Secondary trauma, resulting in undesirable injury and bleeding during wound dressing treatment, which will cause the treatment of chronic wounds ineffective. The medical cotton gauzes often bring strong adhesion due t...Secondary trauma, resulting in undesirable injury and bleeding during wound dressing treatment, which will cause the treatment of chronic wounds ineffective. The medical cotton gauzes often bring strong adhesion due to the exudates absorbed and clots formed. Conversely, the easily detachable wound dressings neglect the wound seepage management, rendering them ineffective in facing the complexities of chronic wounds. To address this challenge, we propose a novel draining anti-adhesion dressings(DAD) by constructing the hydrophilic microchannels array on the superhydrophobic dressing. The superhydrophobic areas facilitate stable wound fiuid repellence leading to achieve the anti-adhesion(18.7% detachment energy of cotton) and the microchannel array ensures the transportation of excess exudates(>92%) by the capillary force. Notably, our dressing demonstrates a significant healing-promoting in a chronic wound model in rats. The development of such dressings holds promise for advancing wound care practices and addressing the unique challenges posed by chronic wounds, offering a valuable solution for improved clinical outcomes.展开更多
BACKGROUND Anxiety and depression are prevalent among patients with chronic heart failure(CHF)and can adversely contribute to treatment adherence and clinical outcomes.Poor fluid restriction adherence is a widespread ...BACKGROUND Anxiety and depression are prevalent among patients with chronic heart failure(CHF)and can adversely contribute to treatment adherence and clinical outcomes.Poor fluid restriction adherence is a widespread challenge in the management of CHF.To effectively manage disease progression and alleviate symptoms,it is crucial to identify key influencing factors to facilitate the implementation of targeted interventions.AIM To investigate the status of anxiety and depression among patients with CHF and determine the factors contributing to poor fluid restriction adherence.METHODS Three hundred CHF patients seeking medical treatment at The First Hospital of Hunan University of Traditional Chinese Medicine between June 2021 and June 2023 were included in the study.Questionnaires,including the Psychosomatic Symptom Scale,Self-Rating Anxiety Scale,Self-Rating Depression Scale,and Fluid Restriction Adherence Questionnaire were administered to patients.Based on their anxiety and depression scores,patients were categorized into anxiety/depression and non-anxiety/depression groups,as well as fluid restriction adherence and fluid restriction non-adherence groups.General patient data were collected,and univariate and logistic regression analyses were conducted to determine the occurrence of depression and anxiety.Logistic regression analysis was used to identify independent factors influencing fluid restriction adherence.RESULTS Statistically significant differences in age,New York Heart Association(NYHA)grading,marital status,educational attainment,and family support were observed between depressed and non-depressed CHF patients(P<0.05).Age,NYHA grading,marital status,educational attainment,and family support were identified as factors influencing the development of depression.The anxiety and non-anxiety groups differed statistically in terms of gender,age,NYHA grading,smoking history,alcohol consumption history,monthly income,educational attainment,and family support(P<0.05).Gender,smoking,alcohol consumption,monthly income,and educational attainment affected anxiety in these patients.The fluid restriction adherence rate was 28.0%,and thirst sensation,anxiety,and depression were identified as independent influencing factors.CONCLUSION CHF patients are susceptible to anxiety and depression,with multiple associated influencing factors.Moreover,anxiety and depression are independent factors that can influence fluid restriction adherence in these patients.展开更多
Superhydrophobic surface(SHS) has been well developed, as SHS renders the property of minimizing the water/solid contact interface. Water droplets deposited onto SHS with contact angles exceeding 150°, allow them...Superhydrophobic surface(SHS) has been well developed, as SHS renders the property of minimizing the water/solid contact interface. Water droplets deposited onto SHS with contact angles exceeding 150°, allow them to retain spherical shapes, and the low adhesion of SHS facilitates easy droplet collection when tilting the substrate. These characteristics make SHS suitable for a wide range of applications. One particularly promising application is the fabrication of microsphere and supraparticle materials. SHS offers a distinct advantage as a universal platform capable of providing customized services for a variety of microspheres and supraparticles. In this review, an overview