Objectives Infantile hemangioma(IH)is defined as a benign vascular tumor composed of immature vascular endothelial cells,with the unique characteristics of rich vascularization and self-regression into fibro-fatty tis...Objectives Infantile hemangioma(IH)is defined as a benign vascular tumor composed of immature vascular endothelial cells,with the unique characteristics of rich vascularization and self-regression into fibro-fatty tissue.CD133-positive hemangioma stem cells(HemSCs),present in the proliferating IH tissue,can be used to establish the IH animal model,which has highlighted the pathogenesis of IH in recent years.This study focused on the biological characteristics and differentiation capacity of HemSCs and aimed to provide a theoretical possibility for its application in tissue engineering.Methods To further confirm our hypothesis,we used fluorescence-activated cell sorting(FACS),in vitro multipotent induced differentiation,angiogenesis assay,and antibody array to identify the surface markers,multipotent differential potential,angiogenesis potential,and secreted factors of HemSCs,respectively,utilizing human adipose stem cells(hADSCs)as the control.Results We successfully isolated and cultured HemSCs.FACS indicated that,on average,more than 80%of HemSCs matched the criteria of mesenchymal stem cell(MSC)surface markers.Our results confirmed that HemSCs could differentiate into adipocytes,osteocytes,and chondrocytes.Additionally,compared with fibroblasts or hADSCs,HemSCs could promote angiogenesis through para-secretion.Conclusions HemSCs may originate from normal MSCs,and owing to their powerful proliferative and angiogenic abilities,they could be considered an IH pathogenic factor.These characteristics demonstratet heir potential as a candidate seed cell in tissue engineering.展开更多
Solid-state batteries have been considered as promising next-generation energy storage devices for potentially higher energy density and better safety compared with commercial lithium-ion batteries that are based on o...Solid-state batteries have been considered as promising next-generation energy storage devices for potentially higher energy density and better safety compared with commercial lithium-ion batteries that are based on organic liquid electrolytes.However,in terms of indispensable solid-state electrolytes,there are remaining issues to be solved before entering the market.Most solid-state electrolytes are air-sensitive,which causes a complex and expensive cell assembly and impressible interface.Therefore,the solid-state electrolytes are expected to be atmosphere-stable,which will undoubtedly bring significant benefits to solid-state battery manufacturing.This review covers air-stabilityrelated issues of different types of inorganic solid-state electrolytes and the corresponding strategies.First,we provide an overview of solid-state electrolytes and solid-state batteries,including their history and advantages/disadvantages.Then,different types of solid-state electrolytes are selected as examples to illustrate the unfavorable interactions in air and the corresponding adverse effects.Next,according to recent advances,we summarize the effective strategies of constructing different types of air-stable inorganic solid-state electrolytes.Finally,perspectives on designing accessible air-stable solid-state electrolytes are provided,aiming to achieve the assembly of high-performance solid-state batteries in the atmosphere.展开更多
The development of electrocatalysts with high catalytic activity is conducive to enhancing polysulfides adsorption and reducing activation energy of polysulfides conversion, which can effectively reduce polysulfide sh...The development of electrocatalysts with high catalytic activity is conducive to enhancing polysulfides adsorption and reducing activation energy of polysulfides conversion, which can effectively reduce polysulfide shuttling in Li-S batteries. Herein, a novel catalyst NiCo-MoO_(x)/rGO (rGO = reduced graphene oxides) with ultra-nanometer scale and high dispersity is derived from the Anderson-type polyoxometalate precursors, which are electrostatically assembled on the multilayer rGO. The catalyst material possesses dual active sites, in which Ni-doped MoO_(x) exhibits strong polysulfide anchoring ability, while Co-doped MoO_(x) facilitates the polysulfides conversion reaction kinetics, thus breaking the Sabatier effect in the conventional electrocatalytic process. In addition, the prepared NiCo-MoO_(x)/rGO modified PP separator (NiCo-MoO_(x)/rGO@PP) can serve as a physical barrier to further inhibit the polysulfide shuttling effect and realize the rapid Li+ migration. The results demonstrate that Li-S coin cell with NiCo-MoO_(x)/rGO@PP separator shows excellent cycling performance with the discharge capacity of 680 mAh·g^(−1) after 600 cycles at 1 C and the capacity fading of 0.064% per cycle. The rate performance is also impressive with the remained capacity of 640 mAh·g^(−1) after 200 cycles even at 4 C. When the sulfur loading is 4.0 mg·cm^(−2) and electrolyte volume/sulfur mass ratio (E/S) ratio is 6.0 μL·mg^(−1), a specific capacity of 830 mAh·g^(−1) is achieved after 200 cycles with a capacity decay of 0.049% per cycle. More importantly, the cell with NiCo-MoO_(x)/rGO@PP separator exhibits cycling performance under wide operating temperature with the reversible capacities of 518, 715, and 915 mAh·g^(−1) after 100 cycles at −20, 0, and 60 °C, respectively. This study provides a new design approach of highly efficient catalysts for sulfur conversion reaction in Li-S batteries.展开更多
基金This study was supported by grants of the National Natural Science Foundation of China(81571917 and 81772100)。
文摘Objectives Infantile hemangioma(IH)is defined as a benign vascular tumor composed of immature vascular endothelial cells,with the unique characteristics of rich vascularization and self-regression into fibro-fatty tissue.CD133-positive hemangioma stem cells(HemSCs),present in the proliferating IH tissue,can be used to establish the IH animal model,which has highlighted the pathogenesis of IH in recent years.This study focused on the biological characteristics and differentiation capacity of HemSCs and aimed to provide a theoretical possibility for its application in tissue engineering.Methods To further confirm our hypothesis,we used fluorescence-activated cell sorting(FACS),in vitro multipotent induced differentiation,angiogenesis assay,and antibody array to identify the surface markers,multipotent differential potential,angiogenesis potential,and secreted factors of HemSCs,respectively,utilizing human adipose stem cells(hADSCs)as the control.Results We successfully isolated and cultured HemSCs.FACS indicated that,on average,more than 80%of HemSCs matched the criteria of mesenchymal stem cell(MSC)surface markers.Our results confirmed that HemSCs could differentiate into adipocytes,osteocytes,and chondrocytes.Additionally,compared with fibroblasts or hADSCs,HemSCs could promote angiogenesis through para-secretion.Conclusions HemSCs may originate from normal MSCs,and owing to their powerful proliferative and angiogenic abilities,they could be considered an IH pathogenic factor.These characteristics demonstratet heir potential as a candidate seed cell in tissue engineering.
