With the development of the city and the increase of the population, the de<span style="font-family:Verdana;">mand for transportation is increasing. The increases in transportation ways </span>&l...With the development of the city and the increase of the population, the de<span style="font-family:Verdana;">mand for transportation is increasing. The increases in transportation ways </span><span style="font-family:Verdana;">and demand have also brought certain energy and environmental problems t</span><span style="font-family:Verdana;">o transportati</span><span style="font-family:Verdana;">on construction. A good transportation environment and green travel experience have an important role in promoting the happiness of urban lif</span><span style="font-family:Verdana;">e and the sustainable development of society. Based on this, the follo</span><span style="font-family:Verdana;">wing solutions are proposed for the construction and development of urban green </span><span style="font-family:Verdana;">transportation. First, as a guiding role, the government should formulate active transportation and green transportation policies to promote the reform of multiple p</span><span style="font-family:Verdana;">ublic transportation methods. Second, as a leading role, the market can support a variety of the construction of green travel modes, which could encourage the development of shared bicycles and new energy vehicles. Third, </span><span style="font-family:Verdana;">as the main role of city, the citizens would like to choose green travel tools wi</span><span style="font-family:Verdana;">th the guid</span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">ance</span></span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> in the conscious level. If we built green behavior into a fashionable business card of the city, green behavior will lead the city’s transportation construction and development.</span></span></span></span></span>展开更多
Photocatalytic CO_(2)reduction to valuable product exhibit promising prospect for solving the energy crisis and the greenhouse effect.Herein,Co-Ti_(3)C_(2)T_(x)/g-C_(3)N_(4)(Co-TC/CN)composite with enhanced photocatal...Photocatalytic CO_(2)reduction to valuable product exhibit promising prospect for solving the energy crisis and the greenhouse effect.Herein,Co-Ti_(3)C_(2)T_(x)/g-C_(3)N_(4)(Co-TC/CN)composite with enhanced photocatalytic performance for converting CO_(2)to CO and CH_(4)was constructed by electrostatic self-assembly method.The close contact interface between Co-Ti_(3)C_(2)T_(x)and g-C_(3)N_(4)nanosheets can be used as fast transport channels of photogenerated electrons and effectively promote the separation of photogenerated electrons and holes,and the interface between the Co and Ti_(3)C_(2)T_(x)might be the active sites for CO_(2)adsorption and activation.The optimized Co-Ti_(3)C_(2)T_(x)/g-C_(3)N_(4)composite exhibited the highest photocatalytic performance with the CO and CH_(4)production of 55.04 μmol·g^(-1)and 2.29 μmol·g^(-1),respectively,which were 7.5 times and 5.8 times than those of g-C_(3)N_(4).Furthermore,the stability of g-C_(3)N_(4)was improved after coupling with Co-Ti_(3)C_(2)T_(x).展开更多
Entanglement is the key resource in quantum information processing,and an entanglement witness(EW)is designed to detect whether a quantum system has any entanglement.However,prior knowledge of the target states should...Entanglement is the key resource in quantum information processing,and an entanglement witness(EW)is designed to detect whether a quantum system has any entanglement.However,prior knowledge of the target states should be known first to design a suitable EW,which weakens this method.Nevertheless,a recent theory shows that it is possible to design a universal entanglement witness(UEW)to detect negative-partial-transpose(NPT)entanglement in unknown bipartite states with measurement-device-independent(MDI)characteristic.The outcome of a UEW can also be upgraded to be an entanglement measure.In this study,we experimentally design and realize an MDI UEW for two-qubit entangled states.All of the tested states are well-detected without any prior knowledge.We also show that it is able to quantify entanglement by comparing it with concurrence estimated through state tomography.The relation between them is also revealed.The entire experimental framework ensures that the UEW is MDI.展开更多
