Zinc oxide(ZnO),as a broadband gap semiconductor material,exhibits unique physical and chemical properties that make it highly suitable for optoelectronics,piezoelectric devices,and gas-sensitive sensors,showing signi...Zinc oxide(ZnO),as a broadband gap semiconductor material,exhibits unique physical and chemical properties that make it highly suitable for optoelectronics,piezoelectric devices,and gas-sensitive sensors,showing significant potential for various applications.This paper focuses on the regulation and application of ZnO-based p-n junctions and piezoelectric devices.It discusses in detail the preparation of ZnO materials,the construction of p-n junctions,the optimization of piezoelectric device performance,and its application in various fields.By employing different preparation methods and strategies,high-quality ZnO thin films can be grown,and effective control of p-type conductivity achieved.This study provides both a theoretical foundation and technical support for controlling the performance of ZnO-based piezoelectric devices,as well as paving new pathways for the broader application of ZnO materials.展开更多
This study investigates the multifield vibration behavior of a porosity-dependent bidirectional functionally graded piezoelectric nano-plate(FGPN)subjected to hygrothermal and thermoelectric loading.The material compo...This study investigates the multifield vibration behavior of a porosity-dependent bidirectional functionally graded piezoelectric nano-plate(FGPN)subjected to hygrothermal and thermoelectric loading.The material composition is defined by sigmoid and power-law distributions along both transverse and axial directions,accommodating even,uneven,and symmetrically centered porosity patterns.The model incorporates nonclassical elasticity theory and von Kármán nonlinear strains,with the governing equations formulated using a modified first-order shear deformation theory and derived through the energy principle.A higher-order finite element formulation,coupled with a modified Newton-Raphson procedure,ensures robust computational accuracy,validated through convergence tests.The analysis delves into the influence of porosity distribution,bidirectional material variations,non-uniform thickness,thickness ratios,variable elastic foundations,and boundary conditions on vibrational behavior.Additionally,the study explores the interplay of hygrothermal and electrical loading conditions in diverse configurations.The findings highlight the pivotal role of bidirectional material gradation in shaping the vibrational response of porous FGPN structures,offering valuable insights for the design of nano-plates in hygrothermal and thermoelectric applications.展开更多
Gallbladder cancer(GBC)is a highly invasive disease and the most prevalent malignancy of the biliary system.Patients with GBC are commonly diagnosed at a late stage and have an unfavorable prognosis.Palliative chemoth...Gallbladder cancer(GBC)is a highly invasive disease and the most prevalent malignancy of the biliary system.Patients with GBC are commonly diagnosed at a late stage and have an unfavorable prognosis.Palliative chemotherapy has been the standard care for recurrent or metastatic disease in the past decades.Recently,several targeted therapies have been investigated in advanced biliary tract cancer(BTC)including inhibitors of genes or pathways such as FGFR2 fusions or rearrangements,IDH1 mutations,and NTRK gene fusions.Also,several clinical studies involving molecular stratification have been performed in defined patient groups,for example,BRAF V600E and HER2.Mesenchymal epithelial transition(MET)encodes a tyrosine kinase receptor and its ligand hepatocyte growth factor is a proto-oncogene.Targeting the MET signaling pathway is an effective strategy in numerous cancer types.However,the poor efficacy of MET inhibitors has been demonstrated in several phase II studies,but currently no reports have explained the potential mechanisms of resistance to MET inhibitors in BTC.In this article,we report a case of metastatic GBC with MET amplification that exhibited a rapid response to crizotinib after the failure of two lines of chemotherapy.After the patient had progressed and discontinued crizotinib,cabozantinib was introduced.Analysis of circulating tumor DNA(ctDNA)by nextgeneration sequencing(NGS)indicated a loss of MET amplification status.To our knowledge,this is the first case study demonstrating the use of NGS in ctDNA to monitor the development of acquired resistance during anti-MET treatment in GBC.展开更多
基金The Natural Science Foundation of Guangdong Province(Project No.2023A1515012352)。
文摘Zinc oxide(ZnO),as a broadband gap semiconductor material,exhibits unique physical and chemical properties that make it highly suitable for optoelectronics,piezoelectric devices,and gas-sensitive sensors,showing significant potential for various applications.This paper focuses on the regulation and application of ZnO-based p-n junctions and piezoelectric devices.It discusses in detail the preparation of ZnO materials,the construction of p-n junctions,the optimization of piezoelectric device performance,and its application in various fields.By employing different preparation methods and strategies,high-quality ZnO thin films can be grown,and effective control of p-type conductivity achieved.This study provides both a theoretical foundation and technical support for controlling the performance of ZnO-based piezoelectric devices,as well as paving new pathways for the broader application of ZnO materials.
文摘This study investigates the multifield vibration behavior of a porosity-dependent bidirectional functionally graded piezoelectric nano-plate(FGPN)subjected to hygrothermal and thermoelectric loading.The material composition is defined by sigmoid and power-law distributions along both transverse and axial directions,accommodating even,uneven,and symmetrically centered porosity patterns.The model incorporates nonclassical elasticity theory and von Kármán nonlinear strains,with the governing equations formulated using a modified first-order shear deformation theory and derived through the energy principle.A higher-order finite element formulation,coupled with a modified Newton-Raphson procedure,ensures robust computational accuracy,validated through convergence tests.The analysis delves into the influence of porosity distribution,bidirectional material variations,non-uniform thickness,thickness ratios,variable elastic foundations,and boundary conditions on vibrational behavior.Additionally,the study explores the interplay of hygrothermal and electrical loading conditions in diverse configurations.The findings highlight the pivotal role of bidirectional material gradation in shaping the vibrational response of porous FGPN structures,offering valuable insights for the design of nano-plates in hygrothermal and thermoelectric applications.
基金This work was supported by the National Key Development Plan for Precision Medicine Research(Grant No.2017YFC0910004).
文摘Gallbladder cancer(GBC)is a highly invasive disease and the most prevalent malignancy of the biliary system.Patients with GBC are commonly diagnosed at a late stage and have an unfavorable prognosis.Palliative chemotherapy has been the standard care for recurrent or metastatic disease in the past decades.Recently,several targeted therapies have been investigated in advanced biliary tract cancer(BTC)including inhibitors of genes or pathways such as FGFR2 fusions or rearrangements,IDH1 mutations,and NTRK gene fusions.Also,several clinical studies involving molecular stratification have been performed in defined patient groups,for example,BRAF V600E and HER2.Mesenchymal epithelial transition(MET)encodes a tyrosine kinase receptor and its ligand hepatocyte growth factor is a proto-oncogene.Targeting the MET signaling pathway is an effective strategy in numerous cancer types.However,the poor efficacy of MET inhibitors has been demonstrated in several phase II studies,but currently no reports have explained the potential mechanisms of resistance to MET inhibitors in BTC.In this article,we report a case of metastatic GBC with MET amplification that exhibited a rapid response to crizotinib after the failure of two lines of chemotherapy.After the patient had progressed and discontinued crizotinib,cabozantinib was introduced.Analysis of circulating tumor DNA(ctDNA)by nextgeneration sequencing(NGS)indicated a loss of MET amplification status.To our knowledge,this is the first case study demonstrating the use of NGS in ctDNA to monitor the development of acquired resistance during anti-MET treatment in GBC.
