Controllable synthesis of ultrathin metallene nanosheets and rational design of their spatial arrangement in favor of electrochemical catalysis are critical for their renewable energy applications.Here,a biomimetic de...Controllable synthesis of ultrathin metallene nanosheets and rational design of their spatial arrangement in favor of electrochemical catalysis are critical for their renewable energy applications.Here,a biomimetic design of“Trunk-Branch-Leaf”strategy is proposed to prepare the ultrathin edge-riched Zn-ene“leaves”with a thickness of~2.5 nm,adjacent Zn-ene cross-linked with each other,which are supported by copper nanoneedle“branches”on copper mesh“trunks,”named as Zn-ene/Cu-CM.The resulting superstructure enables the formation of an interconnected network and multiple channels,which can be used as an electrocatalytic CO_(2) reduction reaction(CO_(2)RR)electrode to allow a fast charge and mass transfer as well as a large electrolyte reservoir.By virtue of the distinctive structure,the obtained Zn-ene/Cu-CM electrode exhibits excellent selectivity and activity toward CO production with a maximum Faradaic efficiency of 91.3%and incredible partial current density up to 40 mA cm^(−2),outperforming most of the state-of-the-art Zn-based electrodes for CO_(2) reduction.The phenolphthalein color probe combined with in situ attenuated total reflection-infrared spectroscopy uncovered the formation of the localized pseudo-alkaline microenvironment at the interface of the Zn-ene/Cu-CM electrode.Theoretical calculations confirmed that the localized pH as the origin is responsible for the adsorption of CO_(2) at the interface and the generation of *COOH and *CO intermediates.This study offers valuable insights into developing efficient electrodes through synergistic regulation of reaction microenvironments and active sites,thereby facilitating the electrolysis of practical CO_(2) conversion.展开更多
Human parainfluenza viruses(HPIV)are common viral pathogens in acute respiratory infection(ARI).We aimed to describe the epidemiological and molecular characteristics of HPIV from ARI patients.This cross-sectional stu...Human parainfluenza viruses(HPIV)are common viral pathogens in acute respiratory infection(ARI).We aimed to describe the epidemiological and molecular characteristics of HPIV from ARI patients.This cross-sectional study was conducted using respiratory samples from 9,696 ARI patients between 2016 and 2020 in southern China.All samples were analyzed by quantitative real-time polymerase chain reaction to determine the presence of HPIV and other common respiratory viruses.Descriptive statistics were performed to determine the temporal and population distribution of HPIV.The fulllength hemagglutinin-neuraminidase(HN)gene of HPIV3-positive samples was sequenced for phylogenetic analysis.A total of 577(6.0%)patients tested positive for HPIV,with HPIV3 being the predominant serotype,accounting for 46.8%of cases.Notably,66.0%of these HPIV-positive cases were children aged 0-2 years.The prevalence of HPIV infections showed a decreased trend and altered peak during 2016-2020.Cough,fever,sputum production,and rhinorrhea were common respiratory symptoms in HPIV-positive patients.The majority of cases had pneumonia(63.4%).Human rhinovirus(HRV)and human coronavirus(HCoV)were the most common coinfection viruses in HPIV-positive cases,with proportions of 20.1%and 14.4%,respectively.Phylogenetic analysis revealed that the predominant lineage of HPIV3 was C3f(86.0%),followed by lineage C3a(8.0%),C3d(4.0%),and C3b(2.0%).These findings help to better understand the epidemiology of HPIV,and improve public health strategies to prevent and control HPIV infections in southern China.展开更多
Configurational information entropy(CIE)analysis has been shown to be applicable for determining the neutron skin thickness(δnp)of neutron-rich nuclei from fragment production in projectile fragmentation reactions.Th...Configurational information entropy(CIE)analysis has been shown to be applicable for determining the neutron skin thickness(δnp)of neutron-rich nuclei from fragment production in projectile fragmentation reactions.The BNN+FRACS machine learning model was adopted to predict the fragment mass cross-sections(σ_(A))of the projectile fragmentation reactions induced by calcium isotopes from ^(36)Ca to ^(56)Ca on a ^(9)Be target at 140MeV/u.The fast Fourier transform was adopted to decompose the possible information compositions inσA distributions and determine the quantity of CIE(S_(A)[f]).It was found that the range of fragments significantly influences the quantity of S_(A)[f],which results in different trends of S_(A)[f]~δnp correlation.The linear S_(A)[f]~δnp correlation in a previous study[Nucl.Sci.Tech.33,6(2022)]could be reproduced using fragments with relatively large mass fragments,which verifies that S_(A)[f]determined from fragmentσAis sensitive to the neutron skin thickness of neutron-rich isotopes.展开更多
