance and industrialization, including layer defects, energy level mismatch, and chemical instability. MXenes are a promising class of two-dimensional (2D) transition metal carbides and nitrides with excellent hydrophilicity, the tunable figure of merit, desirable electrical conductivity, abundant surface chemical end groups, and low-temperature solution processability. These properties make MXenes easy to combine with other materials and enrich their composites' physical and chemical properties, making them more useful in PSCs. This review systematically summarizes the relationship and development of PSCs and MXenes. Several strategies for combining MXenes with various layer components in PSCs were introduced. Further, we discussed the advantages of MXenes as the hole-transporting layer, electron-transporting layer, perovskite active layer, and electrodes. Finally, we look forward to future research on MXene-based materials in the field of PSC and the next step of commercialization.展开更多
Research on hard carbon(HC)anodes for sodium-ion storage has focused on sodium storage mechanisms in both the high-potential slope and low-potential plateau regions,with the latter being particularly critical for enha...Research on hard carbon(HC)anodes for sodium-ion storage has focused on sodium storage mechanisms in both the high-potential slope and low-potential plateau regions,with the latter being particularly critical for enhancing energy density.Herein,a novel approach that combines ion exchange with low-temperature pyrolysis is presented to develop a closed-pore structure within HC.Leveraging a hard-template design,this approach precisely controls pore distribution and morphology,leading to a significant increase in the proportion of closed pores.In-situ characterization,density functional theory(DFT)calculations,and multi-scale simulations are used to investigate the micropore filling by sodium ions and the formation of clusters within the closed-pore structure.The findings underscore the crucial role of these structural features in enhancing electrochemical performance and offer a quantitative framework for the design of advanced HC materials.The optimized HC demonstrates a high reversible capacity of 413 mAh g^(-1)at a current density of 0.1 A g^(-1),excellent rate capability,and exceptional stability over 10,000 cycles.This study offers valuable insights into sodium-ion storage mechanisms in closed-pore HC and lays the groundwork for developing efficient and durable sodium storage materials.展开更多
Objective:The aim of the study was to evaluate the feasibility of functional MR in predicting the clinical response to chemotherapy in patients with colorectal liver metastases(CLM).Methods:A total of 196 eligible pat...Objective:The aim of the study was to evaluate the feasibility of functional MR in predicting the clinical response to chemotherapy in patients with colorectal liver metastases(CLM).Methods:A total of 196 eligible patients were enrolled in the study between August 2016 and January 2023.Functional MR was performed at baseline and after one cycle of chemotherapy.The diffusion kurtosis radiomic texture features were extracted and a signature model was built using the R package.The initial 100 cases were designated as the training set,the following 48 cases were designated as the validation set,and the final 48 cases were designated as the intervention validation set.Results:Good performance for the response prediction(AUC=0.818 in the training set and 0.755 in the validation set)was demonstrated.The objective response rates(ORRs)in the high-risk subgroup were significantly lower than the low-risk subgroup in the training and validation sets.Worse progression-free survival and overall survival rates were noted in the high-risk population.In the intervention set 22.9%(11/48)of the chemotherapy regimens for patients were changed in response to the model-predicted results and the ORR reached 77.1%(37/48),which was significantly higher than the training and validation sets[47.97%(71/148);P=0.000].Conclusions:A functional MR signature effectively predicted the chemotherapy response and long-term survival.The adjustment of the regimen guided by the model significantly improved the ORR.展开更多
Background:Modern acupuncture anesthesia is a combination of Chinese and Western medicine that integrates the theories of acupuncture with anesthesia.However,some clinical studies of acupuncture anesthesia lack specif...Background:Modern acupuncture anesthesia is a combination of Chinese and Western medicine that integrates the theories of acupuncture with anesthesia.However,some clinical studies of acupuncture anesthesia lack specific descriptions of randomization,allocation concealment,and blinding processes,with subsequent systematic reviews indicating a risk of bias.Objective:Clinical trial registration is essential for the enhancement of the quality of clinical trials.This study aims to summarize the status of clinical trial registrations for acupuncture anesthesia listed on the World Health Organization International Clinical Trials Registry Platform(ICTRP).Search strategy:We searched the ICTRP for clinical trials related to acupuncture anesthesia registered between January 1,2001 and May 31,2023.Additionally,related publications were retrieved from PubMed,Cochrane Library,Embase,China National Knowledge Infrastructure,China Science and Technology Journal Database,and Wanfang Data.Registrations and publications were analyzed for consistency in trial design characteristics.Inclusion criteria:Clinical trials that utilized one of several acupuncture-related therapies in combination with pharmacological anesthesia during the perioperative period were eligible for this review.Data extraction and analysis:Data extracted from articles included type of surgical procedure,perioperative symptoms,study methodology,type of intervention,trial recruitment information,and publication information related to clinical enrollment.Results:A total of 166 trials related to acupuncture anesthesia from 21 countries were included in the analysis.The commonly reported symptoms in the included studies were postoperative nausea and vomiting(19.9%)and postoperative pain(13.3%).The concordance between the publications and the trial protocols in the clinical registry records was poor,with only 31.7%of the studies being fully compatible.Inconsistency rates were high for sample size(39.0%,16/41),blinding(36.6%,15/41),and secondary outcome indicators(24.4%,10/41).Conclusion:The volume of acupuncture anesthesia clinical trials registered in international trial registries over the last 20 years is low,with insufficient disclosure of results.Postoperative nausea and vomiting as well as postoperative pain,are the most investigated for acupuncture intervention.展开更多
