目的:探讨腹腔镜结肠癌(COAD)根治术患者麻醉期间使用氟比洛芬酯与后路腰方肌阻滞(QLB)复合麻醉,患者的镇痛效果和应激状态和疼痛因子变化情况。方法:采用随机数字表法将138例行COAD根治术的患者分为对照组(QLB治疗,n=69)和观察组(对照...目的:探讨腹腔镜结肠癌(COAD)根治术患者麻醉期间使用氟比洛芬酯与后路腰方肌阻滞(QLB)复合麻醉,患者的镇痛效果和应激状态和疼痛因子变化情况。方法:采用随机数字表法将138例行COAD根治术的患者分为对照组(QLB治疗,n=69)和观察组(对照组的基础上结合氟比洛芬酯治疗,n=69)。对比两组术后恢复指标、应激指标、疼痛因子,同时记录两组不良反应发生情况。结果:观察组术后第一次下床活动时间、首次排气时间、首次排便时间短于对照组(P<0.05)。观察组术后1 d β-内啡肽(β-EP)高于对照组,前列腺素E_(2)(PGE_(2))、P物质(SP)、皮质醇(Cor)、肾上腺素(E)、去甲肾上腺素(NE)低于对照组(P<0.05)。两组不良反应的发生率对比未见差异(P>0.05)。结论:氟比洛芬酯联合QLB用于COAD根治术患者,可降低疼痛因子水平进而减轻患者术后疼痛,有利于患者术后早期恢复。展开更多
AIM: To evaluate the 5-year survival after laparoscopic surgery vs open surgery for stages Ⅱ and Ⅲ rectal cancer.METHODS:This study enrolled 406 consecutive patients who underwent curative resection for stagesⅡand...AIM: To evaluate the 5-year survival after laparoscopic surgery vs open surgery for stages Ⅱ and Ⅲ rectal cancer.METHODS:This study enrolled 406 consecutive patients who underwent curative resection for stagesⅡandⅢrectal cancer between January 2000 and December 2009[laparoscopic rectal resection(LRR),n=152;open rectal resection(ORR),n=254].Clinical characteristics,operative outcomes,pathological outcomes,postoperative recovery,and 5-year survival outcomes were compared between the two groups.RESULTS:Most of the clinical characteristics were similar except age(59 years vs 55 years,P=0.033)between the LRR group and ORR group.The proportion of anterior resection was higher in the LRR group than that in the ORR group(81.6%vs 66.1%,P=0.001).The LRR group had less estimated blood loss(50m L vs 200 m L,P<0.001)and a lower rate of blood transfusion(4.6%vs 11.8%,P=0.019)compared to the ORR group.The pathological outcomes of the two groups were comparable.The LRR group was associated with faster recovery of bowel function(2.8 d vs 3.7 d,P<0.001)and shorter postoperative hospital stay(11.7 d vs 13.7 d,P<0.001).The median followup time was 63 mo in the LRR group and 65 mo in the ORR group.As for the survival outcomes,the 5-year local recurrence rate(16.0%vs 16.4%,P=0.753),5-year disease-free survival(DFS)rate(63.0%vs63.1%,P=0.589),and 5-year overall survival(OS)rate(68.1%vs 63.5%,P=0.682)were comparable between the LRR group and the ORR group.Stageby stage,there were also no statistical differences between the LRR group and the ORR group in terms of the 5-year local recurrence rate(stageⅡ:6.3%vs 8.7%,P=0.623;stageⅢ:26.4%vs 23.2%,P=0.747),5-year DFS rate(stageⅡ:77.5%vs 77.6%,P=0.462;stageⅢ:46.5%vs 50.9%,P=0.738),and5-year OS rate(stageⅡ:81.4%vs 74.3%,P=0.242;stageⅢ:53.9%vs 54.1%,P=0.459).CONCLUSION:LRR for stagesⅡandⅢrectal cancer can yield comparable long-term survival while achieving short-term benefits compared to open surgery.展开更多
Crack line field analysis method has become an independent method for crack elastic-plastic analysis, which greatly simplifies the complexity of crack elastic-plastic problems and overcomes the corresponding mathemati...Crack line field analysis method has become an independent method for crack elastic-plastic analysis, which greatly simplifies the complexity of crack elastic-plastic problems and overcomes the corresponding mathematical difficulty. With this method, the precise elastic-plastic solutions near crack lines for variety of crack problems can be obtained. But up to now all solutions obtained by this method were for different concrete problems, no general steps and no general form of matching equations near crack line are given out. With crack line analysis method, this paper proposes the general steps of elastic plastic analysis near crack line for mode I crack in elastic-perfectly plastic solids under plane stress condition, and in turn given out the solving process and result for a specific problem.展开更多