Background:MicroRNA(miRNA) polymorphisms may alter miRNA-related processes,and they likely contribute to cancer susceptibility.Various studies have investigated the associations between genetic variants in several key...Background:MicroRNA(miRNA) polymorphisms may alter miRNA-related processes,and they likely contribute to cancer susceptibility.Various studies have investigated the associations between genetic variants in several key miRNAs and the risk of human cancers;however,few studies have focused on head and neck squamous cell carcinoma(HNSCC) risk.This study aimed to evaluate the associations between several key miRNA polymorphisms and HNSCC risk in a Chinese population.Methods:In this study,we genotyped five common single-nucleotide polymorphisms(SNPs) in several key miRNAs(miR-149 rs2292832,miR-146 a rs2910164,miR-605 rs2043556,miR-608 rs4919510,and miR-196a2 rs11614913) and evaluated the associations between these SNPs and HNSCC risk according to cancer site with a case-control study including 576 cases and 1552 controls,which were matched by age and sex in a Chinese population.Results:The results revealed that miR-605 rs2043556[dominant model:adjusted odds ratio(OR) 0.71,95%confidence interval(CI) 0.58-0.88;additive model:adjusted OR 0.74,95%CI 0.62-0.89]and miR-196a2 rs11614913(dominant model:adjusted OR 1.36,95%C11.08-1.72;additive model:adjusted OR 1.28,95%C11.10-1.48) were significantly associated with the risk of oral squamous cell carcinoma(OSCC).Furthermore,when these two loci were evaluated together based on the number of putative risk alleles(rs2043556 A and rs11614913 G),a significant locus-dosage effect was noted on the risk of OSCC(P_(trend) < 0.001).However,no significant association was detected between the other three SNPs(miR-149 rs2292832,miR- 146 a rs2910164,and miR-608 rs4919510) and HNSCC risk.Conclusion:Our study provided the evidence that miR-605 rs2043556 and miR-196a2 rs11614913 may have an impact on genetic susceptibility to OSCC in Chinese population.展开更多
Thermally regenerative batteries(TRBs) are promising for harvesting low-grade waste heat into electrical power. However, the ammonia crossover from anode to cathode causes self-discharge and then leads to the decay of...Thermally regenerative batteries(TRBs) are promising for harvesting low-grade waste heat into electrical power. However, the ammonia crossover from anode to cathode causes self-discharge and then leads to the decay of capacity. To alleviate the ammonia crossover and improve electricity generation, a stable graphene oxide(GO) modified anion exchange membrane(AEM) was proposed. Compared with the original AEM, the GO modified AEM with a 39.5% lower ammonia permeability induces a 24.3% higher maximal power output and 20.2% higher energy density in TRBs. Together with the visualization result,it was demonstrated the ammonia crossover was effectively alleviated by GO modifying the AEM not at a cost of the reduced battery performance, indicating the promising application in future TRBs.展开更多
This study investigated the important factors that affect the operating parameters of thermally regenerative ammoniabased batteries(TRABs),including the metal electrode type,membrane type,electrode surface area,electr...This study investigated the important factors that affect the operating parameters of thermally regenerative ammoniabased batteries(TRABs),including the metal electrode type,membrane type,electrode surface area,electrode distance,electrolyte concentration,and ammonia concentration.The experimental results showed that the maximum power density of TRABs with a Cu electrode was 40.0 W·m^(2),which was considerably higher than that with Ni(0.34 W·m^(2))and Co(0.14 W·m^(2))electrodes.TRABs with an anion exchange membrane had a 28.6%higher maximum power density than those with a cation exchange membrane.An increased electrode surface resulted in an increased maximum power but a decreased maximum power density.Within a certain range,TRAB performance was enhanced with decreased electrode distance and increased electrolyte concentration.An increased ammonia concentration resulted in enhanced ammonia transfer and improved the TRAB performance.展开更多
Ribavirin has been used in urgency to treat SARS patients recently.In order to study its antiviral mechanism by photolabeling approach,we have synthesized and characterized 5-azido-1-β-D-ribofuranosyl-1,2,4-triazole-...Ribavirin has been used in urgency to treat SARS patients recently.In order to study its antiviral mechanism by photolabeling approach,we have synthesized and characterized 5-azido-1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxiamide 1 as a photolabeling probe of ribavirin.The azidotriazole nucleoside showed rapid and clean photochemical reaction,suggesting that l is a promising probe to study the antiviral mechanism of ribarivin by photolabeling.展开更多
To efficiently remove perfluorooctanoic acid(PFOA),we developed a composite of magnetic Fe_(3)O_(4)nanocrystals and MIL-101(an iron-based metal organic framework).Because of its high surface area,porous structure,and ...To efficiently remove perfluorooctanoic acid(PFOA),we developed a composite of magnetic Fe_(3)O_(4)nanocrystals and MIL-101(an iron-based metal organic framework).Because of its high surface area,porous structure,and complexation between PFOA as confirmed by experimental results and density functional theory simulation,the magnetic composite showed a Langmuir adsorption capacity of 415 mg/g in the presence of various groundwater components,and thus adsorbed PFOA at environment-relevant concentration within 20 min.The catalyst loaded with PFOA can then be magnetically separated from the synthetic groundwater.This adsorption step concentrated PFOA near MIL-101 and resulted in a fast decomposition rate in the decomposition step,where MIL-101 served as an efficient Fenton agent due to its abundant Fe^(3+)/Fe^(2+)sites.Meanwhile,the alternative magnetic field was introduced to change the production pathway of reactive oxygen species and superoxide radical anions were produced,which was critical for PFOA degradation.In addition,the inductive heating effect heat the magnetic particles to445 K through an in-situ approach,which thus further accelerated Fenton reactions rate.In addition,and achieved a complete degradation of PFOA within 30 min.This newly developed Fenton catalyst demonstrates advantages over conventionally heterogeneous and homogeneous catalysts,and thus is promising for practical applications.展开更多
