Rivers and groundwater are the main water sources for cities.The mutual transformation between river water and groundwater makes it difficult to accurately evaluate and rationally utilize water resources.Scientificall...Rivers and groundwater are the main water sources for cities.The mutual transformation between river water and groundwater makes it difficult to accurately evaluate and rationally utilize water resources.Scientifically quantifying the interaction of surface water and groundwater remains challenging.Taking Chan River Basin as an example,this study aimed to determine the interconversion processes of groundwater and surface water by hydrogeochemical genesis mechanism analysis,isotope tracing,and end-member mixing analysis(EMMA).28 surface water samples and 23 groundwater samples were collected and analyzed during December 2023 and January 2024.Results showed thewater bodies in the study area were dominated by the HCO_(3)-Ca,HCO_(3)-Ca·Mg·Na,and HCO_(3)·SO_(4)-Ca·Na types,with hydrogeochemical processes controlled by the weathering and dissolution of both carbonate and silicate rock minerals.The river water in the upper reaches of the study area is mainly recharged by groundwater,with the average recharge ratio of 54.10%.Similarly,river water is still recharged by groundwater in the middle reaches,the average recharge ratio changes to 28.61%.In the downstream area,where Xi’an City located,due to the heavy exploitation of groundwater,the river water recharges to groundwater with an average recharge ratio of 85.23%,although in the immediate middle reaches,groundwater still replenishes surface waterwith a recharge rate of 75.00%.The results laid the bases for the reasonable utilization of water resources in the Chan River Basin and also served as a reference in other regions of the world.展开更多
The regulation of superconductivity in thin films can provide important information on low-dimensional superconducting properties,and also has important reference values for the application in superconducting devices....The regulation of superconductivity in thin films can provide important information on low-dimensional superconducting properties,and also has important reference values for the application in superconducting devices.Herein,we report the successful regulation of both the superconductivity and normal-state properties of Nb films in a wide range by the controllable introduction of interstitial oxygen atoms.The lattice parameter is enhanced for an extent as large as 4.4%,and the normal-state resistivityρ_(n)is tuned for more than 15 times.The slope of upper critical field near T_(c)shows a close correlation withρ_(n)in a wide range.Importantly,it is found that the suppression of T_(c)by disorder reveals a linear dependence withρ_(n)in the region with an unchanged crystalline quality,which can be understood based on the picture of three-dimensional ballistic motion.展开更多
Rapidly deactivation of Cu/SiO2 catalysts at high liquid hour space velocity(LHSV) has been an important obstacle for scale-up application.Herein,silver modified copper phyllosilicate nanotubes were fabricated by diff...Rapidly deactivation of Cu/SiO2 catalysts at high liquid hour space velocity(LHSV) has been an important obstacle for scale-up application.Herein,silver modified copper phyllosilicate nanotubes were fabricated by different strategies,and implemented to the selective hydrogenation of ethylene carbonate(EC) to methanol and ethylene glycol(EG) as alternative route for the indirect utilization of CO2.The CuPs Ag-copre catalyst synthesized by the co-ammonia evaporation hydrothermal process achieved79% methanol and 99% EG yield within various ranges of EC LHSV,which was attributed to the balanced Cu+/CuO ratio and the enhanced H2 dissociation ability.Inlaid silver species over copper phyllosilicate promoted the interaction between the metal and the support,which substantially regulated the reducibility and dispersion of copper species,meanwhile,increased the stability for long-term running of the catalyst.展开更多
Additive manufacturing(AM)has the advantages of rapid prototyping,high design freedom,and flexible manufacturing,while the mechanical properties of additively manufactured products are not uniform due to inherent defe...Additive manufacturing(AM)has the advantages of rapid prototyping,high design freedom,and flexible manufacturing,while the mechanical properties of additively manufactured products are not uniform due to inherent defects and residual stresses.Integration of interlayer surface enhancement(SE)technologies into AM is a potential solution to improve the microstructure,close defects,residual stress state,mechanical properties,and chemical properties of formed materials.This paper reviews the current literature on hybrid AM process through the combination of SE and AM,and proves the possibility of integrating SE technologies into AM from the technical level.Then the improvement effects of SE processes on AM parts are introduced in terms of microstructure,defects,residual stress,mechanical properties,and chemical properties.Finally,considering the commonly used directed energy deposition(DED)process and ultrasonic impact treatment(UIT),a closed-loop quality control framework for integration of interlayer UIT into the DED process is proposed.Future research directions to the hybrid AM and interlayer SE are pointed out.展开更多