Purpose: To explore the preventive effect of Regional cooling comprehensive nursing on hand foot syndrome caused by pegylated liposomal doxorubicin (PLD). Method: Adopt overall sampling method. Patients who used the s...Purpose: To explore the preventive effect of Regional cooling comprehensive nursing on hand foot syndrome caused by pegylated liposomal doxorubicin (PLD). Method: Adopt overall sampling method. Patients who used the same adjuvant drugs from January to December 2020 were randomly divided into an intervention group and a control group. The patients in the two groups received routine nursing guidance and drug prevention for the use of amygdalin. The patients in the intervention group were required to take protective measures of Regional cooling during chemotherapy. The occurrence of hand foot syndrome during adriamycin liposome administration was compared between the two groups. Results: By comparing the adverse reactions of cases during Adriamycin Administration, the incidence rates of grade I, II and III hand foot syndrome in the control group were 28.8%, 7.6% and 27.5% respectively, and the incidence rates of grade I, II and III hand foot syndrome in the intervention group were 42.1%, 12.3% and 7.0% respectively, with statistical significance (P Conclusion: Regional cooling nursing and preventive behavior guidance can effectively reduce the severity of hand foot syndrome caused by adriamycin.展开更多
Background: The focus of recent research has been directed toward the probiotic potential of Bacillus amyloliquefaciens(BA) on the gut health of animals. However, little is known about BA's effects on piglets with...Background: The focus of recent research has been directed toward the probiotic potential of Bacillus amyloliquefaciens(BA) on the gut health of animals. However, little is known about BA's effects on piglets with intra-uterine growth retardation(IUGR). Therefore, this study investigated the effects of BA supplementation on the growth performance,intestinal morphology, inflammatory response, and microbiota of IUGR piglets.Methods: Eighteen litters of newborn piglets were selected at birth, with one normal birth weight(NBW) and two IUGR piglets in each litter(i.e., 18 NBW and 36 IUGR piglets in total). At weaning, the NBW piglet and one of the IUGR piglets were assigned to groups fed a control diet(i.e., the NBW-CON and IUGR-CON groups). The other IUGR piglet was assigned to a group fed the control diet supplemented with 2.0 g BA per kg of diet(i.e., IUGR-BA group). The piglets were thus distributed across three groups for a four-week period.Results: IUGR reduced the growth performance of the IUGR-CON piglets compared with the NBW-CON piglets. It was also associated with decreased vil us sizes, increased apoptosis rates, reduced goblet cel numbers, and an imbalance between pro-and anti-inflammatory cytokines in the smal intestine. Supplementation with BA improved the average daily weight gain and the feed efficiency of the IUGR-BA group compared with the IUGR-CON group(P < 0.05). The IUGR-BA group exhibited increases in the ratio of jejunal vil us height to crypt depth, in ileal vil us height, and in ileal goblet cel density. They also exhibited decreases in the numbers of jejunal and ileal apoptotic cel s and ileal proliferative cel s(P < 0.05). Supplementation with BA increased interleukin 10 content, but it decreased tumor necrosis factor alpha level in the smal intestines of the IUGR-BA piglets(P < 0.05). Furthermore, compared with the IUGR-CON piglets, the IUGR-BA piglets had less Escherichia coli in their jejunal digesta, but more Lactobacil us and Bifidobacterium in their ileal digesta(P < 0.05).Conclusions: Dietary supplementation with BA improves morphology, decreases inflammatory response, and regulates microbiota in the smal intestines of IUGR piglets, which may contribute to improved growth performance during early life.展开更多
基金financially supported by the National Natural Science Foundation of China(No.52204284)the China Postdoctoral Science Foundation(No.2025MD784125)+2 种基金the Natural Science Foundation of Shaanxi Province,China(No.2024JC-YBQN-0365)the Shaanxi Province Postdoctoral Science Foundation,China(No.2025BSHSDZZ363)Outstanding Youth Science Fund of Xi’an University of Science and Technology,China(No.202308)。
文摘Interfacial interactions between rough mineral particles have garnered considerable attention as they directly determine particle agglomeration and floatability.This study comprehensively investigates the agglomeration characteristics of siderite particles after argon(Ar)plasma surface modification through settling tests,flocs size measurements,and fractal dimension calculations.Ar plasma surface modification promotes the agglomeration of siderite particles,as evidenced by increased floc size and density.The agglomeration mechanism induced by Ar plasma surface modification is evaluated using a theoretical model combining the surface element integration(SEI)approach,differential geometry,and the composite Simpson's rule.Changes in surface roughness,wettability,and charge are considered in this model.Compared to the unpretreated siderite particles,the energy barrier for interaction of the 30-min Ar plasma-pretreated siderite particles decreases from 2.3×10-^(17)J to 1.6×10^(-17)J.This reduction provides strong evidence for the agglomeration behavior of siderite particles.Furthermore,flotation experiments confirm that Ar plasma surface modification is conducive to the aggregation flotation of siderite.These findings offer crucial insights into particle aggregation and dispersion behaviors,with notable application in mineral flotation.
