To investigate the effects of thyme(Thymus vulgaris L.)addition on the flavor modification of mutton broth during boiling,three mutton-broth samples with various thyme contents 0.06%(S1),0.30%(S2),and1.50%(S3)were ana...To investigate the effects of thyme(Thymus vulgaris L.)addition on the flavor modification of mutton broth during boiling,three mutton-broth samples with various thyme contents 0.06%(S1),0.30%(S2),and1.50%(S3)were analyzed and compared,without thyme as control(0.00%,S0).The meaty,fatty,pastoral flavor and spicy were chosen as sensory attributes to evaluate the flavor of the mutton-broth samples.Sensory results were significantly different(P<0.001),with S2 having the optimum overall acceptability.A total of 99 volatile compounds were identified by gas chromatography-mass spectrometry,among which19 compounds were considered as the odor-active compounds according to their odor activity values.Significant changes(P<0.05)appeared in most volatiles in S0 with thyme addition,especially aldehydes.Free fatty acids(FFAs)were also identified,and all of them significantly increased with increased thyme(P<0.05).Correlation analysis of odor-active compounds,FFAs,and sensory attributes through partial least squares regression indicated the important volatiles and FFAs remarkably contributed to the mutton broth samples,and further confirmed that the 0.30%of thyme may be a desirable addition amount for the sensory characteristics of mutton broth.展开更多
Introduction:Recent sentinel surveillance has revealed a rising prevalence of human adenovirus type 21(HAdV-21)among HAdV infections in China.This study aimed to elucidate the molecular features of currently circulati...Introduction:Recent sentinel surveillance has revealed a rising prevalence of human adenovirus type 21(HAdV-21)among HAdV infections in China.This study aimed to elucidate the molecular features of currently circulating HAdV-21 strains in China.Methods:Whole-genome sequencing(WGS)was performed on 23 HAdV-21 strains isolated from acute respiratory infection cases,56.5%involving lower respiratory tract infections,across 7 Chinese sentinel surveillance provincial-level administrative divisions(PLADs)(2023-2024).These sequences,along with 50 previously reported HAdV-21 genomes from 6 countries(1956-2019),were integrated into a WGS dataset for comprehensive phylogenetic,genetic variation,and recombination analyses.Results:WGS categorized the HAdV-21 strains into 3 subtypes:HAdV-21a,HAdV-21b,and historical HAdV-21p(isolated in the 1950s).HAdV-21a(1956-2024,involving 5 of the 6 countries)and HAdV-21b(2005-2024,involving 3 of the 6 countries)exhibited extensive spatiotemporal distributions.Recent Chinese strains(2023-2024)belonged to HAdV-21a and HAdV-21b(HAdV-21a/b),showing extremely high genetic homology with Chinese 2019 strains(genetic distance:0.00007)and global strains(distance:<0.00040).Phylogenetic analysis confirmed that HAdV-21a/b shared a common ancestor and maintained a highly conserved genome despite decades of circulation.Sequence variation analysis identified shared and subtype-specific mutations in these two subtypes.Recombination pattern analysis further revealed that HAdV-21a/b acquired an HAdV-3-derived fragment in the E4 region(breakpoint:nt32,843).Conclusions:Recombinant HAdV-21a/b subtypes have co-circulated in China in recent years with remarkable genetic conservation.Enhanced surveillance is essential to quantify associated disease burden and guide targeted prevention and control strategies.展开更多
Accessible chromatin regions(ACRs)provide physical scaffolds to recruit transcriptional co-regulators and displace their nearby nucleosomes in multiple plant species.Characterization of ACRs and investigation of their...Accessible chromatin regions(ACRs)provide physical scaffolds to recruit transcriptional co-regulators and displace their nearby nucleosomes in multiple plant species.Characterization of ACRs and investigation of their biological effects in Sorghum bicolor has lagged behind.Regulation of gene expression relies on the transcriptional co-regulators that are recruited to ACRs to affect epigenomic modifications of surrounding nucleosomes.In this