The main geolocation technology currently used in COSPAS-SARSAT system is TDOA/FDOA or three-star TDOA,the principle is to determine the location of the signal source by using the difference in arrival time and freque...The main geolocation technology currently used in COSPAS-SARSAT system is TDOA/FDOA or three-star TDOA,the principle is to determine the location of the signal source by using the difference in arrival time and frequency of the wireless signal between different receivers.Therefore,ground monitoring stations need to be equipped with more than two antenna receiving stations,and multiple satellites should be able to simultaneously relay the distress signal from the target source in order to achieve the geolocation function.However,when the ground receiving system has only one antenna receiving station,or the target source is in a heavily obscured environment,the ground side is unable to receive the forwarded signals from multiple satellites at the same time,which will make it impossible to locate.To address these problems,in this paper,a time-sharing single satellite geolocations method based on different orbits is proposed for the first time.This method uses one or several low-earth orbit satellites(LEO)and mediumearth orbit satellites(MEO)in the visible area,and the receiving station only needs one pair of receiving antennas to complete the positioning.It can effectively compensate for the shortcomings of the traditional TDOA using the same moment and have better positioning accuracy compared with the single satellite in the same orbit.Due to the limited experimental conditions,this paper tests the navigation satellite using different orbit time-sharing single satellite geolocations,and proves that the positioning method has high positioning accuracy and has certain promotion and application value.展开更多
Fatty acid photodecarboxylase of Chlorella variabilis NC64A(CvFAP) is a novel photoenzyme with great potential in the treatment of waste lipids and production of sustainable aviation fuel. However, the fragile nature ...Fatty acid photodecarboxylase of Chlorella variabilis NC64A(CvFAP) is a novel photoenzyme with great potential in the treatment of waste lipids and production of sustainable aviation fuel. However, the fragile nature of Cv FAP to blue light is an urgent challenge. Herein, we demonstrated anaerobic environment could significantly improve the photostability of Cv FAP for the first time. The decarboxylation of palmitic acid by Cv FAP for 3 h under anaerobic environment increased pentadecane yield by 44.7% as compared to that under aerobic environment. The residual activity of Cv FAP after blue-light preillumination in the absence of palmitic acid for 0.5 h under anaerobic environment was 80.4%, which was 258.7 times higher than that under aerobic environment. Remarkable accumulation of superoxide radical and singlet oxygen in Cv FAP under aerobic environment led to the poor photostability of Cv FAP. Anaerobic environment helped to mitigate the production of superoxide radical and singlet oxygen in Cv FAP, improving the photostability of Cv FAP.展开更多
Coronavirus Disease 2019(COVID-19),caused by the novel coronavirus,has spread rapidly across China.Consequently,there is an urgent need to sort and develop novel agents for the prevention and treatment of viral infect...Coronavirus Disease 2019(COVID-19),caused by the novel coronavirus,has spread rapidly across China.Consequently,there is an urgent need to sort and develop novel agents for the prevention and treatment of viral infections.A rapid structure-based virtual screening is used for the evaluation of current commercial drugs,with structures of human angiotensin converting enzymeⅡ(ACE2),and viral main protease,spike,envelope,membrane and nucleocapsid proteins.Our results reveal that the reported drugs Arbidol,Chloroquine and Remdesivir may hinder the entry and release of virions through the bindings with ACE2,spike and envelope proteins.Due to the similar binding patterns,NHC(β-d-N4-hydroxycytidine)and Triazavirin are also in prospects for clinical use.Main protease(3 CLpro)is likely to be a feasible target of drug design.The screening results to target 3 CLpro reveal that Mitoguazone,Metformin,Biguanide Hydrochloride,Gallic acid,Caffeic acid,Sulfaguanidine and Acetylcysteine seem be possible inhibitors and have potential application in the clinical therapy of COVID-19.展开更多
In the article“Long non-coding RNA LINC02163 accelerates malignant tumor behaviors in breast cancer by regulating the microRNA-511-3p/HMGA2 axis as a competing endogenous RNA”(Oncology Research,2020,Vol.28,No.5,pp....In the article“Long non-coding RNA LINC02163 accelerates malignant tumor behaviors in breast cancer by regulating the microRNA-511-3p/HMGA2 axis as a competing endogenous RNA”(Oncology Research,2020,Vol.28,No.5,pp.483–495.doi:10.3727/096504020X15928179818438),there was an error in the processing of data.To further confirm our observation,we repeated multiple experiments involving in this study,including Flow Cytometry,Transwell Cell Migration and Invasion Assays,Xenograft Tumor Model,and Western Blotting.We have revised the figures to correct these errors.Corrected versions of the Figs.2,4,5,6,and 7 are provided.The corrections do not change any results or conclusion of the article.We apologize for any inconvenience caused.展开更多
