背景:H型血管因其独特的功能为深入理解血管介导的骨代谢调控机制提供了新的视角和切入点。目的:探讨H型血管在不同骨骼疾病动物模型中的生成机制及对骨代谢的影响。方法:系统检索CNKI、维普、万方、PubMed、Scopus和Web of Science数...背景:H型血管因其独特的功能为深入理解血管介导的骨代谢调控机制提供了新的视角和切入点。目的:探讨H型血管在不同骨骼疾病动物模型中的生成机制及对骨代谢的影响。方法:系统检索CNKI、维普、万方、PubMed、Scopus和Web of Science数据库中2014年1月至2025年2月收录的H型血管相关中英文文献。剔除重复及不符合纳入标准的文献,对141篇涉及不同骨骼疾病动物模型中H型血管生成的文献进行系统分析。结果与结论:研究表明,H型血管在不同的骨骼疾病模型中表现出特定的生成机制和生物学功能。H型血管不仅在骨内血管生成中发挥重要作用,还与骨代谢密切相关,能够作为评估骨量水平的早期标志物。不同骨骼疾病动物模型中H型血管生成及作用不尽相同。在骨质疏松症、骨折、骨坏死等骨骼疾病中,通过促进H型血管表达,可显著改善血管重塑与骨再生能力;而在骨关节炎、骨肿瘤等恶性骨骼疾病中,选择性抑制H型血管表达则成为潜在的治疗干预策略。研究还揭示了多条关键信号通路在H型血管生成中的重要作用,如缺氧诱导因子1α/血管内皮生长因子、血小板源性生长因子BB、Wnt/β-catenin等,为理解血管介导的骨代谢调控机制提供了新的科学视角,同时为H型血管作为潜在治疗靶点的临床应用价值提供了重要理论基础。通过分析不同骨骼疾病动物模型中H型血管生成的作用,将为进一步深入探究人类骨关节疾病机制及治疗靶点提供重要依据。展开更多
目的:通过系统综述和Meta分析,评估专项运动者身体姿势异常及脊柱曲度紊乱与运动训练之间的关系,为专项运动者脊柱健康管理提供科学依据。方法:系统检索了CNKI、维普、万方、CBM、PubMed、Embase、Cochrane Library和Web of Science数...目的:通过系统综述和Meta分析,评估专项运动者身体姿势异常及脊柱曲度紊乱与运动训练之间的关系,为专项运动者脊柱健康管理提供科学依据。方法:系统检索了CNKI、维普、万方、CBM、PubMed、Embase、Cochrane Library和Web of Science数据库自2000年至今有关专项运动者脊柱健康与运动训练相关的中英文文献。3名独立研究者根据预先设定的纳入和排除标准,对文献进行筛选、数据提取和质量评估。采用Review Manager 5.4软件进行数据分析,评估脊柱侧弯发生率、胸椎后凸角度、腰椎前凸角度等结局指标的差异。结果:共纳入17篇文献,涵盖18项研究,总计48234名参与者。研究发现,专项运动者群体中脊柱侧弯发生率的比值比为3.52(95%CI:2.18-5.69)。专项运动者的胸椎后凸角度平均升高0.93°(95%CI:0.23-1.62),而腰椎前凸角度平均降低1.95°(95%CI:-2.71至-1.18);此外,躯干倾角平均增加1.57°(95%CI:0.96-2.17),躯干倾斜偏移距离增加10.64 mm(95%CI:3.21-18.06)。结论:长期专项训练运动者可能面临更高的脊柱疾病风险。应重视不同运动项目、训练方式和个体差异对脊柱健康的影响,制定针对性的预防和干预策略,以降低脊柱疾病的发生率,提高运动者的运动表现和生活质量。展开更多
Endothelial PAS domain protein 1（EPAS1）, also called hypoxia-inducible factor-2, is a key regulatory factor of hypoxic responses and plays an essential role in high-altitude adaptation in mammalian species. In this ...Endothelial PAS domain protein 1（EPAS1）, also called hypoxia-inducible factor-2, is a key regulatory factor of hypoxic responses and plays an essential role in high-altitude adaptation in mammalian species. In this study, polymorphisms of EPAS1 were detected in 217 individuals from 2 Tibetan pig populations and 3 low-altitude pig breeds by DNA pooling, PCR-SSCP, PCR-RFLP and DNA sequencing methods. A total of 14 synonymous polymorphisms were identified in the coding region. The analysis suggested that SNP1（G963A）, SNP7（C1632T）, SNP10（G1929A） and SNP11（G1947A） showed potential association with high-altitude environment because of their particular variation patterns in Tibetan pigs. Linkage disequilibrium（LD） of these SNPs was analyzed. One common LD block including 5 SNPs clustering in exon 12 was identified in all studied pig populations. Haplotype H1（AGGTC） in LD block was dominant in Tibetan pigs（76.6 and 74.2% in Linzhi（LZ） and Chayu（CY） pigs, respectively） and segregated at higher frequency than that in low-altitude pig breeds（52.3, 58.7 and 56.2% in Wuzhishan（WZS）, Min（M） and Laiwu（LW） pigs, respectively）, indicating that H1 may relate to adaptation to high altitude in Tibetan pigs. These findings raise hope that EPAS1 gene can be a candidate gene that involved in adaptation of high altitude in Tibetan pigs.展开更多
Taking No.3 alfalfa(Medicago sativa)as the material,the effects of selenium and cobalt elements on seed germination of alfalfa at different temperatures were studied through germination test.The results showed that se...Taking No.3 alfalfa(Medicago sativa)as the material,the effects of selenium and cobalt elements on seed germination of alfalfa at different temperatures were studied through germination test.The results showed that selenium and cobalt promoted seed germination of alfalfa,and improved germination potential,germination rate,germination index and vigor index.With the increasing proportion of selenium and cobalt,the numerical value of each index first increased then decreased.The seed germinations in A15 and B12 treatments were the best at 10℃ and 20℃,while those in A1 and B1 treatments were the worst.展开更多
