In this study, 27 pairs of EST-SSR primers were employed to analyze the genetic diversity and genetic relationship of 100 wild tea plant germplasm re- sources and 22 cultivars, according to the results, a total of 88 ...In this study, 27 pairs of EST-SSR primers were employed to analyze the genetic diversity and genetic relationship of 100 wild tea plant germplasm re- sources and 22 cultivars, according to the results, a total of 88 polymorphic bands were amplified with 27 pairs of primers; the variation of effective alleles accounted for 69.01% ; a total of 183 genotypes were detected, with a variation range of 4 -11 ; averagely 6.78 genotypes were amplified with each primer pair; Shannon index （I） of 27 primer pairs ranged from 0.32 to I. 35, with an average of 0.88 ; the observed heterozygosity （0.52） was basically consistent with the expected het- erozygosity （0.52） ; the average polymorphism heterozygosity was 0.48, which was very close to 0.50 ; the average Nei＇s index was 0.51, which was higher than 0. 50 ; the average polymorphism information content （PIC） was 0.52, which was higher than 0.50, indicating high genetic diversity among wild tea germplasm resources in Yuunan Province. According to the clustering results, based on geographical origins and genetic backgrounds, 122 materials were clustered into 14 categories. Dendrogram based on Nei＇s genetic distance revealed complex genetic relationships among wild tea germplasm resources in Yunnan Province. This study provided certain reference for subsequent preservation, development and research of wild tea germplasm resources in China.展开更多
Highly efficient and stable bifunctional electrocatalysts that can be used for large-current-density electrolysis of alkaline seawater are highly desirable for carbon-neutral economies,but their facile and controllabl...Highly efficient and stable bifunctional electrocatalysts that can be used for large-current-density electrolysis of alkaline seawater are highly desirable for carbon-neutral economies,but their facile and controllable synthesis remains a challenge.Here,self-assembled ultralow Ru,Ni-doped Fe_(2)O_(3) with a lily shaped morphology was synthesized on iron foam(RuNi-Fe_(2)O_(3)/IF)via a facile one-step hydrothermal process,in which the intact lily shaped RuNi-Fe_(2)O_(3)/IF was obtained by adjusting the ratio of Ru/Ni.Benefitting from the Ru/Ni chemical substitution,the as-synthesized RuNi-Fe_(2)O_(3)/IF can act as free-standing dual-function electrodes that are applied to electrocatalysis for the hydrogen evolution(HER)and oxygen evolution reactions(OER)in 1.0 mol L^(-1) KOH,requiring an overpotential of 75.0 mV to drive 100 mA cm^(-2) for HER and 329.0 mV for OER.Moreover,the overall water splitting catalyzed by RuNi-Fe_(2)O_(3)/IF only demands ultralow cell voltages of 1.66 and 1.73 V to drive 100 mA cm^(-2) in 1.0 mol L^(-1) KOH and 1.0 mol L^(-1) KOH seawater electrolytes,respectively.The electrodes show remarkable long-term durability,maintaining current densities exceeding 100 mA cm^(-2) for more than 100 h and thus outperforming the two-electrode system composed of noble catalysts.This work provides an efficient,economical method to synthesize self-standing bifunctional electrodes for large-current-density alkaline seawater electrolysis,which is of significant importance for ecological protection and energy exploitation.展开更多
Two varieties of Jerusalem artichoke (early maturing variety Qingyu No.1 and middle maturing variety Qingyu No.2),which were bred independently by Research and Development Center of Jerusalem Artichoke,Qinghai Academy...Two varieties of Jerusalem artichoke (early maturing variety Qingyu No.1 and middle maturing variety Qingyu No.2),which were bred independently by Research and Development Center of Jerusalem Artichoke,Qinghai Academy of Agriculture and Forestry,were used as materials,and the content and dynamic changes of three kinds of carbohydrates (sucrose,glucose and fructose) in various organs of Jerusalem artichoke in different periods in two natural habitats (water plain and low hill dry land) were studied.The results showed that the content of the three kinds of carbohydrates in Qingyu No.1 and Qingyu No.2 in the water plain and low hill dry land was relatively high in late June and late August.The total content of the three carbohydrates in Qingyu No.1 peaked earlier than that of Qingyu No.2.The total content of the three carbohydrates in the water plain peaked earlier than that of the low hill dry land.In the whole growth period,the total content of the three carbohydrates in the stems and roots of Jerusalem artichoke was higher than that of the leaves.In the leaves,fructose accumulation was relatively obvious in the whole growth period,and the content was high,followed by glucose.In the stems and roots,fructose content was high,followed by sucrose.In the tubers,glucose accumulation was obvious,and sucrose content was lower than glucose and fructose content.When the tubers were harvested,fructose content was high.展开更多
Objective:To explore the preventive effect of comprehensive nursing intervention on arteriovenous fistula failure in patients in the hemodialysis room.Methods:82 patients with arteriovenous fistula in the hemodialysis...Objective:To explore the preventive effect of comprehensive nursing intervention on arteriovenous fistula failure in patients in the hemodialysis room.Methods:82 patients with arteriovenous fistula in the hemodialysis chamber treated in our hospital from July 2022 to October 2023 were selected as the research subjects.The random number table method divided them into a control group and an experimental group of 41 cases each.The control group received general nursing intervention measures,while the experimental group underwent comprehensive nursing intervention.The incidence of complications(internal fistula failure,bleeding,thrombosis,infection),psychological emotions(SAS scale,SDS scale),quality of life(physical pain,physiological function,emotional function,social function),and nursing satisfaction(very satisfied,basically satisfied,satisfied,dissatisfied)were compared between the two groups of patients.Results:The incidence of complications in the experimental group(4,9.76%)was significantly lower than that in the control group(29,70.73%);the SAS scores and SDS scores of the patients in the experimental group after intervention were both lower than those in the control group;the quality of life score(physical pain,physiological function,emotional function,and social function)was all higher than those of the control group;the post-intervention nursing satisfaction of the experimental group(40,97.57%)was also significantly higher than that of the control group(29,73.17%);and the listed differences were statistically significant(P<0.01).Conclusion:For patients with hemodialysis ventricular arteriovenous fistula failure,comprehensive nursing intervention can reduce the incidence of complications,relieve anxiety and stress,improve quality of life and nursing satisfaction,and achieve better preventive effects.展开更多
