AIM The purpose of this study was to evaluate the diagnostic value of trefoil factor family 3(TFF3) for the early detection of colorectal cancer(CC). METHODS Serum TFF3 and carcino-embryonic antigen(CEA) were detected...AIM The purpose of this study was to evaluate the diagnostic value of trefoil factor family 3(TFF3) for the early detection of colorectal cancer(CC). METHODS Serum TFF3 and carcino-embryonic antigen(CEA) were detected in 527 individuals, including 115 healthy control(HC), 198 colorectal adenoma(CA), and 214 CC individuals in the training group. RESULTS Serum TFF3 showed no significant correlation with age, gender, or tumor location but showed significant correlation with the tumor stage. Serum TFF3 in the CC group was significantly higher than in the HC or CA group. The AUC values of TFF3 for discriminating between HC and CC and between CA and CC were 0.930(0.903, 0.958) and 0.834(0.796, 0.873). A multivariate model combining TFF3 and CEA was built. Compared to TFF3 or CEA alone, the multivariate model showed significant improvement(P < 0.001). For discriminating between HC and CC, HC and early stage CC, HC and advanced stage CC, CA and CC, CA and early stage CC, and CA and advanced stage CC in the training group, the sensitivities were 92.99%, 91.46%, 93.18%, 73.83%, 76.83%, and 81.82%, and the specificities were 91.30%, 91.30%, 93.91%, 88.38%, 77.27%, and 88.38%, respectively. After validation, the sensitivities were 89.39%, 85.71%, 90.79%, 72.73%, 71.43%, and 78.95%, and the specificities were 87.85%, 87.85%, 2.52%, 87.85%, 80.77%, and 87.50%, respectively. CONCLUSION The multivariate diagnostic model that included TFF3 and CEA showed significant improvement over the conventional biomarker CEA and might provide a potential method for the early detection of CC.展开更多
The oil-gas two-phase hybrid transportation technology is one of the innovative technology directions for the exploitation and transportation of marginal and deep ocean oilfields.The helical-axial multiphase pump is a...The oil-gas two-phase hybrid transportation technology is one of the innovative technology directions for the exploitation and transportation of marginal and deep ocean oilfields.The helical-axial multiphase pump is a key equipment for oil and gas extraction.At this stage,most of the research on this kind of pump focuses on the improvement of the structure and conveying performance.However,because of insufficient understanding of the flow behavior and mechanism of bubbles,it is easy to cause the gas-liquid separation.In this paper,the numerical simulation and test are combined to explore the changes in the bubble trajectory and flow structure of the helical-axial multiphase pump.The results shown that when the speed is lower than 1200 r/min,the bubble reaches the maximum volume at 1/2 of the midline of the impeller blade and it contact with the pressure surface,broken to the suction surface.When the rotation speed is higher than 1450 r/min,the number of bubbles in the impeller increases and the size decreases.The backflow occurs in the tip clearance and strength increases continuously.The research results have important significance for the theoretical design and engineering application of the helical-axial multiphase pump.展开更多
基金Supported by The Capital Health Development Special Scientific Research Projects,No.2014-2-2154National Natural Science Foundation of China,No.81471761 and No.81501568
文摘AIM The purpose of this study was to evaluate the diagnostic value of trefoil factor family 3(TFF3) for the early detection of colorectal cancer(CC). METHODS Serum TFF3 and carcino-embryonic antigen(CEA) were detected in 527 individuals, including 115 healthy control(HC), 198 colorectal adenoma(CA), and 214 CC individuals in the training group. RESULTS Serum TFF3 showed no significant correlation with age, gender, or tumor location but showed significant correlation with the tumor stage. Serum TFF3 in the CC group was significantly higher than in the HC or CA group. The AUC values of TFF3 for discriminating between HC and CC and between CA and CC were 0.930(0.903, 0.958) and 0.834(0.796, 0.873). A multivariate model combining TFF3 and CEA was built. Compared to TFF3 or CEA alone, the multivariate model showed significant improvement(P < 0.001). For discriminating between HC and CC, HC and early stage CC, HC and advanced stage CC, CA and CC, CA and early stage CC, and CA and advanced stage CC in the training group, the sensitivities were 92.99%, 91.46%, 93.18%, 73.83%, 76.83%, and 81.82%, and the specificities were 91.30%, 91.30%, 93.91%, 88.38%, 77.27%, and 88.38%, respectively. After validation, the sensitivities were 89.39%, 85.71%, 90.79%, 72.73%, 71.43%, and 78.95%, and the specificities were 87.85%, 87.85%, 2.52%, 87.85%, 80.77%, and 87.50%, respectively. CONCLUSION The multivariate diagnostic model that included TFF3 and CEA showed significant improvement over the conventional biomarker CEA and might provide a potential method for the early detection of CC.
基金supported by the National Natural Science Foundation of China(Grant Nos.51969014,51609113)supported by the China Postdoctoral Science Foundation(Grant No.2018M633651XB)+2 种基金the Natural Science Foundation of Gansu(Grant No.20JR5RA456)the Outstanding Young Talents Funding Scheme of Gansu province(Grant No.20JR10RA204)the Hong liu Outstanding Young Talents Funding Schemeof Lanzhou University of Technology.
文摘The oil-gas two-phase hybrid transportation technology is one of the innovative technology directions for the exploitation and transportation of marginal and deep ocean oilfields.The helical-axial multiphase pump is a key equipment for oil and gas extraction.At this stage,most of the research on this kind of pump focuses on the improvement of the structure and conveying performance.However,because of insufficient understanding of the flow behavior and mechanism of bubbles,it is easy to cause the gas-liquid separation.In this paper,the numerical simulation and test are combined to explore the changes in the bubble trajectory and flow structure of the helical-axial multiphase pump.The results shown that when the speed is lower than 1200 r/min,the bubble reaches the maximum volume at 1/2 of the midline of the impeller blade and it contact with the pressure surface,broken to the suction surface.When the rotation speed is higher than 1450 r/min,the number of bubbles in the impeller increases and the size decreases.The backflow occurs in the tip clearance and strength increases continuously.The research results have important significance for the theoretical design and engineering application of the helical-axial multiphase pump.
