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Targeting novel sites represents an effective strategy for combating drug resistance
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作者 Shaoqing Du Xinyong Liu +1 位作者 xueping hu Peng Zhan 《Chinese Chemical Letters》 2025年第1期3-5,共3页
Drug resistance poses an escalating global challenge in the battle against infections.The effectiveness of conventional antibiotics and other anti-infective drugs is waning as microbes develop heightened resistance to... Drug resistance poses an escalating global challenge in the battle against infections.The effectiveness of conventional antibiotics and other anti-infective drugs is waning as microbes develop heightened resistance to existing treatments.Antimicrobial resistance poses a formidable challenge to global health and development,ranking among the top 10 public health threats to humanity as declared by the World Health Organization.Projections indicate that if left unaddressed,antimicrobial resistance could inflict an annual economic burden on the global GDP ranging from$1trillion to$3.4 trillion by 2030.Consequently,the management of common infections becomes increasingly arduous,while the likelihood of disease transmission,severe illness,and mortality escalates. 展开更多
关键词 resistance DRUGS HUMANITY
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Editorial of virtual special issue:The development of antiviral drug discovery
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作者 Shaoqing Du xueping hu +1 位作者 Xinyong Liu Peng Zhan 《Acta Pharmaceutica Sinica B》 2025年第5期2801-2804,共4页
Acta Pharmaceutica Sinica B is pleased to introduce a collection on The Development of Antiviral Drug Discovery,featuring articles published in the journal between January 2020 and January 2025.The discovery of antivi... Acta Pharmaceutica Sinica B is pleased to introduce a collection on The Development of Antiviral Drug Discovery,featuring articles published in the journal between January 2020 and January 2025.The discovery of antiviral drugs is a complex and significant process that requires an in-depth understanding of the viral life cycle,as well as the identification and validation of potential drug targets.Historically,the development of antiviral drugs began in the 1950s. 展开更多
关键词 drug discovery viral life cycle antiviral drug identification validation potential drug targetshistoricallythe antiviral drugs drug targets
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脑岛自发神经活动强度可预测个体错误后反应调整速度 被引量:4
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作者 王丽君 胡学平 +2 位作者 索涛 赵国祥 陈安涛 《科学通报》 EI CAS CSCD 北大核心 2019年第21期2207-2215,共9页
错误后行为调整是指错误反应发生后,个体为了避免错误再次发生和优化未来行为执行而进行的行为调整.本研究旨在采用静息态fMRI技术考察大脑自发神经活动对个体错误后行为调整的预测作用.研究发现, ACC自发神经活动低频振幅(ALFF)值与个... 错误后行为调整是指错误反应发生后,个体为了避免错误再次发生和优化未来行为执行而进行的行为调整.本研究旨在采用静息态fMRI技术考察大脑自发神经活动对个体错误后行为调整的预测作用.研究发现, ACC自发神经活动低频振幅(ALFF)值与个体错误后行为调整效应量相关不显著,但是双侧脑岛自发神经活动ALFF值与个体错误后行为调整效应量呈显著正相关.双侧脑岛ALFF值越大的个体,错误后试次反应时越长,错误后调整反应速度越慢.该结果说明,双侧脑岛参与错误后行为调整,并对个体错误后反应速度调整有预测作用. 展开更多
关键词 错误后行为调整 静息态fMRI 双侧脑岛 低频振幅(ALFF)
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