A 30-year-old male with a history of hepatitis B virus(HBV)infection for over 10 years presented with a liver lesion found on routine medical examination on December 8,2024.An enhanced abdominal magnetic resonance ima...A 30-year-old male with a history of hepatitis B virus(HBV)infection for over 10 years presented with a liver lesion found on routine medical examination on December 8,2024.An enhanced abdominal magnetic resonance imaging(MRI)showed nodular abnormal signals in liver segments S7 and S3,and a subcapsular low signal nodule in S3.Physical examination did not reveal any abnormalities,including hepatomegaly or liver masses.展开更多
This consensus on multiple myeloma-related bone diseases(MBDs)underscores the importance of a multidisciplinary approach that encompasses hematology,radiology,orthopedics,and additional specialties to tackle its intri...This consensus on multiple myeloma-related bone diseases(MBDs)underscores the importance of a multidisciplinary approach that encompasses hematology,radiology,orthopedics,and additional specialties to tackle its intricate challenges.MBD,a prevalent and debilitating complication of multiple myeloma,leads to bone pain,fractures,and skeletal-related events(SREs),which profoundly impact patients’quality of life.The guidelines offer a thorough framework for diagnosis,treatment,and continual assessment,emphasizing early detection and consistent monitoring using imaging techniques such as positron emission tomography-computed tomography(PET-CT)and magnetic resonance imaging(MRI).Treatment strategies prioritize the careful application of antimyeloma agents,bisphosphonates,and denosumab to minimize bone loss and decrease SRE risk,complemented by surgical and radiotherapy interventions for structural or pain-related issues.Supportive care measures,including pain management,rehabilitation,nutritional support,and dental evaluations,play a crucial role in enhancing patient outcomes and preserving quality of life.This consensus advocates a standardized,evidencebased approach to managing MBD,ensuring comprehensive and coordinated care for patients.展开更多
Hepatocellular carcinoma(HCC),the primary form of liver cancer,is associated with a poor 5-year survival rate,underscoring the urgent need for novel therapeutic strategies.Photodynamic therapy(PDT)is a promising cance...Hepatocellular carcinoma(HCC),the primary form of liver cancer,is associated with a poor 5-year survival rate,underscoring the urgent need for novel therapeutic strategies.Photodynamic therapy(PDT)is a promising cancer treatment modality that employs reactive oxygen species(ROS)to induce tumor cell death while stimulating anti-tumor immune responses through damage-associated molecular patterns(DAMPs)released by dying cells.However,conventional photosensitizers are hindered by their low ROS production efficiency and high oxygen dependency,which limit their efficacy against hypoxic solid tumors.To address these limitations,we synthesized axially substituted bis[3-(N-morpholinyl)propoxy]phthalocyaninato silicon(SiPc),which self-assembles into nanoparticles capable of generating ROS via a hypoxia-tolerant type-I mechanism.SiPc nanoparticles(SiPcNPs)have demonstrated potent cytotoxicity against cancer cells at low concentrations.Furthermore,SiPcNP-mediated PDT promotes dendritic cell maturation in vitro and enhances CD8^(+)T cell infiltration in vivo.These findings suggest that SiPcNPs are potential candidates for overcoming microenvironmental resistance in PDT,with dual mechanisms of direct tumor eradication and immune potentiation,thereby providing a foundation for clinical translation in HCC management.展开更多
Aqueous zinc-ion batteries have emerged as promising candidates for large-scale energy storage.Despite its potential as a cathode material for AZIBs,H_(2)V_(3)O_(8) suffers from poor electrical conductivity,vanadium d...Aqueous zinc-ion batteries have emerged as promising candidates for large-scale energy storage.Despite its potential as a cathode material for AZIBs,H_(2)V_(3)O_(8) suffers from poor electrical conductivity,vanadium dissolution,and structural instability,which severely compromises its rate performance and cycling stability.To address these limitations,we have developed a polypyrrole-coated H_(2)V_(3)O_(8) composite(H_(2)V_(3)O_(8)@Ppy).Density functional theory calculations demonstrate that Ppy exhibits substantially stronger interactions with HVO_(3)(−1.97 eV)compared to hydrated Zn^(2+) ions(−0.205 eV).This selective interaction enables the Ppy coating to effectively capture dissolved HVO_(3) species while maintaining efficient transport of solvated Zn2+ion clusters,thereby preventing structural degradation of the cathode.The optimized H_(2)V_(3)O_(8)@Ppy cathode delivers an impressive initial capacity of 405 mA h g^(-1) at 100 mA g^(-1) and demonstrates exceptional cycling stability,maintaining nearly 100%capacity retention after 800 cycles at 2 A g^(−1).Furthermore,a quasisolid-state zinc-ion battery incorporating H_(2)V_(3)O_(8)@Ppy cathode exhibits excellent mechanical flexibility and superior longterm cycling performance.Notably,in situ XRD analysis reveals for the first time a two-step phase transformation mechanism of H_(2)V_(3)O_(8) during discharge/charge processes.This study presents an effective strategy for enhancing the structural stability of H_(2)V_(3)O_(8) cathodes in aqueous zinc-ion batteries.展开更多