By introducing the hyperbolic sine function to Airy beam, the dynamic behavior and propagation characteristics of partially coherent sinh-Airy beams in oceanic turbulence are studied using approximate analytical inten...By introducing the hyperbolic sine function to Airy beam, the dynamic behavior and propagation characteristics of partially coherent sinh-Airy beams in oceanic turbulence are studied using approximate analytical intensity expression. The influence of sinh modulation parameter, coherence length and ocean parameters on intensity evolution, beam width and kurtosis parameter is mainly discussed. The results show that a non-zero sinh modulation parameter presents not only the insensitivity to oceanic turbulence, but a smaller beam width. Furthermore, it also improves kurtosis parameter. These findings bring advantages in signal reception for long distance. In addition, a larger relative intensity of temperature or salinity fluctuations, mean square temperature dissipation rate, or a smaller dissipation rate of turbulence kinetic energy is more liable to increase beam width, or decrease intensity and kurtosis parameter of partially coherent sinh-Airy beams. The results provide an opportunity for improving signal reception of underwater communication or target detection by Airy beams or their groups.展开更多
In order to improve the intelligence of the English teaching management, so as to improve the English teaching resource scheduling and sharing ability, a design method of teaching management system is proposed based o...In order to improve the intelligence of the English teaching management, so as to improve the English teaching resource scheduling and sharing ability, a design method of teaching management system is proposed based on Web. The system adopts Web network architecture design, mainly it is divided into MUC main control module, database module, data management module and man-machine interaction module, Network management and online scheduling of English teaching resources are obtained based on C/S framework, data exchange of English teaching resources is realized on client side and server side, the control component of the English teaching resource distribution database uses MBM29LV400BC as the logic decoding controller. The intelligent algorithm is used to analyze the big data to realize the scheduling and access control of the English teaching management system resources. The test results show that the design of the English teaching management system has good resource scheduling and database construction ability, and the overall intelligence of the system is better.展开更多
文摘背景:H型血管因其独特的功能为深入理解血管介导的骨代谢调控机制提供了新的视角和切入点。目的:探讨H型血管在不同骨骼疾病动物模型中的生成机制及对骨代谢的影响。方法:系统检索CNKI、维普、万方、PubMed、Scopus和Web of Science数据库中2014年1月至2025年2月收录的H型血管相关中英文文献。剔除重复及不符合纳入标准的文献,对141篇涉及不同骨骼疾病动物模型中H型血管生成的文献进行系统分析。结果与结论:研究表明,H型血管在不同的骨骼疾病模型中表现出特定的生成机制和生物学功能。H型血管不仅在骨内血管生成中发挥重要作用,还与骨代谢密切相关,能够作为评估骨量水平的早期标志物。不同骨骼疾病动物模型中H型血管生成及作用不尽相同。在骨质疏松症、骨折、骨坏死等骨骼疾病中,通过促进H型血管表达,可显著改善血管重塑与骨再生能力;而在骨关节炎、骨肿瘤等恶性骨骼疾病中,选择性抑制H型血管表达则成为潜在的治疗干预策略。研究还揭示了多条关键信号通路在H型血管生成中的重要作用,如缺氧诱导因子1α/血管内皮生长因子、血小板源性生长因子BB、Wnt/β-catenin等,为理解血管介导的骨代谢调控机制提供了新的科学视角,同时为H型血管作为潜在治疗靶点的临床应用价值提供了重要理论基础。通过分析不同骨骼疾病动物模型中H型血管生成的作用,将为进一步深入探究人类骨关节疾病机制及治疗靶点提供重要依据。
基金supported by the National Natural Science Foundation of China(31272403)the Determination of Molecular Characterization for Genetically Modified Organism,China(2013ZX08012-002)the Livestock and Poultry Sharing Platform in China(2013)