The viscosity of fracturing fluid and in-situ stress difference are the two important factors that affect the hydraulic fracturing pressure and propagation morphology. In this study, raw coal was used to prepare coal ...The viscosity of fracturing fluid and in-situ stress difference are the two important factors that affect the hydraulic fracturing pressure and propagation morphology. In this study, raw coal was used to prepare coal samples for experiments, and clean fracturing fluid samples were prepared using CTAB surfactant. A series of hydraulic fracturing tests were conducted with an in-house developed triaxial hydraulic fracturing simulator and the fracturing process was monitored with an acoustic emission instrument to analyze the influences of fracturing fluid viscosity and horizontal in-situ stress difference on coal fracture propagation. The results show that the number of branched fractures decreased, the fracture pattern became simpler, the fractures width increased obviously, and the distribution of AE event points was concentrated with the increase of the fracturing fluid viscosity or the horizontal in-situ stress difference. The acoustic emission energy decreases with the increase of fracturing fluid viscosity and increases with the increase of horizontal in situ stress difference. The low viscosity clean fracturing fluid has strong elasticity and is easy to be compressed into the tip of fractures, resulting in complex fractures. The high viscosity clean fracturing fluids are the opposite. Our experimental results provide a reference and scientific basis for the design and optimization of field hydraulic fracturing parameters.展开更多
Ultrasonic surface rolling process(USRP)is one of the effective mechanical surface enhancement techniques.During the USRP,unstable static force will easily do harm to the surface quality.In order to achieve a higher s...Ultrasonic surface rolling process(USRP)is one of the effective mechanical surface enhancement techniques.During the USRP,unstable static force will easily do harm to the surface quality.In order to achieve a higher surface quality on the part with a curved surface,an active and passive compliant USRP system has been developed.The compliant USRP tool can produce the natural obedience deformation along the part surface.Force control based on the fuzzy Proportional-integral-derivative(PID)method is then designed to maintain the static force during the USRP.Experiments have been performed on a real aero-engine blade with curved surface.It is proved that the deigned active and passive compliant USRP system can significantly reduce the force variation from 42.2 N to 4.2 N,and achieve a uniform surface quality after processing.展开更多
The newly discovered early Paleozoic Delenuoer ophiolite,in the western margin of the Central Qilian Shan,is composed of serpentinized peridotite,cumulate gabbro,diabase,massive basalt,and pillow basalt.This study pre...The newly discovered early Paleozoic Delenuoer ophiolite,in the western margin of the Central Qilian Shan,is composed of serpentinized peridotite,cumulate gabbro,diabase,massive basalt,and pillow basalt.This study presents geochronological and geochemical data for the cumulate gabbro and basalt.LA-ICP-MS U-Pb dating of zircons from the cumulate gabbro yielded a magmatic crystallization age of 472±4 Ma.The basalts have normal mid-ocean ridge basalt(N-MORB)compositions and a narrow range ofεNd(t)values(+4.5 to+5.3),which indicates they were derived from a depleted mantle source.On the basis of regional geological constraints,it is proposed that the Delenuoer ophiolite is a westward extension of the South Ophiolite Belt(Yushigou-Youhulugou-Donggou-Dongcaohe Ophiolite Belt)in the North Qilian Shan.The Delenuoer ophiolite,along with the Gulangxia-Delenuoer fault,defines the westernmost part of the tectonic boundary between the North and Central Qilian Shan.This ophiolite may have formed during southward subduction of the Qilian Ocean slab during the early Paleozoic.展开更多
The tobacco Ralstonia Solanacearum were both cultured on nutrient agar plates and inoculated in seedling stage of tobacco, then treated with K1 and K2, two anti-bacterial agents, at a serial con-centrations to study t...The tobacco Ralstonia Solanacearum were both cultured on nutrient agar plates and inoculated in seedling stage of tobacco, then treated with K1 and K2, two anti-bacterial agents, at a serial con-centrations to study their inhibitory efficiency. The result indicated that K1 can inhibit R. Solanacearum growth entirely, at the concentration range from 1/50 to 1/5000. K2 can reach the same result at the concentration range from 1/50 to 1/50000. Compared with the control plates, K1, at the concentration 1/50000, had no significant differences, and the average number of colony per plate was 112-115. The immature tobacco shown wilt as soon as inoculated with R. Solanacearum, and recovered gradually after using K1, K2. The densities of microbial suspension, handled by K1, K2 within 10 hs, were both significantly lower than the controlled ones. The optical microscopy also shown that handled microbial body differed from the controlled, whose body was regular short, rod shape as opposed to the handled ones with irregular rod shape and damaged body. All the results indicated that K1 and K2 both had inhibitory effects on tobacco R. Solanacearum, and K2 was more efficient than K1.展开更多
Drastic surges in intracellular reactive oxygen species(ROS)induce cell apoptosis,while most chemotherapy drugs lead to the accumulation of ROS.Here,we constructed an organic compound,arsenical N-(4-(1,3,2-dithiarsina...Drastic surges in intracellular reactive oxygen species(ROS)induce cell apoptosis,while most chemotherapy drugs lead to the accumulation of ROS.Here,we constructed an organic compound,arsenical N-(4-(1,3,2-dithiarsinan-2-yl)phenyl)acrylamide(AAZ2),which could prompt the ROS to trigger mitochondrial-dependent apoptosis in gastric cancer(GC).Mechanistically,by targeting pyruvate dehydrogenase kinase 1(PDK1),AAZ2 caused metabolism alteration and the imbalance of redox homeostasis,followed by the inhibition of phosphoinositide-3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)pathway and leading to the activation of B-cell lymphoma 2(Bcl2)/Bcl2-associated X(Bax)/caspase-9(Cas9)/Cas3 cascades.Importantly,our in vivo data demonstrated that AAZ2 could inhibit the growth of GC xenograft.Overall,our data suggested that AAZ2 could contribute to metabolic abnormalities,leading to mitochondrial-dependent apoptosis by targeting PDK1 in GC.展开更多