The Solanaceae family contains many agriculturally important crops,including tomato,potato,pepper,and tobacco,as well as other species with potential for agricultural development,such as the orphan crops groundcherry,...The Solanaceae family contains many agriculturally important crops,including tomato,potato,pepper,and tobacco,as well as other species with potential for agricultural development,such as the orphan crops groundcherry,wolfberry,and pepino.Research progress varies greatly among these species,with model crops like tomato being far ahead.This disparity limits the broader agricultural application of other Solanaceae species.In this study,we constructed an interspecies pan-genome for the Solanaceae family and identified various gene retention patterns.Our findings reveal that the activity of specific transposable elements is closely associated with gene fractionation and transposition.The pan-genome was further resolved at the level of T subgenomes,which were generated by Solanaceae-specific paleohexaploidization(T event).We demonstrate substantial gene fractionation(loss)and divergence events following ancient duplications.For example,all class A and E flower model genes in Solanaceae originated from two tandemly duplicated genes,which expanded through the g and T events before fractionating into 10 genes in tomato,each acquiring distinct functions critical for fruit development.Based on these results,we developed the Solanaceae Pan-Genome Database(SolPGD,http://www.bioinformaticslab.cn/SolPGD),which integrates datasets from both inter-and intra-species pan-genomes of Solanaceae.These findings and resources will facilitate future studies of solanaceous species,including orphan crops.展开更多
Background:The intestinal barrier integrity can be disrupted due to burn injury,which is responsible for local and systemic inflammatory responses.Anti-inflammation strategy is one of the proposed therapeutic approach...Background:The intestinal barrier integrity can be disrupted due to burn injury,which is responsible for local and systemic inflammatory responses.Anti-inflammation strategy is one of the proposed therapeutic approaches to control inflammatory cascade at an early stage.Interleukin-17A(IL-17A)plays a critical role in inflammatory diseases.However,the role of IL-17A in the progression of burn-induced intestinal inflammation is poorly understood.In this study,we aimed to investigate the effect of IL-17A and associated pro-inflammatory cytokines that were deeply involved in the pathogenesis of burn-induced intestinal inflammatory injury,and furthermore,we sought to determine the early source of IL-17A in the intestine.Methods:Mouse burn model was successfully established with infliction of 30%total body surface area scald burn.The histopathological manifestation,intestinal permeability,zonula occludens-1 expression,pro-inflammatory cytokines were determined with or without IL-17A-neutralization.Flow cytometry was used to detect the major source of IL-17A^(+)cells in the intestine.Results:Burn caused intestinal barrier damage,increase of intestinal permeability,alteration of zonula occludens-1 expressions,elevation of IL-17A,IL-6,IL-1βand tumor necrosis factor-α(TNF-α),whereas IL-17A neutralization dramatically alleviated burn-induced intestinal barrier disruption,maintained zonula occludens-1 expression,and noticeably,inhibited pro-inflammatory cytokines elevation.In addition,we observed that the proportion of intestinal IL-17A^(+)Vγ4^(+)T subtype cells(but not IL-17A^(+)Vγ1^(+)T subtype cells)were increased in burn group,and neutralization of IL-17A suppressed this increase.Conclusions:The main original findings of this study are intestinal mucosa barrier is disrupted after burn through affecting the expression of pro-inflammatory cytokines,and a protective role of IL-17A neutralization for intestinal mucosa barrier is determined.Furthermore,Vγ4^(+)T cells are identified as the major early producers of IL-17A that orchestrate an inflammatory response in the burn model.These data suggest that IL-17A blockage may provide a unique target for therapeutic intervention to treat intestinal insult after burn.展开更多
Trauma is one of the leading causes of death worldwide. Approximately 39.5% of deaths occur in the hospital, and the mortality rate of delayed death caused by septic complications is still high. Early prediction of th...Trauma is one of the leading causes of death worldwide. Approximately 39.5% of deaths occur in the hospital, and the mortality rate of delayed death caused by septic complications is still high. Early prediction of the development of sepsis can help promote early intervention and treatment for patients and contribute to improving patient outcomes. Thus so far, biomarkers, patient demo-graphics and injury characteristics are the main methods used for predicting sepsis in trauma patients. However, studies that verify their predictive value are limited, and the results are still controversial. More work should be conducted to explore more efcient and accurate ways to predict post-traumatic sepsis.展开更多