Traditional layered gradient scaffolds are susceptible to delamination owing to abrupt stress alterations,thereby rendering them inefficacious for the integrated repair of osteochondral defects.This study proposed a n...Traditional layered gradient scaffolds are susceptible to delamination owing to abrupt stress alterations,thereby rendering them inefficacious for the integrated repair of osteochondral defects.This study proposed a novel hydrogel possessing continuous magnetic-mechanical and multiple functional metal elements gradients.The establishment of these gradients within the hydrogel was accomplished by first applying a magnetic field to FMHM particles(Fe_(3)O_(4) deposited with Mg-doped hydroxyapatite(MgHA@Fe_(3)O_(4))and grafted withγ-(meth-acryloyloxy)propyl trimethoxysilane)dispersed in poly(ethylene glycol)diacrylate/sodium alginate solution to create a gradient,followed by thermal polymerization to achieve the magnetic and mechanical gradients.Subsequently secondary crosslinking with Mn^(2+)realized the gradient distribution of Mn^(2+)which was reverse to the gradient of MgHA@Fe_(3)O_(4).The on-demand gradient distributions of Mn^(2+)and MgHA@Fe_(3)O_(4) enhanced cartilage and osteogenic differentiation of bone marrow-derived mesenchymal stem cells,respectively.The continuous gradient hydrogel attained remarkable repair effects on full-thickness osteochondral defects in rat knee joints.Its capacity to foster the growth of both cartilage and subchondral bone may be associated with the fact that the mechanical gradient modulated the gradient nuclear localization and expression of the mechano-sensitive factor Yes-associated protein 1.With stiffness and magnetism gradients,along with the on-demand synergistic impacts of multi-gradient metal elements Mn-Fe/Mg/Ca,this hydrogel presents a prospective op-tion for the regeneration of tissues/interface tissues exhibiting physiological gradients.展开更多
Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, ...Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation.展开更多
Precise and continuous monitoring of biochemicals by biosensors assists to understand physiological functions for various diagnostics and therapeutic applications.For implanted biosensors,small size and flexibility ar...Precise and continuous monitoring of biochemicals by biosensors assists to understand physiological functions for various diagnostics and therapeutic applications.For implanted biosensors,small size and flexibility are essential for minimizing tissue damage and achieving accurate detection.However,the active surface area of sensor decreases as the sensor becomes smaller,which will increase the impedance and decrease the signal to noise ratio,resulting in a poor detection limit.Taking advantages of local amplification effect,organic electrochemical transistors(OECTs)constitute promising candidates for high-sensitive monitoring.However,their detections in deep tissues are rarely reported.Herein,we report a family of implantable,fiber-shaped all-in-one OECTs based on carbon nanotube fibers for versatile biochemical detection including H2O2,glucose,dopamine and glutamate.These fiber-shaped OECTs demonstrated high sensitivity,dynamical stability in physiological environment and antiinterference capability.After implantation in mouse brain,7-day dopamine monitoring in vivo was realized for the first time.These fiber-shaped OECTs could be great additions to the"life science"tool box and represent promising avenue for biomedical monitoring.展开更多
As an im portant branch of fiber-shaped energy storage devices, the fiber-shaped supercapacitor has been widely studied recently. However, it remains challenging to simultaneously achieve fast electron transport and e...As an im portant branch of fiber-shaped energy storage devices, the fiber-shaped supercapacitor has been widely studied recently. However, it remains challenging to simultaneously achieve fast electron transport and excellent ion accessibility in one single fiber electrode of the fibershaped supercapacitor. Herein, a novel family of amphiphilic core-sheath structured carbon nanotube composite fibers has been developed and applied to the fiber-shaped supercapacitor to address the above challenge. The polyaniline-modified hydrophilic sheath of the composite fiber electrode effectively enhanced the electrochemical property via advancing ion accessibility, while Au-deposited hydrophobic core demonstrated improved electrical conductivity by fast electron supply. On the basis of a synergistic effect, a remarkable specific capacitance of 324 F cm^-3 at 0.5 A cm^-3 and greatly enhanced rate performance were achieved, i.e” a 79% retention (256 F cm 3) at 50 A cm^-3. The obtained fiber-shaped supercapacitor finally displayed remarkable energy and power densities of 7.2 mW h cm 3 and 10 W cm^-3, respectively. The strategy developed herein also presents a general pathway towards novel fiber electrodes for high-performance wearable devices.展开更多
Mechanoluminescence has attracted increasing attentions because it can convert the kinetic energy during human daily motions into light to be used in sensors and displays. However, its practical applications are still...Mechanoluminescence has attracted increasing attentions because it can convert the kinetic energy during human daily motions into light to be used in sensors and displays. However, its practical applications are still hindered by the weak brightness and limited color while under large forces. Herein, we developed novel piezoluminescent devices(PLDs) which could effectively emit visible light under low pressing forces through the stress-concentration and enhancing deformation on the basis of carefully-designed array structures. The emitting colors were also tunable by using bilayer luminescent film under different pressures. This work not only provides a new strategy to effectively harvest mechanical energy into light,but also presents a scalable, low-cost and color-tunable PLD which shows great potentials in various applications such as luminescent floors, shoes and stress-activated displays.展开更多
Fiber organic electrochemical transistors(OECTs)have received extensive attention in wearable and implantable biosensors because of their high flexibility and low working voltage.However,the transconductance of fiber ...Fiber organic electrochemical transistors(OECTs)have received extensive attention in wearable and implantable biosensors because of their high flexibility and low working voltage.However,the transconductance of fiber OECTs is much lower compared with the planar counterparts,leading to low sensitivity.Here,we developed fiber OECTs in a coaxial configuration with microscale channel length to achieve the highest transconductance of 135 mS,which is one to two orders of magnitude higher than that of the state-of-the-art fiber OECTs.Coaxial fiber OECT based sensors showed high sensitivities of 12.78,20.53 and 3.78 mA/decade to ascorbic acid,hydrogen peroxide and glucose,respectively.These fiber OECTs were woven into a fabric to monitor the glucose in sweat during exercise and implanted in mouse brain to detect ascorbic acid.This coaxial architectural design offers an effective way to promote the performance of fiber OECTs and realize highly sensitive detection of biochemicals.展开更多