We report an in-depth investigation on the out-of-plane lower critical field Hc1 of the KCa2(Fe1-xCox)4As4F2(12442-type,x=0,0.1).The multi-gap feature is revealed by the kink in the temperature-dependent Hc1(T)curve f...We report an in-depth investigation on the out-of-plane lower critical field Hc1 of the KCa2(Fe1-xCox)4As4F2(12442-type,x=0,0.1).The multi-gap feature is revealed by the kink in the temperature-dependent Hc1(T)curve for the two samples with different doping levels.Based on a simplified two-gap model,the magnitudes of the two gaps are determined to beΔ1=1.2 meV andΔ2=5.0 meV for the sample with x=0,Δ1=0.86 meV andΔ2=2.8 meV for that with x=0.1.With the cobalt doping,the ratio of energy gap to critical transition temperature(Δ/kBTc)remains almost unchanged for the smaller gap and is suppressed by 20%for the larger gap.For the undoped KCa2Fe4As4F2,the obtained gap sizes are generally consistent with the results of angle-resolved photoemission spectroscopy experiments.展开更多
With the rising popularity of the Internet and the development of big data technology,an increasing number of organizations are opting to cooperate across domains to maximize their benefits.Most organizations use publ...With the rising popularity of the Internet and the development of big data technology,an increasing number of organizations are opting to cooperate across domains to maximize their benefits.Most organizations use public key infrastructure to ensure security in accessing their data and applications.However,with the continuous development of identity-based encryption(IBE)technology,small-and medium-sized enterprises are increasingly using IBE to deploy internal authentication systems.To solve the problems that arise when crossing heterogeneous authentication domains and to guarantee the security of the certification process,we propose using blockchain technology to establish a reliable cross-domain authentication scheme.Using the distributed and tamper-resistant characteristics of the blockchain,we design a cross-domain authentication model based on blockchain to guarantee the security of the heterogeneous authentication process and present a cross-domain authentication protocol based on blockchain.This model does not change the internal trust structure of each authentication domain and is highly scalable.Furthermore,on the premise of ensuring security,the process of verifying the signature of the root certificate in the traditional cross-domain authentication protocol is improved to verify the hash value of the root certificate,thereby improving the authentication efficiency.The developed prototype exhibits generality and simplicity compared to previous methods.展开更多
Cell migration proceeds in 3D matrices in vivo,which can naturally switch to distinct phenotypes for bet-ter invasion in confined microenvironments.The studies of important metabolites under confinement are extremely ...Cell migration proceeds in 3D matrices in vivo,which can naturally switch to distinct phenotypes for bet-ter invasion in confined microenvironments.The studies of important metabolites under confinement are extremely meaningful for comprehensive insights into cancer metastasis.The integration of cell confine-ment device and analytical techniques is a key point for in-situ analysis of significant metabolites in vitro.Herein,an electrochemiluminescence(ECL)sensing platform was designed for in-situ monitoring of cell-secreted lactate in highly confined microenvironments.The 3-μm confiner was exactly fabricated via mi-crofabrication and microfluidics technique,and cells in high confinement and low adhesion tended to be round with contractile blebs on cell margins.Significantly,in-situ monitoring of lactate was successfully achieved on the ECL platform with the catalysis of lactate oxidase,in which the levels in different time intervals were acquired in the luminol-hydrogen peroxide system.Furthermore,the results were verified by the liquid chromatography-tandem mass spectrometry(LC-MS/MS)technology,which showed similar fluctuations with the ECL platform.This system offered an available avenue for metabolites analysis in highly confined microenvironments,which may advance deeper insights into metabolic mechanisms of cancer metastasis.展开更多
Objective:The study aimed to assess medication management compliance and mental health in elderly patients with hypertension.Method:The study evaluated medication compliance and mental health status of elderly hyperte...Objective:The study aimed to assess medication management compliance and mental health in elderly patients with hypertension.Method:The study evaluated medication compliance and mental health status of elderly hypertensive patients in China using simple random sampling.Data was collected using the Morisky Medication Compliance Questionnaire,Hospital Anxiety and Depression Scale,and a checklist.Ethical practices were strictly observed.Results:A study of 100 elderly hypertensive patients found poor drug management compliance,with female patients showing worse compliance.Female patients were more vulnerable to anxiety and depression.The study also found no significant association between gender,age,education level,marital status,living standards,and medication compliance.Barriers to medication management included food and daily necessities,lack of awareness about the importance of drug treatment,and basic family needs.The lowest-ranked barriers were lack of support from government health clinics,low income,and lack of family support.Conclusion:Based on the results,the study proposes an educational plan for elderly hypertensive patients and their families,to be evaluated and implemented by the hospital and township community service center.The plan aims to improve medication management and lifestyle modification compliance,encourage active participation,and provide access to medical and mental health clinics,support groups,and counseling services.展开更多
We regret to inform that a calibration error has led to an incorrect statement in the last sentence of the Methods section of the abstract.Additionally,due to Zikai Zhao's increased guidance during the article'...We regret to inform that a calibration error has led to an incorrect statement in the last sentence of the Methods section of the abstract.Additionally,due to Zikai Zhao's increased guidance during the article's revision stage,we have modified the order of the corresponding authors.The corrected sentence and updated author list are provided below.We sincerely apologize for this oversight and appreciate your understanding.展开更多