基金supported by Natural Science Foundation of Shandong Province(Nos.ZR2022YQ42,ZR2021JQ15,ZR2021QE011,ZR2021ZD20,2022GJJLJRC-01)Innovative Team Project of Jinan(No.2021GXRC019)the National Natural Science Foundation of China(Nos.52022037,52202366).
文摘In contrast to research on active sites in nanomaterials,lithium tantalate single crystals,known for their exceptional optical properties and long-range ordered lattice structure,present a promising avenue for in-depth exploration of photocatalytic reaction systems with fewer constraints imposed by surface chemistry.Typically,the isotropy of a specific facet provides a perfect support for studying heteroatom doping.Herein,this work delves into the intrinsic catalytic sites for photocatalytic nitrogen fixation in iron-doped lithium tantalate single crystals.The presence of iron not only modifies the electronic structure of lithium tantalate,improving its light absorption capacity,but also functions as an active site for the nitrogen adsorption and activation.The photocatalytic ammonia production rate of the iron-doped lithium tantalate in pure water is maximum 26.95μg cm^(−2)h^(−1),which is three times higher than that of undoped lithium tantalate.The combination of first-principles simulations with in situ characterizations confirms that iron doping promotes the rate-determining step and changes the pathway of hydrogenation to associative alternating.This study provides a new perspective on in-depth investigation of intrinsic catalytic active sites in photocatalysis and other catalytic processes.
基金supported by Guangdong Province Rural Science and Technology Commissioner Project,Zen Tea Reliable Traceability and Intelligent Planting Key Technology Research and Development,Promotion and Application(KTP20210199)Special Project of Guangdong Provincial Education Department,Research on Abnormal Behavior Recognition Technology of Pregnant Sows Based onGraph Convolution(2021ZDZX1091)+2 种基金Guangdong Basic and Applied Basic Research Foundation under Grant 2023A1515110729Shenzhen Science and Technology Program under Grant 20231128093642002the Research Foundation of Shenzhen Polytechnic University under Grant 6023312007K.
文摘This paper introduces an advanced and efficient method for distributed drone-based fruit recognition and localization, tailored to satisfy the precision and security requirements of autonomous agricultural operations. Our method incorporates depth information to ensure precise localization and utilizes a streamlined detection network centered on the RepVGG module. This module replaces the traditional C2f module, enhancing detection performance while maintaining speed. To bolster the detection of small, distant fruits in complex settings, we integrate Selective Kernel Attention (SKAttention) and a specialized small-target detection layer. This adaptation allows the system to manage difficult conditions, such as variable lighting and obstructive foliage. To reinforce security, the tasks of recognition and localization are distributed among multiple drones, enhancing resilience against tampering and data manipulation. This distribution also optimizes resource allocation through collaborative processing. The model remains lightweight and is optimized for rapid and accurate detection, which is essential for real-time applications. Our proposed system, validated with a D435 depth camera, achieves a mean Average Precision (mAP) of 0.943 and a frame rate of 169 FPS, which represents a significant improvement over the baseline by 0.039 percentage points and 25 FPS, respectively. Additionally, the average localization error is reduced to 0.82 cm, highlighting the model’s high precision. These enhancements render our system highly effective for secure, autonomous fruit-picking operations, effectively addressing significant performance and cybersecurity challenges in agriculture. This approach establishes a foundation for reliable, efficient, and secure distributed fruit-picking applications, facilitating the advancement of autonomous systems in contemporary agricultural practices.