Biomass hydrothermal conversion has received extensive attention due to its advantages of strong adaptability of raw materials,no need to dry feedstock,and relatively mild conditions.Chlorella pyrenoidosa(CP)and oilse...Biomass hydrothermal conversion has received extensive attention due to its advantages of strong adaptability of raw materials,no need to dry feedstock,and relatively mild conditions.Chlorella pyrenoidosa(CP)and oilseed rape straw(OS),two kinds of typical biomass,were hydrothermally treated at 230℃ for 6 h to produce carbon dots(CDs),hydrochar(HC),bio-oil(OR),aqueous product(AQ),and volatile product(VO).The CP hydrothermal process generated the highest yield of CDs(16.3%),and the OS hydrothermal process produced the most HC(26.3%).The co-hydrothermal treatment of CP/OS promoted the production of HC and VO via carbonization,decarboxylation,and dehydration reactions between CP and OS degradation products.The CP,OS,and CP/OS based CDs(CD-CP,CD-OS,and CD-CP/OS)in the size of 1.5‒26.5 nm emitted blue light and displayed 3.3‒11.1%of fluorescence quantum yield.More than 42.3%of methylene blue could be photodegraded by CD-CP,which was 2.1 and 1.4 times higher than that by CD-OS and CD-CP/OS.The higher heating values of HCs and ORs were 23.0‒27.8 MJ kg^(−1)and 25.5‒38.5 MJ kg^(−1),showing potential to apply as biofuels.The HCs were confirmed to be outstanding bio-adsorbents that could remove 15.4‒68.9%methylene blue with an absorption capacity of up to 275.6 mg g−1.Moreover,the AQs were verified to be potentially used as biological nutrients for microalgae cultivation.This study co-produced CDs,BO,HC,and AQ through the hydrothermal conversion of CP and OS,efficiently utilizing them as photocatalysts,biofuels,bio-adsorbents,and biological nutrients.展开更多
Electrochemical CO_(2) reduction(CO_(2)RR)to value-added fuels and chemicals offers a promising route toward carbon neutrality.However,developing efficient and selective catalysts for the generation of multi-carbon(C^...Electrochemical CO_(2) reduction(CO_(2)RR)to value-added fuels and chemicals offers a promising route toward carbon neutrality.However,developing efficient and selective catalysts for the generation of multi-carbon(C^(2+))products remains a significant challenge.In this work,we propose a combined density functional theory(DFT)and machine learning(ML)approach to systematically screen CuSb-based catalysts with varying surface Sb atomic fractions and non-metal dopants(O,N,S,Se,and P)on the Cu_(2)Sb(100)surface for CO_(2)RR.Approximately 200 representative adsorption configurations were randomly selected for DFT calculations,which were then used to train a predictive ML model.This model enables high-accuracy predictions of the adsorption energies of key intermediates(*CO and*H)for the remaining uncalculated configurations.By integrating the K-means clustering analysis and the optimal adsorption energy selection criteria based on the Sabatier principle,the candidate configuration with the best potential for C^(2+)product formation was identified:O-doped CuSb with a surface Sb atomic fraction of 3/12.Mechanistic studies further reveal that O doping significantly strengthens *CO adsorption while suppressing *H adsorption by modulating the electronic structure,thereby lowering the CO_(2)RR energy barrier and improving the thermodynamic selectivity toward C^(2+)products.This work not only elucidates the synergistic effect of surface Sb atomic fraction and non-metal dopants on CO_(2)RR activity,but also establishes a scalable ML prediction and screening framework,providing theoretical support and methodological pathways for the design of high-performance CuSb-based catalysts.展开更多
Developing advanced electrocatalysts to convert CO_(2) into liquid fuels such as C_(2)H_(5)OH is critical for utilizing intermittent renewable energy.The formation of C_(2)H_(5)OH,however,is generally less favored com...Developing advanced electrocatalysts to convert CO_(2) into liquid fuels such as C_(2)H_(5)OH is critical for utilizing intermittent renewable energy.The formation of C_(2)H_(5)OH,however,is generally less favored compared with the other hydrocarbon products from Cu-based electrocatalysts.In this work,an alkanethiolmodified Cu_(2)O nanowire array(OTT-Cu_(2)O) was constructed with asymmetric Cu sites consisting of paired Cu-O and Cu-S motifs to overcome previous limitations of C_(2)H_(5)OH electrosynthesis via CO_(2)RR pathway.This catalyst achieves a high Faradaic efficiency of 45 % for CO_(2)-to-C_(2)H_(5)OH conversion at 300 m A/cm^(2),representing a more than two-fold enhancement over the Cu_(2)O electrode.Mechanistic investigations reveal that the Cu-S site exhibits distinct C-binding capability that stabilizes key intermediates(^(*)OCH_(2) and ^(*)CO),in contrast to the O-affinitive Cu-O site.The asymmetric S-Cu-O configuration promotes thermodynamically favorable asymmetric C-C coupling between ^(*)CO and ^(*)OCH_(2),forming the critical CO-OCH_(2) intermediate and facilitating C_(2)H_(5)OH production,as opposed to symmetric O-Cu-O sites that mainly generate HCOOH.This work offers an effective strategy for designing multi-active-site catalysts toward highly selective CO_(2) reduction to C_(2)H_(5)OH and provides fundamental insight into the reaction mechanism.展开更多
基金supports of the National Natural Science Foundation of China(NSFC)(52021004,52394202)key project of the Joint Fund for Innovation and Development of Chongqing Natural Science Foundation(CSTB2022NSCQ-LZX0013)+1 种基金the National Natural Science Foundation of China(NSFC)(52301232,and 52476056)the Natural Science Foundation of Chongqing Province(2024NSCQ-MSX1109).