study,we employed transposase-accessible chromatin sequencing to identify ACRs and decipher how the presence of ACRs affects gene expression and epigenetic signatures in the Sorghum genome.As a result,21077 ACRs,which are mapped to 22.9%of genes and 2.7%of repeats,were identified.The profiling of ACRs on gene structures reveals a narrow and sharp peak around the transcription start site,with relatively weak and broad signals covering the entire gene body and an explicit but wide peak from the transcription termination site to its downstream regions.We discovered that the correlations between gene expression levels and profiled ACR densities are dependent on the positions of ACRs.The occurrence of genic ACRs cumulatively enhances the transcriptional activity of intergenic ACR-associated genes.In addition,an intricate crosstalk among ACRs,gene expression,and epigenetic marks has been unveiled by integrating multiple-omics analyses of whole-genome bisulfite sequencing,6mA immunoprecipitation followed by sequencing,RNA sequencing,chromatin immunoprecipitation sequencing,and DNase I hypersensitive sites sequencing datasets.Our study provides a genome-wide landscape of ACRs in sorghum,decrypts their interrelations with various epigenetic marks,and sheds new light on their roles in transcriptional regulation.展开更多
In October 2017,a small outbreak of echovirus 30(E30)associated with aseptic meningitis in nine cases occurred at a primary school in the Ningxia Hui Autonomous Region.That year,we observed a significant increase in E...In October 2017,a small outbreak of echovirus 30(E30)associated with aseptic meningitis in nine cases occurred at a primary school in the Ningxia Hui Autonomous Region.That year,we observed a significant increase in E30 levels in an acute flaccid paralysis(AFP)case surveillance system.To investigate their phylogenetic relationships,we determined the whole genomic sequences of 12 strains isolated from aseptic meningitis cases,AFP cases,and healthy children.We found that the E30 strains circulating in Ningxia belong to two lineages(H and J).The strains isolated in 2010,2012,and 2016 belonged to the H lineage.In 2017,a new lineage,J,emerged as the dominant lineage.Phylogenetic trees were constructed based on the whole genome andP1,P2,andP3 regions;clustering with other types of enterovirus species B was found,suggesting that recombination events had occurred.The recombination sites were mainly in regions2B,2C,and3D.This study confirmed that the E30 strains in Ningxia in 2010,2012,and 2016 had different recombination patterns and were recombined with different enteroviruses.The 2017 epidemic E30 originated from another new lineage with a complex recombination pattern and formed an independent transmission chain in Ningxia.展开更多
What is already known about this topic?Scrub typhus is an acute infectious disease caused by Orientia tsutsugamushi that is transmitted primarily through the bite of infected chigger mite larvae.The disease prevalence...What is already known about this topic?Scrub typhus is an acute infectious disease caused by Orientia tsutsugamushi that is transmitted primarily through the bite of infected chigger mite larvae.The disease prevalence is closely associated with environments characterized by high moisture levels and abundant vegetation.What is added by this report?This study documents the first confirmed case of scrub typhus in Ningxia Hui Autonomous Region,China.The patient presented with characteristic clinical manifestations,including abnormal biochemical indicators and positive serum-specific IgM antibodies against scrub typhus.Epidemiological evidence suggests local acquisition of the disease.What are the implications for public health practice?Enhanced surveillance and preventive measures for scrub typhus are essential in this region,particularly for individuals residing in or visiting areas where the disease may be endemic.展开更多
