[Objectives]To investigate the effects of silicon fertilizer spraying on the growth,yield,quality,and overall benefits of rice cultivation.[Methods]A systematic experiment involving the single-spray multi-promotion te...[Objectives]To investigate the effects of silicon fertilizer spraying on the growth,yield,quality,and overall benefits of rice cultivation.[Methods]A systematic experiment involving the single-spray multi-promotion technology of silicon fertilizer via unmanned aerial vehicles(UAVs)was conducted in three representative rice-growing areas:Ma'an Town,Shuikou Subdistrict,and Luzhou Town.[Results]The spraying of silicon fertilizer markedly enhanced the root development of rice,resulting in increased tiller number,plant height,stem thickness,panicle length,and 1000-grain weight,thereby effectively improving both yield and quality.This treatment exerted six primary beneficial effects:promoting robust and stable seedling growth,enhancing stress resistance,reducing reliance on chemical fertilizers,improving quality,increasing economic benefits,and significantly advancing ecological and social benefits.[Conclusions]The application of silicon fertilizer through spraying is an effective agronomic practice that simultaneously promotes increased rice yield,improved quality,enhanced efficiency,and the sustainable development of resources and the environment.展开更多
The late Ming and early Qing dynasties were among the periods with a high incidence of infectious diseases in Chinese history.In this study,we aimed to analyze historical data to investigate the geographical factors a...The late Ming and early Qing dynasties were among the periods with a high incidence of infectious diseases in Chinese history.In this study,we aimed to analyze historical data to investigate the geographical factors and disease spectrum of infectious diseases during that time.Our objective was to provide insights for the modern prevention and control of infectious diseases.We collected and organized historical materials from this period.Descriptive statistical methods were used to explore the correlation between epidemics and natural factors.Furthermore,we collected traditional Chinese medicine prescriptions for preventing and treating infectious diseases during this period.By predicting potential diseases treatable through core prescriptions,we aimed to clarify the disease spectrum of epidemics.Cluster analysis results showed that among geographical factors such as famine,drought,and locusts,as well as social phenomena such as wars and inflation,drought had the highest clustering value and the strongest correlation with other factors.Disease spectrum analysis revealed three common types of drug combinations used to treat epidemics:Rheum officinale-ginger-aurantium fruit-magnolia bark-mirabilite,licorice-anemarrhena root-ginseng-poria-atractylodes,and white peony root-licorice-ginger-Chinese angelica-bupleurum.Diseases with a high degree of enrichment for these drugs included Kaposi's sarcoma-associated herpesvirus infection,human cytomegalovirus infection,and hepatitis B.During the late Ming and early Qing dynasties in China,epidemics occurred frequently and were closely related to factors such as drought,locusts,war,and inflation.The epidemics likely involved a combination of various infectious diseases,including Kaposi's sarcoma-associated herpesvirus infection,human cytomegalovirus infection,and hepatitis B.展开更多
Sense mutations in several conserved modifiable sites of histone H3 have been found to be strongly correlated with multiple tissuespecific clinical cancers.These clinical site mutants acquire a distinctively new epige...Sense mutations in several conserved modifiable sites of histone H3 have been found to be strongly correlated with multiple tissuespecific clinical cancers.These clinical site mutants acquire a distinctively new epigenetic role and mediate cancer evolution.In this study,we mimicked histone H3 at the 56th lysine(H3K56)mutant incorporation in mouse embryonic stem cells(mESCs)by lentivirus-mediated ectopic expression and analyzed the effects on replication and epigenetic regulation.The data show that two types of H3K56 mutants,namely H3 lysine 56-to-methionine(H3K56M)and H3 lysine 56-to-alanine(H3K56A),promote replication by recruiting more minichromosome maintenance complex component 3 and checkpoint kinase 1 onto chromatin compared with wild-type histone H3 and other site substitution mutants.Under this condition,the frequency of genomic copy number gain in H3K56M and H3K56A cells globally increases,especially in the Mycl1 region,a known molecular marker frequently occurring in multiple malignant cancers.Additionally,we found the disruption of H3K56 acetylation distribution in the copy-gain regions,which indicates a probable epigenetic mechanism of H3K56M and H3K56A.We then identified that H3K56M and H3K56A can trigger a potential adaptation to transcription;genes involved in the mitogen-activated protein kinase pathway are partially upregulated,whereas genes associated with intrinsic apoptotic function show obvious downregulation.The final outcome of ectopic H3K56M and H3K56A incorporation in mESCs is an enhanced ability to form carcinomas.This work indicates that H3K56 site conservation and proper modification play important roles in harmonizing the function of the replication machinery in mESCs.展开更多
基金Supported by Huizhou Municipal Stable Grain and Oil Production Award and Subsidy Project"2025 Single-spray Multi-Promotion Project of Silicon Fertilizer on Rice Crops Using UAVs of Huicheng District".