Eight common red tide species including the Dinoflagellates Alejcandrium tamarense,Prorocentrum minimum , Prorocentrum mican , Diatoms Skeletonema costatum , Cerataulina pelag-ica, Leptocylindrus minimus, a Raphidophy...Eight common red tide species including the Dinoflagellates Alejcandrium tamarense,Prorocentrum minimum , Prorocentrum mican , Diatoms Skeletonema costatum , Cerataulina pelag-ica, Leptocylindrus minimus, a Raphidophyte Heterosigma akashiwo and a Chrysophyte Isochrysis galbana were chosen to study the effect of four nitrogen substrates (NOs ?N, NHi - N, Urea ?N, Mixed ?N) on the growth of these algae. After two transfers, the results showed that at N concentration of 550 fano\, NO; - N was the best nitrogen source among these four nitrogen substrates; Urea - N and Mixed ~ N were also good for the growth of most algae, but not as good as NQj ?N for some species; NH??N inhibited the growth of all these species except H. akashrwo. At concentrations of 280 and 50 fimol experiments on the growth of /. galbana , P. minimum and L. minimus in Nri( - N and NO; - N substrates were also performed. The results showed that the growth rates of /. galbana were not significantly different from each other in NO; - N and NH?- N substrates both concentrations of 280 and 50 fonol. In concentration of 280 (anol NHt - N substrate, the growth rates of P. minimum and L. minimus were slower than in same concentration of NO? ~~ N; At concentration of 50 (unol , the growth rate of P. minimum in NH?- N was not significantly different from that in NOj ?N, while the growth rate of L. minimus was only about 30% of that in NQ3 ~ N substrate. The results indicated that each alga had its own preference in N-substrate and concentration, therefore, different nitrogen substrates may play a role in red tide formation.展开更多
Firstly, using the improved homogeneous balance method, an auto-Darboux transformation (ADT) for the Brusselator reaction diffusion model is found. Based on the ADT, several exact solutions are obtained which contain ...Firstly, using the improved homogeneous balance method, an auto-Darboux transformation (ADT) for the Brusselator reaction diffusion model is found. Based on the ADT, several exact solutions are obtained which contain some authors' results known. Secondly, by using a series of transformations, the model is reduced into a nonlinear reaction diffusion equation and then through using sine-cosine method, more exact solutions are found which contain soliton solutions.展开更多
Support Vector Machines(SVM) is a powerful machine learning method developed from statistical learning theory and is currently an active field in artificial intelligent technology. SVM is sensitive to noise vectors ne...Support Vector Machines(SVM) is a powerful machine learning method developed from statistical learning theory and is currently an active field in artificial intelligent technology. SVM is sensitive to noise vectors near hyperplane since it is determined only by few support vectors. In this paper, Multi SVM decision model(MSDM) was proposed. MSDM consists of multiple SVMs and makes decision by synthetic information based on multi SVMs. MSDM is applied to heart disease diagnoses based on UCI benchmark data set. MSDM somewhat inproves the robust of decision system.展开更多
