目的基于2020年中国健康与养老追踪调查(China health and retirement longitudinal study,CHARLS)数据探讨中国老年人群中疼痛状况与抑郁之间的相关性。方法基于CHARLS数据,收集受访者的人口学特征、健康状况及功能状态等资料。依据是...目的基于2020年中国健康与养老追踪调查(China health and retirement longitudinal study,CHARLS)数据探讨中国老年人群中疼痛状况与抑郁之间的相关性。方法基于CHARLS数据,收集受访者的人口学特征、健康状况及功能状态等资料。依据是否存在抑郁症状将受访者分为抑郁组和非抑郁组。采用描述性统计和卡方检验比较两组在基线特征方面的差异。本研究采用横断面研究设计,探究疼痛状况与抑郁风险之间的关联。运用多因素Logistic回归模型分析疼痛与抑郁之间的相关性,并进一步开展亚组及交互作用分析。采用限制性立方样条(Restricted cubic splines,RCS)模型评估疼痛与抑郁之间的非线性剂量反应关系。结果本研究共纳入8558例受访者,其中有3528例(41.22%)受访者存在抑郁症状,4904例(57.30%)受访者存在疼痛状况。抑郁组和非抑郁组受访者在年龄、性别、教育程度、婚姻状况、是否患有高血压、是否患有糖尿病、是否患有中风、是否饮酒、是否吸烟、IADL能力、ADL能力以及是否有疼痛状况方面差异均具有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,在控制了社会人口学特征、慢性病情况、生活方式及功能状态变量后,疼痛评分每增加1分,抑郁风险增加8%(OR=1.08,95%CI:1.06~1.09,P<0.001),以非疼痛组为参照,疼痛组老年人的抑郁风险为非疼痛组的2.07倍(OR=2.07,95%CI:1.85~2.35,P<0.001)。亚组和交互作用分析结果显示,疼痛与抑郁在年龄、性别、教育程度、婚姻状况、IADL能力、ADL能力、是否饮酒、是否吸烟亚组中均呈显著正相关,其中在不同IADL能力和饮酒情况亚组中观察到显著交互作用(P交互分别为0.027和0.023)。RCS模型结果显示,疼痛评分与抑郁风险呈非线性剂量反应关系(P<0.001)。结论中国老年人群中疼痛与抑郁风险显著正相关,且存在非线性关系。建议将疼痛管理纳入抑郁防控策略,促进老年人身心健康与生活质量的整体提升。展开更多
Isochrysis zhanjiangensis is a dietary microalga renowned for its high content of polyunsaturated fatty acids(PUFAs).However,research on the genes essential for PUFA synthesis in Isochrysis zhanjiangensis is limited.T...Isochrysis zhanjiangensis is a dietary microalga renowned for its high content of polyunsaturated fatty acids(PUFAs).However,research on the genes essential for PUFA synthesis in Isochrysis zhanjiangensis is limited.This study successfully isolated twoΔ9 fatty acid desaturase genes,IZ-delta9-1 and IZ-delta9-2,from Isochrysis zhanjiangensis,which are classified as acyl-lipid desaturases based on phylogenetic analysis.When heterologously expressed in yeast,both genes were confirmed to catalyze the conversion of C16:0 and C18:0 into C16:1 and C18:1,respectively.Furthermore,the impacts of environmental factors on algal growth,fatty acid composition,and transcription levels were explored.Using gas chromatography-mass spectrometry(GC-MS),the fatty acid profiles of I.zhanjiangensis were evaluated.The findings showed that under low temperature(LT)and low nitrogen(LN)conditions,the saturated fatty acids(SFAs)content decreased,and the monounsaturated(MUFAs)and unsaturated fatty acids(UFAs)contents increased.Changes in salinity had a minimal impact on the fatty acid composition.The qPCR analysis revealed that high temperature(HT)and high salt(HS)increased the transcription of IZ-delta9-1,while low nitrogen(LN)and high nitrogen(HN)decreased it.Unlike IZ-delta9-1,the transcription of IZ-delta9-2 significantly increased under both low and high temperature treatments,especially in LT groups.Moreover,compared to the control,the transcription levels of IZ-delta9-1 decreased under improper salinity and nitrogen concentrations.This study is helpful for understanding the fatty acid synthesis pathway in I.zhanjiangensis.展开更多