文摘Controllable synthesis of ultrathin metallene nanosheets and rational design of their spatial arrangement in favor of electrochemical catalysis are critical for their renewable energy applications.Here,a biomimetic design of“Trunk-Branch-Leaf”strategy is proposed to prepare the ultrathin edge-riched Zn-ene“leaves”with a thickness of~2.5 nm,adjacent Zn-ene cross-linked with each other,which are supported by copper nanoneedle“branches”on copper mesh“trunks,”named as Zn-ene/Cu-CM.The resulting superstructure enables the formation of an interconnected network and multiple channels,which can be used as an electrocatalytic CO_(2) reduction reaction(CO_(2)RR)electrode to allow a fast charge and mass transfer as well as a large electrolyte reservoir.By virtue of the distinctive structure,the obtained Zn-ene/Cu-CM electrode exhibits excellent selectivity and activity toward CO production with a maximum Faradaic efficiency of 91.3%and incredible partial current density up to 40 mA cm^(−2),outperforming most of the state-of-the-art Zn-based electrodes for CO_(2) reduction.The phenolphthalein color probe combined with in situ attenuated total reflection-infrared spectroscopy uncovered the formation of the localized pseudo-alkaline microenvironment at the interface of the Zn-ene/Cu-CM electrode.Theoretical calculations confirmed that the localized pH as the origin is responsible for the adsorption of CO_(2) at the interface and the generation of *COOH and *CO intermediates.This study offers valuable insights into developing efficient electrodes through synergistic regulation of reaction microenvironments and active sites,thereby facilitating the electrolysis of practical CO_(2) conversion.
基金supported by grants from the National Mega Project on Major Infectious Disease Prevention of China(2017ZX10103011)Guangdong Marine Economy Development Special Project of China(NO.GDNRC[2022]35)+1 种基金the National Natural Science Foundation of China(82171675,82101775,82071352,82341094)Guangdong Basic and Applied Basic Research Foundation of China(2022A1515011156).
文摘Human parainfluenza viruses(HPIV)are common viral pathogens in acute respiratory infection(ARI).We aimed to describe the epidemiological and molecular characteristics of HPIV from ARI patients.This cross-sectional study was conducted using respiratory samples from 9,696 ARI patients between 2016 and 2020 in southern China.All samples were analyzed by quantitative real-time polymerase chain reaction to determine the presence of HPIV and other common respiratory viruses.Descriptive statistics were performed to determine the temporal and population distribution of HPIV.The fulllength hemagglutinin-neuraminidase(HN)gene of HPIV3-positive samples was sequenced for phylogenetic analysis.A total of 577(6.0%)patients tested positive for HPIV,with HPIV3 being the predominant serotype,accounting for 46.8%of cases.Notably,66.0%of these HPIV-positive cases were children aged 0-2 years.The prevalence of HPIV infections showed a decreased trend and altered peak during 2016-2020.Cough,fever,sputum production,and rhinorrhea were common respiratory symptoms in HPIV-positive patients.The majority of cases had pneumonia(63.4%).Human rhinovirus(HRV)and human coronavirus(HCoV)were the most common coinfection viruses in HPIV-positive cases,with proportions of 20.1%and 14.4%,respectively.Phylogenetic analysis revealed that the predominant lineage of HPIV3 was C3f(86.0%),followed by lineage C3a(8.0%),C3d(4.0%),and C3b(2.0%).These findings help to better understand the epidemiology of HPIV,and improve public health strategies to prevent and control HPIV infections in southern China.
基金the National Natural Science Foundation of China(No.11975091)the Program for Innovative Research Team(in Science and Technology)in the University of Henan Province,China(No.21IRTSTHN011).
文摘Configurational information entropy(CIE)analysis has been shown to be applicable for determining the neutron skin thickness(δnp)of neutron-rich nuclei from fragment production in projectile fragmentation reactions.The BNN+FRACS machine learning model was adopted to predict the fragment mass cross-sections(σ_(A))of the projectile fragmentation reactions induced by calcium isotopes from ^(36)Ca to ^(56)Ca on a ^(9)Be target at 140MeV/u.The fast Fourier transform was adopted to decompose the possible information compositions inσA distributions and determine the quantity of CIE(S_(A)[f]).It was found that the range of fragments significantly influences the quantity of S_(A)[f],which results in different trends of S_(A)[f]~δnp correlation.The linear S_(A)[f]~δnp correlation in a previous study[Nucl.Sci.Tech.33,6(2022)]could be reproduced using fragments with relatively large mass fragments,which verifies that S_(A)[f]determined from fragmentσAis sensitive to the neutron skin thickness of neutron-rich isotopes.