Tacrolimus(FK506)is a potent immunosuppressant widely used to prevent rejection following organ transplantation.In this study,we employed a photonic crystal microarray-based competitive assay to measure tacrolimus blo...Tacrolimus(FK506)is a potent immunosuppressant widely used to prevent rejection following organ transplantation.In this study,we employed a photonic crystal microarray-based competitive assay to measure tacrolimus blood concentrations,facilitating bedside and at-home monitoring for transplant recipients.The photonic crystal microarray technology offers flexibility,cost-effectiveness,and high efficiency.When integrated with a portable fluorescence intensity detector,it enables rapid and quantitative analysis.By fabricating the photonic crystal microarray and leveraging the photonic crystal bandgap enhancement effect to amplify the fluorescence intensity of probe molecules,the detection sensitivity is significantly improved.The photonic crystal microarray demonstrated a remarkable fluorescence enhancement factor of 17.2-fold compared to conventional substrates,significantly improving the sensitivity of tacrolimus detection.The optimized system achieved a detection limit of 0.4 ng·mL^(-1),enabling rapid and accurate quantification of tacrolimus concentration within 20 min.展开更多
Background:The aim of this study was to develop and validate a fatty liver index based on laboratory data(FLI-L)and a fatty liver index based on both physical examination and laboratory data(FLI-PL)in the hope of prov...Background:The aim of this study was to develop and validate a fatty liver index based on laboratory data(FLI-L)and a fatty liver index based on both physical examination and laboratory data(FLI-PL)in the hope of providing a more convenient,accurate,and quantitative method for the diagnosis of fatty liver disease.Methods:The study included data for 12,391 patients obtained from the Third Medical Center of Chinese PLA General Hospital.FLI-L and FLI-PL were developed using binary logistic regression analysis.The diagnostic performance of the FLI-L and FLI-PL was evaluated using the area under the receiver-operating characteristic curve(AUC-ROC)with sensitivity,specificity,and positive and negative likelihood ratios.FLI-L and FLI-PL were subsequently validated in 3170 patients from the same hospital.Results:The AUC-ROC for FLI-L was 0.876 with a cut-off value of 55.03.Sensitivity was 81.35 and specificity was 78.28,with an accuracy of 79.99%for discriminating between patients with and without fatty liver disease.The AUC-ROC for FLI-PL was 0.902 with a cut-off value of 20.51.Sensitivity was 85.10 and specificity was 79.64.FLI-PL classified 91.65%of patients correctly.Conclusion:FLI-L and FLI-PL is used for simple and accurate quantitative diagnosis of fatty liver disease.This study provides evidence to support the use of this index in clinical management.展开更多
The Global Boundary Stratotype Sections and Points(GSSPs) for the bases of all seven international Devonian stages have been formally defined and ratified by IUGS till 1996, and nowadays, the main tasks for Devonian s...The Global Boundary Stratotype Sections and Points(GSSPs) for the bases of all seven international Devonian stages have been formally defined and ratified by IUGS till 1996, and nowadays, the main tasks for Devonian stratigraphers include further subdivision of these standard stages, strictly constrained absolute ages for the boundaries, and precise neritic-pelagic and marine-terrestrial correlations using multidisciplinary stratigraphy methods. Establishment of high-resolution Devonian integrative stratigraphy framework and timescale of China would play an important role in improving regional and international correlation, facilitating the recognition of important stratigraphic levels in different paleogeographic settings, and understanding the evolution pattern of biota, paleoclimate and paleoenvironment during this critical interval. Based on well-studied bio-and chronostratigraphy of Devonian in South China and adjacent areas, in combination with recent achievements in carbon isotope stratigraphy, event stratigraphy and radioactive isotope ages, this paper briefly summarize the research history and current status of Devonian chronostratigraphy of China, and for the first time introduce Devonian integrative stratigraphy framework of China.Up to date, few studies have been conducted on the astronomical cyclostratigraphy and high-resolution radioactive isotope dating in Devonian of China, which should be our main focuses in the near future.展开更多
