Increasing soil phosphorus(P)availability and plant P uptake are potential approaches to alleviate low P stress in plants and mitigate P resource shortages.Application of fulvic acid(FA)in soil is observed to increase...Increasing soil phosphorus(P)availability and plant P uptake are potential approaches to alleviate low P stress in plants and mitigate P resource shortages.Application of fulvic acid(FA)in soil is observed to increase plant growth and P uptake.However,the biological mechanisms underlying these effects remain largely unknown.In this study,based on a three-year field experiment,multi-omics analyses were performed to reveal the effects of FA on rice growth and P uptake,the expression of P transporter genes,root exudates,and rhizosphere bacterial communities in a P-deficient soil.The results showed that FA application significantly promoted rice growth and P absorption under P deficiency,in association with the upregulation of P transporter genes expression and increased rhizosphere P mobilization.FA increased the transformation of non-labile to labile P in the rhizosphere by increasing the secretion of Pdissolving exudates and changing a rhizosphere bacterial community with high P-mobilization capacity,and the variations in the rhizosphere bacterial community were coupled with those of the root exudates,especially glutamylproline,tryptophanamide,5-chloro-2′-deoxyuridine,L-menthyl(R,S)-3-hydroxybutyrate,and 2,7-diamino-7-iminoheptanoic acid.These findings reveal the multiple positive effects of FA on rice P uptake and indicate the potential utilization of FA in increasing P utilization in rice production.展开更多
Objective To investigate the association between long-term glycemic control and cerebral infarction risk in patients with diabetes through a large-scale cohort study.Methods This prospective,community-based cohort stu...Objective To investigate the association between long-term glycemic control and cerebral infarction risk in patients with diabetes through a large-scale cohort study.Methods This prospective,community-based cohort study included 12,054 patients with diabetes.From 2006 to 2012,38,272 fasting blood glucose(FBG)measurements were obtained from these participants.FBG trajectory patterns were generated using latent mixture modelling.Cox proportional hazards models were applied to assess the subsequent risk of cerebral infarction associated with different FBG trajectory patterns.Results At baseline,the mean age of the participants was 55.2 years.Four distinct FBG trajectories were identified based on FBG concentrations and their changes over the 6-year follow-up period.After a median follow-up of 6.9 years,786 cerebral infarction events were recorded.Different trajectory patterns were associated with significantly varied outcome risks(Log-Rank P<0.001).Compared with the low-stability group,Hazard Ratio(HR)adjusted for potential confounders were 1.37 for the moderate-increasing group,1.23 for the elevated-decreasing group,and 2.08 for the elevated-stable group.Conclusion Sustained high FBG levels were found to play a critical role in the development of ischemic stroke among patients with diabetes.Controlling FBG levels may reduce the risk of cerebral infarction.展开更多
An ultrafast framing camera with a pulse-dilation device,a microchannel plate(MCP)imager,and an electronic imaging system were reported.The camera achieved a temporal resolution of 10 ps by using a pulse-dilation devi...An ultrafast framing camera with a pulse-dilation device,a microchannel plate(MCP)imager,and an electronic imaging system were reported.The camera achieved a temporal resolution of 10 ps by using a pulse-dilation device and gated MCP imager,and a spatial resolution of 100μm by using an electronic imaging system comprising combined magnetic lenses.The spatial resolution characteristics of the camera were studied both theoretically and experimentally.The results showed that the camera with combined magnetic lenses reduced the field curvature and acquired a larger working area.A working area with a diameter of 53 mm was created by applying four magnetic lenses to the camera.Furthermore,the camera was used to detect the X-rays produced by the laser-targeting device.The diagnostic results indicated that the width of the X-ray pulse was approximately 18 ps.展开更多
CuZnAl catalysts with different La loadings were prepared by a complete liquid phase method and tested for higher alcohols（C_（2＋）OH） synthesis from syngas at the conditions of 250–290 ℃, 4.5 MPa, feed low rate ...CuZnAl catalysts with different La loadings were prepared by a complete liquid phase method and tested for higher alcohols（C_（2＋）OH） synthesis from syngas at the conditions of 250–290 ℃, 4.5 MPa, feed low rate = 150 mL/min and H_2/CO = 2. The catalysts were characterized by XRD, H_2-TPR, NH_3-TPD, N_2 adsorption, XPS, and TEM techniques. Characterization results showed that the incorporation of La into CuZnAl catalysts resulted in the decrease of crystallite size of Cu^0 and a strong interaction among copper and zinc or aluminum oxides. Especially, the incorporation of La increased the amount of weak acid and the Cu content on catalyst surface, which was speculated to contribute the formation of higher alcohols. Among these La-promoted CuZnAl catalysts, the La0.1 catalyst exhibited the best catalytic performance and the selectivity to higher alcohols reached above 60% when the reaction temperature was 290 ℃.展开更多