Lenvatinib is widely used as a first-line chemotherapy for advanced hepatocellular carcinoma(HCC),a highly metastatic and recurrent cancer.However,HCC cells often develop resistance to lenvatinib,thus reducing its eff...Lenvatinib is widely used as a first-line chemotherapy for advanced hepatocellular carcinoma(HCC),a highly metastatic and recurrent cancer.However,HCC cells often develop resistance to lenvatinib,thus reducing its efficacy.This study aims to investigate the impact of STARD4,a crucial cholesterol transporter,on HCC growth and lenvatinib resistance,as well as explore the involvement of the EGFR/PI3K/AKT signaling pathway in STARD4's role.Analysis of clinical samples from HCC patients revealed increased expression of both STARD4 and EGFR in tumor tissues,with a strong correlation between STARD4 expression and malignancy progression.In vitro and in vivo studies demonstrated that STARD4 promoted HCC growth and hindered lenvatinib's anti-tumor effect,while STARD4 down-regulation exerted opposite effects.Further investigation revealed that depletion of STARD4 increased cholesterol accumulation in the plasma membrane,resulting in reduced EGFR phosphorylation.Moreover,cholesterol depletion attenuated these effects,suggesting STARD4 activates EGFR/PI3K/AKT signaling in a cholesterol-dependent manner.To elucidate the underlying mechanism of lenvatinib resistance,we established the lenvatinib-resistant HCC cell lines and found increased stimulation of both STARD4 and EGFR signaling.Furthermore,the EGFR inhibitor erlotinib suppressed the promotion of HCC progression by STARD4,reinforcing its role in activating the EGFR/PI3K/AKT pathway.In conclusion,this study demonstrates that STARD4 enhances HCC growth and lenvatinib resistance by regulating cholesterol homeostasis and activating the EGFR/PI3K/AKT pathway.These findings suggest STARD4 as a potential molecular biomarker for predicting lenvatinib resistance and as a therapeutic target in HCC treatment.展开更多
This paper proposes a reactive power and voltage optimal control method for wind farms based on data-driven power flow.Because no prior knowledge of wind farm parameters is necessary,the proposed method is model-free....This paper proposes a reactive power and voltage optimal control method for wind farms based on data-driven power flow.Because no prior knowledge of wind farm parameters is necessary,the proposed method is model-free.Based on Koopman operator-based method,this paper constructs a power flow model of wind farms connected to the grid by using state space mapping and lift-dimension linearization.Considering reactive power devices such as wind turbines and static var generator(SVG)in wind farms,a global sensitivity-based reactive power and voltage linear optimization control model is proposed.Taking minimum reactive power adjustment of wind turbines and SVG as the objective function,combined with the sensitivity relationship between node voltage and reactive power injection,the proposed model-free voltage control method can realize optimal reactive power distribution,effectively reduce active power loss,and satisfy the requirement of rapid voltage control response of wind farms.Based on historical data of a wind farm in Ningxia,feasibility of the proposed voltage optimal control method under inaccurate parameters is verified.Compared with model-based methods,the proposed method exhibits advantages on parameter dependency and efficiency.展开更多
Ficus carica L.,an ancient crop of considerable economic value,exhibits distinctive biological traits,including flowerless fruit(syconium)development,psoralen biosynthesis,and drought tolerance.In this study,we pre-se...Ficus carica L.,an ancient crop of considerable economic value,exhibits distinctive biological traits,including flowerless fruit(syconium)development,psoralen biosynthesis,and drought tolerance.In this study,we pre-sent a chromosome-levelgenome assembly(323.03 Mb,N50=23.82 Mb)of F.carica,revealing an evolutionary divergence from the closely related genus Broussonetia approximately 50 million years ago.Comparative genomic analyses revealed a contraction in the s-domain receptor-like kinase gene family,which is associ-ated with unisexual fruit formation,and identified conserved MADS-box transcription factor genes(FcAGL6,FcAP2,and FcSEP1/2)that regulate syconium development through spatiotemporal expression patterns.Me-tabolomic profiling demonstrated tissue-specific accumulation of bioactive compounds,with roots serving as the primary reservoir for psoralen.We also identified key genes-FcANS and FcCHS10,involved in antho-cyanin biosynthesis,andFcMS,involved in psoralen biosynthesis-and validated their functions using a newly established transient transformation system.Transcriptomic analysis under drought stress identified the NAC transcription factor FcJA2 as a central regulator of stress tolerance that enhances reactive oxygen spe-cies scavenging and osmotic regulation by activating FcPP2C5 and FcP5CS.Overexpression of FcJA2 signif-icantly improved drought resistance.Further analyses demonstrated that FcJA2-mediated drought-response modules are conserved across the Moraceae.These findings provide valuable insights into the genetic mech-anisms underlying fruit development,specialized metabolite biosynthesis,and stress tolerance in F.carica,offering potential applications for crop improvement and advancing our understanding of genome evolution and environmental adaptability in the Moraceae family.展开更多
基金supported by the National Natural Science Foundation of China(Nos.42341102 and 42102288)the Forestry Science and Technology Innovation Project of Shaanxi Province(No.SXLK2023–02–1)+1 种基金the Fundamental Research Funds for the Central Universities,China(No.300102263401)the Fundamental Research Funds for the Central Universities,China(No.300102294905).