文摘Endothelial PAS domain protein 1（EPAS1）, also called hypoxia-inducible factor-2, is a key regulatory factor of hypoxic responses and plays an essential role in high-altitude adaptation in mammalian species. In this study, polymorphisms of EPAS1 were detected in 217 individuals from 2 Tibetan pig populations and 3 low-altitude pig breeds by DNA pooling, PCR-SSCP, PCR-RFLP and DNA sequencing methods. A total of 14 synonymous polymorphisms were identified in the coding region. The analysis suggested that SNP1（G963A）, SNP7（C1632T）, SNP10（G1929A） and SNP11（G1947A） showed potential association with high-altitude environment because of their particular variation patterns in Tibetan pigs. Linkage disequilibrium（LD） of these SNPs was analyzed. One common LD block including 5 SNPs clustering in exon 12 was identified in all studied pig populations. Haplotype H1（AGGTC） in LD block was dominant in Tibetan pigs（76.6 and 74.2% in Linzhi（LZ） and Chayu（CY） pigs, respectively） and segregated at higher frequency than that in low-altitude pig breeds（52.3, 58.7 and 56.2% in Wuzhishan（WZS）, Min（M） and Laiwu（LW） pigs, respectively）, indicating that H1 may relate to adaptation to high altitude in Tibetan pigs. These findings raise hope that EPAS1 gene can be a candidate gene that involved in adaptation of high altitude in Tibetan pigs.
基金Supported by Key Scientific and Technological Project of Guangxi Province(GKG15248003-21)Basic Scientific Research Project of Animal Husbandry Research Institute of Guangxi Zhuang Au-tonomous Region(GMYK2019-10)
文摘Taking No.3 alfalfa(Medicago sativa)as the material,the effects of selenium and cobalt elements on seed germination of alfalfa at different temperatures were studied through germination test.The results showed that selenium and cobalt promoted seed germination of alfalfa,and improved germination potential,germination rate,germination index and vigor index.With the increasing proportion of selenium and cobalt,the numerical value of each index first increased then decreased.The seed germinations in A15 and B12 treatments were the best at 10℃ and 20℃,while those in A1 and B1 treatments were the worst.
基金This work has been supported by the Natural Science Foundation of Sichuan Education Committee(No.17ZA0072)。
文摘By introducing the hyperbolic sine function to Airy beam, the dynamic behavior and propagation characteristics of partially coherent sinh-Airy beams in oceanic turbulence are studied using approximate analytical intensity expression. The influence of sinh modulation parameter, coherence length and ocean parameters on intensity evolution, beam width and kurtosis parameter is mainly discussed. The results show that a non-zero sinh modulation parameter presents not only the insensitivity to oceanic turbulence, but a smaller beam width. Furthermore, it also improves kurtosis parameter. These findings bring advantages in signal reception for long distance. In addition, a larger relative intensity of temperature or salinity fluctuations, mean square temperature dissipation rate, or a smaller dissipation rate of turbulence kinetic energy is more liable to increase beam width, or decrease intensity and kurtosis parameter of partially coherent sinh-Airy beams. The results provide an opportunity for improving signal reception of underwater communication or target detection by Airy beams or their groups.
文摘In order to improve the intelligence of the English teaching management, so as to improve the English teaching resource scheduling and sharing ability, a design method of teaching management system is proposed based on Web. The system adopts Web network architecture design, mainly it is divided into MUC main control module, database module, data management module and man-machine interaction module, Network management and online scheduling of English teaching resources are obtained based on C/S framework, data exchange of English teaching resources is realized on client side and server side, the control component of the English teaching resource distribution database uses MBM29LV400BC as the logic decoding controller. The intelligent algorithm is used to analyze the big data to realize the scheduling and access control of the English teaching management system resources. The test results show that the design of the English teaching management system has good resource scheduling and database construction ability, and the overall intelligence of the system is better.