Ni-Cr alloyed layers were synthesized on the surface of Q235 mild steel by double-glow plasma surface metallurgy with different electrode distance.The microstructure and phases of the alloyed layer were characterized ...Ni-Cr alloyed layers were synthesized on the surface of Q235 mild steel by double-glow plasma surface metallurgy with different electrode distance.The microstructure and phases of the alloyed layer were characterized by scanning electron microscopy(SEM),energy dispersive X-ray spectrometry(EDS),and X-ray diffraction(XRD).The corrosion behavior of the Ni-Cr alloyed layers both in 3.5%NaCl and 0.5 M H_(2)SO_(4) solution were systematically investigated by open-circuit potential(OCP),potentiodynamic polarization and electrochemical impedance spectroscopy(EIS).The obtained results reveal that the Ni-Cr alloyed layer consists of a deposited layer and an inter-diffusion layer.With increasing the electrode distance,the relative thickness,microstructure and phase composition of the Ni-Cr alloyed layers vary greatly.Polarization data show the Ni-Cr alloyed layer with the electrode distance of 15 mm has highest corrosion resistance and lowest corrosion rate,while EIS results reveal the same trend.The highest protective efficiency in 3.5%NaCl and 0.5 M H_(2)SO_(4) solution are 99.23%and 99.92%,respectively,obtained for the Ni-Cr alloyed layer with 15 mm electrode distance.When the electrode distance is too large,a thin and porosity Ni-Cr alloyed layer,caused by low plasma density and Kirkendall effect,will be obtained,and will decrease the protective efficiency in corrosive medium.展开更多
文摘目的基于2020年中国健康与养老追踪调查(China health and retirement longitudinal study,CHARLS)数据探讨中国老年人群中疼痛状况与抑郁之间的相关性。方法基于CHARLS数据,收集受访者的人口学特征、健康状况及功能状态等资料。依据是否存在抑郁症状将受访者分为抑郁组和非抑郁组。采用描述性统计和卡方检验比较两组在基线特征方面的差异。本研究采用横断面研究设计,探究疼痛状况与抑郁风险之间的关联。运用多因素Logistic回归模型分析疼痛与抑郁之间的相关性,并进一步开展亚组及交互作用分析。采用限制性立方样条(Restricted cubic splines,RCS)模型评估疼痛与抑郁之间的非线性剂量反应关系。结果本研究共纳入8558例受访者,其中有3528例(41.22%)受访者存在抑郁症状,4904例(57.30%)受访者存在疼痛状况。抑郁组和非抑郁组受访者在年龄、性别、教育程度、婚姻状况、是否患有高血压、是否患有糖尿病、是否患有中风、是否饮酒、是否吸烟、IADL能力、ADL能力以及是否有疼痛状况方面差异均具有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,在控制了社会人口学特征、慢性病情况、生活方式及功能状态变量后,疼痛评分每增加1分,抑郁风险增加8%(OR=1.08,95%CI:1.06~1.09,P<0.001),以非疼痛组为参照,疼痛组老年人的抑郁风险为非疼痛组的2.07倍(OR=2.07,95%CI:1.85~2.35,P<0.001)。亚组和交互作用分析结果显示,疼痛与抑郁在年龄、性别、教育程度、婚姻状况、IADL能力、ADL能力、是否饮酒、是否吸烟亚组中均呈显著正相关,其中在不同IADL能力和饮酒情况亚组中观察到显著交互作用(P交互分别为0.027和0.023)。RCS模型结果显示,疼痛评分与抑郁风险呈非线性剂量反应关系(P<0.001)。结论中国老年人群中疼痛与抑郁风险显著正相关,且存在非线性关系。建议将疼痛管理纳入抑郁防控策略,促进老年人身心健康与生活质量的整体提升。
基金supported by the Provincial Natural Science Foundation of Zhejiang,China(No.LY22C190001)the Ningbo Science and Technology Research Projects,China(No.2019B10006)the earmarked fund for CARS-49,and the Ningbo Public Welfare Science and Technology Program(No.2022S161).