文摘Rivers and groundwater are the main water sources for cities.The mutual transformation between river water and groundwater makes it difficult to accurately evaluate and rationally utilize water resources.Scientifically quantifying the interaction of surface water and groundwater remains challenging.Taking Chan River Basin as an example,this study aimed to determine the interconversion processes of groundwater and surface water by hydrogeochemical genesis mechanism analysis,isotope tracing,and end-member mixing analysis(EMMA).28 surface water samples and 23 groundwater samples were collected and analyzed during December 2023 and January 2024.Results showed thewater bodies in the study area were dominated by the HCO_(3)-Ca,HCO_(3)-Ca·Mg·Na,and HCO_(3)·SO_(4)-Ca·Na types,with hydrogeochemical processes controlled by the weathering and dissolution of both carbonate and silicate rock minerals.The river water in the upper reaches of the study area is mainly recharged by groundwater,with the average recharge ratio of 54.10%.Similarly,river water is still recharged by groundwater in the middle reaches,the average recharge ratio changes to 28.61%.In the downstream area,where Xi’an City located,due to the heavy exploitation of groundwater,the river water recharges to groundwater with an average recharge ratio of 85.23%,although in the immediate middle reaches,groundwater still replenishes surface waterwith a recharge rate of 75.00%.The results laid the bases for the reasonable utilization of water resources in the Chan River Basin and also served as a reference in other regions of the world.
基金Project supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB0670000)the National Key Research and Development Program of China(Grant No.2023YFB4404904)+1 种基金the Key-Area Research and Development Program of Guangdong Province,China(Grant No.2020B0303030002)the Autonomous Deployment Project of State Key Laboratory of Materials for Integrated Circuits(Grant No.SKLJC-Z2024-B04).
文摘The regulation of superconductivity in thin films can provide important information on low-dimensional superconducting properties,and also has important reference values for the application in superconducting devices.Herein,we report the successful regulation of both the superconductivity and normal-state properties of Nb films in a wide range by the controllable introduction of interstitial oxygen atoms.The lattice parameter is enhanced for an extent as large as 4.4%,and the normal-state resistivityρ_(n)is tuned for more than 15 times.The slope of upper critical field near T_(c)shows a close correlation withρ_(n)in a wide range.Importantly,it is found that the suppression of T_(c)by disorder reveals a linear dependence withρ_(n)in the region with an unchanged crystalline quality,which can be understood based on the picture of three-dimensional ballistic motion.
基金financially supported by the Natural Science Foundation of Shanghai(19ZR1403500)National Natural Science Foundation of China(No.21373054)the Natural Science Foundation of Shanghai Science and Technology Committee(No.08DZ2270500)。
文摘Rapidly deactivation of Cu/SiO2 catalysts at high liquid hour space velocity(LHSV) has been an important obstacle for scale-up application.Herein,silver modified copper phyllosilicate nanotubes were fabricated by different strategies,and implemented to the selective hydrogenation of ethylene carbonate(EC) to methanol and ethylene glycol(EG) as alternative route for the indirect utilization of CO2.The CuPs Ag-copre catalyst synthesized by the co-ammonia evaporation hydrothermal process achieved79% methanol and 99% EG yield within various ranges of EC LHSV,which was attributed to the balanced Cu+/CuO ratio and the enhanced H2 dissociation ability.Inlaid silver species over copper phyllosilicate promoted the interaction between the metal and the support,which substantially regulated the reducibility and dispersion of copper species,meanwhile,increased the stability for long-term running of the catalyst.
基金the National Key Research and Development Project(No.2022YFB4600019)the National Natural Science Foundation of China(No.51805085).
文摘Additive manufacturing(AM)has the advantages of rapid prototyping,high design freedom,and flexible manufacturing,while the mechanical properties of additively manufactured products are not uniform due to inherent defects and residual stresses.Integration of interlayer surface enhancement(SE)technologies into AM is a potential solution to improve the microstructure,close defects,residual stress state,mechanical properties,and chemical properties of formed materials.This paper reviews the current literature on hybrid AM process through the combination of SE and AM,and proves the possibility of integrating SE technologies into AM from the technical level.Then the improvement effects of SE processes on AM parts are introduced in terms of microstructure,defects,residual stress,mechanical properties,and chemical properties.Finally,considering the commonly used directed energy deposition(DED)process and ultrasonic impact treatment(UIT),a closed-loop quality control framework for integration of interlayer UIT into the DED process is proposed.Future research directions to the hybrid AM and interlayer SE are pointed out.
基金National Natural Science Foundation of China (51974176, 52174194, 51934004)Shandong Provincial Colleges and Universities Youth Innovation and Technology Support Program (2019KJH006)+1 种基金Taishan Scholars Project (TS20190935)Shandong outstanding youth fund (ZR2020JQ22).