Givetian through middle Famennian brachiopods of Hunan are used to define five biozones,comprising,in ascending order,the Stringocephalus Abundance Zone,the Ambocoeliid-Leiorhynchid Assemblage Zone,the Cyrtospiriferid...Givetian through middle Famennian brachiopods of Hunan are used to define five biozones,comprising,in ascending order,the Stringocephalus Abundance Zone,the Ambocoeliid-Leiorhynchid Assemblage Zone,the Cyrtospiriferid Assemblage Zone,the Yunnanellina-Sinospirifer Assemblage Zone,and the Yunnanella-Hunanospirifer Assemblage Zone.They correspond approximately to the Po.hemiansatus Zone to Po.varcus Zone,S.hermanni Zone to Pa.punctata Zone,Pa.hassi Zone to Pa.linguiformis Zone,Pa.triangularis Zone to Upper Pa.crepida Zone,and Uppermost Pa.crepida Zone to Pa.marginifera Zone,respectively.Intensified rifting activity in South China during the Devonian began in the middle of the Lower Po.varcus Zone(a level marked by the first appearance of Po.rhenanus),which is consistent with the Lower-Middle Givetian substage boundary suggested by the International Subcommission on Devonian Stratigraphy(SDS).This assumed that rifting activity in the Lower Po.varcus Zone was signified by the deposition of the Baqi Formation in Guangxi and was marked largely by the extensive deposition of the Qiziqiao Formation in central Hunan,which probably led to an opposite pattern of relative sea level change-rising in deeper water trough areas and lowering in carbonate platform areas.The previously recognized S.hermanni Zone sea level rise in platform margin areas of Guangxi can be identified not only in the trough areas but also in platform areas,which probably indicates an overall marine transgression at this time,rather than tectonically induced sea level change.Similarly,this level coincides with the Middle-Upper Givetian substage boundary suggested by the SDS.Although the sea level rise may have occurred in the deeper water trough areas of South China towards the end of the Givetian,platformal areas experienced uplifting at various degrees,especially in the central and northern regions of Hunan where Early Frasnian deposits were apparently absent in many places.Similarly,the end-Frasnian regression led to exposure of many places and absence of early Famennian deposits,which probably accounts for the restricted distribution of the Yunnanellina brachiopod fauna.展开更多
Dear Editor,Patients presenting with acute myocarditis and sudden hemodynamic instability(termed fulminant myocarditis[FM])still have a high mortality and need for heart transplantation,up to 28%at 60 days.1,2,3 Recen...Dear Editor,Patients presenting with acute myocarditis and sudden hemodynamic instability(termed fulminant myocarditis[FM])still have a high mortality and need for heart transplantation,up to 28%at 60 days.1,2,3 Recent scientific statements and expert opinion consensus suggests early use of temporary mechanical circulatory supports(t-MCS).3,4 Specifically,Chinese scientific statement proposed an extensive use of t-MCS combined with immunoregulatory therapy(IT),4 although formal trials are lacking.We present a multicenter,retrospective study to compare the outcome of patients who were treated with t-MCS and IT vs.patients who didn’t receive these treatments.We included patients with the diagnosis of FM based on the presence of viral prodromal signs/symptoms followed by acute onset of severe heart failure(HF)without other relevant differential diagnosis or pre-existing cardiac disorders.Patients who received both t-MCS and IT during hospitalization were classified as t-MCS+IT group.展开更多
Fulminant myocarditis is an acute diffuse inflammatory disease of myocardium.It is characterized by acute onset,rapid progress and high risk of death.Its pathogenesis involves excessive immune activation of the innate...Fulminant myocarditis is an acute diffuse inflammatory disease of myocardium.It is characterized by acute onset,rapid progress and high risk of death.Its pathogenesis involves excessive immune activation of the innate immune system and formation of inflammatory storm.According to China’s practical experience,the adoption of the“life support-based comprehensive treatment regimen”(with mechanical circulation support and immunomodulation therapy as the core)can significantly improve the survival rate and long-term prognosis.Special emphasis is placed on very early identification,very early diagnosis,very early prediction and very early treatment.展开更多
