Purpose Lateral ankle sprains(LAS)are associated with corticospinal pathway deficits.Existing evidence is primarily based on cross-sectional investigations and noncausal speculations.This study aims to determine wheth...Purpose Lateral ankle sprains(LAS)are associated with corticospinal pathway deficits.Existing evidence is primarily based on cross-sectional investigations and noncausal speculations.This study aims to determine whether maladaptive corticospinal pathway alterations occur pre-and postligament transection in LAS mouse models.Additionally,this study explores whether the alterations are more pronounced in adolescent mice than adults.Methods Twenty-four 8-week-old adolescent and twenty-four 24-week-old adult mice were randomly assigned to lateral ankle ligament transection or sham surgery.Diffusion-weighted imaging of the corticospinal pathway was performed presurgery and 8 weeks postsurgery.Fractional anisotropy(FA)values,reflecting fiber integrity within the corticospinal subregions of the medulla,pons,midbrain,and cerebrum,were extracted.Results Overall,41 mice completed repeated image acquisition.Before surgery,no significant group effects on FA within the four corticospinal subregions were detected in either adolescent or adult mice.Two months after surgery,the adolescent cohort displayed a significant reduction in FA in the medulla subregion following ankle ligament transection(β-baseline-adjusted=-0.083,95%CI,-0.145 to-0.021,p-corrected=0.048).Conversely,no significant effects of ankle ligament transection on corticospinal FA were observed in the adult cohort.Conclusion The maladaptive alterations in the corticospinal tract could be observed in the adolescent LAS mouse model,characterized by reduced fiber integrity in the medulla subregion.While these results are derived from an animal model,they provide a foundation for future investigations into the mechanisms underlying neurological deficits following musculoskeletal injuries.展开更多
Image segmentation refers to the technique and process of partitioning a digital image into multiple segments based on image characteristics so as to extract the object of interest from it. It is a key step from image...Image segmentation refers to the technique and process of partitioning a digital image into multiple segments based on image characteristics so as to extract the object of interest from it. It is a key step from image processing to image analysis. In the mid-1950s, people began to study image segmentation. For decades, various methods for image segmentation have been proposed. In this paper, traditional image segmentation methods and some new methods appearing in recent years were reviewed. Thresholding segmentation methods, region-based, edge detection-based and segmentation methods based on specific theoretical tools were introduced in detail.展开更多
Traumatic aortic injury(TAI)is an acute,critical,and severe disease,and then combined with multiple organ damage,it is even more dangerous.TAI progresses very rapidly,with a pre-hospital mortality rate of 57%-80%,and ...Traumatic aortic injury(TAI)is an acute,critical,and severe disease,and then combined with multiple organ damage,it is even more dangerous.TAI progresses very rapidly,with a pre-hospital mortality rate of 57%-80%,and even when arriving at the hospital,more than one-third of the patients die within 4 h,and it is the 2nd leading cause of death in individuals aged 4-34 years.In addition,the incidence of TAI combined with injury was 81.4%.Therefore,early diagnosis,expeditious surgery,and timely and effective multidisciplinary cooperation are essential for successful rescue.The authors report 2 patients with acute traumatic aortic dissection combined with multiple organ injuries and treated with emergency endovascular surgery to discuss their clinical characteristics and treatment experience,and to provide experience in the diagnosis and treatment of such patients.展开更多
In the controlled synthesis of noble metal nanostructures using wet-chemical methods, normally, metal salts/complexes are used as precursors, and surfactants/ligands are used to tune/stabilize the morphology of nanost...In the controlled synthesis of noble metal nanostructures using wet-chemical methods, normally, metal salts/complexes are used as precursors, and surfactants/ligands are used to tune/stabilize the morphology of nanostructures. Here, we develop a facile electrochemical method to directly convert Pt wires to Pt concave icosahedra and nanocubes on carbon paper through the linear sweep voltammetry in a classic three-electrode electrochemical cell. The Pt wire, carbon paper and Ag/AgCl(3 mol L-1 KCl) are used as the counter, working and reference electrodes, respectively.Impressively, the formed Pt nanostructures exhibit better electrocatalytic activity towards the hydrogen evolution compared to the commercial Pt/C catalyst. This work provides a simple and effective way for direct conversion of Pt wires into well-defined Pt nanocrystals with clean surface. We believe it can also be used for preparation of other metal nanocrystals,such as Au and Pd, from their bulk materials, which could exhibit various promising applications.展开更多
基金supported by the National Natural Science Foundation of China[No.81871823,8207090113,82072510]National Key R&D Program of China[No.2018YFC1312900]+2 种基金Shanghai Natural Science Foundation[No.20ZR1406400]Science and Technology Commission of Shanghai Municipality[No.18JC1410403]Shanghai Municipal Science and Technology Major Project[No.2017SHZDZX01,2018SHZDZX01].