基金supported in part by Grants from the National Natural Science Foundation of China(Nos.81473048 and 81302361)Priority Academic Program Development of Jiangsu Higher Education Institutions(Public Health and Preventive Medicine)+2 种基金Specialized Research Fund for the Doctoral Program of Higher Education of China(No.20133234120013)China Postdoctoral Science Foundation(No.2013M540457)Jiangsu Planned Projects for Postdoctoral Research Funds(No.1301018A)
文摘Background:MicroRNA(miRNA) polymorphisms may alter miRNA-related processes,and they likely contribute to cancer susceptibility.Various studies have investigated the associations between genetic variants in several key miRNAs and the risk of human cancers;however,few studies have focused on head and neck squamous cell carcinoma(HNSCC) risk.This study aimed to evaluate the associations between several key miRNA polymorphisms and HNSCC risk in a Chinese population.Methods:In this study,we genotyped five common single-nucleotide polymorphisms(SNPs) in several key miRNAs(miR-149 rs2292832,miR-146 a rs2910164,miR-605 rs2043556,miR-608 rs4919510,and miR-196a2 rs11614913) and evaluated the associations between these SNPs and HNSCC risk according to cancer site with a case-control study including 576 cases and 1552 controls,which were matched by age and sex in a Chinese population.Results:The results revealed that miR-605 rs2043556[dominant model:adjusted odds ratio(OR) 0.71,95%confidence interval(CI) 0.58-0.88;additive model:adjusted OR 0.74,95%CI 0.62-0.89]and miR-196a2 rs11614913(dominant model:adjusted OR 1.36,95%C11.08-1.72;additive model:adjusted OR 1.28,95%C11.10-1.48) were significantly associated with the risk of oral squamous cell carcinoma(OSCC).Furthermore,when these two loci were evaluated together based on the number of putative risk alleles(rs2043556 A and rs11614913 G),a significant locus-dosage effect was noted on the risk of OSCC(P_(trend) < 0.001).However,no significant association was detected between the other three SNPs(miR-149 rs2292832,miR- 146 a rs2910164,and miR-608 rs4919510) and HNSCC risk.Conclusion:Our study provided the evidence that miR-605 rs2043556 and miR-196a2 rs11614913 may have an impact on genetic susceptibility to OSCC in Chinese population.
基金supported by Innovative Research Group Project of National Natural Science Foundation of China (No. 52021004)National Natural Science Foundation of China (No. 51976018)+1 种基金Scientific Research Foundation for Returned Overseas Chinese Scholars of Chongqing, China (No. cx2021088)Research Funds of Key Laboratory of Low-grade Energy Utilization Technologies and Systems (No. LLEUTS-2018005)。
文摘Thermally regenerative batteries(TRBs) are promising for harvesting low-grade waste heat into electrical power. However, the ammonia crossover from anode to cathode causes self-discharge and then leads to the decay of capacity. To alleviate the ammonia crossover and improve electricity generation, a stable graphene oxide(GO) modified anion exchange membrane(AEM) was proposed. Compared with the original AEM, the GO modified AEM with a 39.5% lower ammonia permeability induces a 24.3% higher maximal power output and 20.2% higher energy density in TRBs. Together with the visualization result,it was demonstrated the ammonia crossover was effectively alleviated by GO modifying the AEM not at a cost of the reduced battery performance, indicating the promising application in future TRBs.
基金the National Natural Science Foundation of China(No.51976018)the National Natural Science Foundation for Young Scientists of China(No.51606022)+3 种基金Natural Science Foundation of Chongqing,China(No.cstc2017jcyjAX0203)Scientific Research Foundation for Returned Overseas Chinese Scholars of Chongqing,China(No.cx2017020)the Fundamental Research Funds for the Central Universities(No.106112016CDJXY145504)Research Funds of Key Laboratory of Low-grade Energy Utilization Technologies and Systems(No.LLEUTS-2018005).
文摘This study investigated the important factors that affect the operating parameters of thermally regenerative ammoniabased batteries(TRABs),including the metal electrode type,membrane type,electrode surface area,electrode distance,electrolyte concentration,and ammonia concentration.The experimental results showed that the maximum power density of TRABs with a Cu electrode was 40.0 W·m^(2),which was considerably higher than that with Ni(0.34 W·m^(2))and Co(0.14 W·m^(2))electrodes.TRABs with an anion exchange membrane had a 28.6%higher maximum power density than those with a cation exchange membrane.An increased electrode surface resulted in an increased maximum power but a decreased maximum power density.Within a certain range,TRAB performance was enhanced with decreased electrode distance and increased electrolyte concentration.An increased ammonia concentration resulted in enhanced ammonia transfer and improved the TRAB performance.
基金Financial support from Wuhan University,Cheung Kong Scholar Foundation and the CNRS is gratefully acknowledged
文摘Ribavirin has been used in urgency to treat SARS patients recently.In order to study its antiviral mechanism by photolabeling approach,we have synthesized and characterized 5-azido-1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxiamide 1 as a photolabeling probe of ribavirin.The azidotriazole nucleoside showed rapid and clean photochemical reaction,suggesting that l is a promising probe to study the antiviral mechanism of ribarivin by photolabeling.
基金financial support from the National Key Research and Development Program of China(No.2022YFC3205300)National Natural Science Foundation of China(Nos.52100178 and 52370072)。
文摘To efficiently remove perfluorooctanoic acid(PFOA),we developed a composite of magnetic Fe_(3)O_(4)nanocrystals and MIL-101(an iron-based metal organic framework).Because of its high surface area,porous structure,and complexation between PFOA as confirmed by experimental results and density functional theory simulation,the magnetic composite showed a Langmuir adsorption capacity of 415 mg/g in the presence of various groundwater components,and thus adsorbed PFOA at environment-relevant concentration within 20 min.The catalyst loaded with PFOA can then be magnetically separated from the synthetic groundwater.This adsorption step concentrated PFOA near MIL-101 and resulted in a fast decomposition rate in the decomposition step,where MIL-101 served as an efficient Fenton agent due to its abundant Fe^(3+)/Fe^(2+)sites.Meanwhile,the alternative magnetic field was introduced to change the production pathway of reactive oxygen species and superoxide radical anions were produced,which was critical for PFOA degradation.In addition,the inductive heating effect heat the magnetic particles to445 K through an in-situ approach,which thus further accelerated Fenton reactions rate.In addition,and achieved a complete degradation of PFOA within 30 min.This newly developed Fenton catalyst demonstrates advantages over conventionally heterogeneous and homogeneous catalysts,and thus is promising for practical applications.
