Objective: to investigate the efficacy of trimebutine combined with probiotics in the treatment of diarrhea type irritable bowel syndrome. Methods: from July 2020 to July 2021, 100 patients with IBS received in our ho...Objective: to investigate the efficacy of trimebutine combined with probiotics in the treatment of diarrhea type irritable bowel syndrome. Methods: from July 2020 to July 2021, 100 patients with IBS received in our hospital were randomly divided into experimental group and control group, and then differentiated treatment schemes were implemented according to the situation after grouping. After 4 weeks of treatment, the specific curative effects of the two groups were evaluated from various indicators. Results: the symptom scores of patients before and after treatment were counted and compared between groups. The results showed that there was no significant difference between the two groups in this regard before the start of treatment (P > 0.05), but after treatment, the symptom scores of the experimental group were significantly lower than those of the control group (P < 0.05);The clinical treatment effect of the two groups was observed. The treatment effective rate of the experimental group (94.00%) was significantly higher than that of the control group (72.00%), and the difference between the groups was statistically significant (P < 0.05);The incidence of adverse reactions in the experimental group was significantly lower than that in the control group (P < 0.05). Conclusion: in clinical practice, patients with diarrhea type irritable bowel syndrome can give priority to the treatment scheme of microecological agents combined with trimebutine. This scheme has high safety and reliable curative effect, and is worthy of promotion.展开更多
The design and synthesis of energetic materials with a compatibility of high energy and insensitivity have always been the research fronts in military and civilian fields.Considering excellent performances of porous o...The design and synthesis of energetic materials with a compatibility of high energy and insensitivity have always been the research fronts in military and civilian fields.Considering excellent performances of porous organic frameworks and the lack of research in the field of energetic materials,in this study,a new concept named energetic porous aromatic frameworks(EPAFs)is proposed.The strategy of coating high energy explosives such as 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane(CL-20)and 1,3,5,7-tetranitro-1,3,5,7-tetrazocane(HMX)in the EPAFs by wet-infiltration method has successfully realized the assembly of target energetic composite materials.The results show that the 75 wt.%CL-20@EPAF-1 possesses the safer impact sensitivity of 31.4 J than that of CL-20(4.0 J).Notably,for 75 wt.%CL-20@EPAF-1,in addition to the superior detonation performances of the detonation velocity(8,761 m·s^(-1))and detonation pressure(31.27 GPa),the synergistic effect of the nitrogen-rich EPAFs and the nitramines high energy explosives results in a higher heat of detonation that surpasses the most of pristine high explosives and reported novel energetic materials.In prospect,energetic porous aromatic frameworks could be a promising and inspiring strategy to build high energy insensitive energetic materials.展开更多
文摘Objective: to investigate the efficacy of trimebutine combined with probiotics in the treatment of diarrhea type irritable bowel syndrome. Methods: from July 2020 to July 2021, 100 patients with IBS received in our hospital were randomly divided into experimental group and control group, and then differentiated treatment schemes were implemented according to the situation after grouping. After 4 weeks of treatment, the specific curative effects of the two groups were evaluated from various indicators. Results: the symptom scores of patients before and after treatment were counted and compared between groups. The results showed that there was no significant difference between the two groups in this regard before the start of treatment (P > 0.05), but after treatment, the symptom scores of the experimental group were significantly lower than those of the control group (P < 0.05);The clinical treatment effect of the two groups was observed. The treatment effective rate of the experimental group (94.00%) was significantly higher than that of the control group (72.00%), and the difference between the groups was statistically significant (P < 0.05);The incidence of adverse reactions in the experimental group was significantly lower than that in the control group (P < 0.05). Conclusion: in clinical practice, patients with diarrhea type irritable bowel syndrome can give priority to the treatment scheme of microecological agents combined with trimebutine. This scheme has high safety and reliable curative effect, and is worthy of promotion.
基金supported by the Key Project of National Defense Basic Research Program of China(No.2019-JCJQ-ZD-139-00)the National Natural Science Foundation of China(No.22075040).
文摘The design and synthesis of energetic materials with a compatibility of high energy and insensitivity have always been the research fronts in military and civilian fields.Considering excellent performances of porous organic frameworks and the lack of research in the field of energetic materials,in this study,a new concept named energetic porous aromatic frameworks(EPAFs)is proposed.The strategy of coating high energy explosives such as 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane(CL-20)and 1,3,5,7-tetranitro-1,3,5,7-tetrazocane(HMX)in the EPAFs by wet-infiltration method has successfully realized the assembly of target energetic composite materials.The results show that the 75 wt.%CL-20@EPAF-1 possesses the safer impact sensitivity of 31.4 J than that of CL-20(4.0 J).Notably,for 75 wt.%CL-20@EPAF-1,in addition to the superior detonation performances of the detonation velocity(8,761 m·s^(-1))and detonation pressure(31.27 GPa),the synergistic effect of the nitrogen-rich EPAFs and the nitramines high energy explosives results in a higher heat of detonation that surpasses the most of pristine high explosives and reported novel energetic materials.In prospect,energetic porous aromatic frameworks could be a promising and inspiring strategy to build high energy insensitive energetic materials.