基金Supported by the Chongqing Medical University Program for Youth Innovation in Future Medicine,No.W0019Chongqing Municipal Education Commission’s 14th Five-Year Key Discipline Support Project,No.20240101 and No.20240102。
文摘BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social lives.However,these survivors encounter significant challenges during their RTW process.Hence,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC survivors.AIM To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW outcomes.METHODS A cross-sectional investigation was adopted in this study.From September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in Chongqing.The investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and FT.To analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were used.RESULTS A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 days.Cox regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further improvement.Elevated levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC survivors.Health professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.
基金supported by the Innovation Program for Quantum Science and Technology (Grant No.2021ZD0301603)the National Natural Science Foundation of China (Grant No.92165206)。
文摘Trapped-ion systems are one of the leading platforms for quantum information processing, where a key challenge is to scale up system size while maintaining high-fidelity two-qubit operations. A promising approach is to build high-performance modules interconnected via strong coupling. In particular, axial motional modes offer a practical mechanism to couple the ions in a chain, enabling the preparation of Greenberger–Horne–Zeilinger states with up to 24 ions using global operations, as well as high-fidelity two-qubit gates(96.6%–98.0%) in fully connected five-ion chains. Here, we demonstrate two-qubit quantum logic gates in a 5-ion^(40)Ca^(+)chain using axial modes, achieving fidelities exceeding 99% for adjacent pairs and over 98% for arbitrary pairs by carefully tackling dominant error sources. Our results are beneficial to the development of scalable ion-trap quantum processors,quantum simulation and quantum-enhanced metrology.
基金supported by the National Nature Science Foundation of China(No.82370336&No.82330014)the Key Research and Development Plan of Heilongjiang Province(2022ZX06C23&JD2023SJ44)the Research Project of the First Affiliated Hospital of Harbin Medical University(No.2021M19).
文摘BACKGROUND Blood glucose and serum albumin have been associated with cardiovascular disease prognosis,but the impact of admission-blood-glucose-to-albumin ratio(AAR)on adverse outcomes in critical ill coronary artery disease(CAD)patients was not investigated.METHODS Patients diagnosed with CAD were non-consecutively selected from the MIMIC-IV database and categorized into quartiles based on their AAR.The primary outcome was 1-year mortality,and secondary endpoints were in-hospital mortality,acute kidney injury(AKI),and renal replacement therapy(RRT).A restricted cubic splines model and Cox proportional hazard models assessed the association between AAR and adverse outcomes in CAD patients.Kaplan-Meier survival analysis determined differences in endpoints across subgroups.RESULTS A total of 8360 patients were included.There were 726 patients(8.7%)died in the hospital and 1944 patients(23%)died at 1 year.The incidence of AKI and RRT was 63%and 4.3%,respectively.High AAR was markedly associated with in-hospital mortality(HR=1.587,P=0.003),1-year mortality(HR=1.502,P<0.001),AKI incidence(HR=1.579,P<0.001),and RRT(HR=1.640,P<0.016)in CAD patients in the completely adjusted Cox proportional hazard model.Kaplan-Meier survival analysis noted substantial differences in all endpoints based on AAR quartiles.Stratified analysis and interaction test demonstrated stable correlations between AAR and outcomes.CONCLUSIONS The results highlight that AAR may be a potential indicator for assessing in-hospital mortality,1-year mortality,and adverse renal prognosis in critical CAD patients.
基金supported by the National Natural Science Foundation of China(Grant Nos.92165206,12275090,and 12304554)the Innovation Program for Quantum Science and Technology(Grant Nos.2021ZD0301603 and 2021ZD0302303)。
文摘In the lattice system,when the synthetic flux reaches aπphase along a closed loop under the synthetic gauge field,destructive interference occurs and gives rise to the localization phenomenon.This is known as the Aharonov-Bohm(AB)caging effect.It provides a powerful tool for the study of quantum transport and dynamical effects.In the system where lattice sites possess internal structure and the underlying gauge field is non-Abelian,localization can also occur,forming the non-Abelian AB caging.Here,we propose an experimental scheme to synthesize non-Abelian gauge fields with a single trapped ion by coupling multiple internal levels and Fock states in its motion via laser fields.In contrast to the Abelian AB caging,we numerically observe that the non-Abelian AB caging occurs either when the interference matrix is nilpotent,or when the initial state is specifically set.Our experimental scheme broadens the study of localization phenomena and provides a novel tool for the study of non-Abelian physics.
基金Supported by the National Natural Science Foundation of China,No.82270914 and No.82401043.