文摘[Objectives]To investigate the effects of silicon fertilizer spraying on the growth,yield,quality,and overall benefits of rice cultivation.[Methods]A systematic experiment involving the single-spray multi-promotion technology of silicon fertilizer via unmanned aerial vehicles(UAVs)was conducted in three representative rice-growing areas:Ma'an Town,Shuikou Subdistrict,and Luzhou Town.[Results]The spraying of silicon fertilizer markedly enhanced the root development of rice,resulting in increased tiller number,plant height,stem thickness,panicle length,and 1000-grain weight,thereby effectively improving both yield and quality.This treatment exerted six primary beneficial effects:promoting robust and stable seedling growth,enhancing stress resistance,reducing reliance on chemical fertilizers,improving quality,increasing economic benefits,and significantly advancing ecological and social benefits.[Conclusions]The application of silicon fertilizer through spraying is an effective agronomic practice that simultaneously promotes increased rice yield,improved quality,enhanced efficiency,and the sustainable development of resources and the environment.
基金supported by the Science&Technology Fundamental Resources Investigation Program(Grant Nos.2022FY102000,2022FY102003)the Epidemic Inheritance Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(Grant No.ZYYCXTD-C-202006)the Second Tibetan Plateau Scientific Expedition and Research Program(Grant No.2019QZKK0608)。
文摘The late Ming and early Qing dynasties were among the periods with a high incidence of infectious diseases in Chinese history.In this study,we aimed to analyze historical data to investigate the geographical factors and disease spectrum of infectious diseases during that time.Our objective was to provide insights for the modern prevention and control of infectious diseases.We collected and organized historical materials from this period.Descriptive statistical methods were used to explore the correlation between epidemics and natural factors.Furthermore,we collected traditional Chinese medicine prescriptions for preventing and treating infectious diseases during this period.By predicting potential diseases treatable through core prescriptions,we aimed to clarify the disease spectrum of epidemics.Cluster analysis results showed that among geographical factors such as famine,drought,and locusts,as well as social phenomena such as wars and inflation,drought had the highest clustering value and the strongest correlation with other factors.Disease spectrum analysis revealed three common types of drug combinations used to treat epidemics:Rheum officinale-ginger-aurantium fruit-magnolia bark-mirabilite,licorice-anemarrhena root-ginseng-poria-atractylodes,and white peony root-licorice-ginger-Chinese angelica-bupleurum.Diseases with a high degree of enrichment for these drugs included Kaposi's sarcoma-associated herpesvirus infection,human cytomegalovirus infection,and hepatitis B.During the late Ming and early Qing dynasties in China,epidemics occurred frequently and were closely related to factors such as drought,locusts,war,and inflation.The epidemics likely involved a combination of various infectious diseases,including Kaposi's sarcoma-associated herpesvirus infection,human cytomegalovirus infection,and hepatitis B.
基金supported by grants from the National Key Research and Development Program of China(2017YFA0103301)the National Natural Science Foundation of China(81972743)China Postdoctoral Science Foundation(2020M671205).
文摘Sense mutations in several conserved modifiable sites of histone H3 have been found to be strongly correlated with multiple tissuespecific clinical cancers.These clinical site mutants acquire a distinctively new epigenetic role and mediate cancer evolution.In this study,we mimicked histone H3 at the 56th lysine(H3K56)mutant incorporation in mouse embryonic stem cells(mESCs)by lentivirus-mediated ectopic expression and analyzed the effects on replication and epigenetic regulation.The data show that two types of H3K56 mutants,namely H3 lysine 56-to-methionine(H3K56M)and H3 lysine 56-to-alanine(H3K56A),promote replication by recruiting more minichromosome maintenance complex component 3 and checkpoint kinase 1 onto chromatin compared with wild-type histone H3 and other site substitution mutants.Under this condition,the frequency of genomic copy number gain in H3K56M and H3K56A cells globally increases,especially in the Mycl1 region,a known molecular marker frequently occurring in multiple malignant cancers.Additionally,we found the disruption of H3K56 acetylation distribution in the copy-gain regions,which indicates a probable epigenetic mechanism of H3K56M and H3K56A.We then identified that H3K56M and H3K56A can trigger a potential adaptation to transcription;genes involved in the mitogen-activated protein kinase pathway are partially upregulated,whereas genes associated with intrinsic apoptotic function show obvious downregulation.The final outcome of ectopic H3K56M and H3K56A incorporation in mESCs is an enhanced ability to form carcinomas.This work indicates that H3K56 site conservation and proper modification play important roles in harmonizing the function of the replication machinery in mESCs.