The evolution of electronic systems towards small,flexible,portable and human-centered forms drives the demand for onbody power supplies with lightweight and high flexibility.Fiber solar cells that can be integrated i...The evolution of electronic systems towards small,flexible,portable and human-centered forms drives the demand for onbody power supplies with lightweight and high flexibility.Fiber solar cells that can be integrated into soft and lightweight textiles are considered as potential sustainable power sources for the next generation of wearable electronics.To this end,they have been extensively investigated in the past decade aiming to improve their photovoltaic performances,but there is still a big gap between the high-performance devices and real applications.Herein,the key advances of configurations,fabrications and performances of fiber solar cells are highlighted and analyzed.Based on the current progress,the latest ideas with regard to the remaining challenges and opportunities beyond the reach of the previous studies are presented.展开更多
Objective:Ban Fenghe recorded in the Quality Standard of Yao Medicine of Guangxi Zhuang Autonomous Region(Volume 1)is derived from the dried stems and leaves of Semiliquidambar cathayensis.It is usually confused with ...Objective:Ban Fenghe recorded in the Quality Standard of Yao Medicine of Guangxi Zhuang Autonomous Region(Volume 1)is derived from the dried stems and leaves of Semiliquidambar cathayensis.It is usually confused with medicinal herbs from Pterospermum heterophyllum and Dendropanax dentiger.However,they are very different in chemical composition,and should not be used as the same drug.To ensure their safety and efficacy,a method based on macroscopic and microscopic characteristics was developed to distinguish them.Methods:A total of 14 batches of Ban Fenghe samples from three species were collected from different producing areas in China.The macroscopic characteristics were examined by observing external traits.The tissue structures of transverse sections of stems and leaves,the leaf epidermis,and the powder were observed microscopically.Results:The branchlets and leaf surfaces of S.cathayensis and P.heterophyllum were hairy,especially the lower leaf surfaces of P.heterophyllum were densely covered with hairs,but those of D.dentiger were hairless.The pericyclic fibers of S.cathayensis stems were intermittently distributed in a circular shape and accompanied by stone cells,whereas those of P.heterophyllum and D.dentiger were bundled without stone cells.So stone cells and hairs were present in S.cathayensis powder,stone cells were not found in P.heterophyllum and D.dentiger powder,and hairs were not present in D.dentiger powder.The distribution sites,sizes and types of secretory tissues of these three species were also different in transverse sections of stems and leaves.Stomata on the lower epidermis of S.cathayensis leaves were paracytic,whereas those of P.heterophyllum and D.dentiger were anomocytic.Conclusion:Ban Fenghe drugs derived from S.cathayensis could readily be distinguished from those of P.heterophyllum and D.dentiger by macroscopic and microscopic features.展开更多
Long-term in vivo monitoring of chemicals with implanted sensors has received considerable interests over the past decades owing to their significant contributions in reflecting health conditions and assistance in dia...Long-term in vivo monitoring of chemicals with implanted sensors has received considerable interests over the past decades owing to their significant contributions in reflecting health conditions and assistance in diagnosing diseases.However,the widely explored chemical sensors outside the body fail to meet the requirements of in vivo applications.This perspective reviews main challenges,recent advances and future directions of long-term in vivo monitoring of chemicals,related to immune response and sensing performance.Challenges in terms of the immune response caused by unstable interfaces between sensors and tissues and improper implanting methods,and the insufficient performance of chemical sensors in complex physiological environment are discussed.Therewith,recent advances in fabricating biocompatible,flexible and thin sensors,developing effective implanting methods with reduced injury and improving the sensitivity,selectivity and stability of chemical sensors for accurate monitoring in vivo are summarized.Finally,we propose the future directions to address these challenges by fiber chemical sensors through the combination of soft fiber configuration,facile implanting methods and new recognition elements,which will provide new platforms for health monitoring and physiological mechanism revealing.展开更多
基金Supported by National Natural Science Foundation of China(31160175,31440034)Project for Protection and Utilization of Crop Germplasm Resources,Ministry of Agriculture(NB2012-2130135)+2 种基金Program of Technological Innovation Talents of Yunnan Province(2011CI068)Project for Construction of National Tea Modern Industrial Technology System of China(NYCYTX-23)Special Fund of Yunnan Academy of Agricultural Sciences(YAAS2012ZY002)
文摘In this study, 27 pairs of EST-SSR primers were employed to analyze the genetic diversity and genetic relationship of 100 wild tea plant germplasm re- sources and 22 cultivars, according to the results, a total of 88 polymorphic bands were amplified with 27 pairs of primers; the variation of effective alleles accounted for 69.01% ; a total of 183 genotypes were detected, with a variation range of 4 -11 ; averagely 6.78 genotypes were amplified with each primer pair; Shannon index （I） of 27 primer pairs ranged from 0.32 to I. 35, with an average of 0.88 ; the observed heterozygosity （0.52） was basically consistent with the expected het- erozygosity （0.52） ; the average polymorphism heterozygosity was 0.48, which was very close to 0.50 ; the average Nei＇s index was 0.51, which was higher than 0. 50 ; the average polymorphism information content （PIC） was 0.52, which was higher than 0.50, indicating high genetic diversity among wild tea germplasm resources in Yuunan Province. According to the clustering results, based on geographical origins and genetic backgrounds, 122 materials were clustered into 14 categories. Dendrogram based on Nei＇s genetic distance revealed complex genetic relationships among wild tea germplasm resources in Yunnan Province. This study provided certain reference for subsequent preservation, development and research of wild tea germplasm resources in China.