The security threats to software-defined networks(SDNs)have become a significant problem,generally because of the open framework of SDNs.Among all the threats,distributed denial-of-service(DDoS)attacks can have a deva...The security threats to software-defined networks(SDNs)have become a significant problem,generally because of the open framework of SDNs.Among all the threats,distributed denial-of-service(DDoS)attacks can have a devastating impact on the network.We propose a method to discover DDoS attack behaviors in SDNs using a feature-pattern graph model.The feature-pattern graph model presented employs network patterns as nodes and similarity as weighted links;it can demonstrate not only the traffc header information but also the relationships among all the network patterns.The similarity between nodes is modeled by metric learning and the Mahalanobis distance.The proposed method can discover DDoS attacks using a graph-based neighborhood classification method;it is capable of automatically finding unknown attacks and is scalable by inserting new nodes to the graph model via local or global updates.Experiments on two datasets prove the feasibility of the proposed method for attack behavior discovery and graph update tasks,and demonstrate that the graph-based method to discover DDoS attack behaviors substantially outperforms the methods compared herein.展开更多
Background:The breakdown of intestinal barrier integrity occurs after severe burn injury and is responsible for the subsequent reactions of inflammation and oxidative stress.A new protective strategy for the intestina...Background:The breakdown of intestinal barrier integrity occurs after severe burn injury and is responsible for the subsequent reactions of inflammation and oxidative stress.A new protective strategy for the intestinal barrier is urgently needed due to the limitations of the traditional methods.Recently,the application of nanoparticles has become one of the promising therapies for many inflammation-related diseases or oxidative damage.Herein,we developed a new antiinflammatory and antioxidant nanoparticle named luminol-conjugated cyclodextrin(LCD)and aimed to evaluate its protective effects in severe burn-induced intestinal injury.Methods:First,LCD nanoparticles,engineered with covalent conjugation between luminol andβ-cyclodextrin(β-CD),were synthesized and examined.Then a mouse burn model was successfully established before the mouse body weight,intestinal histopathological manifestation,permeability,tight junction(TJ)expression and pro-inflammatory cytokines were determined in different groups.The proliferation,apoptosis,migration and reactive oxygen species(ROS)of intestinal epithelial cells(IECs)were assessed.Intraepithelial lymphocytes(IELs)were isolated and cultured for analysis by flow cytometry.Results:LCD nanoparticle treatment significantly relieved the symptoms of burn-induced intestinal injury in the mouse model,including body weight loss and intestinal permeability abnormalities.Moreover,LCD nanoparticles remarkably recovered the mechanical barrier of the intestine after severe burn,renewed TJ structures,promoted IEC proliferation and migration,and inhibited IEC apoptosis.Mechanistically,LCD nanoparticles dramatically alleviated pro-inflammation factors(tumor necrosis factor-α,IL-17A)and ROS accumulation,which could be highly involved in intestinal barrier disruption.Furthermore,an increase in IL-17A and the proportion of IL-17A+Vγ4+γδT subtype cells was also observed in vitro in LPS-treated Vγ4+γδT cells,but the use of LCD nanoparticles suppressed this increase.Conclusions:Taken together,these findings demonstrate that LCD nanoparticles have the protective ability to ameliorate intestinal barrier disruption and provide a therapeutic intervention for burn-induced intestinal injury.展开更多