文摘The viscosity of fracturing fluid and in-situ stress difference are the two important factors that affect the hydraulic fracturing pressure and propagation morphology. In this study, raw coal was used to prepare coal samples for experiments, and clean fracturing fluid samples were prepared using CTAB surfactant. A series of hydraulic fracturing tests were conducted with an in-house developed triaxial hydraulic fracturing simulator and the fracturing process was monitored with an acoustic emission instrument to analyze the influences of fracturing fluid viscosity and horizontal in-situ stress difference on coal fracture propagation. The results show that the number of branched fractures decreased, the fracture pattern became simpler, the fractures width increased obviously, and the distribution of AE event points was concentrated with the increase of the fracturing fluid viscosity or the horizontal in-situ stress difference. The acoustic emission energy decreases with the increase of fracturing fluid viscosity and increases with the increase of horizontal in situ stress difference. The low viscosity clean fracturing fluid has strong elasticity and is easy to be compressed into the tip of fractures, resulting in complex fractures. The high viscosity clean fracturing fluids are the opposite. Our experimental results provide a reference and scientific basis for the design and optimization of field hydraulic fracturing parameters.
基金sponsored by the National Natural Science Foundation of China(No.51725503,No.51975214)Innovation Program of Shanghai Municipal Education Commission(2019-01-07-00-02-E00068)+2 种基金support by Shanghai Technology Innovation Program of SHEITC(CXY-2015-001)Fok Ying Tung Education FoundationYoung Program of Yangtze River Scholars。
文摘Ultrasonic surface rolling process(USRP)is one of the effective mechanical surface enhancement techniques.During the USRP,unstable static force will easily do harm to the surface quality.In order to achieve a higher surface quality on the part with a curved surface,an active and passive compliant USRP system has been developed.The compliant USRP tool can produce the natural obedience deformation along the part surface.Force control based on the fuzzy Proportional-integral-derivative(PID)method is then designed to maintain the static force during the USRP.Experiments have been performed on a real aero-engine blade with curved surface.It is proved that the deigned active and passive compliant USRP system can significantly reduce the force variation from 42.2 N to 4.2 N,and achieve a uniform surface quality after processing.
基金funded by the Science and Technology Major Project of Gansu Province(No.1002FKDA04)the Fundamental Research Funds for the Central Universities,China(Lzujbky2016-197,Lzujbky2018it20)the National Nature Science Foundation of China(No.41702044)。
文摘The newly discovered early Paleozoic Delenuoer ophiolite,in the western margin of the Central Qilian Shan,is composed of serpentinized peridotite,cumulate gabbro,diabase,massive basalt,and pillow basalt.This study presents geochronological and geochemical data for the cumulate gabbro and basalt.LA-ICP-MS U-Pb dating of zircons from the cumulate gabbro yielded a magmatic crystallization age of 472±4 Ma.The basalts have normal mid-ocean ridge basalt(N-MORB)compositions and a narrow range ofεNd(t)values(+4.5 to+5.3),which indicates they were derived from a depleted mantle source.On the basis of regional geological constraints,it is proposed that the Delenuoer ophiolite is a westward extension of the South Ophiolite Belt(Yushigou-Youhulugou-Donggou-Dongcaohe Ophiolite Belt)in the North Qilian Shan.The Delenuoer ophiolite,along with the Gulangxia-Delenuoer fault,defines the westernmost part of the tectonic boundary between the North and Central Qilian Shan.This ophiolite may have formed during southward subduction of the Qilian Ocean slab during the early Paleozoic.
文摘The tobacco Ralstonia Solanacearum were both cultured on nutrient agar plates and inoculated in seedling stage of tobacco, then treated with K1 and K2, two anti-bacterial agents, at a serial con-centrations to study their inhibitory efficiency. The result indicated that K1 can inhibit R. Solanacearum growth entirely, at the concentration range from 1/50 to 1/5000. K2 can reach the same result at the concentration range from 1/50 to 1/50000. Compared with the control plates, K1, at the concentration 1/50000, had no significant differences, and the average number of colony per plate was 112-115. The immature tobacco shown wilt as soon as inoculated with R. Solanacearum, and recovered gradually after using K1, K2. The densities of microbial suspension, handled by K1, K2 within 10 hs, were both significantly lower than the controlled ones. The optical microscopy also shown that handled microbial body differed from the controlled, whose body was regular short, rod shape as opposed to the handled ones with irregular rod shape and damaged body. All the results indicated that K1 and K2 both had inhibitory effects on tobacco R. Solanacearum, and K2 was more efficient than K1.
基金supported by the Wuhan University Zhongnan Hospital Translational Medicine and Interdisciplinary Research Joint Fund(No.ZNJC201910),China.
文摘Drastic surges in intracellular reactive oxygen species(ROS)induce cell apoptosis,while most chemotherapy drugs lead to the accumulation of ROS.Here,we constructed an organic compound,arsenical N-(4-(1,3,2-dithiarsinan-2-yl)phenyl)acrylamide(AAZ2),which could prompt the ROS to trigger mitochondrial-dependent apoptosis in gastric cancer(GC).Mechanistically,by targeting pyruvate dehydrogenase kinase 1(PDK1),AAZ2 caused metabolism alteration and the imbalance of redox homeostasis,followed by the inhibition of phosphoinositide-3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)pathway and leading to the activation of B-cell lymphoma 2(Bcl2)/Bcl2-associated X(Bax)/caspase-9(Cas9)/Cas3 cascades.Importantly,our in vivo data demonstrated that AAZ2 could inhibit the growth of GC xenograft.Overall,our data suggested that AAZ2 could contribute to metabolic abnormalities,leading to mitochondrial-dependent apoptosis by targeting PDK1 in GC.