文摘Highly efficient and stable bifunctional electrocatalysts that can be used for large-current-density electrolysis of alkaline seawater are highly desirable for carbon-neutral economies,but their facile and controllable synthesis remains a challenge.Here,self-assembled ultralow Ru,Ni-doped Fe_(2)O_(3) with a lily shaped morphology was synthesized on iron foam(RuNi-Fe_(2)O_(3)/IF)via a facile one-step hydrothermal process,in which the intact lily shaped RuNi-Fe_(2)O_(3)/IF was obtained by adjusting the ratio of Ru/Ni.Benefitting from the Ru/Ni chemical substitution,the as-synthesized RuNi-Fe_(2)O_(3)/IF can act as free-standing dual-function electrodes that are applied to electrocatalysis for the hydrogen evolution(HER)and oxygen evolution reactions(OER)in 1.0 mol L^(-1) KOH,requiring an overpotential of 75.0 mV to drive 100 mA cm^(-2) for HER and 329.0 mV for OER.Moreover,the overall water splitting catalyzed by RuNi-Fe_(2)O_(3)/IF only demands ultralow cell voltages of 1.66 and 1.73 V to drive 100 mA cm^(-2) in 1.0 mol L^(-1) KOH and 1.0 mol L^(-1) KOH seawater electrolytes,respectively.The electrodes show remarkable long-term durability,maintaining current densities exceeding 100 mA cm^(-2) for more than 100 h and thus outperforming the two-electrode system composed of noble catalysts.This work provides an efficient,economical method to synthesize self-standing bifunctional electrodes for large-current-density alkaline seawater electrolysis,which is of significant importance for ecological protection and energy exploitation.
基金Supported by Xining Comprehensive Test Station Project of National Staple Vegetable Industry Technology System(CARS-23-G-23)
文摘Two varieties of Jerusalem artichoke (early maturing variety Qingyu No.1 and middle maturing variety Qingyu No.2),which were bred independently by Research and Development Center of Jerusalem Artichoke,Qinghai Academy of Agriculture and Forestry,were used as materials,and the content and dynamic changes of three kinds of carbohydrates (sucrose,glucose and fructose) in various organs of Jerusalem artichoke in different periods in two natural habitats (water plain and low hill dry land) were studied.The results showed that the content of the three kinds of carbohydrates in Qingyu No.1 and Qingyu No.2 in the water plain and low hill dry land was relatively high in late June and late August.The total content of the three carbohydrates in Qingyu No.1 peaked earlier than that of Qingyu No.2.The total content of the three carbohydrates in the water plain peaked earlier than that of the low hill dry land.In the whole growth period,the total content of the three carbohydrates in the stems and roots of Jerusalem artichoke was higher than that of the leaves.In the leaves,fructose accumulation was relatively obvious in the whole growth period,and the content was high,followed by glucose.In the stems and roots,fructose content was high,followed by sucrose.In the tubers,glucose accumulation was obvious,and sucrose content was lower than glucose and fructose content.When the tubers were harvested,fructose content was high.
文摘Objective:To explore the preventive effect of comprehensive nursing intervention on arteriovenous fistula failure in patients in the hemodialysis room.Methods:82 patients with arteriovenous fistula in the hemodialysis chamber treated in our hospital from July 2022 to October 2023 were selected as the research subjects.The random number table method divided them into a control group and an experimental group of 41 cases each.The control group received general nursing intervention measures,while the experimental group underwent comprehensive nursing intervention.The incidence of complications(internal fistula failure,bleeding,thrombosis,infection),psychological emotions(SAS scale,SDS scale),quality of life(physical pain,physiological function,emotional function,social function),and nursing satisfaction(very satisfied,basically satisfied,satisfied,dissatisfied)were compared between the two groups of patients.Results:The incidence of complications in the experimental group(4,9.76%)was significantly lower than that in the control group(29,70.73%);the SAS scores and SDS scores of the patients in the experimental group after intervention were both lower than those in the control group;the quality of life score(physical pain,physiological function,emotional function,and social function)was all higher than those of the control group;the post-intervention nursing satisfaction of the experimental group(40,97.57%)was also significantly higher than that of the control group(29,73.17%);and the listed differences were statistically significant(P<0.01).Conclusion:For patients with hemodialysis ventricular arteriovenous fistula failure,comprehensive nursing intervention can reduce the incidence of complications,relieve anxiety and stress,improve quality of life and nursing satisfaction,and achieve better preventive effects.
基金funded by National High Level Hospital Clinical Research Funding(No.2022-PUMCH-B-062)Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(No.2023-I2M-2-002).