Rubus corchorifolius(Shanmei or mountain berry,2n=14)is widely distributed in China,and its fruits possess high nutritional and medicinal values.Here,we reported a highquality chromosome-scale genome assembly of Shanm...Rubus corchorifolius(Shanmei or mountain berry,2n=14)is widely distributed in China,and its fruits possess high nutritional and medicinal values.Here,we reported a highquality chromosome-scale genome assembly of Shanmei,with contig size of 215.69 Mb and 26,696 genes.Genome comparison among Rosaceae species showed that Shanmei and Fupenzi(Rubus chingii Hu)were most closely related,followed by blackberry(Rubus occidentalis),and that environmental adaptation-related genes were expanded in the Shanmei genome.Further resequencing of 101 samples of Shanmei collected from four regions in the provinces of Yunnan,Hunan,Jiangxi,and Sichuan in China revealed that among these samples,the Hunan population of Shanmei possessed the highest diversity and represented the more ancestral population.Moreover,the Yunnan population underwent strong selection based on the nucleotide diversity,linkage disequilibrium,and historical effective population size analyses.Furthermore,genes from candidate genomic regions that showed strong divergence were significantly enriched in the flavonoid biosynthesis and plant hormone signal transduction pathways,indicating the genetic basis of adaptation of Shanmei to the local environment.The high-quality assembled genome and the variome dataset of Shanmei provide valuable resources for breeding applications and for elucidating the genome evolution and ecological adaptation of Rubus species.展开更多
Entanglement has been recognized as being crucial when implementing various quantum information tasks.Nevertheless, quantifying entanglement for an unknown quantum state requires nonphysical operations or post-process...Entanglement has been recognized as being crucial when implementing various quantum information tasks.Nevertheless, quantifying entanglement for an unknown quantum state requires nonphysical operations or post-processing measurement data. For example, evaluation methods via quantum state tomography require vast amounts of measurement data and likely estimation.展开更多
文摘With the development of the city and the increase of the population, the de<span style="font-family:Verdana;">mand for transportation is increasing. The increases in transportation ways </span><span style="font-family:Verdana;">and demand have also brought certain energy and environmental problems t</span><span style="font-family:Verdana;">o transportati</span><span style="font-family:Verdana;">on construction. A good transportation environment and green travel experience have an important role in promoting the happiness of urban lif</span><span style="font-family:Verdana;">e and the sustainable development of society. Based on this, the follo</span><span style="font-family:Verdana;">wing solutions are proposed for the construction and development of urban green </span><span style="font-family:Verdana;">transportation. First, as a guiding role, the government should formulate active transportation and green transportation policies to promote the reform of multiple p</span><span style="font-family:Verdana;">ublic transportation methods. Second, as a leading role, the market can support a variety of the construction of green travel modes, which could encourage the development of shared bicycles and new energy vehicles. Third, </span><span style="font-family:Verdana;">as the main role of city, the citizens would like to choose green travel tools wi</span><span style="font-family:Verdana;">th the guid</span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">ance</span></span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> in the conscious level. If we built green behavior into a fashionable business card of the city, green behavior will lead the city’s transportation construction and development.</span></span></span></span></span>
基金the National Natural Science Foundation of China(22208065)Guangxi Natural Science Foundation(2022GXNSFBA035483,2020GXNSFDA297007)+1 种基金Opening Project of Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology(2021K009,2020K002)Special funding for‘Guangxi Bagui Scholars’.
文摘Photocatalytic CO_(2)reduction to valuable product exhibit promising prospect for solving the energy crisis and the greenhouse effect.Herein,Co-Ti_(3)C_(2)T_(x)/g-C_(3)N_(4)(Co-TC/CN)composite with enhanced photocatalytic performance for converting CO_(2)to CO and CH_(4)was constructed by electrostatic self-assembly method.The close contact interface between Co-Ti_(3)C_(2)T_(x)and g-C_(3)N_(4)nanosheets can be used as fast transport channels of photogenerated electrons and effectively promote the separation of photogenerated electrons and holes,and the interface between the Co and Ti_(3)C_(2)T_(x)might be the active sites for CO_(2)adsorption and activation.The optimized Co-Ti_(3)C_(2)T_(x)/g-C_(3)N_(4)composite exhibited the highest photocatalytic performance with the CO and CH_(4)production of 55.04 μmol·g^(-1)and 2.29 μmol·g^(-1),respectively,which were 7.5 times and 5.8 times than those of g-C_(3)N_(4).Furthermore,the stability of g-C_(3)N_(4)was improved after coupling with Co-Ti_(3)C_(2)T_(x).