基金supported by the National key research and development program(grant number 2016YFD0400705)。
文摘To investigate the effects of thyme(Thymus vulgaris L.)addition on the flavor modification of mutton broth during boiling,three mutton-broth samples with various thyme contents 0.06%(S1),0.30%(S2),and1.50%(S3)were analyzed and compared,without thyme as control(0.00%,S0).The meaty,fatty,pastoral flavor and spicy were chosen as sensory attributes to evaluate the flavor of the mutton-broth samples.Sensory results were significantly different(P<0.001),with S2 having the optimum overall acceptability.A total of 99 volatile compounds were identified by gas chromatography-mass spectrometry,among which19 compounds were considered as the odor-active compounds according to their odor activity values.Significant changes(P<0.05)appeared in most volatiles in S0 with thyme addition,especially aldehydes.Free fatty acids(FFAs)were also identified,and all of them significantly increased with increased thyme(P<0.05).Correlation analysis of odor-active compounds,FFAs,and sensory attributes through partial least squares regression indicated the important volatiles and FFAs remarkably contributed to the mutton broth samples,and further confirmed that the 0.30%of thyme may be a desirable addition amount for the sensory characteristics of mutton broth.
基金Supported by the National Key R&D Program of China(2022YFC2305303)and the Health and Wellness Sector Research Program of Gansu(GSWSON2021-010).
文摘Introduction:Recent sentinel surveillance has revealed a rising prevalence of human adenovirus type 21(HAdV-21)among HAdV infections in China.This study aimed to elucidate the molecular features of currently circulating HAdV-21 strains in China.Methods:Whole-genome sequencing(WGS)was performed on 23 HAdV-21 strains isolated from acute respiratory infection cases,56.5%involving lower respiratory tract infections,across 7 Chinese sentinel surveillance provincial-level administrative divisions(PLADs)(2023-2024).These sequences,along with 50 previously reported HAdV-21 genomes from 6 countries(1956-2019),were integrated into a WGS dataset for comprehensive phylogenetic,genetic variation,and recombination analyses.Results:WGS categorized the HAdV-21 strains into 3 subtypes:HAdV-21a,HAdV-21b,and historical HAdV-21p(isolated in the 1950s).HAdV-21a(1956-2024,involving 5 of the 6 countries)and HAdV-21b(2005-2024,involving 3 of the 6 countries)exhibited extensive spatiotemporal distributions.Recent Chinese strains(2023-2024)belonged to HAdV-21a and HAdV-21b(HAdV-21a/b),showing extremely high genetic homology with Chinese 2019 strains(genetic distance:0.00007)and global strains(distance:<0.00040).Phylogenetic analysis confirmed that HAdV-21a/b shared a common ancestor and maintained a highly conserved genome despite decades of circulation.Sequence variation analysis identified shared and subtype-specific mutations in these two subtypes.Recombination pattern analysis further revealed that HAdV-21a/b acquired an HAdV-3-derived fragment in the E4 region(breakpoint:nt32,843).Conclusions:Recombinant HAdV-21a/b subtypes have co-circulated in China in recent years with remarkable genetic conservation.Enhanced surveillance is essential to quantify associated disease burden and guide targeted prevention and control strategies.
基金supported by funds from the National Natural Science Foundation of China,grants 31900427(to C.Z.),31600981(to X.L.),and 32000609(to Y.Z.)the Project of Youth Talent in the Hubei Provincial Department of Education(Q20191207)to C.Z.+1 种基金the Open Project of Hubei Key Laboratory of Wudang Local Chinese Medicine Research(Hubei University of Medicine)(grant WDCM2019009)to C.Z.the Initial Project for High-Level Personnel of China Three Gorges University to C.Z.
