We proposed a high-intensity focused ultrasound(HIFU)visualization approach based on photoacoustic tomography(PAT),exploiting the linear relationship between the Grüneisen parameter and temperature to map the HIF...We proposed a high-intensity focused ultrasound(HIFU)visualization approach based on photoacoustic tomography(PAT),exploiting the linear relationship between the Grüneisen parameter and temperature to map the HIFU-induced temperature field.A differential photoacoustic(DPA)method was employed to effectively suppress background noise caused by changes in the optical absorption coefficient due to structural tissue damage,thereby successfully decoupling the temperaturedependent photoacoustic(PA)signal enhancement.Furthermore,a quantitative model was established to describe the relationship between the temperature rise(ΔT)and the PA signal variation(ΔPA),enabling reconstruction of the temperature distribution within the HIFU focal region.Under short-duration irradiation conditions,where thermal diffusion can be neglected,axial scanning was used to reconstruct the three-dimensional acoustic field distribution of HIFU.The proposed visualization strategy effectively resolves the challenge of characterizing high-energy focal zones,significantly enhancing the ability to assess HIFU acoustic fields and providing a reliable foundation for pre-treatment dose planning and intraoperative precision therapy.展开更多
Optical dispersion is an inherent property of all materials in nature. Due to the dispersion of the optical material and the phase accumulation of the light field at different wavelengths, chromatic aberration is inev...Optical dispersion is an inherent property of all materials in nature. Due to the dispersion of the optical material and the phase accumulation of the light field at different wavelengths, chromatic aberration is inevitable in commercial optical lens. When taking pictures by lenses with severe chromatic aberration, the images will look blurred or noticeably colored edges (red, green, blue) around the objects, especially in high-contrast situations. Thus, achromatism, correction of the chromatic aberration, is extremely important in broadband optical applications. There are mainly two approaches in the correction of the chromatic aberration in existing optical systems: combining the refractive lenses with different dispersions or introducing the diffractive optical elements. However, it is still a technical challenge to achieve that goal in the entire visible light band.展开更多
基金supported by the National Natural Science Foundation of China(Nos.52394162 and 52027803)the National Key R&D Program of China(No.2022YFA1404404)+2 种基金the Basic Research Program of Jiangsu(No.BK20244002)the Postgraduate Research&Practice Innovation Program of Jiangsu Provincethe Open Research Fund of Suzhou Laboratory(No.SZLAB-1608-2024-ZD020)。
文摘We proposed a high-intensity focused ultrasound(HIFU)visualization approach based on photoacoustic tomography(PAT),exploiting the linear relationship between the Grüneisen parameter and temperature to map the HIFU-induced temperature field.A differential photoacoustic(DPA)method was employed to effectively suppress background noise caused by changes in the optical absorption coefficient due to structural tissue damage,thereby successfully decoupling the temperaturedependent photoacoustic(PA)signal enhancement.Furthermore,a quantitative model was established to describe the relationship between the temperature rise(ΔT)and the PA signal variation(ΔPA),enabling reconstruction of the temperature distribution within the HIFU focal region.Under short-duration irradiation conditions,where thermal diffusion can be neglected,axial scanning was used to reconstruct the three-dimensional acoustic field distribution of HIFU.The proposed visualization strategy effectively resolves the challenge of characterizing high-energy focal zones,significantly enhancing the ability to assess HIFU acoustic fields and providing a reliable foundation for pre-treatment dose planning and intraoperative precision therapy.
基金support from the National Key Research and Development Program of China(NKRDP)(2018YFA0306200 and 2017YFA0303702)the National Natural Science Foundation of China(NNSFC)(11625418 and 51732006)
文摘Optical dispersion is an inherent property of all materials in nature. Due to the dispersion of the optical material and the phase accumulation of the light field at different wavelengths, chromatic aberration is inevitable in commercial optical lens. When taking pictures by lenses with severe chromatic aberration, the images will look blurred or noticeably colored edges (red, green, blue) around the objects, especially in high-contrast situations. Thus, achromatism, correction of the chromatic aberration, is extremely important in broadband optical applications. There are mainly two approaches in the correction of the chromatic aberration in existing optical systems: combining the refractive lenses with different dispersions or introducing the diffractive optical elements. However, it is still a technical challenge to achieve that goal in the entire visible light band.
