Background Early autism screening is of great value,but there is lack of a screening tool of early age (2-5 years) in China.The Autism Spectrum Rating Scale (ASRS,2-5 years) is a newly developed autism screening tool ...Background Early autism screening is of great value,but there is lack of a screening tool of early age (2-5 years) in China.The Autism Spectrum Rating Scale (ASRS,2-5 years) is a newly developed autism screening tool in the USA.This study aimed to evaluate the reliability and validity of the translated Chinese version of ASRS (C_ASRS) in Chinese children population before its application in China for early autism screening.Methods Caregivers of general children aged 2-5 years from 17 kindergartens and autism spectrum disorder (ASD) cases from five special education schools in five cities were recruited to complete the C_ASRS.1910 valid questionnaires from kindergarteners and 192 from ASD cases were included for analyses.Results The item reliability (Cronbach's alpha) was more than 0.80 in the screening scale and DSM-5 scale,and 0.51-0.81 in the treatment scale.ASD cases scored higher on total score and most subscales compared to the kindergarteners (Cohen's d ranging from 1.34 to 3.37).C_ASRS showed good discriminatory validity with an area under the receiver operating characteristic curve of 0.850 (95% confidence interval:0.819-0.881).The cutoff ≥ 60 achieved sensitivity of 65.63% and specificity of 85.63% in discriminating autism children from the general population.Conclusion The results indicate that C_ASRS (2-5 years) could be used as an early level-2 screening tool for autism screening in China and should be further revised for level-1 screening.展开更多
Background:Early-onset schizophrenia(EOS)and autism spectrum disorder(ASD)are two mental disorders with abnormal neurodevelopment and overlapping clinical symptoms.However,few prospective multi-center imaging studies ...Background:Early-onset schizophrenia(EOS)and autism spectrum disorder(ASD)are two mental disorders with abnormal neurodevelopment and overlapping clinical symptoms.However,few prospective multi-center imaging studies explored their pathophysiological differences and similarities comprehensively.Methods:We utilized a large cohort of functional magnetic resonance imaging data with standardized scanning protocols from 594 participants(276 participants with high-functioning ASD,187 participants with EOS,and 131 normal controls(NCs))recruited at five centers.A comprehensive evaluation of anatomical and connectomic features,in-cluding cortical thickness,subcortical nuclei volume,functional connectivity,functional gradients,and network efficiency,was conducted,culminating in the construction of imaging-based neuro-profiles for individuals with EOS and ASD.Results:The derived neuro-profiles revealed that EOS is characterized by more pro-nounced reductions in cortical thickness and subcortical nuclei volumes.In contrast,ASD exhibited more pronounced abnormalities in connectomic attributes.The de-creased network functional connectivity and compressed functional gradients in ASD are likely to contribute to reduced network efficiency.Classifiers based on imaging profiles successfully distinguished individuals with EOS,ASD,and NCs with com-mendable performance in leave-site-out cross-validation(area under the operating characteristic curve(AUC)for ASD vs.NC:0.769,AUC for ASD vs.EOS:0.792,AUC for EOS vs.NC:0.854).Conclusion:The neuro-profiles revealed that EOS and ASD exhibit overlapping as well as unique imaging characteristics;however,EOS exhibits greater structural variation,while ASD presents with more subtle connectomic abnormalities.These findings offer valuable insights into the distinct neurobiological mechanisms of EOS and ASD and enhance the prospect of early diagnosis through objective imaging-based biomarkers.展开更多
文摘Background Early autism screening is of great value,but there is lack of a screening tool of early age (2-5 years) in China.The Autism Spectrum Rating Scale (ASRS,2-5 years) is a newly developed autism screening tool in the USA.This study aimed to evaluate the reliability and validity of the translated Chinese version of ASRS (C_ASRS) in Chinese children population before its application in China for early autism screening.Methods Caregivers of general children aged 2-5 years from 17 kindergartens and autism spectrum disorder (ASD) cases from five special education schools in five cities were recruited to complete the C_ASRS.1910 valid questionnaires from kindergarteners and 192 from ASD cases were included for analyses.Results The item reliability (Cronbach's alpha) was more than 0.80 in the screening scale and DSM-5 scale,and 0.51-0.81 in the treatment scale.ASD cases scored higher on total score and most subscales compared to the kindergarteners (Cohen's d ranging from 1.34 to 3.37).C_ASRS showed good discriminatory validity with an area under the receiver operating characteristic curve of 0.850 (95% confidence interval:0.819-0.881).The cutoff ≥ 60 achieved sensitivity of 65.63% and specificity of 85.63% in discriminating autism children from the general population.Conclusion The results indicate that C_ASRS (2-5 years) could be used as an early level-2 screening tool for autism screening in China and should be further revised for level-1 screening.
基金supported by the National Key R&D Program of China(2017YFC1309900)the National Natural Science Foundation of China(82122035,81671774,81630031,and 81571339)+3 种基金the Key Research Program of the Chinese Academy of Sciences(ZDBS-SSW-JSC006)the Beijing Nova Program of Science and Technology(Z191010001119104)the Key-Area Research and Development Program of Guangdong Province(2019B030335001)the Scientific Foundation of Institute of Psychology,Chinese Academy of Sciences(E3CX1425 and E2CX4425YZ).
文摘Background:Early-onset schizophrenia(EOS)and autism spectrum disorder(ASD)are two mental disorders with abnormal neurodevelopment and overlapping clinical symptoms.However,few prospective multi-center imaging studies explored their pathophysiological differences and similarities comprehensively.Methods:We utilized a large cohort of functional magnetic resonance imaging data with standardized scanning protocols from 594 participants(276 participants with high-functioning ASD,187 participants with EOS,and 131 normal controls(NCs))recruited at five centers.A comprehensive evaluation of anatomical and connectomic features,in-cluding cortical thickness,subcortical nuclei volume,functional connectivity,functional gradients,and network efficiency,was conducted,culminating in the construction of imaging-based neuro-profiles for individuals with EOS and ASD.Results:The derived neuro-profiles revealed that EOS is characterized by more pro-nounced reductions in cortical thickness and subcortical nuclei volumes.In contrast,ASD exhibited more pronounced abnormalities in connectomic attributes.The de-creased network functional connectivity and compressed functional gradients in ASD are likely to contribute to reduced network efficiency.Classifiers based on imaging profiles successfully distinguished individuals with EOS,ASD,and NCs with com-mendable performance in leave-site-out cross-validation(area under the operating characteristic curve(AUC)for ASD vs.NC:0.769,AUC for ASD vs.EOS:0.792,AUC for EOS vs.NC:0.854).Conclusion:The neuro-profiles revealed that EOS and ASD exhibit overlapping as well as unique imaging characteristics;however,EOS exhibits greater structural variation,while ASD presents with more subtle connectomic abnormalities.These findings offer valuable insights into the distinct neurobiological mechanisms of EOS and ASD and enhance the prospect of early diagnosis through objective imaging-based biomarkers.