文摘A 30-year-old male with a history of hepatitis B virus(HBV)infection for over 10 years presented with a liver lesion found on routine medical examination on December 8,2024.An enhanced abdominal magnetic resonance imaging(MRI)showed nodular abnormal signals in liver segments S7 and S3,and a subcapsular low signal nodule in S3.Physical examination did not reveal any abnormalities,including hepatomegaly or liver masses.
文摘This consensus on multiple myeloma-related bone diseases(MBDs)underscores the importance of a multidisciplinary approach that encompasses hematology,radiology,orthopedics,and additional specialties to tackle its intricate challenges.MBD,a prevalent and debilitating complication of multiple myeloma,leads to bone pain,fractures,and skeletal-related events(SREs),which profoundly impact patients’quality of life.The guidelines offer a thorough framework for diagnosis,treatment,and continual assessment,emphasizing early detection and consistent monitoring using imaging techniques such as positron emission tomography-computed tomography(PET-CT)and magnetic resonance imaging(MRI).Treatment strategies prioritize the careful application of antimyeloma agents,bisphosphonates,and denosumab to minimize bone loss and decrease SRE risk,complemented by surgical and radiotherapy interventions for structural or pain-related issues.Supportive care measures,including pain management,rehabilitation,nutritional support,and dental evaluations,play a crucial role in enhancing patient outcomes and preserving quality of life.This consensus advocates a standardized,evidencebased approach to managing MBD,ensuring comprehensive and coordinated care for patients.
基金supported by the Guangxi Natural Science Foundation(2022GXNSFAA035512)Guangxi Key Technologies R&D Program(AB24206003)+1 种基金National Natural Science Foundation of China(82260581)the Innovation Project of Guangxi Graduate Education(YCBZ2025121).
文摘Hepatocellular carcinoma(HCC),the primary form of liver cancer,is associated with a poor 5-year survival rate,underscoring the urgent need for novel therapeutic strategies.Photodynamic therapy(PDT)is a promising cancer treatment modality that employs reactive oxygen species(ROS)to induce tumor cell death while stimulating anti-tumor immune responses through damage-associated molecular patterns(DAMPs)released by dying cells.However,conventional photosensitizers are hindered by their low ROS production efficiency and high oxygen dependency,which limit their efficacy against hypoxic solid tumors.To address these limitations,we synthesized axially substituted bis[3-(N-morpholinyl)propoxy]phthalocyaninato silicon(SiPc),which self-assembles into nanoparticles capable of generating ROS via a hypoxia-tolerant type-I mechanism.SiPc nanoparticles(SiPcNPs)have demonstrated potent cytotoxicity against cancer cells at low concentrations.Furthermore,SiPcNP-mediated PDT promotes dendritic cell maturation in vitro and enhances CD8^(+)T cell infiltration in vivo.These findings suggest that SiPcNPs are potential candidates for overcoming microenvironmental resistance in PDT,with dual mechanisms of direct tumor eradication and immune potentiation,thereby providing a foundation for clinical translation in HCC management.
基金supported by the National Key Research and Development Program of China(2021YFB2400400)the National Natural Science Foundation of China(Key Project,52131306)+2 种基金the Guangdong Basic and Applied Basic Research Foundation(2023B1515040011)the Project on Carbon Emission Peak and Neutrality of Jiangsu Province(BE2022031-4)the Fundamental Research Funds for the Central Universities(2242023R10001 and 2242024K30047)。
文摘Aqueous zinc-ion batteries have emerged as promising candidates for large-scale energy storage.Despite its potential as a cathode material for AZIBs,H_(2)V_(3)O_(8) suffers from poor electrical conductivity,vanadium dissolution,and structural instability,which severely compromises its rate performance and cycling stability.To address these limitations,we have developed a polypyrrole-coated H_(2)V_(3)O_(8) composite(H_(2)V_(3)O_(8)@Ppy).Density functional theory calculations demonstrate that Ppy exhibits substantially stronger interactions with HVO_(3)(−1.97 eV)compared to hydrated Zn^(2+) ions(−0.205 eV).This selective interaction enables the Ppy coating to effectively capture dissolved HVO_(3) species while maintaining efficient transport of solvated Zn2+ion clusters,thereby preventing structural degradation of the cathode.The optimized H_(2)V_(3)O_(8)@Ppy cathode delivers an impressive initial capacity of 405 mA h g^(-1) at 100 mA g^(-1) and demonstrates exceptional cycling stability,maintaining nearly 100%capacity retention after 800 cycles at 2 A g^(−1).Furthermore,a quasisolid-state zinc-ion battery incorporating H_(2)V_(3)O_(8)@Ppy cathode exhibits excellent mechanical flexibility and superior longterm cycling performance.Notably,in situ XRD analysis reveals for the first time a two-step phase transformation mechanism of H_(2)V_(3)O_(8) during discharge/charge processes.This study presents an effective strategy for enhancing the structural stability of H_(2)V_(3)O_(8) cathodes in aqueous zinc-ion batteries.
基金supported by funds from National Natural Science Foundation of China(NSFC)Research Grants(52072015,62273019,82350003,12332019,U20A20390)supported by the 111 Project(B13003)Academic Excellence Foundation of BUAA for PHD Students(BY2010154).