文摘Accessible chromatin regions(ACRs)provide physical scaffolds to recruit transcriptional co-regulators and displace their nearby nucleosomes in multiple plant species.Characterization of ACRs and investigation of their biological effects in Sorghum bicolor has lagged behind.Regulation of gene expression relies on the transcriptional co-regulators that are recruited to ACRs to affect epigenomic modifications of surrounding nucleosomes.In this study,we employed transposase-accessible chromatin sequencing to identify ACRs and decipher how the presence of ACRs affects gene expression and epigenetic signatures in the Sorghum genome.As a result,21077 ACRs,which are mapped to 22.9%of genes and 2.7%of repeats,were identified.The profiling of ACRs on gene structures reveals a narrow and sharp peak around the transcription start site,with relatively weak and broad signals covering the entire gene body and an explicit but wide peak from the transcription termination site to its downstream regions.We discovered that the correlations between gene expression levels and profiled ACR densities are dependent on the positions of ACRs.The occurrence of genic ACRs cumulatively enhances the transcriptional activity of intergenic ACR-associated genes.In addition,an intricate crosstalk among ACRs,gene expression,and epigenetic marks has been unveiled by integrating multiple-omics analyses of whole-genome bisulfite sequencing,6mA immunoprecipitation followed by sequencing,RNA sequencing,chromatin immunoprecipitation sequencing,and DNase I hypersensitive sites sequencing datasets.Our study provides a genome-wide landscape of ACRs in sorghum,decrypts their interrelations with various epigenetic marks,and sheds new light on their roles in transcriptional regulation.
基金supported by the Science and Natural Science of Ningxia (Grant No.2021AAC03415)the Science and Natural Science of China (Grant No.81960607)+1 种基金Science and Natural Science of Ningxia (Grant No.2022AAC03708)the National Key Research and Development Program of China (Project No.2021YFC2302003).
文摘In October 2017,a small outbreak of echovirus 30(E30)associated with aseptic meningitis in nine cases occurred at a primary school in the Ningxia Hui Autonomous Region.That year,we observed a significant increase in E30 levels in an acute flaccid paralysis(AFP)case surveillance system.To investigate their phylogenetic relationships,we determined the whole genomic sequences of 12 strains isolated from aseptic meningitis cases,AFP cases,and healthy children.We found that the E30 strains circulating in Ningxia belong to two lineages(H and J).The strains isolated in 2010,2012,and 2016 belonged to the H lineage.In 2017,a new lineage,J,emerged as the dominant lineage.Phylogenetic trees were constructed based on the whole genome andP1,P2,andP3 regions;clustering with other types of enterovirus species B was found,suggesting that recombination events had occurred.The recombination sites were mainly in regions2B,2C,and3D.This study confirmed that the E30 strains in Ningxia in 2010,2012,and 2016 had different recombination patterns and were recombined with different enteroviruses.The 2017 epidemic E30 originated from another new lineage with a complex recombination pattern and formed an independent transmission chain in Ningxia.
基金Supported by the National Key Research and Development Program of China(2022YFC2602203).
文摘What is already known about this topic?Scrub typhus is an acute infectious disease caused by Orientia tsutsugamushi that is transmitted primarily through the bite of infected chigger mite larvae.The disease prevalence is closely associated with environments characterized by high moisture levels and abundant vegetation.What is added by this report?This study documents the first confirmed case of scrub typhus in Ningxia Hui Autonomous Region,China.The patient presented with characteristic clinical manifestations,including abnormal biochemical indicators and positive serum-specific IgM antibodies against scrub typhus.Epidemiological evidence suggests local acquisition of the disease.What are the implications for public health practice?Enhanced surveillance and preventive measures for scrub typhus are essential in this region,particularly for individuals residing in or visiting areas where the disease may be endemic.
基金supported by the National Key Research and Development Program of China(No.2023YFE0111500)the National Natural Science Foundation of China(Nos.52222313,22075296,52321006,T2394480,and T2394484)the Beijing National Laboratory for Molecular Sciences(No.BNLMS-CXXM-202005).