文摘BACKGROUND Laparoscopic sleeve gastrectomy(LSG)can lead to complete resolution of hypertension in most patients with obesity within one year.However,the preoperative factors related to this resolution are still unclear.AIM To clarify the impact of relevant factors,particularly perirenal fat,on postoperative hypertension resolution.METHODS In this retrospective single-center study,a total of 138 patients with obesity and hypertension were included,all of whom underwent LSG in the hospital and were followed up for one year.Multivariate logistic regression models were used to identify independent risk factors for postoperative hypertension resolution.Generalized additive models were employed to clarify the nonlinear relationships between these factors and hypertension resolution,and their predictive values were compared using fivefold cross-validation.RESULTS After LSG,107 patients(77.5%)experienced hypertension resolution,while 31 patients(22.5%)did not achieve resolution.Both the preoperative perirenal fat area(PrFA)and perirenal fat thickness were independent risk factors for postoperative hypertension resolution(P<0.001 vs P=0.002).These factors are curvilinearly correlated with the hypertension resolution rate,but PrFA has a better predictive value than perirenal fat thickness dose(area under the curve=0.846 vs 0.809).Compared with those with PrFA≥18 cm2,patients with PrFA<18 cm2 had a higher hypertension resolution rate[87%vs 68.1%;odds ratio(95%confidence interval)=3.513(1.367-9.902),P=0.012].CONCLUSION PrFA is a preoperative predictor of postoperative hypertension resolution.It is curvilinearly associated with the resolution rate,and patients with PrFA<18 cm²have better hypertension resolution outcomes after LSG.
基金supported by the National Natural Science Foundation of China(Nos.22001026,22171233,22201193)Sichuan Science and Technology Program(No.2023NSFSC0109)+1 种基金the Fundamental Research Funds for the Central Universitiesthe Hundred Talent Program of Sichuan University(No.YJ2021158)。
文摘The linker defect engineering for MOFs is a viable strategy that usually can effectively augment conductivity to further promote charge carrier separation,which is the most excellent conductivity of preserved metal clusters.However,the partially missing photosensitive linker often leads to the diminished light utilization efficiency.As we know,in the linker defect engineering,addressing the lack of photosensitivity while maintaining outstanding conductivity is still in its infancy.In this essay,the linkerdefective NH_(2)-MIL-125 was obtained by adding the glacial acetic acid regulator,subsequently,the excellent light-responsive Pt/CQDs with up-conversion effect was in-situ encapsulated into the enlarged pore space of linker-defective NH_(2)-MIL-125.It is excited that the fabricated dual-functional composite ideally integrates photosensitivity and conductivity for photocatalytic hydrogen evolution and NO elimination.The optimal Pt/CQDs@NM-125-4 exhibited very superior photocatalytic hydrogen evolution(28.75mmol/g),it was 11.63 times as that of the initial NH_(2)-MIL-125(2.47 mmol/g)and 1.4 times as that of the defective NM-125-4(20.46 mmol/g).In addition,the excellent photocatalytic NO removal efficiency was 52.12%for Pt/CQDs@NM-125-4,whereas the original NH_(2)-MIL-125 only reached 30%and the defective NM-125-4 achieved 44.96%.The corresponding optical and electrical characterization based on UV-vis,up-conversion photoluminescence(UCPL),and electrochemical impedance spectroscopy(EIS)etc.demonstrated the defect engineering accelerates the charge carriers transfer via enhancing conductivity,and the in-situ confined up-conversion Pt/CQDs promote the visible light response.Our work presents a feasible avenue to integrate photosensitivity and conductivity via in-situ fabricating excellent lightresponsive Pt/CQDs within linker-defective NH_(2)-MIL-125 for further significantly boosting photocatalytic performance.
基金supported by the National Natural Science Foundation of China(Nos.52273002 and 52333008)the funding of Boya Postdoctoral Fellowship at Peking University,BMS Junior Fellow Program and the National Funding Program for Postdoctoral Researchers(No.GZC20230031).
文摘A series of optically active copolymers with various feed ratios have been synthesized through helix-sense-selective copolymerization catalyzed by[Rh(norbornadiene)Cl]2-triethylamine.This process involves two proline-derived acetylene monomers,(S)-N-(4-chlorophenyl)carbamoyl-2-ethynyl pyrrolidine(MCl)and(S)-N-(tert-butoxycarbonyl)-2-ethynyl pyrrolidine,followed by acidic deprotection and neutralization.These copolymers adopt helical conformations with a preferred handedness,as demonstrated by nuclear magnetic resonance spectroscopy and a series of spectroscopic analyses.The chiroptical activity intensity of copolymer has been found to increase with MCl content.Consequently,the enantioseparation capabilities of copolymers containing 95 mol%,90 mol%,and 85 mol%MCl units have been assessed as chiral stationary phases in high-performance liquid chromatography because of their good chiroptical activities.These chiral stationary phases effectively enantioseparate racemic alcohols,sulfoxides,amides,and metal complexes.Notably,the copolymer with 90 mol%MCl shows superior chiral recognition ability,especially for 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol(α=1.19)and 4-methylbenzenesulfinamide(α=1.47).Insights from molecular dynamic simulation and autodock analysis indicate that hydrogen bonding andπ-πstacking interactions between the chiral stationary phases and enantiomers play a key role for successful chiral separation.Our contribution not only demonstrates the importance of hydrogen bonding donor and copolymer chiroptical activity of chiral stationary phases for chiral resolution,but will also provide valuable insights for the future development of novel stationary phases.