A new type of inorganic organic biomimetic bone cement consisting of nano hydroxyapatite and polyamide 66 composite was investigated. This cement can be handled as paste and easily shaped into any contour. Nanoapatite...A new type of inorganic organic biomimetic bone cement consisting of nano hydroxyapatite and polyamide 66 composite was investigated. This cement can be handled as paste and easily shaped into any contour. Nanoapatite and polyamide composite cement has a reasonable setting time, excellent washout resistance, high mechanical strength and bioactivity, and it is easily handled and shaped, which can be developed as a clinical cement. It can be predicted that nanoapatite/polymer composite cement would be a new trend of biomedical material, showing a promising prospect.展开更多
文摘目的:探讨腹腔镜结肠癌(COAD)根治术患者麻醉期间使用氟比洛芬酯与后路腰方肌阻滞(QLB)复合麻醉,患者的镇痛效果和应激状态和疼痛因子变化情况。方法:采用随机数字表法将138例行COAD根治术的患者分为对照组(QLB治疗,n=69)和观察组(对照组的基础上结合氟比洛芬酯治疗,n=69)。对比两组术后恢复指标、应激指标、疼痛因子,同时记录两组不良反应发生情况。结果:观察组术后第一次下床活动时间、首次排气时间、首次排便时间短于对照组(P<0.05)。观察组术后1 d β-内啡肽(β-EP)高于对照组,前列腺素E_(2)(PGE_(2))、P物质(SP)、皮质醇(Cor)、肾上腺素(E)、去甲肾上腺素(NE)低于对照组(P<0.05)。两组不良反应的发生率对比未见差异(P>0.05)。结论:氟比洛芬酯联合QLB用于COAD根治术患者,可降低疼痛因子水平进而减轻患者术后疼痛,有利于患者术后早期恢复。
基金Supported by National Key Clinical Specialty Construction Project of China,the National High Technology Research and Development Program of China No.2012AA021103the Research Fund of Public Welfare in Health Industry,National Health and Family Planning Commission of China,No.201502039
文摘AIM: To evaluate the 5-year survival after laparoscopic surgery vs open surgery for stages Ⅱ and Ⅲ rectal cancer.METHODS:This study enrolled 406 consecutive patients who underwent curative resection for stagesⅡandⅢrectal cancer between January 2000 and December 2009[laparoscopic rectal resection(LRR),n=152;open rectal resection(ORR),n=254].Clinical characteristics,operative outcomes,pathological outcomes,postoperative recovery,and 5-year survival outcomes were compared between the two groups.RESULTS:Most of the clinical characteristics were similar except age(59 years vs 55 years,P=0.033)between the LRR group and ORR group.The proportion of anterior resection was higher in the LRR group than that in the ORR group(81.6%vs 66.1%,P=0.001).The LRR group had less estimated blood loss(50m L vs 200 m L,P<0.001)and a lower rate of blood transfusion(4.6%vs 11.8%,P=0.019)compared to the ORR group.The pathological outcomes of the two groups were comparable.The LRR group was associated with faster recovery of bowel function(2.8 d vs 3.7 d,P<0.001)and shorter postoperative hospital stay(11.7 d vs 13.7 d,P<0.001).The median followup time was 63 mo in the LRR group and 65 mo in the ORR group.As for the survival outcomes,the 5-year local recurrence rate(16.0%vs 16.4%,P=0.753),5-year disease-free survival(DFS)rate(63.0%vs63.1%,P=0.589),and 5-year overall survival(OS)rate(68.1%vs 63.5%,P=0.682)were comparable between the LRR group and the ORR group.Stageby stage,there were also no statistical differences between the LRR group and the ORR group in terms of the 5-year local recurrence rate(stageⅡ:6.3%vs 8.7%,P=0.623;stageⅢ:26.4%vs 23.2%,P=0.747),5-year DFS rate(stageⅡ:77.5%vs 77.6%,P=0.462;stageⅢ:46.5%vs 50.9%,P=0.738),and5-year OS rate(stageⅡ:81.4%vs 74.3%,P=0.242;stageⅢ:53.9%vs 54.1%,P=0.459).CONCLUSION:LRR for stagesⅡandⅢrectal cancer can yield comparable long-term survival while achieving short-term benefits compared to open surgery.
