A 13-m long sediment core from Borsog Bay of Lake Khuvsgul,northern Mongolia records hydro-environmental changes during the past 10000 years;three rapid environmental changes(ca.2700 a BP,ca.6000 a BP and ca.8000 a BP...A 13-m long sediment core from Borsog Bay of Lake Khuvsgul,northern Mongolia records hydro-environmental changes during the past 10000 years;three rapid environmental changes(ca.2700 a BP,ca.6000 a BP and ca.8000 a BP based on ^(14)C dates of organic carbon materials) are detected in depth profiles of sediment physical properties.Temporal changes in the physical properties of the core(grain size,grain density and water content) also suggest three periods of large discharge from outside and three periods of stable input(200-500 cm,800-980 cm and 1050-1200 cm).The sedimentation rates in the stable period are 0.102 cm·a^(-1),0.085 cm·a^(-1) and 0.139 cm·a^(-1),respectively.The periods of large discharge likely correspond to the intervals of the three rapid environmental changes,indicating that there were three rapid and high discharge periods related to melt water and/or heavy rainfall during the past 10000 years in this region.The analytical results also show that the physical properties are valuable in reconstructing past hydro-geomorphological fluctuations in the lake-catchment system.展开更多
Background: Nodular scleroderma is a fibrosing reaction, presenting well-defined, firm, raised nodules, which resembles keloid. Recent studies suggest that connective tissue growth factor (CTGF) is involved in the fib...Background: Nodular scleroderma is a fibrosing reaction, presenting well-defined, firm, raised nodules, which resembles keloid. Recent studies suggest that connective tissue growth factor (CTGF) is involved in the fibrotic process, and its expression is increased in many fibrosing diseases. Objective: In this study, we report 3 cases of nodular scleroderma, and the expression of CTGF is also investigated. Methods: Three patients who developed nodular scleroderma are described. Expression of CTGF protein and transcripts in nodular scleroderma was examined by immunohistochemistry and in situ hybridization. Results: Patients were 1 female and 2 males, and all cases were associated with diffuse systemic sclerosis. Nodular lesions were found on the chest (2 cases), back (1 case), upper arm (1 case) and nape (1 case). Histol ogy of the nodular lesions showed thickened collagen bundles in the dermis. Resu lts of immunohistochemistry showed that expression of CTGF was detected on the s clerotic fibroblasts in the lesions of nodular scleroderma, while it was not det ected in fibroblasts in normal skin. In situ expression of CTGF transcripts was abundantly detected on the fibroblastic cells in nodular scleroderma. Conclusion : Our data showed increased expression of CTGF in the sclerotic fibroblasts of n odular scleroderma, suggesting that CTGF plays an important role in its pathogenesis.展开更多
基金Grants-in-Aid for Scientific Research from Ministry of Education,Science and Culture(Japan)to K.Kashiwaya[(A2)20253002]
文摘A 13-m long sediment core from Borsog Bay of Lake Khuvsgul,northern Mongolia records hydro-environmental changes during the past 10000 years;three rapid environmental changes(ca.2700 a BP,ca.6000 a BP and ca.8000 a BP based on ^(14)C dates of organic carbon materials) are detected in depth profiles of sediment physical properties.Temporal changes in the physical properties of the core(grain size,grain density and water content) also suggest three periods of large discharge from outside and three periods of stable input(200-500 cm,800-980 cm and 1050-1200 cm).The sedimentation rates in the stable period are 0.102 cm·a^(-1),0.085 cm·a^(-1) and 0.139 cm·a^(-1),respectively.The periods of large discharge likely correspond to the intervals of the three rapid environmental changes,indicating that there were three rapid and high discharge periods related to melt water and/or heavy rainfall during the past 10000 years in this region.The analytical results also show that the physical properties are valuable in reconstructing past hydro-geomorphological fluctuations in the lake-catchment system.
文摘Background: Nodular scleroderma is a fibrosing reaction, presenting well-defined, firm, raised nodules, which resembles keloid. Recent studies suggest that connective tissue growth factor (CTGF) is involved in the fibrotic process, and its expression is increased in many fibrosing diseases. Objective: In this study, we report 3 cases of nodular scleroderma, and the expression of CTGF is also investigated. Methods: Three patients who developed nodular scleroderma are described. Expression of CTGF protein and transcripts in nodular scleroderma was examined by immunohistochemistry and in situ hybridization. Results: Patients were 1 female and 2 males, and all cases were associated with diffuse systemic sclerosis. Nodular lesions were found on the chest (2 cases), back (1 case), upper arm (1 case) and nape (1 case). Histol ogy of the nodular lesions showed thickened collagen bundles in the dermis. Resu lts of immunohistochemistry showed that expression of CTGF was detected on the s clerotic fibroblasts in the lesions of nodular scleroderma, while it was not det ected in fibroblasts in normal skin. In situ expression of CTGF transcripts was abundantly detected on the fibroblastic cells in nodular scleroderma. Conclusion : Our data showed increased expression of CTGF in the sclerotic fibroblasts of n odular scleroderma, suggesting that CTGF plays an important role in its pathogenesis.