基金supported by National Science Foundation of China(No.91738201,U21A20450)。
文摘The main geolocation technology currently used in COSPAS-SARSAT system is TDOA/FDOA or three-star TDOA,the principle is to determine the location of the signal source by using the difference in arrival time and frequency of the wireless signal between different receivers.Therefore,ground monitoring stations need to be equipped with more than two antenna receiving stations,and multiple satellites should be able to simultaneously relay the distress signal from the target source in order to achieve the geolocation function.However,when the ground receiving system has only one antenna receiving station,or the target source is in a heavily obscured environment,the ground side is unable to receive the forwarded signals from multiple satellites at the same time,which will make it impossible to locate.To address these problems,in this paper,a time-sharing single satellite geolocations method based on different orbits is proposed for the first time.This method uses one or several low-earth orbit satellites(LEO)and mediumearth orbit satellites(MEO)in the visible area,and the receiving station only needs one pair of receiving antennas to complete the positioning.It can effectively compensate for the shortcomings of the traditional TDOA using the same moment and have better positioning accuracy compared with the single satellite in the same orbit.Due to the limited experimental conditions,this paper tests the navigation satellite using different orbit time-sharing single satellite geolocations,and proves that the positioning method has high positioning accuracy and has certain promotion and application value.
基金supported by the National Natural Science Foundation of China (Nos. 52022015, 51876016)the Innovative Research Group Project of National Natural Science Foundation of China (No.52021004)+3 种基金the State Key Program of National Natural Science of China (No. 51836001)the Chongqing Talents:Exceptional Young Talents Project (No. CQYC_(2)02005081)the Natural Science Foundation of Chongqing (No. cstc2021ycjh-bgzxm0160)Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project (No.TSBICIPCXRC-032)。
文摘Fatty acid photodecarboxylase of Chlorella variabilis NC64A(CvFAP) is a novel photoenzyme with great potential in the treatment of waste lipids and production of sustainable aviation fuel. However, the fragile nature of Cv FAP to blue light is an urgent challenge. Herein, we demonstrated anaerobic environment could significantly improve the photostability of Cv FAP for the first time. The decarboxylation of palmitic acid by Cv FAP for 3 h under anaerobic environment increased pentadecane yield by 44.7% as compared to that under aerobic environment. The residual activity of Cv FAP after blue-light preillumination in the absence of palmitic acid for 0.5 h under anaerobic environment was 80.4%, which was 258.7 times higher than that under aerobic environment. Remarkable accumulation of superoxide radical and singlet oxygen in Cv FAP under aerobic environment led to the poor photostability of Cv FAP. Anaerobic environment helped to mitigate the production of superoxide radical and singlet oxygen in Cv FAP, improving the photostability of Cv FAP.
基金National Natural Science Foundation of China(Grant Nos.11774279 and 11774280)Fundamental Research Funds for the Central Universities of China(Grant Nos.xjj2017029 and xzy032020038)Natural Science Basic Research Plan in Shaanxi Province of China(Grant No.2019JQ-603)。
文摘Coronavirus Disease 2019(COVID-19),caused by the novel coronavirus,has spread rapidly across China.Consequently,there is an urgent need to sort and develop novel agents for the prevention and treatment of viral infections.A rapid structure-based virtual screening is used for the evaluation of current commercial drugs,with structures of human angiotensin converting enzymeⅡ(ACE2),and viral main protease,spike,envelope,membrane and nucleocapsid proteins.Our results reveal that the reported drugs Arbidol,Chloroquine and Remdesivir may hinder the entry and release of virions through the bindings with ACE2,spike and envelope proteins.Due to the similar binding patterns,NHC(β-d-N4-hydroxycytidine)and Triazavirin are also in prospects for clinical use.Main protease(3 CLpro)is likely to be a feasible target of drug design.The screening results to target 3 CLpro reveal that Mitoguazone,Metformin,Biguanide Hydrochloride,Gallic acid,Caffeic acid,Sulfaguanidine and Acetylcysteine seem be possible inhibitors and have potential application in the clinical therapy of COVID-19.
文摘In the article“Long non-coding RNA LINC02163 accelerates malignant tumor behaviors in breast cancer by regulating the microRNA-511-3p/HMGA2 axis as a competing endogenous RNA”(Oncology Research,2020,Vol.28,No.5,pp.483–495.doi:10.3727/096504020X15928179818438),there was an error in the processing of data.To further confirm our observation,we repeated multiple experiments involving in this study,including Flow Cytometry,Transwell Cell Migration and Invasion Assays,Xenograft Tumor Model,and Western Blotting.We have revised the figures to correct these errors.Corrected versions of the Figs.2,4,5,6,and 7 are provided.The corrections do not change any results or conclusion of the article.We apologize for any inconvenience caused.
基金supported by the National Natural Science Foundation of China(Nos.52236009,52106224)the Innovative Research Group Project of the National Natural Science Foundation of China(No.52021004)+2 种基金the Natural Science Foundation of Chongqing(Nos.CSTB2023NSCQ-JQX0005)the Venture&Innovation Support Program for Chongqing Overseas Returnees(No.cx2022027)Key Laboratory of Low-grade Energy Utilization Technologies and Systems permanent staff research fund(LLEUTS 2024001).