Background:The American Heart Association(AHA)introduced the concept of cardiovascular-kidney-metabolic(CKM)health and stage,reflecting the interaction among metabolism,chronic kidney disease(CKD),and the cardiovascul...Background:The American Heart Association(AHA)introduced the concept of cardiovascular-kidney-metabolic(CKM)health and stage,reflecting the interaction among metabolism,chronic kidney disease(CKD),and the cardiovascular system.However,the association between CKM stage and the long-term risk of cardiovascular disease(CVD)has not been validated.This study aimed to evaluate the long-term CVD risk associated with CKM health metrics and CKM stage using data from a population-based cohort study.Methods:In total,5293 CVD-free participants were followed up to around 13 years in the Chinese Multi-provincial Cohort Study(CMCS).Considering the pathophysiologic progression of CKM health metrics abnormalities(comprising obesity,central adiposity,prediabetes,diabetes,hypertriglyceridemia,CKD,and metabolic syndrome),participants were divided into CKM stages 0,1,and 2.The time-dependent Cox regression models were used to estimate the cardiovascular risk associated with CKM health metrics and stage.Additionally,broader CVD outcomes were examined,with a specific assessment of the impact of stage 3 in 2581 participants from the CMCS-Beijing subcohort.Results:Among participants,91.2%(4825/5293)had at least one abnormal CKM health metric,8.8%(468/5293),13.3%(704/5293),and 77.9%(4121/5293)were in CKM stages 0,1,and 2,respectively;and 710 incident CVD cases occurred during a median follow-up time of 13.3 years(interquartile range:12.1 to 13.6 years).Participants with each poor CKM health metric exhibited significantly higher CVD risk.Compared with stage 0,the hazard ratio(HR)(95%confidence interval[CI])for CVD incidence was 1.31(0.84-2.04)in stage 1 and 2.27(1.57-3.28)in stage 2.Significant interactive impacts existed between CKM stage and age or sex,with higher CVD risk related to increased CKM stages in participants aged<60 years or females.Conclusion:These findings highlight the contribution of CKM health metrics and CKM stage to the long-term risk of CVD,suggesting the importance of multi-component recognition and management of poor CKM health in CVD prevention.展开更多
An investigation of the mangrove-derived fungus Penicillium sp.DM27 led to the isolation of 19 new compounds,including three pairs of piperidinone enantiomers(±)-1,(±)-2,and(±)-3,two pairs of pyrrolidin...An investigation of the mangrove-derived fungus Penicillium sp.DM27 led to the isolation of 19 new compounds,including three pairs of piperidinone enantiomers(±)-1,(±)-2,and(±)-3,two pairs of pyrrolidinone enantiomers(±)-4 and(±)-5,and nine pyrrolidine derivatives 6−14.The structures of 1−14 were elucidated through NMR and HRESIMS analysis,coupled with experimental and calculated ECD spectroscopy and the modified Mosher method.Quantitative real time PCR and Western bolt analyses revealed that 11 blocked EMT in TGF-β1-treated HK-2 cells and suppressed fibroblast activation in TGF-β1-stimulated NIH-3T3 cells.Molecular simulations demonstrated that compound 11 could dock ADAM17,showing a high negative binding affinity.Additionally,the overexpression of ADAM17 by lentiviral infection triggered renal tubular EMT,while compound 11 suppressed this process.Overall,our research suggests that pyrrolidine derivatives may be potential therapeutic agents for the treatment of fibrotic kidney disease.展开更多
Two-dimensional(2D)materials hold immense potential for next-generation information devices due to their ambipolar transport and tunable electronic states.However,conventional electric-field-driven architectures suffe...Two-dimensional(2D)materials hold immense potential for next-generation information devices due to their ambipolar transport and tunable electronic states.However,conventional electric-field-driven architectures suffer from inherent carrier-type degeneracy:Electrons and holes generate unidirectional currents,leading to ambiguous state overlaps in multi-level operation.Here,we demonstrate that surface acoustic waves(SAWs)break this symmetry in optically reconfigurable MoTe_(2)/h-BN heterostructures.SAWs induce type-II band modulation in the heterostructure and spatially separate electrons and holes into distinct valleys,enabling bidirectional acoustoelectric currents,whose polarity reverses with carrier type,controlled dynamically via ultraviolet(UV)illumination and gating.Leveraging this mechanism,we realize an 8-state memory device where SAW-driven readout currents changed between positive and negative polarities,achieving enhanced inter-state differentiation compared to voltage-read schemes.For synaptic applications,SAW-driven weight updates in n-and p-type regimes produce anti-symmetric conductance trajectories,eliminating state collisions observed in electric-field-driven counterparts.This work pioneers acoustic wave manipulation of ambipolar transport,offering transformative strategies for degeneracy-free,high-precision neuromorphic electronics.展开更多
