The newly discovered Yangchongli gold deposit is a unique independent gold deposit in the Tongling ore-cluster region controlled by the tectonic alteration firstly discovered in the Lower Yangtze Metallogenic Belt （L...The newly discovered Yangchongli gold deposit is a unique independent gold deposit in the Tongling ore-cluster region controlled by the tectonic alteration firstly discovered in the Lower Yangtze Metallogenic Belt （LYMB）. The host magmatic rocks mainly consist of monzodiorite and K-feldspar granite. The LA-ICP-MS U-Pb zircons dating yielded weighted mean 206pb/23SU ages of 140.7 ± 1.8 Ma and 126.4 ±1.2 Ma for the monzodiorite and K-feldspar granite, respectively. Monzodiorites are enriched in Sr, Ba, Rb, and depleted in Y, Yb with high Sr/Y and La/Yb ratios, similar to the geochemical features of adakite, considered as products of differentiation of mafic magmas originating from lithospheric mantle melt/fluids caused by metasomatism during paleo-Pacific Plate subduction in the Mesozic. In contrast, the compositions of K-feldspar granites are A-type granites, indicating an extensional tectonic background. Gold ores hosted in the fracture zone occurred as quartz vein within cataclastic rock. Sulfur and lead isotopes from pyrites show crust-mantle mixing characteristics. Metal components from strata also took part in the gold mineralization, and resulted from two episodes of magmatism that were probably related to tectonic transition from a compressive to an extensional setting between 140-126 Ma, which led to the Mesozoic large-scale polymetallic mineralization events in eastern China.展开更多
The newly discovered Paodaoling porphyry Au deposit from the Guichi region, Lower Yangtze River Metallogenic Belt （LYRB）, contains 〉35 tons of Au at an average grade of -1.7 g/t. It is a porphyry ＇Au-only＇ deposi...The newly discovered Paodaoling porphyry Au deposit from the Guichi region, Lower Yangtze River Metallogenic Belt （LYRB）, contains 〉35 tons of Au at an average grade of -1.7 g/t. It is a porphyry ＇Au-only＇ deposit, as revealed by current exploration in the depths, mostly above -400 m, which is quite uncommon among coeval porphyry mineralization along the LYRB. Additionally, there are also Cu-Au bearing porphyries and barren alkaline granitoids in the Paodaoling district. Zircon LA-ICP-MS U-Pb dating of the Cu-Au-bearing porphyries yield an age of 141-140 Ma, falling within the main magmatic stage of the LYRB, whereas the barren granites give an age of 125-120 Ma, coeval with the regional A- type granites. The Cu-Au-bearing porphyries are LILE-, LREE-enriched and HFSE-depleted, typical of arc magmatic affinities. The barren granites are HFSE-enriched, with lower LREE/HREE ratios and pronounced negative Eu anomalies. The Cu-Au-bearing porphyries in the Paodaoling district have high oxygen fugacities and high water content. Pyrite sulfur isotopes of the Paodaoling gold deposit indicate a magmatic-sedimentary mixed source for the ore-forming fluids. Based on the alteration and poly-metal zonation of the deepest exploration drill hole from the Paodaoling Au deposit, we propose that Cu ore bodies could lie at depth beneath the current Au ore bodies. The magmatism and associated Cu-Au mineralization of the Paodaoling district are likely to have formed in a subduction setting, during slab rollback of the paleo-Pacific plate.展开更多
目的:探索不同病理类型前列腺癌患者根治性前列腺切除术(radical prostatectomy,RP)围术期临床及病理特征差异,分析可能影响前列腺导管腺癌腺外侵犯的影响因素。方法:回顾性收集2011年12月至2021年4月北京大学第三医院收治的行RP且病理...目的:探索不同病理类型前列腺癌患者根治性前列腺切除术(radical prostatectomy,RP)围术期临床及病理特征差异,分析可能影响前列腺导管腺癌腺外侵犯的影响因素。方法:回顾性收集2011年12月至2021年4月北京大学第三医院收治的行RP且病理明确为前列腺癌患者的临床资料,获取其基本临床特征及术后病理结果。根据病理结果将患者分为导管腺癌组(混有导管腺癌)及单纯腺泡腺癌组,并进行1∶1倾向评分匹配,比较两组患者临床特征差异,并对导管腺癌组腺外侵犯的相关因素进行单因素及多因素分析。结果:共获得764例前列腺癌患者信息,其中术后病理明确混有导管腺癌成分者62例。倾向评分匹配前两组患者基线特征中既往有糖尿病史的比例差异有统计学意义(29.5%vs.17.7%,P=0.027),共有61例单纯腺泡腺癌患者和导管腺癌患者成功匹配,匹配后基线特征在两组间差异无统计学意义(P>0.05)。对两组围术期临床及病理特征进行比较,导管腺癌组国际泌尿病理协会(International Society of Urology Pathology,ISUP)分级(P=0.003)、pT分期(P=0.004)、腺外侵犯率(P=0.018)及脉管癌栓率(P=0.019)均明显高于单纯腺泡腺癌组。单因素分析显示,前列腺特异性抗原(prostate-specific antigen,PSA)水平、前列腺体积、ISUP分级、精囊侵犯及神经侵犯可能是导管腺癌腺外侵犯的影响因素(P<0.10);二元Logistic回归分析表明,神经侵犯是前列腺导管腺癌腺外侵犯的独立影响因素(OR=11.78,95%CI:1.97~70.56,P=0.007)。结论:前列腺导管腺癌比单纯腺泡腺癌预后更差,神经侵犯是前列腺导管腺癌腺外侵犯的独立影响因素。展开更多