文摘Traditional layered gradient scaffolds are susceptible to delamination owing to abrupt stress alterations,thereby rendering them inefficacious for the integrated repair of osteochondral defects.This study proposed a novel hydrogel possessing continuous magnetic-mechanical and multiple functional metal elements gradients.The establishment of these gradients within the hydrogel was accomplished by first applying a magnetic field to FMHM particles(Fe_(3)O_(4) deposited with Mg-doped hydroxyapatite(MgHA@Fe_(3)O_(4))and grafted withγ-(meth-acryloyloxy)propyl trimethoxysilane)dispersed in poly(ethylene glycol)diacrylate/sodium alginate solution to create a gradient,followed by thermal polymerization to achieve the magnetic and mechanical gradients.Subsequently secondary crosslinking with Mn^(2+)realized the gradient distribution of Mn^(2+)which was reverse to the gradient of MgHA@Fe_(3)O_(4).The on-demand gradient distributions of Mn^(2+)and MgHA@Fe_(3)O_(4) enhanced cartilage and osteogenic differentiation of bone marrow-derived mesenchymal stem cells,respectively.The continuous gradient hydrogel attained remarkable repair effects on full-thickness osteochondral defects in rat knee joints.Its capacity to foster the growth of both cartilage and subchondral bone may be associated with the fact that the mechanical gradient modulated the gradient nuclear localization and expression of the mechano-sensitive factor Yes-associated protein 1.With stiffness and magnetism gradients,along with the on-demand synergistic impacts of multi-gradient metal elements Mn-Fe/Mg/Ca,this hydrogel presents a prospective op-tion for the regeneration of tissues/interface tissues exhibiting physiological gradients.
基金supported by the National Natural Science Foundation of China (52073218, 22135005, 51873162, 51933006,51988102, 52122310, 22075050, 51833008, 51733006, 51733001,52122304)Jiangsu Province Science Foundation for Youths(BK20200241)+3 种基金Science and Technology Commission of Shanghai Municipality (20JC1414902, 21511104900)Shanghai Municipal Education Commission (2017-01-07-00-07-E00062)the National Key Research and Development Program (2021YFA1201200) of Chinathe Zhejiang Provincial Key Research and Development Program (2020C01123)。
文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation.
基金the National Natural Science Foundation of China(2163400351673043)+3 种基金Ministry of Science and Technology of China(2016YFA0203302)Science and Technology Commission of Shanghai Municipality(17QA1400400)Shanghai Municipal Education Commission(2017-01-07-00-07-E00062)Yanchang Petroleum Group。
文摘Precise and continuous monitoring of biochemicals by biosensors assists to understand physiological functions for various diagnostics and therapeutic applications.For implanted biosensors,small size and flexibility are essential for minimizing tissue damage and achieving accurate detection.However,the active surface area of sensor decreases as the sensor becomes smaller,which will increase the impedance and decrease the signal to noise ratio,resulting in a poor detection limit.Taking advantages of local amplification effect,organic electrochemical transistors(OECTs)constitute promising candidates for high-sensitive monitoring.However,their detections in deep tissues are rarely reported.Herein,we report a family of implantable,fiber-shaped all-in-one OECTs based on carbon nanotube fibers for versatile biochemical detection including H2O2,glucose,dopamine and glutamate.These fiber-shaped OECTs demonstrated high sensitivity,dynamical stability in physiological environment and antiinterference capability.After implantation in mouse brain,7-day dopamine monitoring in vivo was realized for the first time.These fiber-shaped OECTs could be great additions to the"life science"tool box and represent promising avenue for biomedical monitoring.
基金supported by the Ministry of Science and Technology (2016YFA0203302)the National Natural Science Foundation of China (21634003, 51573027, 51673043, 21604012, 21805044 and 21875042)+1 种基金Shanghai Science and Technology Committee (16JC1400702, 17QA1400400, 18QA1400700 and 18QA1400800)SHMEC (2017-01-07-00-07-E00062)
文摘As an im portant branch of fiber-shaped energy storage devices, the fiber-shaped supercapacitor has been widely studied recently. However, it remains challenging to simultaneously achieve fast electron transport and excellent ion accessibility in one single fiber electrode of the fibershaped supercapacitor. Herein, a novel family of amphiphilic core-sheath structured carbon nanotube composite fibers has been developed and applied to the fiber-shaped supercapacitor to address the above challenge. The polyaniline-modified hydrophilic sheath of the composite fiber electrode effectively enhanced the electrochemical property via advancing ion accessibility, while Au-deposited hydrophobic core demonstrated improved electrical conductivity by fast electron supply. On the basis of a synergistic effect, a remarkable specific capacitance of 324 F cm^-3 at 0.5 A cm^-3 and greatly enhanced rate performance were achieved, i.e” a 79% retention (256 F cm 3) at 50 A cm^-3. The obtained fiber-shaped supercapacitor finally displayed remarkable energy and power densities of 7.2 mW h cm 3 and 10 W cm^-3, respectively. The strategy developed herein also presents a general pathway towards novel fiber electrodes for high-performance wearable devices.
基金supported by the National Key R&D Program of China (2016YFA0203302)the National Natural Science Foundation of China (21634003, 51573027, 51673043, 21604012, 21805044, 21875042, 11602058, and 11872150)+3 种基金Shanghai Science and Technology Committee (16JC1400702, 17QA1400400, 18QA1400700, and 18QA1400800)Shanghai Municipal Education Commission (2017-01-07-00-07-E00062)Shanghai Chenguang Program (16CG01)Yanchang Petroleum Group
文摘Mechanoluminescence has attracted increasing attentions because it can convert the kinetic energy during human daily motions into light to be used in sensors and displays. However, its practical applications are still hindered by the weak brightness and limited color while under large forces. Herein, we developed novel piezoluminescent devices(PLDs) which could effectively emit visible light under low pressing forces through the stress-concentration and enhancing deformation on the basis of carefully-designed array structures. The emitting colors were also tunable by using bilayer luminescent film under different pressures. This work not only provides a new strategy to effectively harvest mechanical energy into light,but also presents a scalable, low-cost and color-tunable PLD which shows great potentials in various applications such as luminescent floors, shoes and stress-activated displays.