文摘Crack line field analysis method has become an independent method for crack elastic-plastic analysis, which greatly simplifies the complexity of crack elastic-plastic problems and overcomes the corresponding mathematical difficulty. With this method, the precise elastic-plastic solutions near crack lines for variety of crack problems can be obtained. But up to now all solutions obtained by this method were for different concrete problems, no general steps and no general form of matching equations near crack line are given out. With crack line analysis method, this paper proposes the general steps of elastic plastic analysis near crack line for mode I crack in elastic-perfectly plastic solids under plane stress condition, and in turn given out the solving process and result for a specific problem.
基金This study was supported by NSFC Project under contract Nos 39950001, 49906007, 20177023 and 40076030 Projects of No.2001CB409700 KZCX2-206, PREPP from the Government of the Hong Kong Special Administrative Region of the PRC and Science Committee of
文摘Eight common red tide species including the Dinoflagellates Alejcandrium tamarense,Prorocentrum minimum , Prorocentrum mican , Diatoms Skeletonema costatum , Cerataulina pelag-ica, Leptocylindrus minimus, a Raphidophyte Heterosigma akashiwo and a Chrysophyte Isochrysis galbana were chosen to study the effect of four nitrogen substrates (NOs ?N, NHi - N, Urea ?N, Mixed ?N) on the growth of these algae. After two transfers, the results showed that at N concentration of 550 fano\, NO; - N was the best nitrogen source among these four nitrogen substrates; Urea - N and Mixed ~ N were also good for the growth of most algae, but not as good as NQj ?N for some species; NH??N inhibited the growth of all these species except H. akashrwo. At concentrations of 280 and 50 fimol experiments on the growth of /. galbana , P. minimum and L. minimus in Nri( - N and NO; - N substrates were also performed. The results showed that the growth rates of /. galbana were not significantly different from each other in NO; - N and NH?- N substrates both concentrations of 280 and 50 fonol. In concentration of 280 (anol NHt - N substrate, the growth rates of P. minimum and L. minimus were slower than in same concentration of NO? ~~ N; At concentration of 50 (unol , the growth rate of P. minimum in NH?- N was not significantly different from that in NOj ?N, while the growth rate of L. minimus was only about 30% of that in NQ3 ~ N substrate. The results indicated that each alga had its own preference in N-substrate and concentration, therefore, different nitrogen substrates may play a role in red tide formation.
基金国家自然科学基金，NKBRD of China，Doctor Foundation of Education Commission of China
文摘Firstly, using the improved homogeneous balance method, an auto-Darboux transformation (ADT) for the Brusselator reaction diffusion model is found. Based on the ADT, several exact solutions are obtained which contain some authors' results known. Secondly, by using a series of transformations, the model is reduced into a nonlinear reaction diffusion equation and then through using sine-cosine method, more exact solutions are found which contain soliton solutions.
基金Special Funds for Major State Basic Research of China (Project 973 ,G19980 3 0 415 )
文摘Support Vector Machines(SVM) is a powerful machine learning method developed from statistical learning theory and is currently an active field in artificial intelligent technology. SVM is sensitive to noise vectors near hyperplane since it is determined only by few support vectors. In this paper, Multi SVM decision model(MSDM) was proposed. MSDM consists of multiple SVMs and makes decision by synthetic information based on multi SVMs. MSDM is applied to heart disease diagnoses based on UCI benchmark data set. MSDM somewhat inproves the robust of decision system.
文摘A new type of inorganic organic biomimetic bone cement consisting of nano hydroxyapatite and polyamide 66 composite was investigated. This cement can be handled as paste and easily shaped into any contour. Nanoapatite and polyamide composite cement has a reasonable setting time, excellent washout resistance, high mechanical strength and bioactivity, and it is easily handled and shaped, which can be developed as a clinical cement. It can be predicted that nanoapatite/polymer composite cement would be a new trend of biomedical material, showing a promising prospect.