基金supported by the Innovation-Driven Project of Central South University(No.2019CX033)the National Natural Science Foundation of China(Nos.51622210,51904344,51925207,U1910210 and 51872277)+1 种基金the National Synchrotron Radiation Laboratory(KY2060000173)the Joint Fund of the Yulin University and the Dalian National Laboratory for Clean Energy(grant nos.YLU-DNL Fund 2021002).
文摘Solid-state batteries have been considered as promising next-generation energy storage devices for potentially higher energy density and better safety compared with commercial lithium-ion batteries that are based on organic liquid electrolytes.However,in terms of indispensable solid-state electrolytes,there are remaining issues to be solved before entering the market.Most solid-state electrolytes are air-sensitive,which causes a complex and expensive cell assembly and impressible interface.Therefore,the solid-state electrolytes are expected to be atmosphere-stable,which will undoubtedly bring significant benefits to solid-state battery manufacturing.This review covers air-stabilityrelated issues of different types of inorganic solid-state electrolytes and the corresponding strategies.First,we provide an overview of solid-state electrolytes and solid-state batteries,including their history and advantages/disadvantages.Then,different types of solid-state electrolytes are selected as examples to illustrate the unfavorable interactions in air and the corresponding adverse effects.Next,according to recent advances,we summarize the effective strategies of constructing different types of air-stable inorganic solid-state electrolytes.Finally,perspectives on designing accessible air-stable solid-state electrolytes are provided,aiming to achieve the assembly of high-performance solid-state batteries in the atmosphere.
基金the National Natural Science Foundation of China(No.52172264)the Natural Science Foundation of Hunan Province of China(Nos.2021JJ10060 and 2022GK2033).
文摘The development of electrocatalysts with high catalytic activity is conducive to enhancing polysulfides adsorption and reducing activation energy of polysulfides conversion, which can effectively reduce polysulfide shuttling in Li-S batteries. Herein, a novel catalyst NiCo-MoO_(x)/rGO (rGO = reduced graphene oxides) with ultra-nanometer scale and high dispersity is derived from the Anderson-type polyoxometalate precursors, which are electrostatically assembled on the multilayer rGO. The catalyst material possesses dual active sites, in which Ni-doped MoO_(x) exhibits strong polysulfide anchoring ability, while Co-doped MoO_(x) facilitates the polysulfides conversion reaction kinetics, thus breaking the Sabatier effect in the conventional electrocatalytic process. In addition, the prepared NiCo-MoO_(x)/rGO modified PP separator (NiCo-MoO_(x)/rGO@PP) can serve as a physical barrier to further inhibit the polysulfide shuttling effect and realize the rapid Li+ migration. The results demonstrate that Li-S coin cell with NiCo-MoO_(x)/rGO@PP separator shows excellent cycling performance with the discharge capacity of 680 mAh·g^(−1) after 600 cycles at 1 C and the capacity fading of 0.064% per cycle. The rate performance is also impressive with the remained capacity of 640 mAh·g^(−1) after 200 cycles even at 4 C. When the sulfur loading is 4.0 mg·cm^(−2) and electrolyte volume/sulfur mass ratio (E/S) ratio is 6.0 μL·mg^(−1), a specific capacity of 830 mAh·g^(−1) is achieved after 200 cycles with a capacity decay of 0.049% per cycle. More importantly, the cell with NiCo-MoO_(x)/rGO@PP separator exhibits cycling performance under wide operating temperature with the reversible capacities of 518, 715, and 915 mAh·g^(−1) after 100 cycles at −20, 0, and 60 °C, respectively. This study provides a new design approach of highly efficient catalysts for sulfur conversion reaction in Li-S batteries.