基金the Youth Innovation Promotion Association of the Chinese Academy of Sciences(Grant No.2015187)the“Strategic Priority Research Program(B)”of the Chinese Academy of Sciences(Grant No.XDB30000000)the National Natural Science Foundation of China(Grant Nos.11704395 and 11204338)。
文摘We report an in-depth investigation on the out-of-plane lower critical field Hc1 of the KCa2(Fe1-xCox)4As4F2(12442-type,x=0,0.1).The multi-gap feature is revealed by the kink in the temperature-dependent Hc1(T)curve for the two samples with different doping levels.Based on a simplified two-gap model,the magnitudes of the two gaps are determined to beΔ1=1.2 meV andΔ2=5.0 meV for the sample with x=0,Δ1=0.86 meV andΔ2=2.8 meV for that with x=0.1.With the cobalt doping,the ratio of energy gap to critical transition temperature(Δ/kBTc)remains almost unchanged for the smaller gap and is suppressed by 20%for the larger gap.For the undoped KCa2Fe4As4F2,the obtained gap sizes are generally consistent with the results of angle-resolved photoemission spectroscopy experiments.
基金This work was supported in part by Beijing Municipal Natural Science Foundation(19L2020)Foundation of Science and Technology on Information Assurance Laboratory(614211204031117)Industrial Internet Innovation and Development Project(Typical Application and Promotion Project of the Security Technology for the Electronics Industry)of the Ministry of Industry and Information Technology of China in 2018,Foundation of Shanxi Key Laboratory of Network and System Security(NSSOF1900105).
文摘With the rising popularity of the Internet and the development of big data technology,an increasing number of organizations are opting to cooperate across domains to maximize their benefits.Most organizations use public key infrastructure to ensure security in accessing their data and applications.However,with the continuous development of identity-based encryption(IBE)technology,small-and medium-sized enterprises are increasingly using IBE to deploy internal authentication systems.To solve the problems that arise when crossing heterogeneous authentication domains and to guarantee the security of the certification process,we propose using blockchain technology to establish a reliable cross-domain authentication scheme.Using the distributed and tamper-resistant characteristics of the blockchain,we design a cross-domain authentication model based on blockchain to guarantee the security of the heterogeneous authentication process and present a cross-domain authentication protocol based on blockchain.This model does not change the internal trust structure of each authentication domain and is highly scalable.Furthermore,on the premise of ensuring security,the process of verifying the signature of the root certificate in the traditional cross-domain authentication protocol is improved to verify the hash value of the root certificate,thereby improving the authentication efficiency.The developed prototype exhibits generality and simplicity compared to previous methods.
基金supported by the National Natural Science Foundation of China(Nos.21934001 and 31870978)the Natu-ral Science Foundation of Zhejiang Province(No.LQ20B050002).
文摘Cell migration proceeds in 3D matrices in vivo,which can naturally switch to distinct phenotypes for bet-ter invasion in confined microenvironments.The studies of important metabolites under confinement are extremely meaningful for comprehensive insights into cancer metastasis.The integration of cell confine-ment device and analytical techniques is a key point for in-situ analysis of significant metabolites in vitro.Herein,an electrochemiluminescence(ECL)sensing platform was designed for in-situ monitoring of cell-secreted lactate in highly confined microenvironments.The 3-μm confiner was exactly fabricated via mi-crofabrication and microfluidics technique,and cells in high confinement and low adhesion tended to be round with contractile blebs on cell margins.Significantly,in-situ monitoring of lactate was successfully achieved on the ECL platform with the catalysis of lactate oxidase,in which the levels in different time intervals were acquired in the luminol-hydrogen peroxide system.Furthermore,the results were verified by the liquid chromatography-tandem mass spectrometry(LC-MS/MS)technology,which showed similar fluctuations with the ECL platform.This system offered an available avenue for metabolites analysis in highly confined microenvironments,which may advance deeper insights into metabolic mechanisms of cancer metastasis.
文摘Objective:The study aimed to assess medication management compliance and mental health in elderly patients with hypertension.Method:The study evaluated medication compliance and mental health status of elderly hypertensive patients in China using simple random sampling.Data was collected using the Morisky Medication Compliance Questionnaire,Hospital Anxiety and Depression Scale,and a checklist.Ethical practices were strictly observed.Results:A study of 100 elderly hypertensive patients found poor drug management compliance,with female patients showing worse compliance.Female patients were more vulnerable to anxiety and depression.The study also found no significant association between gender,age,education level,marital status,living standards,and medication compliance.Barriers to medication management included food and daily necessities,lack of awareness about the importance of drug treatment,and basic family needs.The lowest-ranked barriers were lack of support from government health clinics,low income,and lack of family support.Conclusion:Based on the results,the study proposes an educational plan for elderly hypertensive patients and their families,to be evaluated and implemented by the hospital and township community service center.The plan aims to improve medication management and lifestyle modification compliance,encourage active participation,and provide access to medical and mental health clinics,support groups,and counseling services.