基金the National Key Research and Development Program of China(Grant No.2016YFA0302700)the National Natural Science Foundation of China(Grant Nos.11674304,11822408,11774335,61490711,11474267,11821404,and 91321313)+3 种基金the Youth Innovation Promotion Association of Chinese Academy of Sciences(Grant No.2017492)the Foundation for Scientific Instrument and Equipment Development of Chinese Academy of Sciences(Grant No.YJKYYQ20170032)the Key Research Program of Frontier Sciences of the Chinese Academy of Sciences(Grant No.QYZDY-SSW-SLH003)the Fundamental Research Funds for the Central Universities,China(Grant No.WK2470000026)。
文摘Entanglement is the key resource in quantum information processing,and an entanglement witness(EW)is designed to detect whether a quantum system has any entanglement.However,prior knowledge of the target states should be known first to design a suitable EW,which weakens this method.Nevertheless,a recent theory shows that it is possible to design a universal entanglement witness(UEW)to detect negative-partial-transpose(NPT)entanglement in unknown bipartite states with measurement-device-independent(MDI)characteristic.The outcome of a UEW can also be upgraded to be an entanglement measure.In this study,we experimentally design and realize an MDI UEW for two-qubit entangled states.All of the tested states are well-detected without any prior knowledge.We also show that it is able to quantify entanglement by comparing it with concurrence estimated through state tomography.The relation between them is also revealed.The entire experimental framework ensures that the UEW is MDI.
基金supported by the National Natural Science Foundation of China(NSFC grants U23A20210,32102382,and 32102386)the China Agricultural Research System(CARS-23-A15)+1 种基金the Central Publicinterest Scientific Institution Basal Research Fund(Y2024QC05)the Innovation Program of the Chinese Academy of Agricultural Sciences,and the Key Laboratory of Biology and Genetic Improvement of Horticultural Crops,Ministry of Agriculture and Rural Affairs,China.
文摘The Solanaceae family contains many agriculturally important crops,including tomato,potato,pepper,and tobacco,as well as other species with potential for agricultural development,such as the orphan crops groundcherry,wolfberry,and pepino.Research progress varies greatly among these species,with model crops like tomato being far ahead.This disparity limits the broader agricultural application of other Solanaceae species.In this study,we constructed an interspecies pan-genome for the Solanaceae family and identified various gene retention patterns.Our findings reveal that the activity of specific transposable elements is closely associated with gene fractionation and transposition.The pan-genome was further resolved at the level of T subgenomes,which were generated by Solanaceae-specific paleohexaploidization(T event).We demonstrate substantial gene fractionation(loss)and divergence events following ancient duplications.For example,all class A and E flower model genes in Solanaceae originated from two tandemly duplicated genes,which expanded through the g and T events before fractionating into 10 genes in tomato,each acquiring distinct functions critical for fruit development.Based on these results,we developed the Solanaceae Pan-Genome Database(SolPGD,http://www.bioinformaticslab.cn/SolPGD),which integrates datasets from both inter-and intra-species pan-genomes of Solanaceae.These findings and resources will facilitate future studies of solanaceous species,including orphan crops.
基金supported by the National Natural Science Foundation of China(NO.81570675,NO.31872742)Clinical Innovation Foundation of Southwest Hospital(SWH2017JCZD-06)Top Talent Training Programme Foundation of Southwest Hospital(SWH2018BJKJ-04).