基金the High-level construction discipline of the National Administration of Traditional Chinese Medicine(zyyzdxk-2023272).
文摘Objective:To improve the efficiency of drug delivery,a mannose vinyl stearate mannose ligand(Man ligand)with active liver-targeting properties was synthesized.Methods:Non-aqueous enzymatic synthesis was used to modify the structure of mannose.Glycyrrhetinic acid-tanshinone lipid nanoparticles(GT-LN)and liver-targeted glycyrrhetinic acid-tanshinone mannose-modified lipid nanoparticles(GT-MLN)were prepared.The physicochemical properties and release profiles of both formulations were evaluated,and their pharmacokinetic behavior and tissue distribution were investigated.Results:The average particle sizes of GT-LN and GT-MLN were 190.20±1.35 and 204.83±3.86 nm,respectively,with corresponding surface Zeta potentials of-28.0±1.68 and-30.24±2.10 mV.The drug release profile of GT-LN conformed to the Higuchi equation,whereas that of GT-MLN followed both the first-order kinetic and RitgerePeppas equations.Both formulations significantly enhanced the gastrointestinal stability of the drug.In vivo studies in mice demonstrated that hepatic GA and TSN concentrations in both groups were significantly higher than those in the original drug suspension group(P=.01).Notably,the concentrations in the GT-MLN group were significantly higher compared to the GTLN group(P=.01).Conclusion:Man ligand was formed via the linkage of vinyl stearate with the hydroxyl group at C-6 in mannose.The Manligand endowed these lipid nanoparticles with obvious active liver-targeting properties.Our results provide an efficient and stable route of drug delivery to the liver with improved drug availability.
基金the financial support from the Natural Science Foundation of Shanghai(24ZR1453900)Project for AI-Driven Reform of Research Paradigms to Empower Advancement of Disciplines(Z-2024-369-036)。
文摘Rational design of catalytic interfaces at the atomic level is crucial for enhancing electrocatalytic CO_(2)reduction.In this study,a Zeolite imidazolate frameworks-8 derived catalyst is developed,featuring atomically dispersed Ni–Zn dual-atom sites(NiZnN_(6))coexisting with Ni_(3)ZnC_(0.7) nanoparticles on nitrogen-doped carbon nanotubes.Strong interaction between the NiZnN_(6) moieties and Ni_(3)ZnC_(0.7) nanoparticle induces charge redistribution,enhancing the electron-donating ability of Ni active sites.Simultaneously,the dual-atom configuration creates an asymmetric electronic environment,where interfacial electronic coupling facilitates partial electron transfer from Zn to Ni,leading to electron enrichment at the Ni center.Consequently,Ni sites preferentially donate electrons to active CO_(2)molecules,lowering the ^(*)COOH formation energy,while Zn sites promote ^(*)CO desorption,thus achieving high CO selectivity(99.6%@-0.7V vs.Reversible Hydrogen Electrode(RHE)).The in-depth investigation in this work provides guidance for establishing the relationship between structure and electrocatalytic activity,holding significant implications for fundamental research on the CO_(2)reduction mechanism.
基金supported by the National Natural Science Foundation of China(Grant No.11972194).
文摘By combining with an improved model on engraving process,a two-phase flow interior ballistic model has been proposed to accurately predict the flow and energy conversion behaviors of pyrotechnic actuators.Using computational fluid dynamics(CFD),the two-phase flow and piston engraving characteristics of a pyrotechnic actuator are investigated.Initially,the current model was utilized to examine the intricate,multi-dimensional flow,and energy conversion characteristics of the propellant grains and combustion gas within the pyrotechnic actuator chamber.It was discovered that the combustion gas on the wall's constant transition from potential to kinetic energy,along with the combined effect of the propellant motion,are what create the pressure oscillation within the chamber.Additionally,a numerical analysis was conducted to determine the impact of various parameters on the pressure oscillation and piston motion,including pyrotechnic charge,pyrotechnic particle size,and chamber structural dimension.The findings show that decreasing the pyrotechnic charge will lower the terminal velocity,while increasing and decreasing the pyrotechnic particle size will reduce the pressure oscillation in the chamber.The pyrotechnic particle size has minimal bearing on the terminal velocity.The results of this investigation offer a trustworthy forecasting instrument for comprehending and creating pyrotechnic actuator designs.
基金supported by the National Natural Science Foundation of China(No.11375136).