of the strategies for fabricating microspheres and supraparticles with the aid of SHS, including cross-linking process, polymer melting,and droplet template evaporation methods, is first presented. Then, the applications of microspheres and supraparticles formed onto SHS are discussed in detail, for example, fabricating photonic devices with controllable structures and tunable structural colors, acting as catalysts with emerging or synergetic properties, being integrated into the biomedical field to construct the devices with different medicinal purposes, being utilized for inducing protein crystallization and detecting trace amounts of analytes. Finally,the perspective on future developments involved with this research field is given, along with some obstacles and opportunities.展开更多
Passive daytime radiative cooling(PDRC)technology is emerging as one of the most promising solutions to the global problem of spacing cooling,but its practical application is limited due to reduced cooling effectivene...Passive daytime radiative cooling(PDRC)technology is emerging as one of the most promising solutions to the global problem of spacing cooling,but its practical application is limited due to reduced cooling effectiveness caused by daily wear and tear,as well as dirt contamination.To tackle this problem,we report a novel strategy by introducing a renewable armor structure for prolonging the anti-fouling and cooling effectiveness properties of the PDRC coatings.The armor structure is designed by decorating fluorinated hollow glass microspheres(HGM)inside rigid resin composite matrices.The HGM serve triple purposes,including providing isolated cavities for enhanced solar reflectance,reinforcing the matrices to form robust armored structures,and increasing thermal emittance.When the coatings are worn,the HGM on the surface expose their concave cavities with numerous hydrophobic fragments,generating a highly rough surface that guarantee the superhydrophobic function.The coatings show a high sunlight reflectance(0.93)and thermal emittance(0.94)in the long-wave infrared window,leading to a cooling of 5℃ below ambient temperature under high solar flux(∼900 W/m^(2)).When anti-fouling functions are reduced,they can be regenerated more than 100 cycles without compromising the PDRC function by simple wearing treatment.Furthermore,these coatings can be easily prepared using a one-pot spray method with low-cost materials,exhibit strong adhesion to a variety of substrates,and demonstrate exceptional environmental stability.Therefore,we anticipate their immediate application opportunities for spacing cooling.展开更多
Iminosugars,a class of polyhydroxylated cyclic alkaloids with intriguing properties,hold promising therapeutic potentials against a broad spectrum of enveloped viruses,including DENV,HCV,HIV,and influenza viruses.Mech...Iminosugars,a class of polyhydroxylated cyclic alkaloids with intriguing properties,hold promising therapeutic potentials against a broad spectrum of enveloped viruses,including DENV,HCV,HIV,and influenza viruses.Mechanistically,iminosugars act as the competitive inhibitors of host endoplasmic reticularα-glucosidases I and II to disrupt the proper folding of viral nascent glycoproteins,which thereby exerts antiviral effects.Remarkably,the glycoproteins of many enveloped viruses are significantly more dependent on the calnexin pathway of the protein folding than most host glycoproteins.Therefore,extensive interests and efforts have been devoted to exploit iminosugars as broad-spectrum antiviral agents.This review provides the summary and insights into the recent advancements in the development of novel iminosugars as effective and selective antiviral agents against a variety of enveloped viruses,as well as the understandings of their antiviral mechanisms.展开更多
Regioselective and enantioselective hydroxylation of propargylic C-H bonds are useful reactions but often lack appropriate catalysts.Here a green and efficient asymmetric hydroxylation of primary and secondary C-H bon...Regioselective and enantioselective hydroxylation of propargylic C-H bonds are useful reactions but often lack appropriate catalysts.Here a green and efficient asymmetric hydroxylation of primary and secondary C-H bonds at propargylic positions has been established.A series of optically active propargylic alcohols were prepared with high regio-and enantioselectivity(up to 99%ee)under mild reaction conditions by using P450tol,while the C≡C bonds in the molecule remained unreacted.This protocol provides a green and practical method for constructing enantiomerically chiral propargylic alcohols.In addition,we also demonstrated that the biohydroxylation strategy was able to scaled up to 2.25 mmol scale with the production of chiral propargyl alcohol 2a at a yield of 196 mg with 96%ee,which’s an important synthetic intermediate of antifungal drug Ravuconazole.展开更多
