Heavy use of conventional fertilizers can lead to negative environmental concerns.Controlled-release fertilizers(CRFs)can effectively reduce the amounts of fertilizers used,improve the availability of fer-tilizers,and...Heavy use of conventional fertilizers can lead to negative environmental concerns.Controlled-release fertilizers(CRFs)can effectively reduce the amounts of fertilizers used,improve the availability of fer-tilizers,and which is conducive to the protection of the ecological environment and sustainable devel-opment of agriculture.Therefore,it is imperative to develop and use CRFs as an alternative to traditional fertilizers.This review aims to present the classification,raw material composition,benefits,release process,release mode,and manufacturing methods of fertilizers coated with organic-inorganic com-posite membranes(OICMs)in order to provide an overall update and summarize CRFs encapsulated by OICMs and provide an insight for future trends in the field of fertilizers.It is expected that utilizing CRFs encapsulated by OICMs and their characteristics for agricultural applications can provide innovative ideas and suggestions for developing novel CRFs suitable for modern and sustainable agriculture.展开更多
In this study,sodium alginate(SA),a non-toxic natural polysaccharide with good biocompatibility and biodegradability,was developed for targeted delivery of curcumin(CUR)in tumor therapy.The strategy is to sulfhydrylat...In this study,sodium alginate(SA),a non-toxic natural polysaccharide with good biocompatibility and biodegradability,was developed for targeted delivery of curcumin(CUR)in tumor therapy.The strategy is to sulfhydrylate the folic acid(FA)modified SA,and the CUR dissolved in ethyl acetate(EAC)phase is coated in microcapsules by a quick,efficient and environment-friendly sonochemical method.The EAC in the microcapsule core is volatile,which can be recycled and reused to reduce cost.The prepared mi-crocapsules(FA-RSMCs@CUR)exhibited similar toxicity to free curcumin in anti-tumour evaluation in vitro.FA-RSMCs@CUR also exhibited effective antibacterial properties in the antibacterial evaluation in vitro.It is expected to become a low-cost tumor targeting vector in the future,and has the potential to be promoted in clinical application.展开更多
The animal experiment is the best method for therapeutic efficacy testing of various treatment methods before clinical application and serves as an irreplaceable“live reagent”and“live precise instrument,”thus play...The animal experiment is the best method for therapeutic efficacy testing of various treatment methods before clinical application and serves as an irreplaceable“live reagent”and“live precise instrument,”thus playing a vital role in biomedical science research.However,there were significant differences between the results of animal experiments and clinical efficacy in previousfindings that are hard to ignore,especially in cerebrovascular accident research due to the unsatisfactory specification of animal experiments.Accordingly,more prescriptive and standard tools are required for evaluating the quality of animal experiments.This study will introduce the current commonly used quality evaluation tools for animal experiments.展开更多
基金funded by the Key Project of the Science and Technology Department of Jilin Province,China(grant No.20220203079SF)Independent Research Project in 2020 of State Key Laboratory of Supramolecular Structure and Materials(grant No.CXKT202008).
文摘Heavy use of conventional fertilizers can lead to negative environmental concerns.Controlled-release fertilizers(CRFs)can effectively reduce the amounts of fertilizers used,improve the availability of fer-tilizers,and which is conducive to the protection of the ecological environment and sustainable devel-opment of agriculture.Therefore,it is imperative to develop and use CRFs as an alternative to traditional fertilizers.This review aims to present the classification,raw material composition,benefits,release process,release mode,and manufacturing methods of fertilizers coated with organic-inorganic com-posite membranes(OICMs)in order to provide an overall update and summarize CRFs encapsulated by OICMs and provide an insight for future trends in the field of fertilizers.It is expected that utilizing CRFs encapsulated by OICMs and their characteristics for agricultural applications can provide innovative ideas and suggestions for developing novel CRFs suitable for modern and sustainable agriculture.
基金supported by the Pharmaceutical Health Industry Development Special Project of the Science and Technology Department of Jilin Province,China(grant No.20210401172YY)Interdisciplinary Research Funding Program for Doctoral Students of jilin University(grant No.101832020DjX026).
文摘In this study,sodium alginate(SA),a non-toxic natural polysaccharide with good biocompatibility and biodegradability,was developed for targeted delivery of curcumin(CUR)in tumor therapy.The strategy is to sulfhydrylate the folic acid(FA)modified SA,and the CUR dissolved in ethyl acetate(EAC)phase is coated in microcapsules by a quick,efficient and environment-friendly sonochemical method.The EAC in the microcapsule core is volatile,which can be recycled and reused to reduce cost.The prepared mi-crocapsules(FA-RSMCs@CUR)exhibited similar toxicity to free curcumin in anti-tumour evaluation in vitro.FA-RSMCs@CUR also exhibited effective antibacterial properties in the antibacterial evaluation in vitro.It is expected to become a low-cost tumor targeting vector in the future,and has the potential to be promoted in clinical application.
基金supported by the National Natural Science Foundation of China(No.82174409 for Min Yao,No.82074454 for Xuejun Cui,No.81930116 for Yongjun Wang)Rising Star Project(22QA1409200 for Min Yao)+3 种基金Shanghai Natural Science Foundation(22ZR1461700 for Xuejun Cui)Shanghai Collaborative Innovation Center of Industrial Transformation of HospitalTCMPreparation(No.602092D for Min Yao)Combination of Medical and Nursing Care(No.602056D for Xuejun Cui)China Association of Traditional Chinese Medicine Youth Talent Promotion Project(No.CACM-2021-QNRC2-B23 for Min Yao).
文摘The animal experiment is the best method for therapeutic efficacy testing of various treatment methods before clinical application and serves as an irreplaceable“live reagent”and“live precise instrument,”thus playing a vital role in biomedical science research.However,there were significant differences between the results of animal experiments and clinical efficacy in previousfindings that are hard to ignore,especially in cerebrovascular accident research due to the unsatisfactory specification of animal experiments.Accordingly,more prescriptive and standard tools are required for evaluating the quality of animal experiments.This study will introduce the current commonly used quality evaluation tools for animal experiments.