文摘Tacrolimus(FK506)is a potent immunosuppressant widely used to prevent rejection following organ transplantation.In this study,we employed a photonic crystal microarray-based competitive assay to measure tacrolimus blood concentrations,facilitating bedside and at-home monitoring for transplant recipients.The photonic crystal microarray technology offers flexibility,cost-effectiveness,and high efficiency.When integrated with a portable fluorescence intensity detector,it enables rapid and quantitative analysis.By fabricating the photonic crystal microarray and leveraging the photonic crystal bandgap enhancement effect to amplify the fluorescence intensity of probe molecules,the detection sensitivity is significantly improved.The photonic crystal microarray demonstrated a remarkable fluorescence enhancement factor of 17.2-fold compared to conventional substrates,significantly improving the sensitivity of tacrolimus detection.The optimized system achieved a detection limit of 0.4 ng·mL^(-1),enabling rapid and accurate quantification of tacrolimus concentration within 20 min.
基金supported by the National Natural Science Foundation of China(grant number 81972696).
文摘Background:The aim of this study was to develop and validate a fatty liver index based on laboratory data(FLI-L)and a fatty liver index based on both physical examination and laboratory data(FLI-PL)in the hope of providing a more convenient,accurate,and quantitative method for the diagnosis of fatty liver disease.Methods:The study included data for 12,391 patients obtained from the Third Medical Center of Chinese PLA General Hospital.FLI-L and FLI-PL were developed using binary logistic regression analysis.The diagnostic performance of the FLI-L and FLI-PL was evaluated using the area under the receiver-operating characteristic curve(AUC-ROC)with sensitivity,specificity,and positive and negative likelihood ratios.FLI-L and FLI-PL were subsequently validated in 3170 patients from the same hospital.Results:The AUC-ROC for FLI-L was 0.876 with a cut-off value of 55.03.Sensitivity was 81.35 and specificity was 78.28,with an accuracy of 79.99%for discriminating between patients with and without fatty liver disease.The AUC-ROC for FLI-PL was 0.902 with a cut-off value of 20.51.Sensitivity was 85.10 and specificity was 79.64.FLI-PL classified 91.65%of patients correctly.Conclusion:FLI-L and FLI-PL is used for simple and accurate quantitative diagnosis of fatty liver disease.This study provides evidence to support the use of this index in clinical management.
基金supported by the Strategic Priority Research Program (B) of Chinese Academy of Sciences (Grant Nos. XDB26000000, XDB18000000)the National Natural Science Foundation of China (Grant Nos. 41290260, 41772004, 41772012)the Special Program for Basic Research of the Ministry of Science and Techology, China (Grant No. 2013FY111000)
文摘The Global Boundary Stratotype Sections and Points(GSSPs) for the bases of all seven international Devonian stages have been formally defined and ratified by IUGS till 1996, and nowadays, the main tasks for Devonian stratigraphers include further subdivision of these standard stages, strictly constrained absolute ages for the boundaries, and precise neritic-pelagic and marine-terrestrial correlations using multidisciplinary stratigraphy methods. Establishment of high-resolution Devonian integrative stratigraphy framework and timescale of China would play an important role in improving regional and international correlation, facilitating the recognition of important stratigraphic levels in different paleogeographic settings, and understanding the evolution pattern of biota, paleoclimate and paleoenvironment during this critical interval. Based on well-studied bio-and chronostratigraphy of Devonian in South China and adjacent areas, in combination with recent achievements in carbon isotope stratigraphy, event stratigraphy and radioactive isotope ages, this paper briefly summarize the research history and current status of Devonian chronostratigraphy of China, and for the first time introduce Devonian integrative stratigraphy framework of China.Up to date, few studies have been conducted on the astronomical cyclostratigraphy and high-resolution radioactive isotope dating in Devonian of China, which should be our main focuses in the near future.