文摘Background:The intestinal barrier integrity can be disrupted due to burn injury,which is responsible for local and systemic inflammatory responses.Anti-inflammation strategy is one of the proposed therapeutic approaches to control inflammatory cascade at an early stage.Interleukin-17A(IL-17A)plays a critical role in inflammatory diseases.However,the role of IL-17A in the progression of burn-induced intestinal inflammation is poorly understood.In this study,we aimed to investigate the effect of IL-17A and associated pro-inflammatory cytokines that were deeply involved in the pathogenesis of burn-induced intestinal inflammatory injury,and furthermore,we sought to determine the early source of IL-17A in the intestine.Methods:Mouse burn model was successfully established with infliction of 30%total body surface area scald burn.The histopathological manifestation,intestinal permeability,zonula occludens-1 expression,pro-inflammatory cytokines were determined with or without IL-17A-neutralization.Flow cytometry was used to detect the major source of IL-17A^(+)cells in the intestine.Results:Burn caused intestinal barrier damage,increase of intestinal permeability,alteration of zonula occludens-1 expressions,elevation of IL-17A,IL-6,IL-1βand tumor necrosis factor-α(TNF-α),whereas IL-17A neutralization dramatically alleviated burn-induced intestinal barrier disruption,maintained zonula occludens-1 expression,and noticeably,inhibited pro-inflammatory cytokines elevation.In addition,we observed that the proportion of intestinal IL-17A^(+)Vγ4^(+)T subtype cells(but not IL-17A^(+)Vγ1^(+)T subtype cells)were increased in burn group,and neutralization of IL-17A suppressed this increase.Conclusions:The main original findings of this study are intestinal mucosa barrier is disrupted after burn through affecting the expression of pro-inflammatory cytokines,and a protective role of IL-17A neutralization for intestinal mucosa barrier is determined.Furthermore,Vγ4^(+)T cells are identified as the major early producers of IL-17A that orchestrate an inflammatory response in the burn model.These data suggest that IL-17A blockage may provide a unique target for therapeutic intervention to treat intestinal insult after burn.
基金This study was supported by grants from the key project of"twelfth five-year plan" for medical science and technology of PLA (BWS11J038)
文摘Trauma is one of the leading causes of death worldwide. Approximately 39.5% of deaths occur in the hospital, and the mortality rate of delayed death caused by septic complications is still high. Early prediction of the development of sepsis can help promote early intervention and treatment for patients and contribute to improving patient outcomes. Thus so far, biomarkers, patient demo-graphics and injury characteristics are the main methods used for predicting sepsis in trauma patients. However, studies that verify their predictive value are limited, and the results are still controversial. More work should be conducted to explore more efcient and accurate ways to predict post-traumatic sepsis.
基金project supported by the National Key R&D Program of China(Nos.2017YFB0802300 and 2017YFC0803700)
文摘The security threats to software-defined networks(SDNs)have become a significant problem,generally because of the open framework of SDNs.Among all the threats,distributed denial-of-service(DDoS)attacks can have a devastating impact on the network.We propose a method to discover DDoS attack behaviors in SDNs using a feature-pattern graph model.The feature-pattern graph model presented employs network patterns as nodes and similarity as weighted links;it can demonstrate not only the traffc header information but also the relationships among all the network patterns.The similarity between nodes is modeled by metric learning and the Mahalanobis distance.The proposed method can discover DDoS attacks using a graph-based neighborhood classification method;it is capable of automatically finding unknown attacks and is scalable by inserting new nodes to the graph model via local or global updates.Experiments on two datasets prove the feasibility of the proposed method for attack behavior discovery and graph update tasks,and demonstrate that the graph-based method to discover DDoS attack behaviors substantially outperforms the methods compared herein.
基金supported by the General Project of Natural Science Foundation Project of Chongqing(No.cstc2021jcyj-msxmX0611)the Chongqing Doctor“Through Train”Scientific Research Project(CSTBBSXM2022-JCX0007)the Education and Training Reform Project of the Army Medical University(CSTBBSXM2022-JCX0007).