文摘Biomass hydrothermal conversion has received extensive attention due to its advantages of strong adaptability of raw materials,no need to dry feedstock,and relatively mild conditions.Chlorella pyrenoidosa(CP)and oilseed rape straw(OS),two kinds of typical biomass,were hydrothermally treated at 230℃ for 6 h to produce carbon dots(CDs),hydrochar(HC),bio-oil(OR),aqueous product(AQ),and volatile product(VO).The CP hydrothermal process generated the highest yield of CDs(16.3%),and the OS hydrothermal process produced the most HC(26.3%).The co-hydrothermal treatment of CP/OS promoted the production of HC and VO via carbonization,decarboxylation,and dehydration reactions between CP and OS degradation products.The CP,OS,and CP/OS based CDs(CD-CP,CD-OS,and CD-CP/OS)in the size of 1.5‒26.5 nm emitted blue light and displayed 3.3‒11.1%of fluorescence quantum yield.More than 42.3%of methylene blue could be photodegraded by CD-CP,which was 2.1 and 1.4 times higher than that by CD-OS and CD-CP/OS.The higher heating values of HCs and ORs were 23.0‒27.8 MJ kg^(−1)and 25.5‒38.5 MJ kg^(−1),showing potential to apply as biofuels.The HCs were confirmed to be outstanding bio-adsorbents that could remove 15.4‒68.9%methylene blue with an absorption capacity of up to 275.6 mg g−1.Moreover,the AQs were verified to be potentially used as biological nutrients for microalgae cultivation.This study co-produced CDs,BO,HC,and AQ through the hydrothermal conversion of CP and OS,efficiently utilizing them as photocatalysts,biofuels,bio-adsorbents,and biological nutrients.
基金supported by the National Natural Science Foundation of China(No.No.52394202,No.52476056)State Key Laboratory of Engines,Tianjin University(K2025-10)+2 种基金the Natural Science Foundation of Chongqing(CSTB2024NSCQ-MSX0915)the China Postdoctoral Science Foundation(No.BX20240449)the Innovative Research Group Project of the National Natural Science Foundation of China(No.52021004).
文摘Electrochemical CO_(2) reduction(CO_(2)RR)to value-added fuels and chemicals offers a promising route toward carbon neutrality.However,developing efficient and selective catalysts for the generation of multi-carbon(C^(2+))products remains a significant challenge.In this work,we propose a combined density functional theory(DFT)and machine learning(ML)approach to systematically screen CuSb-based catalysts with varying surface Sb atomic fractions and non-metal dopants(O,N,S,Se,and P)on the Cu_(2)Sb(100)surface for CO_(2)RR.Approximately 200 representative adsorption configurations were randomly selected for DFT calculations,which were then used to train a predictive ML model.This model enables high-accuracy predictions of the adsorption energies of key intermediates(*CO and*H)for the remaining uncalculated configurations.By integrating the K-means clustering analysis and the optimal adsorption energy selection criteria based on the Sabatier principle,the candidate configuration with the best potential for C^(2+)product formation was identified:O-doped CuSb with a surface Sb atomic fraction of 3/12.Mechanistic studies further reveal that O doping significantly strengthens *CO adsorption while suppressing *H adsorption by modulating the electronic structure,thereby lowering the CO_(2)RR energy barrier and improving the thermodynamic selectivity toward C^(2+)products.This work not only elucidates the synergistic effect of surface Sb atomic fraction and non-metal dopants on CO_(2)RR activity,but also establishes a scalable ML prediction and screening framework,providing theoretical support and methodological pathways for the design of high-performance CuSb-based catalysts.
基金financial supports of the National Natural Science Foundation of China (NSFC,Nos.52394202,52476056,and 52301232)the Natural Science Foundation of Chongqing Province (No.2024NSCQ-MSX1109)。
文摘Developing advanced electrocatalysts to convert CO_(2) into liquid fuels such as C_(2)H_(5)OH is critical for utilizing intermittent renewable energy.The formation of C_(2)H_(5)OH,however,is generally less favored compared with the other hydrocarbon products from Cu-based electrocatalysts.In this work,an alkanethiolmodified Cu_(2)O nanowire array(OTT-Cu_(2)O) was constructed with asymmetric Cu sites consisting of paired Cu-O and Cu-S motifs to overcome previous limitations of C_(2)H_(5)OH electrosynthesis via CO_(2)RR pathway.This catalyst achieves a high Faradaic efficiency of 45 % for CO_(2)-to-C_(2)H_(5)OH conversion at 300 m A/cm^(2),representing a more than two-fold enhancement over the Cu_(2)O electrode.Mechanistic investigations reveal that the Cu-S site exhibits distinct C-binding capability that stabilizes key intermediates(^(*)OCH_(2) and ^(*)CO),in contrast to the O-affinitive Cu-O site.The asymmetric S-Cu-O configuration promotes thermodynamically favorable asymmetric C-C coupling between ^(*)CO and ^(*)OCH_(2),forming the critical CO-OCH_(2) intermediate and facilitating C_(2)H_(5)OH production,as opposed to symmetric O-Cu-O sites that mainly generate HCOOH.This work offers an effective strategy for designing multi-active-site catalysts toward highly selective CO_(2) reduction to C_(2)H_(5)OH and provides fundamental insight into the reaction mechanism.
