For early hepatocellular carcinoma(HCC),curative therapies include surgical excision and radiofrequency ablation.Other treatment modes for advanced HCC involve transarterial chemoembolization.For HCC patients who do n...For early hepatocellular carcinoma(HCC),curative therapies include surgical excision and radiofrequency ablation.Other treatment modes for advanced HCC involve transarterial chemoembolization.For HCC patients who do not fit the Milan criteria or are waiting for liver transplantation(LT),studies of transarterial radioembolization with Yttrium-90(Y-90)demonstrated that Y-90 may accomplish a good downstaging or bridging effect before LT and can even achieve complete pathological necrosis.The present review discussed Y-90 radioembolization as a local regional treatment option for advanced and unresectable HCC,with a focus on neoadjuvant intervention before LT.展开更多
We propose a novel machine learning approach to reconstruct meshless surface wind speed fields,i.e.,to reconstruct the surface wind speed at any location,based on meteorological background fields and geographical info...We propose a novel machine learning approach to reconstruct meshless surface wind speed fields,i.e.,to reconstruct the surface wind speed at any location,based on meteorological background fields and geographical information.The random forest method is selected to develop the machine learning data reconstruction model(MLDRM-RF)for wind speeds over Beijing from 2015-19.We use temporal,geospatial attribute and meteorological background field features as inputs.The wind speed field can be reconstructed at any station in the region not used in the training process to cross-validate model performance.The evaluation considers the spatial distribution of and seasonal variations in the root mean squared error(RMSE)of the reconstructed wind speed field across Beijing.The average RMSE is 1.09 m s^(−1),considerably smaller than the result(1.29 m s^(−1))obtained with inverse distance weighting(IDW)interpolation.Finally,we extract the important feature permutations by the method of mean decrease in impurity(MDI)and discuss the reasonableness of the model prediction results.MLDRM-RF is a reasonable approach with excellent potential for the improved reconstruction of historical surface wind speed fields with arbitrary grid resolutions.Such a model is needed in many wind applications,such as wind energy and aviation safety assessments.展开更多
Intrahepatic arterioportal fistulas(APFs)are abnormal hepatic artery and portal vein(PV)communications that develop as a result of congenital malformation,trauma,ruptured hepatic aneurysm,cirrhosis,tumor-related chang...Intrahepatic arterioportal fistulas(APFs)are abnormal hepatic artery and portal vein(PV)communications that develop as a result of congenital malformation,trauma,ruptured hepatic aneurysm,cirrhosis,tumor-related changes,biopsy,chemotherapy or iatrogenic causes[1,2].The most common symptoms are gastrointestinal bleeding and ascites secondary to portal hypertension;other symptoms include abdominal pain,pyrexia,edema,back pain and jaundice[3].The main goal of therapy is to decrease the portal pressure with variceal bleeding being the absolute indi-cation for surgical management.Transarterial embolization(TAE)should be the first choice to treat APFs,while resection,portocaval shunt and even transplantation may cure APFs in the case of TAE failure[4].In previous reports,caudate lobe-sparing subtotal hep-atectomy(CLSSH)has been applied for the treatment of primary hepatolithiasis and hepatocellular carcinoma[5,6].As far as we know,this is the first report describing CLSSH as treatment for an extensive intrahepatic APF,which involved segments 2 to 8,with corresponding hypertrophy of the caudate lobe.展开更多
A 19-year-old female complains of an abdominal lump and intermittent pain in the upper abdomen,as well as gradually occurring skin,sclera jaundice over the past 6 months.She does not have a fever and has no complaints...A 19-year-old female complains of an abdominal lump and intermittent pain in the upper abdomen,as well as gradually occurring skin,sclera jaundice over the past 6 months.She does not have a fever and has no complaints of bloating,nausea,or vomiting.Defecation is also normal,including the color of stool.Ten days ago,the patient experienced a high fever with a maximum body temperature of 39℃,accompanied by chills.This patient has no history of other illnesses or blood transfusions.展开更多