文摘Perovskite solar cells (PSCs) exhibit significant development potential in the last decade due to their high efficiency and low manufacturing cost, with power conversion efficiencies (PCE) as high as 26.1 %. However, several problems still limit PSCs' performance and industrialization, including layer defects, energy level mismatch, and chemical instability. MXenes are a promising class of two-dimensional (2D) transition metal carbides and nitrides with excellent hydrophilicity, the tunable figure of merit, desirable electrical conductivity, abundant surface chemical end groups, and low-temperature solution processability. These properties make MXenes easy to combine with other materials and enrich their composites' physical and chemical properties, making them more useful in PSCs. This review systematically summarizes the relationship and development of PSCs and MXenes. Several strategies for combining MXenes with various layer components in PSCs were introduced. Further, we discussed the advantages of MXenes as the hole-transporting layer, electron-transporting layer, perovskite active layer, and electrodes. Finally, we look forward to future research on MXene-based materials in the field of PSC and the next step of commercialization.
基金supported by the National Natural Science Foundation of China(22269020,U23A20582,42167068)the Outstanding Youth Fund of Gansu Province(20JR5RA539)+1 种基金the Gansu Province Higher Education Industry Support Plan Project(2023CYZC-17)2024 Major Cultivation Project for University Research and Innovation Platforms(2024CXPT-10)。
文摘Research on hard carbon(HC)anodes for sodium-ion storage has focused on sodium storage mechanisms in both the high-potential slope and low-potential plateau regions,with the latter being particularly critical for enhancing energy density.Herein,a novel approach that combines ion exchange with low-temperature pyrolysis is presented to develop a closed-pore structure within HC.Leveraging a hard-template design,this approach precisely controls pore distribution and morphology,leading to a significant increase in the proportion of closed pores.In-situ characterization,density functional theory(DFT)calculations,and multi-scale simulations are used to investigate the micropore filling by sodium ions and the formation of clusters within the closed-pore structure.The findings underscore the crucial role of these structural features in enhancing electrochemical performance and offer a quantitative framework for the design of advanced HC materials.The optimized HC demonstrates a high reversible capacity of 413 mAh g^(-1)at a current density of 0.1 A g^(-1),excellent rate capability,and exceptional stability over 10,000 cycles.This study offers valuable insights into sodium-ion storage mechanisms in closed-pore HC and lays the groundwork for developing efficient and durable sodium storage materials.
基金supported by the National Natural Science Foundation of China(Grant nos.82271946 and 82202101)Innovative Achievement Transformation of Shenkang MedicalEnterprise Integration(Grant no.SHDC2023CRD014)。
文摘Objective:The aim of the study was to evaluate the feasibility of functional MR in predicting the clinical response to chemotherapy in patients with colorectal liver metastases(CLM).Methods:A total of 196 eligible patients were enrolled in the study between August 2016 and January 2023.Functional MR was performed at baseline and after one cycle of chemotherapy.The diffusion kurtosis radiomic texture features were extracted and a signature model was built using the R package.The initial 100 cases were designated as the training set,the following 48 cases were designated as the validation set,and the final 48 cases were designated as the intervention validation set.Results:Good performance for the response prediction(AUC=0.818 in the training set and 0.755 in the validation set)was demonstrated.The objective response rates(ORRs)in the high-risk subgroup were significantly lower than the low-risk subgroup in the training and validation sets.Worse progression-free survival and overall survival rates were noted in the high-risk population.In the intervention set 22.9%(11/48)of the chemotherapy regimens for patients were changed in response to the model-predicted results and the ORR reached 77.1%(37/48),which was significantly higher than the training and validation sets[47.97%(71/148);P=0.000].Conclusions:A functional MR signature effectively predicted the chemotherapy response and long-term survival.The adjustment of the regimen guided by the model significantly improved the ORR.