文摘Background:The breakdown of intestinal barrier integrity occurs after severe burn injury and is responsible for the subsequent reactions of inflammation and oxidative stress.A new protective strategy for the intestinal barrier is urgently needed due to the limitations of the traditional methods.Recently,the application of nanoparticles has become one of the promising therapies for many inflammation-related diseases or oxidative damage.Herein,we developed a new antiinflammatory and antioxidant nanoparticle named luminol-conjugated cyclodextrin(LCD)and aimed to evaluate its protective effects in severe burn-induced intestinal injury.Methods:First,LCD nanoparticles,engineered with covalent conjugation between luminol andβ-cyclodextrin(β-CD),were synthesized and examined.Then a mouse burn model was successfully established before the mouse body weight,intestinal histopathological manifestation,permeability,tight junction(TJ)expression and pro-inflammatory cytokines were determined in different groups.The proliferation,apoptosis,migration and reactive oxygen species(ROS)of intestinal epithelial cells(IECs)were assessed.Intraepithelial lymphocytes(IELs)were isolated and cultured for analysis by flow cytometry.Results:LCD nanoparticle treatment significantly relieved the symptoms of burn-induced intestinal injury in the mouse model,including body weight loss and intestinal permeability abnormalities.Moreover,LCD nanoparticles remarkably recovered the mechanical barrier of the intestine after severe burn,renewed TJ structures,promoted IEC proliferation and migration,and inhibited IEC apoptosis.Mechanistically,LCD nanoparticles dramatically alleviated pro-inflammation factors(tumor necrosis factor-α,IL-17A)and ROS accumulation,which could be highly involved in intestinal barrier disruption.Furthermore,an increase in IL-17A and the proportion of IL-17A+Vγ4+γδT subtype cells was also observed in vitro in LPS-treated Vγ4+γδT cells,but the use of LCD nanoparticles suppressed this increase.Conclusions:Taken together,these findings demonstrate that LCD nanoparticles have the protective ability to ameliorate intestinal barrier disruption and provide a therapeutic intervention for burn-induced intestinal injury.
基金supported by the grants from the Biodiversity Survey and Assessment Project of the Ministry of Ecology and Environment, China (Grant No. 2019HJ2096001006)the Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciencesthe Key Laboratory of Biology and Genetic Improvement of Horticultural Crops, Ministry of Agriculture and Rural Affairs, China
文摘Rubus corchorifolius(Shanmei or mountain berry,2n=14)is widely distributed in China,and its fruits possess high nutritional and medicinal values.Here,we reported a highquality chromosome-scale genome assembly of Shanmei,with contig size of 215.69 Mb and 26,696 genes.Genome comparison among Rosaceae species showed that Shanmei and Fupenzi(Rubus chingii Hu)were most closely related,followed by blackberry(Rubus occidentalis),and that environmental adaptation-related genes were expanded in the Shanmei genome.Further resequencing of 101 samples of Shanmei collected from four regions in the provinces of Yunnan,Hunan,Jiangxi,and Sichuan in China revealed that among these samples,the Hunan population of Shanmei possessed the highest diversity and represented the more ancestral population.Moreover,the Yunnan population underwent strong selection based on the nucleotide diversity,linkage disequilibrium,and historical effective population size analyses.Furthermore,genes from candidate genomic regions that showed strong divergence were significantly enriched in the flavonoid biosynthesis and plant hormone signal transduction pathways,indicating the genetic basis of adaptation of Shanmei to the local environment.The high-quality assembled genome and the variome dataset of Shanmei provide valuable resources for breeding applications and for elucidating the genome evolution and ecological adaptation of Rubus species.
基金National Natural Science Foundation of China (11821404, 12004358, 61725504, U19A2075)Postdoctoral Innovative Talents Support Program(BX20230349)+6 种基金Innovation Program for Quantum Science and Technology (2021ZD0301400, 2021ZD0301200)Anhui Initiative in Quantum Information Technologies(AHY060300)JSPS KAKENHI (17K05082, 18KK0079,19H05156)JSPS PRESTO (JPMJPR20M4)Fundamental Research Funds for the Central Universities(WK2030000085, 202041012, 841912027)Natural Science Foundation of Shandong Province (ZR2021ZD19)Young Talents Project at Ocean University of China(861901013107)。
文摘Entanglement has been recognized as being crucial when implementing various quantum information tasks.Nevertheless, quantifying entanglement for an unknown quantum state requires nonphysical operations or post-processing measurement data. For example, evaluation methods via quantum state tomography require vast amounts of measurement data and likely estimation.