Luminescent materials with tunable emission wavelengths/colors hold great potential for smart response devices,data security,sensors,and so on.However,development of stimuli-responsive luminescent materials with tradi...Luminescent materials with tunable emission wavelengths/colors hold great potential for smart response devices,data security,sensors,and so on.However,development of stimuli-responsive luminescent materials with traditional organic or inorganic luminophores remains challenging due to their lack of tunability.Herein,we report the tunable luminescence and ratiometric temperature sensing applications with a europium-organic cage(Eu4L4)featuring concentration-dependent hierarchical self-assembly behavior.Notably,white light emission was achieved by adjusting the equilibrium ratio between the red-emissive cage monomer and cyan-emissive cage aggregate.Taking advantage of the dual emissive nature of the system,ratiometric luminescent temperature sensing has also been achieved,exhibiting a sensitivity of 2.04% and linear correlation coefficient of 0.997 from 250 to 320 K.展开更多
基金supported by the Higher Education Scientific Research Project of the Anhui Province(Natural Sciences)(2023AH051039)Anhui Provincial Natural Resources Science and Technology Project(2023-K-4)+1 种基金the National Key Research&Development Program of China(2023YFD1902300)Anhui Provincial Natural Science Foundation(2108085QC123).
文摘Increasing soil phosphorus(P)availability and plant P uptake are potential approaches to alleviate low P stress in plants and mitigate P resource shortages.Application of fulvic acid(FA)in soil is observed to increase plant growth and P uptake.However,the biological mechanisms underlying these effects remain largely unknown.In this study,based on a three-year field experiment,multi-omics analyses were performed to reveal the effects of FA on rice growth and P uptake,the expression of P transporter genes,root exudates,and rhizosphere bacterial communities in a P-deficient soil.The results showed that FA application significantly promoted rice growth and P absorption under P deficiency,in association with the upregulation of P transporter genes expression and increased rhizosphere P mobilization.FA increased the transformation of non-labile to labile P in the rhizosphere by increasing the secretion of Pdissolving exudates and changing a rhizosphere bacterial community with high P-mobilization capacity,and the variations in the rhizosphere bacterial community were coupled with those of the root exudates,especially glutamylproline,tryptophanamide,5-chloro-2′-deoxyuridine,L-menthyl(R,S)-3-hydroxybutyrate,and 2,7-diamino-7-iminoheptanoic acid.These findings reveal the multiple positive effects of FA on rice P uptake and indicate the potential utilization of FA in increasing P utilization in rice production.
基金supported by the National Key R&D Program of China(2021YFC2500500)National Natural Science Foundation of China(Grant Nos.81973112,92049302,and U22A20364).
文摘Objective To investigate the association between long-term glycemic control and cerebral infarction risk in patients with diabetes through a large-scale cohort study.Methods This prospective,community-based cohort study included 12,054 patients with diabetes.From 2006 to 2012,38,272 fasting blood glucose(FBG)measurements were obtained from these participants.FBG trajectory patterns were generated using latent mixture modelling.Cox proportional hazards models were applied to assess the subsequent risk of cerebral infarction associated with different FBG trajectory patterns.Results At baseline,the mean age of the participants was 55.2 years.Four distinct FBG trajectories were identified based on FBG concentrations and their changes over the 6-year follow-up period.After a median follow-up of 6.9 years,786 cerebral infarction events were recorded.Different trajectory patterns were associated with significantly varied outcome risks(Log-Rank P<0.001).Compared with the low-stability group,Hazard Ratio(HR)adjusted for potential confounders were 1.37 for the moderate-increasing group,1.23 for the elevated-decreasing group,and 2.08 for the elevated-stable group.Conclusion Sustained high FBG levels were found to play a critical role in the development of ischemic stroke among patients with diabetes.Controlling FBG levels may reduce the risk of cerebral infarction.