文摘Isochrysis zhanjiangensis is a dietary microalga renowned for its high content of polyunsaturated fatty acids(PUFAs).However,research on the genes essential for PUFA synthesis in Isochrysis zhanjiangensis is limited.This study successfully isolated twoΔ9 fatty acid desaturase genes,IZ-delta9-1 and IZ-delta9-2,from Isochrysis zhanjiangensis,which are classified as acyl-lipid desaturases based on phylogenetic analysis.When heterologously expressed in yeast,both genes were confirmed to catalyze the conversion of C16:0 and C18:0 into C16:1 and C18:1,respectively.Furthermore,the impacts of environmental factors on algal growth,fatty acid composition,and transcription levels were explored.Using gas chromatography-mass spectrometry(GC-MS),the fatty acid profiles of I.zhanjiangensis were evaluated.The findings showed that under low temperature(LT)and low nitrogen(LN)conditions,the saturated fatty acids(SFAs)content decreased,and the monounsaturated(MUFAs)and unsaturated fatty acids(UFAs)contents increased.Changes in salinity had a minimal impact on the fatty acid composition.The qPCR analysis revealed that high temperature(HT)and high salt(HS)increased the transcription of IZ-delta9-1,while low nitrogen(LN)and high nitrogen(HN)decreased it.Unlike IZ-delta9-1,the transcription of IZ-delta9-2 significantly increased under both low and high temperature treatments,especially in LT groups.Moreover,compared to the control,the transcription levels of IZ-delta9-1 decreased under improper salinity and nitrogen concentrations.This study is helpful for understanding the fatty acid synthesis pathway in I.zhanjiangensis.
基金National Natural Science Foundation of China(51101085,51764041)Aeronautical Science Foundation of China(2015ZF56027,2016ZF56020)Opening Project of Key Laboratory of Lightweight and High Strength Structural Materials of Jiangxi Province of China(20171BCD40003)。
基金by the National Natural Science Foundation of China(51704167 and 51764041)the Aeronautical Science Foundation of China(2016ZF56020)。
文摘Ni-Cr alloyed layers were synthesized on the surface of Q235 mild steel by double-glow plasma surface metallurgy with different electrode distance.The microstructure and phases of the alloyed layer were characterized by scanning electron microscopy(SEM),energy dispersive X-ray spectrometry(EDS),and X-ray diffraction(XRD).The corrosion behavior of the Ni-Cr alloyed layers both in 3.5%NaCl and 0.5 M H_(2)SO_(4) solution were systematically investigated by open-circuit potential(OCP),potentiodynamic polarization and electrochemical impedance spectroscopy(EIS).The obtained results reveal that the Ni-Cr alloyed layer consists of a deposited layer and an inter-diffusion layer.With increasing the electrode distance,the relative thickness,microstructure and phase composition of the Ni-Cr alloyed layers vary greatly.Polarization data show the Ni-Cr alloyed layer with the electrode distance of 15 mm has highest corrosion resistance and lowest corrosion rate,while EIS results reveal the same trend.The highest protective efficiency in 3.5%NaCl and 0.5 M H_(2)SO_(4) solution are 99.23%and 99.92%,respectively,obtained for the Ni-Cr alloyed layer with 15 mm electrode distance.When the electrode distance is too large,a thin and porosity Ni-Cr alloyed layer,caused by low plasma density and Kirkendall effect,will be obtained,and will decrease the protective efficiency in corrosive medium.