文摘We regret to inform that a calibration error has led to an incorrect statement in the last sentence of the Methods section of the abstract.Additionally,due to Zikai Zhao's increased guidance during the article's revision stage,we have modified the order of the corresponding authors.The corrected sentence and updated author list are provided below.We sincerely apologize for this oversight and appreciate your understanding.
基金supported by the Guangdong Basic and Applied Basic Research Foundation of China(No.2023A1515012595,2024A1515012743)Nanfang Hospital Dean's Fund(No.2022A010)+1 种基金Wu Jieping Medical Foundation(No.320.6750.2023-06-18)Hospital Pharmacy Research Foundation of the Guangdong Liver Disease Association of China(No.2023gdsgzbzd01).
文摘Lenvatinib is widely used as a first-line chemotherapy for advanced hepatocellular carcinoma(HCC),a highly metastatic and recurrent cancer.However,HCC cells often develop resistance to lenvatinib,thus reducing its efficacy.This study aims to investigate the impact of STARD4,a crucial cholesterol transporter,on HCC growth and lenvatinib resistance,as well as explore the involvement of the EGFR/PI3K/AKT signaling pathway in STARD4's role.Analysis of clinical samples from HCC patients revealed increased expression of both STARD4 and EGFR in tumor tissues,with a strong correlation between STARD4 expression and malignancy progression.In vitro and in vivo studies demonstrated that STARD4 promoted HCC growth and hindered lenvatinib's anti-tumor effect,while STARD4 down-regulation exerted opposite effects.Further investigation revealed that depletion of STARD4 increased cholesterol accumulation in the plasma membrane,resulting in reduced EGFR phosphorylation.Moreover,cholesterol depletion attenuated these effects,suggesting STARD4 activates EGFR/PI3K/AKT signaling in a cholesterol-dependent manner.To elucidate the underlying mechanism of lenvatinib resistance,we established the lenvatinib-resistant HCC cell lines and found increased stimulation of both STARD4 and EGFR signaling.Furthermore,the EGFR inhibitor erlotinib suppressed the promotion of HCC progression by STARD4,reinforcing its role in activating the EGFR/PI3K/AKT pathway.In conclusion,this study demonstrates that STARD4 enhances HCC growth and lenvatinib resistance by regulating cholesterol homeostasis and activating the EGFR/PI3K/AKT pathway.These findings suggest STARD4 as a potential molecular biomarker for predicting lenvatinib resistance and as a therapeutic target in HCC treatment.
基金supported by the State Key Laboratory of Power System and Generation Equipment(SKLD21KM03)National Natural Science Foundation of China(52007129).
文摘This paper proposes a reactive power and voltage optimal control method for wind farms based on data-driven power flow.Because no prior knowledge of wind farm parameters is necessary,the proposed method is model-free.Based on Koopman operator-based method,this paper constructs a power flow model of wind farms connected to the grid by using state space mapping and lift-dimension linearization.Considering reactive power devices such as wind turbines and static var generator(SVG)in wind farms,a global sensitivity-based reactive power and voltage linear optimization control model is proposed.Taking minimum reactive power adjustment of wind turbines and SVG as the objective function,combined with the sensitivity relationship between node voltage and reactive power injection,the proposed model-free voltage control method can realize optimal reactive power distribution,effectively reduce active power loss,and satisfy the requirement of rapid voltage control response of wind farms.Based on historical data of a wind farm in Ningxia,feasibility of the proposed voltage optimal control method under inaccurate parameters is verified.Compared with model-based methods,the proposed method exhibits advantages on parameter dependency and efficiency.
文摘Ficus carica L.,an ancient crop of considerable economic value,exhibits distinctive biological traits,including flowerless fruit(syconium)development,psoralen biosynthesis,and drought tolerance.In this study,we pre-sent a chromosome-levelgenome assembly(323.03 Mb,N50=23.82 Mb)of F.carica,revealing an evolutionary divergence from the closely related genus Broussonetia approximately 50 million years ago.Comparative genomic analyses revealed a contraction in the s-domain receptor-like kinase gene family,which is associ-ated with unisexual fruit formation,and identified conserved MADS-box transcription factor genes(FcAGL6,FcAP2,and FcSEP1/2)that regulate syconium development through spatiotemporal expression patterns.Me-tabolomic profiling demonstrated tissue-specific accumulation of bioactive compounds,with roots serving as the primary reservoir for psoralen.We also identified key genes-FcANS and FcCHS10,involved in antho-cyanin biosynthesis,andFcMS,involved in psoralen biosynthesis-and validated their functions using a newly established transient transformation system.Transcriptomic analysis under drought stress identified the NAC transcription factor FcJA2 as a central regulator of stress tolerance that enhances reactive oxygen spe-cies scavenging and osmotic regulation by activating FcPP2C5 and FcP5CS.Overexpression of FcJA2 signif-icantly improved drought resistance.Further analyses demonstrated that FcJA2-mediated drought-response modules are conserved across the Moraceae.These findings provide valuable insights into the genetic mech-anisms underlying fruit development,specialized metabolite biosynthesis,and stress tolerance in F.carica,offering potential applications for crop improvement and advancing our understanding of genome evolution and environmental adaptability in the Moraceae family.
