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自噬与铁死亡在肺癌发生发展及治疗中的研究进展
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作者 姜承奇 崔雪萍 +4 位作者 郑莉 邓成坤 黄若山 侯波 王俊峰 《中国肺癌杂志》 北大核心 2025年第10期777-786,共10页
肺癌是严重威胁人类健康的恶性肿瘤,其发病机制复杂多样。本文系统综述自噬与铁死亡相关的信号通路和关键调控因子及其相关机制,包括核受体共激活因子4(nuclear receptor coactivator 4, NCOA4)介导的铁蛋白自噬-铁死亡轴、线粒体自噬... 肺癌是严重威胁人类健康的恶性肿瘤,其发病机制复杂多样。本文系统综述自噬与铁死亡相关的信号通路和关键调控因子及其相关机制,包括核受体共激活因子4(nuclear receptor coactivator 4, NCOA4)介导的铁蛋白自噬-铁死亡轴、线粒体自噬、脂滴自噬、生物钟自噬、分子伴侣介导的自噬等,阐述肿瘤微环境与非编码RNA对肺癌的自噬-铁死亡作用。综述进一步阐述现代药物及中药活性成分通过靶向自噬和铁死亡改善肺癌的潜力,提出靶向二者的交互通路可为肺癌的治疗提供新策略。 展开更多
关键词 肺肿瘤 自噬 铁死亡 信号通路 非编码RNA
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Ambipolar two-dimensional materials-based reconfigurable devices
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作者 Ping He Pengxin Zhan +3 位作者 Yue Liu Lingxin Luo xueping cui Jian Zheng 《Science China Materials》 2025年第7期2161-2190,共30页
Scaling of complementary metal-oxide-semiconductor technology nodes using conventional semiconducting materials is slowing down.The development of semiconductor technology with new materials and new concepts has becom... Scaling of complementary metal-oxide-semiconductor technology nodes using conventional semiconducting materials is slowing down.The development of semiconductor technology with new materials and new concepts has become an important focus of scientific and industrial research.In recent years,emerging ambipolar two-dimensional(2D)materials-based reconfigurable devices have shown their potential in high-integration,multifunctional circuits and have begun to attract the attention of researchers.Here,we summarize the latest progress in the field concerning ambipolar 2D materials-based reconfigurable devices.Firstly,we introduce the basic properties and preparation methods of ambipolar 2D materials.Secondly,we discuss the latest applications of reconfigurable devices based on ambipolar 2D materials.Furthermore,we also introduce the current research status of ambipolar material devices in large-scale integration.Finally,we analyze the challenges faced during the development of ambipolar 2D materials-based reconfigurable devices and provide prospects for their future development. 展开更多
关键词 ambipolar two-dimensional materials electrostatically controllable reconfigurable field-effect diodes reconfigurable logic circuit neuromorphic devices
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Research progress of one-dimensional van der Waals atomic chainmaterials
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作者 Pengxin Zhan Ping He +3 位作者 Zike Wang Lingxin Luo xueping cui Jian Zheng 《Science China Materials》 2025年第2期364-386,共23页
Due to the influence of quantum confinementeffect, two-dimensional (2D) materials like graphene exhibitunique and exceptional properties, highlighting the significance of low-dimensional materials in fundamental resea... Due to the influence of quantum confinementeffect, two-dimensional (2D) materials like graphene exhibitunique and exceptional properties, highlighting the significance of low-dimensional materials in fundamental research and practical applications. This has led to highexpectations for one-dimensional (1D) atomic chain materialswith even lower dimensions. Compared with 2D materials,single 1D atomic chains reach their physical limits in bothdimensions, resulting in a more pronounced quantum confinement effect that gives rise to unexpected physical phenomena and will establish a new field for exploration. Herein,we review the emerging field concerning 1D van der Waals(vdW) atomic chains. We first summarize the various typesand structures of their bulk of the 1D vdW materials. Subsequently,we discuss the methods employed for their preparation and characterization. Finally, we analyze the challengesfaced during the development of 1D atomic chains and provide prospects for their future development. 展开更多
关键词 one-dimensional materials atomic chain van der Waals materials EXFOLIATION quantum materials
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Monolayer single crystal two-dimensional quantum dots via ultrathin cutting and exfoliating 被引量:2
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作者 Yang Hao Wen Su +6 位作者 Lingxiang Hou xueping cui Shaozhi Wang Pengxin Zhan Ye Zou Louzhen Fan Jian Zheng 《Science China Materials》 SCIE EI CSCD 2020年第6期1046-1053,共8页
Two-dimensional(2D)atomically thin quantum dots(QDs)possess extraordinary electrical and optical properties.However,fabricating high quality 2D QDs via a universal and reliable technique remains a challenge.Here,we re... Two-dimensional(2D)atomically thin quantum dots(QDs)possess extraordinary electrical and optical properties.However,fabricating high quality 2D QDs via a universal and reliable technique remains a challenge.Here,we report a simple strategy to prepare high quality,monolayer single crystal 2D QDs via ultrathin cutting 2D bulk single crystals by ultramicrotome,followed by an exfoliation process.The as-prepared 2D QDs have pristine surface,high quality,high monolayer yield and high photoluminescence quantum yield(the highest photoluminescence quantum yield of WS2 is18%),which can be used as promising,low toxic,biocompatible,and good cell-permeability fluorescent labeling agents for in vitro imaging. 展开更多
关键词 two-dimension single crystal quantum dots ultrathin cutting photoluminescence quantum yield
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