To the Editor:We paid attention to the recent article by Xiao et al.[1].They reviewed a new strategy for expanding the allograft pool,which involves using otherwise-wasted resected liver lobes from patients with large...To the Editor:We paid attention to the recent article by Xiao et al.[1].They reviewed a new strategy for expanding the allograft pool,which involves using otherwise-wasted resected liver lobes from patients with large,symptomatic benign liver tumors as liver transplant donors.Liver transplantation is the ultimate curative treatment for patients with acute or chronic end-stage liver diseases,or malignant liver tumors,but it is restricted due to the limited availability of donor organs.展开更多
Up to know,product information for COVID-19 mRNA vaccines do not include their use in patients receiving immunosuppressive medication,since they were not included in trials(1).For the BNT162b2 mRNA vaccine,one case of...Up to know,product information for COVID-19 mRNA vaccines do not include their use in patients receiving immunosuppressive medication,since they were not included in trials(1).For the BNT162b2 mRNA vaccine,one case of otherwise totally asymptomatic elevations of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP)andγ-glutamyl transpeptidase(GGT)serum concentrations in a liver transplant recipient has been reported after the first injection(2).In the present retrospective study,we present safety outcomes of COVID-19 vaccinations in 56 liver transplant patients from two Chinese centers vaccinated with the domestic PiCoVacc,BBIBP-CorV and ZF2001 vaccines.Thirty vaccinated physicians from the Hepatopancreatobiliary Center of Beijing Tsinghua Changgung Hospital served as control,from which 1 participant received an Ad5-nCoV vaccine.The study deadline was 2021-10-31.The observation period for adverse reactions,such as muscle pain and fatigue was 1 week,while for laboratory examinations such as liver function the follow-up period was 1 month.展开更多
To the Editor:Venous thromboembolism(VTE)is a common complication following orthotopic liver transplantation(OLT),with an incidence of 2.8-8.6%,[1-3]which affects the quality of life of post-transplant patients.Curren...To the Editor:Venous thromboembolism(VTE)is a common complication following orthotopic liver transplantation(OLT),with an incidence of 2.8-8.6%,[1-3]which affects the quality of life of post-transplant patients.Current VTE risk assessment tools,such as the Caprini score,have limitations when applied to this population,underscoring the necessity of developing an early VTE risk assessment model tailored for OLT recipients.展开更多
文摘For early hepatocellular carcinoma(HCC),curative therapies include surgical excision and radiofrequency ablation.Other treatment modes for advanced HCC involve transarterial chemoembolization.For HCC patients who do not fit the Milan criteria or are waiting for liver transplantation(LT),studies of transarterial radioembolization with Yttrium-90(Y-90)demonstrated that Y-90 may accomplish a good downstaging or bridging effect before LT and can even achieve complete pathological necrosis.The present review discussed Y-90 radioembolization as a local regional treatment option for advanced and unresectable HCC,with a focus on neoadjuvant intervention before LT.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA19030402)the Key Special Projects for International Cooperation in Science and Technology Innovation between Governments(Grant No.2017YFE0133600the Beijing Municipal Natural Science Foundation Youth Project 8214066:Application Research of Beijing Road Visibility Prediction Based on Machine Learning Methods.
文摘We propose a novel machine learning approach to reconstruct meshless surface wind speed fields,i.e.,to reconstruct the surface wind speed at any location,based on meteorological background fields and geographical information.The random forest method is selected to develop the machine learning data reconstruction model(MLDRM-RF)for wind speeds over Beijing from 2015-19.We use temporal,geospatial attribute and meteorological background field features as inputs.The wind speed field can be reconstructed at any station in the region not used in the training process to cross-validate model performance.The evaluation considers the spatial distribution of and seasonal variations in the root mean squared error(RMSE)of the reconstructed wind speed field across Beijing.The average RMSE is 1.09 m s^(−1),considerably smaller than the result(1.29 m s^(−1))obtained with inverse distance weighting(IDW)interpolation.Finally,we extract the important feature permutations by the method of mean decrease in impurity(MDI)and discuss the reasonableness of the model prediction results.MLDRM-RF is a reasonable approach with excellent potential for the improved reconstruction of historical surface wind speed fields with arbitrary grid resolutions.Such a model is needed in many wind applications,such as wind energy and aviation safety assessments.