基金supported by Major Basic Research Program of China (Grant No. 2006CB806408)National Natural Science Foundation of China (Grant Nos. 40872007 and 40830211)
文摘Givetian through middle Famennian brachiopods of Hunan are used to define five biozones,comprising,in ascending order,the Stringocephalus Abundance Zone,the Ambocoeliid-Leiorhynchid Assemblage Zone,the Cyrtospiriferid Assemblage Zone,the Yunnanellina-Sinospirifer Assemblage Zone,and the Yunnanella-Hunanospirifer Assemblage Zone.They correspond approximately to the Po.hemiansatus Zone to Po.varcus Zone,S.hermanni Zone to Pa.punctata Zone,Pa.hassi Zone to Pa.linguiformis Zone,Pa.triangularis Zone to Upper Pa.crepida Zone,and Uppermost Pa.crepida Zone to Pa.marginifera Zone,respectively.Intensified rifting activity in South China during the Devonian began in the middle of the Lower Po.varcus Zone(a level marked by the first appearance of Po.rhenanus),which is consistent with the Lower-Middle Givetian substage boundary suggested by the International Subcommission on Devonian Stratigraphy(SDS).This assumed that rifting activity in the Lower Po.varcus Zone was signified by the deposition of the Baqi Formation in Guangxi and was marked largely by the extensive deposition of the Qiziqiao Formation in central Hunan,which probably led to an opposite pattern of relative sea level change-rising in deeper water trough areas and lowering in carbonate platform areas.The previously recognized S.hermanni Zone sea level rise in platform margin areas of Guangxi can be identified not only in the trough areas but also in platform areas,which probably indicates an overall marine transgression at this time,rather than tectonically induced sea level change.Similarly,this level coincides with the Middle-Upper Givetian substage boundary suggested by the SDS.Although the sea level rise may have occurred in the deeper water trough areas of South China towards the end of the Givetian,platformal areas experienced uplifting at various degrees,especially in the central and northern regions of Hunan where Early Frasnian deposits were apparently absent in many places.Similarly,the end-Frasnian regression led to exposure of many places and absence of early Famennian deposits,which probably accounts for the restricted distribution of the Yunnanellina brachiopod fauna.
基金the National Natural Science Foundation of China(No.81790624 and 81630010,82070316)National Key R&D Program of China(NO.2017YFC0909400).
文摘Dear Editor,Patients presenting with acute myocarditis and sudden hemodynamic instability(termed fulminant myocarditis[FM])still have a high mortality and need for heart transplantation,up to 28%at 60 days.1,2,3 Recent scientific statements and expert opinion consensus suggests early use of temporary mechanical circulatory supports(t-MCS).3,4 Specifically,Chinese scientific statement proposed an extensive use of t-MCS combined with immunoregulatory therapy(IT),4 although formal trials are lacking.We present a multicenter,retrospective study to compare the outcome of patients who were treated with t-MCS and IT vs.patients who didn’t receive these treatments.We included patients with the diagnosis of FM based on the presence of viral prodromal signs/symptoms followed by acute onset of severe heart failure(HF)without other relevant differential diagnosis or pre-existing cardiac disorders.Patients who received both t-MCS and IT during hospitalization were classified as t-MCS+IT group.
基金supported in part by the National Natural Science Foundation of China(81790624,81630010)Top-Notch Talent Program of Hubei Province and Tongji Hospital(2021YBJRC005)。
文摘Fulminant myocarditis is an acute diffuse inflammatory disease of myocardium.It is characterized by acute onset,rapid progress and high risk of death.Its pathogenesis involves excessive immune activation of the innate immune system and formation of inflammatory storm.According to China’s practical experience,the adoption of the“life support-based comprehensive treatment regimen”(with mechanical circulation support and immunomodulation therapy as the core)can significantly improve the survival rate and long-term prognosis.Special emphasis is placed on very early identification,very early diagnosis,very early prediction and very early treatment.