基金National Natural Science Foundation of China(NSFC)(No.11775147)Guangdong Basic and Applied Basic Research Foundation(Nos.2019A1515110130 and 2024A1515011832)+1 种基金Shenzhen Key Laboratory of Photonics and Biophotonics(ZDSYS20210623092006020)Shenzhen Science and Technology Program(Nos.JCYJ20210324095007020,JCYJ20200109105201936 and JCYJ20230808105019039).
文摘An ultrafast framing camera with a pulse-dilation device,a microchannel plate(MCP)imager,and an electronic imaging system were reported.The camera achieved a temporal resolution of 10 ps by using a pulse-dilation device and gated MCP imager,and a spatial resolution of 100μm by using an electronic imaging system comprising combined magnetic lenses.The spatial resolution characteristics of the camera were studied both theoretically and experimentally.The results showed that the camera with combined magnetic lenses reduced the field curvature and acquired a larger working area.A working area with a diameter of 53 mm was created by applying four magnetic lenses to the camera.Furthermore,the camera was used to detect the X-rays produced by the laser-targeting device.The diagnostic results indicated that the width of the X-ray pulse was approximately 18 ps.
基金supported by the Key Program of the National Natural Science Foundation of China(No.21336006)the National Key Technology R&D Program(Grant No.2013BAC14B04)the National Natural Science Foundation of China(No.21176167)
文摘CuZnAl catalysts with different La loadings were prepared by a complete liquid phase method and tested for higher alcohols（C_（2＋）OH） synthesis from syngas at the conditions of 250–290 ℃, 4.5 MPa, feed low rate = 150 mL/min and H_2/CO = 2. The catalysts were characterized by XRD, H_2-TPR, NH_3-TPD, N_2 adsorption, XPS, and TEM techniques. Characterization results showed that the incorporation of La into CuZnAl catalysts resulted in the decrease of crystallite size of Cu^0 and a strong interaction among copper and zinc or aluminum oxides. Especially, the incorporation of La increased the amount of weak acid and the Cu content on catalyst surface, which was speculated to contribute the formation of higher alcohols. Among these La-promoted CuZnAl catalysts, the La0.1 catalyst exhibited the best catalytic performance and the selectivity to higher alcohols reached above 60% when the reaction temperature was 290 ℃.
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.11972242 and 12272250)China Postdoctoral Science Foundation(Grant No.2020M680913)+1 种基金Shanxi Scholarship Council of China and Shanxi Posigraduate Innovation ProjectShanxi Huajin Orthopaedic Public Foundation.
基金supported by the National Key Research and Development Program of China(No.2022YFC3602501)the National Natural Science Foundation of China(Nos.82073635,82103962,and 12226005)+1 种基金Beijing Municipal Medical Research Institutes Pilot Reform Project sponsored by Beijing Municipal Health Commission(Nos.2021-07 and 2023-09)Capital Funds for Health Improvement and Research(No.CFH 2024-2-1052).
文摘Background:The American Heart Association(AHA)introduced the concept of cardiovascular-kidney-metabolic(CKM)health and stage,reflecting the interaction among metabolism,chronic kidney disease(CKD),and the cardiovascular system.However,the association between CKM stage and the long-term risk of cardiovascular disease(CVD)has not been validated.This study aimed to evaluate the long-term CVD risk associated with CKM health metrics and CKM stage using data from a population-based cohort study.Methods:In total,5293 CVD-free participants were followed up to around 13 years in the Chinese Multi-provincial Cohort Study(CMCS).Considering the pathophysiologic progression of CKM health metrics abnormalities(comprising obesity,central adiposity,prediabetes,diabetes,hypertriglyceridemia,CKD,and metabolic syndrome),participants were divided into CKM stages 0,1,and 2.The time-dependent Cox regression models were used to estimate the cardiovascular risk associated with CKM health metrics and stage.Additionally,broader CVD outcomes were examined,with a specific assessment of the impact of stage 3 in 2581 participants from the CMCS-Beijing subcohort.Results:Among participants,91.2%(4825/5293)had at least one abnormal CKM health metric,8.8%(468/5293),13.3%(704/5293),and 77.9%(4121/5293)were in CKM stages 0,1,and 2,respectively;and 710 incident CVD cases occurred during a median follow-up time of 13.3 years(interquartile range:12.1 to 13.6 years).Participants with each poor CKM health metric exhibited significantly higher CVD risk.Compared with stage 0,the hazard ratio(HR)(95%confidence interval[CI])for CVD incidence was 1.31(0.84-2.04)in stage 1 and 2.27(1.57-3.28)in stage 2.Significant interactive impacts existed between CKM stage and age or sex,with higher CVD risk related to increased CKM stages in participants aged<60 years or females.Conclusion:These findings highlight the contribution of CKM health metrics and CKM stage to the long-term risk of CVD,suggesting the importance of multi-component recognition and management of poor CKM health in CVD prevention.