基金supported by the DREAM project of MOST China (No.2016YFC0600404)the Natural Science Foundation of China (Grant Nos.41372087, 41673040)the Project of Geological Science and Technology of Anhui Province (2015-K-01)
文摘The newly discovered Yangchongli gold deposit is a unique independent gold deposit in the Tongling ore-cluster region controlled by the tectonic alteration firstly discovered in the Lower Yangtze Metallogenic Belt （LYMB）. The host magmatic rocks mainly consist of monzodiorite and K-feldspar granite. The LA-ICP-MS U-Pb zircons dating yielded weighted mean 206pb/23SU ages of 140.7 ± 1.8 Ma and 126.4 ±1.2 Ma for the monzodiorite and K-feldspar granite, respectively. Monzodiorites are enriched in Sr, Ba, Rb, and depleted in Y, Yb with high Sr/Y and La/Yb ratios, similar to the geochemical features of adakite, considered as products of differentiation of mafic magmas originating from lithospheric mantle melt/fluids caused by metasomatism during paleo-Pacific Plate subduction in the Mesozic. In contrast, the compositions of K-feldspar granites are A-type granites, indicating an extensional tectonic background. Gold ores hosted in the fracture zone occurred as quartz vein within cataclastic rock. Sulfur and lead isotopes from pyrites show crust-mantle mixing characteristics. Metal components from strata also took part in the gold mineralization, and resulted from two episodes of magmatism that were probably related to tectonic transition from a compressive to an extensional setting between 140-126 Ma, which led to the Mesozoic large-scale polymetallic mineralization events in eastern China.
基金supported by the National Key R&D Program of China(No.2016YFC0600404)the National Natural Science Foundation of China(Grant Nos.41673040 and 41611540339)the Project of National Land Resource Science and Technology of Anhui Province(2014-K-4)
文摘The newly discovered Paodaoling porphyry Au deposit from the Guichi region, Lower Yangtze River Metallogenic Belt （LYRB）, contains 〉35 tons of Au at an average grade of -1.7 g/t. It is a porphyry ＇Au-only＇ deposit, as revealed by current exploration in the depths, mostly above -400 m, which is quite uncommon among coeval porphyry mineralization along the LYRB. Additionally, there are also Cu-Au bearing porphyries and barren alkaline granitoids in the Paodaoling district. Zircon LA-ICP-MS U-Pb dating of the Cu-Au-bearing porphyries yield an age of 141-140 Ma, falling within the main magmatic stage of the LYRB, whereas the barren granites give an age of 125-120 Ma, coeval with the regional A- type granites. The Cu-Au-bearing porphyries are LILE-, LREE-enriched and HFSE-depleted, typical of arc magmatic affinities. The barren granites are HFSE-enriched, with lower LREE/HREE ratios and pronounced negative Eu anomalies. The Cu-Au-bearing porphyries in the Paodaoling district have high oxygen fugacities and high water content. Pyrite sulfur isotopes of the Paodaoling gold deposit indicate a magmatic-sedimentary mixed source for the ore-forming fluids. Based on the alteration and poly-metal zonation of the deepest exploration drill hole from the Paodaoling Au deposit, we propose that Cu ore bodies could lie at depth beneath the current Au ore bodies. The magmatism and associated Cu-Au mineralization of the Paodaoling district are likely to have formed in a subduction setting, during slab rollback of the paleo-Pacific plate.
文摘目的:探索不同病理类型前列腺癌患者根治性前列腺切除术(radical prostatectomy,RP)围术期临床及病理特征差异,分析可能影响前列腺导管腺癌腺外侵犯的影响因素。方法:回顾性收集2011年12月至2021年4月北京大学第三医院收治的行RP且病理明确为前列腺癌患者的临床资料,获取其基本临床特征及术后病理结果。根据病理结果将患者分为导管腺癌组(混有导管腺癌)及单纯腺泡腺癌组,并进行1∶1倾向评分匹配,比较两组患者临床特征差异,并对导管腺癌组腺外侵犯的相关因素进行单因素及多因素分析。结果:共获得764例前列腺癌患者信息,其中术后病理明确混有导管腺癌成分者62例。倾向评分匹配前两组患者基线特征中既往有糖尿病史的比例差异有统计学意义(29.5%vs.17.7%,P=0.027),共有61例单纯腺泡腺癌患者和导管腺癌患者成功匹配,匹配后基线特征在两组间差异无统计学意义(P>0.05)。对两组围术期临床及病理特征进行比较,导管腺癌组国际泌尿病理协会(International Society of Urology Pathology,ISUP)分级(P=0.003)、pT分期(P=0.004)、腺外侵犯率(P=0.018)及脉管癌栓率(P=0.019)均明显高于单纯腺泡腺癌组。单因素分析显示,前列腺特异性抗原(prostate-specific antigen,PSA)水平、前列腺体积、ISUP分级、精囊侵犯及神经侵犯可能是导管腺癌腺外侵犯的影响因素(P<0.10);二元Logistic回归分析表明,神经侵犯是前列腺导管腺癌腺外侵犯的独立影响因素(OR=11.78,95%CI:1.97~70.56,P=0.007)。结论:前列腺导管腺癌比单纯腺泡腺癌预后更差,神经侵犯是前列腺导管腺癌腺外侵犯的独立影响因素。