基金supported by the National Natural Science Foundation of China(NSFC,Nos.52122310 and 22075050)Science and Technology Commission of Shanghai Municipality(STCSM,Nos.21511104900 and 20JC1414902)+2 种基金China Postdoctoral Science Foundation(CPSF,Nos.VLH1717003,KLH1717015)Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX01)ZJ Lab,and Shanghai Center for Brain Science and Brain-Inspired Technology.
文摘Fiber organic electrochemical transistors(OECTs)have received extensive attention in wearable and implantable biosensors because of their high flexibility and low working voltage.However,the transconductance of fiber OECTs is much lower compared with the planar counterparts,leading to low sensitivity.Here,we developed fiber OECTs in a coaxial configuration with microscale channel length to achieve the highest transconductance of 135 mS,which is one to two orders of magnitude higher than that of the state-of-the-art fiber OECTs.Coaxial fiber OECT based sensors showed high sensitivities of 12.78,20.53 and 3.78 mA/decade to ascorbic acid,hydrogen peroxide and glucose,respectively.These fiber OECTs were woven into a fabric to monitor the glucose in sweat during exercise and implanted in mouse brain to detect ascorbic acid.This coaxial architectural design offers an effective way to promote the performance of fiber OECTs and realize highly sensitive detection of biochemicals.
基金This work was supported by STCSM(20JC1414902,21511104900),SHMEC(2017-01-07-00-07-E00062)the China Postdoctoral Science Foundation(KLH1717008).
文摘The evolution of electronic systems towards small,flexible,portable and human-centered forms drives the demand for onbody power supplies with lightweight and high flexibility.Fiber solar cells that can be integrated into soft and lightweight textiles are considered as potential sustainable power sources for the next generation of wearable electronics.To this end,they have been extensively investigated in the past decade aiming to improve their photovoltaic performances,but there is still a big gap between the high-performance devices and real applications.Herein,the key advances of configurations,fabrications and performances of fiber solar cells are highlighted and analyzed.Based on the current progress,the latest ideas with regard to the remaining challenges and opportunities beyond the reach of the previous studies are presented.
基金funded by the Project Promoting Basic Capacity for Young and Middle-aged University Teachers in Guangxi(No.2018KY0136)the Guangxi First-class Discipline Project for Pharmaceutical Sciences(No.GXFCDP-PS-2018)the Key Project at the Central Government Level:the Ability Establishment of Sustainable Use for Valuable Chinese Medicine Resources(No.2060302)。
文摘Objective:Ban Fenghe recorded in the Quality Standard of Yao Medicine of Guangxi Zhuang Autonomous Region(Volume 1)is derived from the dried stems and leaves of Semiliquidambar cathayensis.It is usually confused with medicinal herbs from Pterospermum heterophyllum and Dendropanax dentiger.However,they are very different in chemical composition,and should not be used as the same drug.To ensure their safety and efficacy,a method based on macroscopic and microscopic characteristics was developed to distinguish them.Methods:A total of 14 batches of Ban Fenghe samples from three species were collected from different producing areas in China.The macroscopic characteristics were examined by observing external traits.The tissue structures of transverse sections of stems and leaves,the leaf epidermis,and the powder were observed microscopically.Results:The branchlets and leaf surfaces of S.cathayensis and P.heterophyllum were hairy,especially the lower leaf surfaces of P.heterophyllum were densely covered with hairs,but those of D.dentiger were hairless.The pericyclic fibers of S.cathayensis stems were intermittently distributed in a circular shape and accompanied by stone cells,whereas those of P.heterophyllum and D.dentiger were bundled without stone cells.So stone cells and hairs were present in S.cathayensis powder,stone cells were not found in P.heterophyllum and D.dentiger powder,and hairs were not present in D.dentiger powder.The distribution sites,sizes and types of secretory tissues of these three species were also different in transverse sections of stems and leaves.Stomata on the lower epidermis of S.cathayensis leaves were paracytic,whereas those of P.heterophyllum and D.dentiger were anomocytic.Conclusion:Ban Fenghe drugs derived from S.cathayensis could readily be distinguished from those of P.heterophyllum and D.dentiger by macroscopic and microscopic features.
基金supported by NSFC(21634003,51673043 and 22075050)MOST(2016YFA0203302)+1 种基金STCSM(20JC1414902)SHMEC(2017-01-07-00-07-E00062).
文摘Long-term in vivo monitoring of chemicals with implanted sensors has received considerable interests over the past decades owing to their significant contributions in reflecting health conditions and assistance in diagnosing diseases.However,the widely explored chemical sensors outside the body fail to meet the requirements of in vivo applications.This perspective reviews main challenges,recent advances and future directions of long-term in vivo monitoring of chemicals,related to immune response and sensing performance.Challenges in terms of the immune response caused by unstable interfaces between sensors and tissues and improper implanting methods,and the insufficient performance of chemical sensors in complex physiological environment are discussed.Therewith,recent advances in fabricating biocompatible,flexible and thin sensors,developing effective implanting methods with reduced injury and improving the sensitivity,selectivity and stability of chemical sensors for accurate monitoring in vivo are summarized.Finally,we propose the future directions to address these challenges by fiber chemical sensors through the combination of soft fiber configuration,facile implanting methods and new recognition elements,which will provide new platforms for health monitoring and physiological mechanism revealing.