基金supported by the National Key Research and Development Program of China(No.2021YFC2100600),the National Natural Science Foundation of China(Nos.81973201,82200773,82370696,82204225,82200807),the Natural Science Foundation of Hubei Province(Nos.2021CFB347,2021CFB061),the Fundamental Research Funds for Central University(2042022kf1140),the Program of Excellent Doctoral(Postdoctoral)of Zhongnan Hospital of Wuhan University(ZNYB2021029),the Hubei Province Health and Family Planning Scientific Research Project(WJ2019MB103),the Clinical Research Project for Wu Jieping Medical Foundation(320.6750.19089-58),and the Research Fund from Medical Sci-Tech Innovation Platform of Zhongnan Hospital,Wuhan University(PTXM2020028,XKJS202035).We thank Dr.Ran Zhang from the Core Facility of Wuhan University and Dr.Xue Zhou from the Core Research Facilities of CCMS(WHU)for their assistance with NMR analysis.
文摘An investigation of the mangrove-derived fungus Penicillium sp.DM27 led to the isolation of 19 new compounds,including three pairs of piperidinone enantiomers(±)-1,(±)-2,and(±)-3,two pairs of pyrrolidinone enantiomers(±)-4 and(±)-5,and nine pyrrolidine derivatives 6−14.The structures of 1−14 were elucidated through NMR and HRESIMS analysis,coupled with experimental and calculated ECD spectroscopy and the modified Mosher method.Quantitative real time PCR and Western bolt analyses revealed that 11 blocked EMT in TGF-β1-treated HK-2 cells and suppressed fibroblast activation in TGF-β1-stimulated NIH-3T3 cells.Molecular simulations demonstrated that compound 11 could dock ADAM17,showing a high negative binding affinity.Additionally,the overexpression of ADAM17 by lentiviral infection triggered renal tubular EMT,while compound 11 suppressed this process.Overall,our research suggests that pyrrolidine derivatives may be potential therapeutic agents for the treatment of fibrotic kidney disease.
基金supported by the National Science Foundation of China(Nos.62431018 and 12034001)the National Key R&D Program(Nos.2024YFA1200125 and 2018YFA0307200).
文摘Two-dimensional(2D)materials hold immense potential for next-generation information devices due to their ambipolar transport and tunable electronic states.However,conventional electric-field-driven architectures suffer from inherent carrier-type degeneracy:Electrons and holes generate unidirectional currents,leading to ambiguous state overlaps in multi-level operation.Here,we demonstrate that surface acoustic waves(SAWs)break this symmetry in optically reconfigurable MoTe_(2)/h-BN heterostructures.SAWs induce type-II band modulation in the heterostructure and spatially separate electrons and holes into distinct valleys,enabling bidirectional acoustoelectric currents,whose polarity reverses with carrier type,controlled dynamically via ultraviolet(UV)illumination and gating.Leveraging this mechanism,we realize an 8-state memory device where SAW-driven readout currents changed between positive and negative polarities,achieving enhanced inter-state differentiation compared to voltage-read schemes.For synaptic applications,SAW-driven weight updates in n-and p-type regimes produce anti-symmetric conductance trajectories,eliminating state collisions observed in electric-field-driven counterparts.This work pioneers acoustic wave manipulation of ambipolar transport,offering transformative strategies for degeneracy-free,high-precision neuromorphic electronics.
基金granted by the National Natural Science Foundation of China(Nos.22171264 and 22301301)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB1170000)the Self-Deployment Project Research Program of Haixi Institutes,Chinese Academy of sciences(No.CXZX-2022-GH02).
文摘Luminescent materials with tunable emission wavelengths/colors hold great potential for smart response devices,data security,sensors,and so on.However,development of stimuli-responsive luminescent materials with traditional organic or inorganic luminophores remains challenging due to their lack of tunability.Herein,we report the tunable luminescence and ratiometric temperature sensing applications with a europium-organic cage(Eu4L4)featuring concentration-dependent hierarchical self-assembly behavior.Notably,white light emission was achieved by adjusting the equilibrium ratio between the red-emissive cage monomer and cyan-emissive cage aggregate.Taking advantage of the dual emissive nature of the system,ratiometric luminescent temperature sensing has also been achieved,exhibiting a sensitivity of 2.04% and linear correlation coefficient of 0.997 from 250 to 320 K.