基金supported by grants from Shanghai Municipal Health Commission and Shanghai Municipal Administration of TCM—Standardization of TCM in 2023“Clinical Practice Guide for Combined Acupuncture-Drug Anesthesia”(No.2023JS05)Shanghai Clinical Medical Research Center of Acupuncture and Moxibustion(No.20MC1920500)+1 种基金Shanghai master Chinese medicine practitioners academic experience research studio construction project(No.SHGZS-202212)Shanghai Key Clinical Specialties 2019 Accreditation Program(No.shslczdzk04701)。
文摘Background:Modern acupuncture anesthesia is a combination of Chinese and Western medicine that integrates the theories of acupuncture with anesthesia.However,some clinical studies of acupuncture anesthesia lack specific descriptions of randomization,allocation concealment,and blinding processes,with subsequent systematic reviews indicating a risk of bias.Objective:Clinical trial registration is essential for the enhancement of the quality of clinical trials.This study aims to summarize the status of clinical trial registrations for acupuncture anesthesia listed on the World Health Organization International Clinical Trials Registry Platform(ICTRP).Search strategy:We searched the ICTRP for clinical trials related to acupuncture anesthesia registered between January 1,2001 and May 31,2023.Additionally,related publications were retrieved from PubMed,Cochrane Library,Embase,China National Knowledge Infrastructure,China Science and Technology Journal Database,and Wanfang Data.Registrations and publications were analyzed for consistency in trial design characteristics.Inclusion criteria:Clinical trials that utilized one of several acupuncture-related therapies in combination with pharmacological anesthesia during the perioperative period were eligible for this review.Data extraction and analysis:Data extracted from articles included type of surgical procedure,perioperative symptoms,study methodology,type of intervention,trial recruitment information,and publication information related to clinical enrollment.Results:A total of 166 trials related to acupuncture anesthesia from 21 countries were included in the analysis.The commonly reported symptoms in the included studies were postoperative nausea and vomiting(19.9%)and postoperative pain(13.3%).The concordance between the publications and the trial protocols in the clinical registry records was poor,with only 31.7%of the studies being fully compatible.Inconsistency rates were high for sample size(39.0%,16/41),blinding(36.6%,15/41),and secondary outcome indicators(24.4%,10/41).Conclusion:The volume of acupuncture anesthesia clinical trials registered in international trial registries over the last 20 years is low,with insufficient disclosure of results.Postoperative nausea and vomiting as well as postoperative pain,are the most investigated for acupuncture intervention.
文摘Purpose: To explore the preventive effect of Regional cooling comprehensive nursing on hand foot syndrome caused by pegylated liposomal doxorubicin (PLD). Method: Adopt overall sampling method. Patients who used the same adjuvant drugs from January to December 2020 were randomly divided into an intervention group and a control group. The patients in the two groups received routine nursing guidance and drug prevention for the use of amygdalin. The patients in the intervention group were required to take protective measures of Regional cooling during chemotherapy. The occurrence of hand foot syndrome during adriamycin liposome administration was compared between the two groups. Results: By comparing the adverse reactions of cases during Adriamycin Administration, the incidence rates of grade I, II and III hand foot syndrome in the control group were 28.8%, 7.6% and 27.5% respectively, and the incidence rates of grade I, II and III hand foot syndrome in the intervention group were 42.1%, 12.3% and 7.0% respectively, with statistical significance (P Conclusion: Regional cooling nursing and preventive behavior guidance can effectively reduce the severity of hand foot syndrome caused by adriamycin.
基金provided by the National Science-Technology Support Plan Projects of China(No.2013BAD10B02–03)the Phase Ⅱ Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘Background: The focus of recent research has been directed toward the probiotic potential of Bacillus amyloliquefaciens(BA) on the gut health of animals. However, little is known about BA's effects on piglets with intra-uterine growth retardation(IUGR). Therefore, this study investigated the effects of BA supplementation on the growth performance,intestinal morphology, inflammatory response, and microbiota of IUGR piglets.Methods: Eighteen litters of newborn piglets were selected at birth, with one normal birth weight(NBW) and two IUGR piglets in each litter(i.e., 18 NBW and 36 IUGR piglets in total). At weaning, the NBW piglet and one of the IUGR piglets were assigned to groups fed a control diet(i.e., the NBW-CON and IUGR-CON groups). The other IUGR piglet was assigned to a group fed the control diet supplemented with 2.0 g BA per kg of diet(i.e., IUGR-BA group). The piglets were thus distributed across three groups for a four-week period.Results: IUGR reduced the growth performance of the IUGR-CON piglets compared with the NBW-CON piglets. It was also associated with decreased vil us sizes, increased apoptosis rates, reduced goblet cel numbers, and an imbalance between pro-and anti-inflammatory cytokines in the smal intestine. Supplementation with BA improved the average daily weight gain and the feed efficiency of the IUGR-BA group compared with the IUGR-CON group(P < 0.05). The IUGR-BA group exhibited increases in the ratio of jejunal vil us height to crypt depth, in ileal vil us height, and in ileal goblet cel density. They also exhibited decreases in the numbers of jejunal and ileal apoptotic cel s and ileal proliferative cel s(P < 0.05). Supplementation with BA increased interleukin 10 content, but it decreased tumor necrosis factor alpha level in the smal intestines of the IUGR-BA piglets(P < 0.05). Furthermore, compared with the IUGR-CON piglets, the IUGR-BA piglets had less Escherichia coli in their jejunal digesta, but more Lactobacil us and Bifidobacterium in their ileal digesta(P < 0.05).Conclusions: Dietary supplementation with BA improves morphology, decreases inflammatory response, and regulates microbiota in the smal intestines of IUGR piglets, which may contribute to improved growth performance during early life.
