目的 探讨表观扩散系数平均值(mean apparent diffusion coefficient,ADCmean)联合前列腺特异性抗原密度(prostate specific antigen density,PSAD)对前列腺影像报告和数据系统(prostate imaging reporting and data system,PI-RADS)≥...目的 探讨表观扩散系数平均值(mean apparent diffusion coefficient,ADCmean)联合前列腺特异性抗原密度(prostate specific antigen density,PSAD)对前列腺影像报告和数据系统(prostate imaging reporting and data system,PI-RADS)≥3分临床显著性前列腺癌(clinical significant prostate cancer,csPCa)的预测价值。材料与方法 回顾性分析2022年2月至2024年8月期间我院行前列腺MRI检查PI-RADS评分≥3分且有病理组织学检查患者的临床资料和影像资料。选择最高PI-RADS评分且最大病灶的最大层面勾画感兴趣区(region of interest,ROI),测量病灶的ADCmean和表观扩散系数最小值(min apparent diffusion coefficient,ADCmin)。单因素和多因素logistic回归分析筛选出预测csPCa的最佳临床和影像指标,采用受试者工作特征(receiver operating characteristics,ROC)曲线比较最佳临床和影像预测模型及两者联合模型的诊断效能,计算曲线下面积(area under the curve,AUC)、敏感度和特异度,并行DeLong检验。结果 本研究共纳入csPCa患者75例(48.39%),非csPCa患者80例(51.61%)。csPCa组的年龄、总前列腺特异性抗原(total prostate specific antigen,tPSA)、游离前列腺特异性抗原(free prostate specific antigen,fPSA)、PSAD大于非csPCa组,csPCa组的前列腺体积(prostate volume,PV)、fPSA和tPSA比值(f/t)、ADCmin、ADCmean均小于非csPCa组,差异具有统计学意义(均P<0.05)。逐步logistic回归筛选和ROC曲线分析,获得预测csPCa的最佳临床指标为PSAD和影像指标ADCmean,AUC分别为0.846、0.898,PSAD诊断阈值为0.307 ng/mL2,敏感度为66.67%,特异度为91.25%,ADCmean诊断阈值为773.5 mm2/s,敏感度为86.67%,特异度为85.00%,两者联合模型的AUC高达0.925。DeLong检验比较联合模型与单一模型的AUC差异有统计学意义(P<0.05),联合模型预测csPCa的敏感性和特异度分别为86.67%和88.75%。结论 ADCmean对PI-RADS≥3分csPCa的预测效能优于ADCmin,与PSAD的联合模型能进一步提高对PI-RADS≥3分csPCa的预测价值,对临床诊疗具有指导意义。展开更多
In this paper,the structure and characteristics of the NS high-efficiency composite trays based on the doublelayer aperture jet sieve plate and compositely structured packing were investigated.The effect of aperture a...In this paper,the structure and characteristics of the NS high-efficiency composite trays based on the doublelayer aperture jet sieve plate and compositely structured packing were investigated.The effect of aperture and opening ratio of plate on the fluid dynamics of the NS high-efficiency composite trays,such as the dry tray pressure drop,the wet tray pressure drop,the entrainment,the froth height,the leakage and mass transfer characteristics,were investigated.As a result, the low pressure drop,the high efficiency and the high capacity are the main advantages of the NS high-efficiency composite trays compared to other types of trays.According to this study,small aperture is useful for reducing the pressure drop and entrainment with a high mass transfer efficiency;while large aperture can achieve high capacity and efficiency in a broader operating range at the same pressure drop and entrainment.展开更多
文摘目的 探讨表观扩散系数平均值(mean apparent diffusion coefficient,ADCmean)联合前列腺特异性抗原密度(prostate specific antigen density,PSAD)对前列腺影像报告和数据系统(prostate imaging reporting and data system,PI-RADS)≥3分临床显著性前列腺癌(clinical significant prostate cancer,csPCa)的预测价值。材料与方法 回顾性分析2022年2月至2024年8月期间我院行前列腺MRI检查PI-RADS评分≥3分且有病理组织学检查患者的临床资料和影像资料。选择最高PI-RADS评分且最大病灶的最大层面勾画感兴趣区(region of interest,ROI),测量病灶的ADCmean和表观扩散系数最小值(min apparent diffusion coefficient,ADCmin)。单因素和多因素logistic回归分析筛选出预测csPCa的最佳临床和影像指标,采用受试者工作特征(receiver operating characteristics,ROC)曲线比较最佳临床和影像预测模型及两者联合模型的诊断效能,计算曲线下面积(area under the curve,AUC)、敏感度和特异度,并行DeLong检验。结果 本研究共纳入csPCa患者75例(48.39%),非csPCa患者80例(51.61%)。csPCa组的年龄、总前列腺特异性抗原(total prostate specific antigen,tPSA)、游离前列腺特异性抗原(free prostate specific antigen,fPSA)、PSAD大于非csPCa组,csPCa组的前列腺体积(prostate volume,PV)、fPSA和tPSA比值(f/t)、ADCmin、ADCmean均小于非csPCa组,差异具有统计学意义(均P<0.05)。逐步logistic回归筛选和ROC曲线分析,获得预测csPCa的最佳临床指标为PSAD和影像指标ADCmean,AUC分别为0.846、0.898,PSAD诊断阈值为0.307 ng/mL2,敏感度为66.67%,特异度为91.25%,ADCmean诊断阈值为773.5 mm2/s,敏感度为86.67%,特异度为85.00%,两者联合模型的AUC高达0.925。DeLong检验比较联合模型与单一模型的AUC差异有统计学意义(P<0.05),联合模型预测csPCa的敏感性和特异度分别为86.67%和88.75%。结论 ADCmean对PI-RADS≥3分csPCa的预测效能优于ADCmin,与PSAD的联合模型能进一步提高对PI-RADS≥3分csPCa的预测价值,对临床诊疗具有指导意义。
基金supported by the Key Project of Chinese National Programs for Fundamental Research and Development(973 Program) (contract number:2005CB221204-5)
文摘In this paper,the structure and characteristics of the NS high-efficiency composite trays based on the doublelayer aperture jet sieve plate and compositely structured packing were investigated.The effect of aperture and opening ratio of plate on the fluid dynamics of the NS high-efficiency composite trays,such as the dry tray pressure drop,the wet tray pressure drop,the entrainment,the froth height,the leakage and mass transfer characteristics,were investigated.As a result, the low pressure drop,the high efficiency and the high capacity are the main advantages of the NS high-efficiency composite trays compared to other types of trays.According to this study,small aperture is useful for reducing the pressure drop and entrainment with a high mass transfer efficiency;while large aperture can achieve high capacity and efficiency in a broader operating range at the same pressure drop and entrainment.