基金supported by a grant from the National Natural Science Foundation of China(81930119).
文摘Intrahepatic arterioportal fistulas(APFs)are abnormal hepatic artery and portal vein(PV)communications that develop as a result of congenital malformation,trauma,ruptured hepatic aneurysm,cirrhosis,tumor-related changes,biopsy,chemotherapy or iatrogenic causes[1,2].The most common symptoms are gastrointestinal bleeding and ascites secondary to portal hypertension;other symptoms include abdominal pain,pyrexia,edema,back pain and jaundice[3].The main goal of therapy is to decrease the portal pressure with variceal bleeding being the absolute indi-cation for surgical management.Transarterial embolization(TAE)should be the first choice to treat APFs,while resection,portocaval shunt and even transplantation may cure APFs in the case of TAE failure[4].In previous reports,caudate lobe-sparing subtotal hep-atectomy(CLSSH)has been applied for the treatment of primary hepatolithiasis and hepatocellular carcinoma[5,6].As far as we know,this is the first report describing CLSSH as treatment for an extensive intrahepatic APF,which involved segments 2 to 8,with corresponding hypertrophy of the caudate lobe.
文摘A 19-year-old female complains of an abdominal lump and intermittent pain in the upper abdomen,as well as gradually occurring skin,sclera jaundice over the past 6 months.She does not have a fever and has no complaints of bloating,nausea,or vomiting.Defecation is also normal,including the color of stool.Ten days ago,the patient experienced a high fever with a maximum body temperature of 39℃,accompanied by chills.This patient has no history of other illnesses or blood transfusions.
文摘To the Editor:We paid attention to the recent article by Xiao et al.[1].They reviewed a new strategy for expanding the allograft pool,which involves using otherwise-wasted resected liver lobes from patients with large,symptomatic benign liver tumors as liver transplant donors.Liver transplantation is the ultimate curative treatment for patients with acute or chronic end-stage liver diseases,or malignant liver tumors,but it is restricted due to the limited availability of donor organs.
基金supported by the National Science&Technology Major Project[grant No.2017ZX100203205]National Natural Science Foundation of China[grant No.81930119]funders had no role in design of the study and collection,analysis,and interpretation of data and in writing the manuscript.
文摘Up to know,product information for COVID-19 mRNA vaccines do not include their use in patients receiving immunosuppressive medication,since they were not included in trials(1).For the BNT162b2 mRNA vaccine,one case of otherwise totally asymptomatic elevations of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP)andγ-glutamyl transpeptidase(GGT)serum concentrations in a liver transplant recipient has been reported after the first injection(2).In the present retrospective study,we present safety outcomes of COVID-19 vaccinations in 56 liver transplant patients from two Chinese centers vaccinated with the domestic PiCoVacc,BBIBP-CorV and ZF2001 vaccines.Thirty vaccinated physicians from the Hepatopancreatobiliary Center of Beijing Tsinghua Changgung Hospital served as control,from which 1 participant received an Ad5-nCoV vaccine.The study deadline was 2021-10-31.The observation period for adverse reactions,such as muscle pain and fatigue was 1 week,while for laboratory examinations such as liver function the follow-up period was 1 month.
文摘To the Editor:Venous thromboembolism(VTE)is a common complication following orthotopic liver transplantation(OLT),with an incidence of 2.8-8.6%,[1-3]which affects the quality of life of post-transplant patients.Current VTE risk assessment tools,such as the Caprini score,have limitations when applied to this population,underscoring the necessity of developing an early VTE risk assessment model tailored for OLT recipients.