文摘Purpose Lateral ankle sprains(LAS)are associated with corticospinal pathway deficits.Existing evidence is primarily based on cross-sectional investigations and noncausal speculations.This study aims to determine whether maladaptive corticospinal pathway alterations occur pre-and postligament transection in LAS mouse models.Additionally,this study explores whether the alterations are more pronounced in adolescent mice than adults.Methods Twenty-four 8-week-old adolescent and twenty-four 24-week-old adult mice were randomly assigned to lateral ankle ligament transection or sham surgery.Diffusion-weighted imaging of the corticospinal pathway was performed presurgery and 8 weeks postsurgery.Fractional anisotropy(FA)values,reflecting fiber integrity within the corticospinal subregions of the medulla,pons,midbrain,and cerebrum,were extracted.Results Overall,41 mice completed repeated image acquisition.Before surgery,no significant group effects on FA within the four corticospinal subregions were detected in either adolescent or adult mice.Two months after surgery,the adolescent cohort displayed a significant reduction in FA in the medulla subregion following ankle ligament transection(β-baseline-adjusted=-0.083,95%CI,-0.145 to-0.021,p-corrected=0.048).Conversely,no significant effects of ankle ligament transection on corticospinal FA were observed in the adult cohort.Conclusion The maladaptive alterations in the corticospinal tract could be observed in the adolescent LAS mouse model,characterized by reduced fiber integrity in the medulla subregion.While these results are derived from an animal model,they provide a foundation for future investigations into the mechanisms underlying neurological deficits following musculoskeletal injuries.
文摘Image segmentation refers to the technique and process of partitioning a digital image into multiple segments based on image characteristics so as to extract the object of interest from it. It is a key step from image processing to image analysis. In the mid-1950s, people began to study image segmentation. For decades, various methods for image segmentation have been proposed. In this paper, traditional image segmentation methods and some new methods appearing in recent years were reviewed. Thresholding segmentation methods, region-based, edge detection-based and segmentation methods based on specific theoretical tools were introduced in detail.
文摘Traumatic aortic injury(TAI)is an acute,critical,and severe disease,and then combined with multiple organ damage,it is even more dangerous.TAI progresses very rapidly,with a pre-hospital mortality rate of 57%-80%,and even when arriving at the hospital,more than one-third of the patients die within 4 h,and it is the 2nd leading cause of death in individuals aged 4-34 years.In addition,the incidence of TAI combined with injury was 81.4%.Therefore,early diagnosis,expeditious surgery,and timely and effective multidisciplinary cooperation are essential for successful rescue.The authors report 2 patients with acute traumatic aortic dissection combined with multiple organ injuries and treated with emergency endovascular surgery to discuss their clinical characteristics and treatment experience,and to provide experience in the diagnosis and treatment of such patients.
基金supported by the Ministry of Education under AcRF Tier 2 (ARC 19/15, No. MOE2014-T2-2-093 MOE2015-T2-2-057+6 种基金 MOE2016-T2-2-103 MOE2017-T2-1-162)AcRF Tier 1 (2016-T1-001-147 2016-T1-002-051 2017-T1-001-150 2017-T1-002-119)Nanyang Technological University under StartUp Grant (M4081296.070.500000) in Singapore
文摘In the controlled synthesis of noble metal nanostructures using wet-chemical methods, normally, metal salts/complexes are used as precursors, and surfactants/ligands are used to tune/stabilize the morphology of nanostructures. Here, we develop a facile electrochemical method to directly convert Pt wires to Pt concave icosahedra and nanocubes on carbon paper through the linear sweep voltammetry in a classic three-electrode electrochemical cell. The Pt wire, carbon paper and Ag/AgCl(3 mol L-1 KCl) are used as the counter, working and reference electrodes, respectively.Impressively, the formed Pt nanostructures exhibit better electrocatalytic activity towards the hydrogen evolution compared to the commercial Pt/C catalyst. This work provides a simple and effective way for direct conversion of Pt wires into well-defined Pt nanocrystals with clean surface. We believe it can also be used for preparation of other metal nanocrystals,such as Au and Pd, from their bulk materials, which could exhibit various promising applications.