设计了一种新型高能量密度化合物2,6-双(二硝基亚甲基)-1,3,4,5,7,8-六硝基十二氢二咪唑[4,5-b:4',5'-e]吡嗪(DNNIP)。首先在B3PW91/6-31G++(d,p)水平下对目标分子进行优化,通过键长和键级的比较分析,判断母环的五元环侧链处N—...设计了一种新型高能量密度化合物2,6-双(二硝基亚甲基)-1,3,4,5,7,8-六硝基十二氢二咪唑[4,5-b:4',5'-e]吡嗪(DNNIP)。首先在B3PW91/6-31G++(d,p)水平下对目标分子进行优化,通过键长和键级的比较分析,判断母环的五元环侧链处N—NO2键为分解引发键,其键解离能是96.40 k J/mol;然后,基于静电势改进的蒙特卡洛法推测出该化合物的理论密度为2.07 g/cm3,采用等键反应计算出生成热为1 907.33 k J/mol,并进一步计算出DNNIP的爆速为10.35 km/s,爆压为51.47 GPa,爆轰性能明显优于现有常见含能材料。DNNIP的撞击感度为12 cm,与CL-20接近;能级差为0.158 78 a.u.(4.32 e V),光热稳定性较高,并且通过态密度分析认为硝基是分子中相对敏感位置。展开更多
Phytochemical investigation of the aerial parts of the monotypic plant,Musella lasiocarpa,led to the isolation of four rare bicyclic diarylheptanoids,musellarins B-E(2-5),two new phenylphenalenones,2-methoxy-9-(3′,4...Phytochemical investigation of the aerial parts of the monotypic plant,Musella lasiocarpa,led to the isolation of four rare bicyclic diarylheptanoids,musellarins B-E(2-5),two new phenylphenalenones,2-methoxy-9-(3′,4′-dihydroxyphenyl)-1H-phenalen-1-one(9),2-methoxy-9-(3′-methoxy-4′-hydroxyphenyl)-1H-phenalen-1-one(10),a new acenaphtylene derivative,trans-(1S,2S)-3-(4′-methoxyphenyl)-acenaphthene-1,2-diol(13),and two new sucrose esters,1,2′,3′,4′,6′-O-pentaacetyl-3-O-trans-p-coumaroylsucrose(16),1,2′,3′,4′,6′-O-pentaacetyl-3-O-cis-p-coumaroylsucrose(17),together with nine known compounds.In addition,(4E,6E)-1-(3′,4′-dihydroxyphenyl)-7-(4′′-hydroxyphenyl)-hepta-4,6-dien-3-one(15)was isolated for the first time from a natural source.The structures of new compounds were elucidated by analysis of their spectroscopic data.Compounds 2,6,8-10,12,and 14 were cytotoxic toward several of the human tumor cell lines(HL-60,SMMC-7721,A-549,MCF-7,and SW480).Of these,the new compound 9 was the most potent one,with IC50 values of 5.8,10.3,6.3,3.3,and 2.3μM,respectively.展开更多
基金funding support by the National Nature Science Foundation of China (Nos. 22275028, 22325201, 52103136 and 22205033)the Shenzhen Science and Technology Program (No. JCYJ20210324142210027)+2 种基金the Sichuan Outstanding Young Scholars Foundation (No. 2021JDJQ0013)the Sichuan Science and Technology Program (No. 2023JDRC0081)the Fundamental Research Funds for the Central Universities (Nos. ZYGX2021YGCX009 and ZYGX2021YGLH207)。
文摘Secondary trauma, resulting in undesirable injury and bleeding during wound dressing treatment, which will cause the treatment of chronic wounds ineffective. The medical cotton gauzes often bring strong adhesion due to the exudates absorbed and clots formed. Conversely, the easily detachable wound dressings neglect the wound seepage management, rendering them ineffective in facing the complexities of chronic wounds. To address this challenge, we propose a novel draining anti-adhesion dressings(DAD) by constructing the hydrophilic microchannels array on the superhydrophobic dressing. The superhydrophobic areas facilitate stable wound fiuid repellence leading to achieve the anti-adhesion(18.7% detachment energy of cotton) and the microchannel array ensures the transportation of excess exudates(>92%) by the capillary force. Notably, our dressing demonstrates a significant healing-promoting in a chronic wound model in rats. The development of such dressings holds promise for advancing wound care practices and addressing the unique challenges posed by chronic wounds, offering a valuable solution for improved clinical outcomes.
基金Huxiang TCM Physique Intervention Clinical Research Center,No.2023SK4061Traditional Chinese Medicine Research Project of Hunan Province,No.B2023065+4 种基金Hunan Province"14th Five-Year Plan"key specialty of TCM,No.[2023]4Hunan University of Chinese Medicine and Hospital Joint Foundation,No.2023XYLH019 and 2024XYLH365R&D Plan for Key Areas of Hunan Provincial Department of Science and Technology,No.2019SK2321Excellent Youth Program of Hunan Education Department,No.24B0346Hunan Provincial Natural Science Foundation for Young Scientists,No.2025JJ60626.
文摘BACKGROUND Anxiety and depression are prevalent among patients with chronic heart failure(CHF)and can adversely contribute to treatment adherence and clinical outcomes.Poor fluid restriction adherence is a widespread challenge in the management of CHF.To effectively manage disease progression and alleviate symptoms,it is crucial to identify key influencing factors to facilitate the implementation of targeted interventions.AIM To investigate the status of anxiety and depression among patients with CHF and determine the factors contributing to poor fluid restriction adherence.METHODS Three hundred CHF patients seeking medical treatment at The First Hospital of Hunan University of Traditional Chinese Medicine between June 2021 and June 2023 were included in the study.Questionnaires,including the Psychosomatic Symptom Scale,Self-Rating Anxiety Scale,Self-Rating Depression Scale,and Fluid Restriction Adherence Questionnaire were administered to patients.Based on their anxiety and depression scores,patients were categorized into anxiety/depression and non-anxiety/depression groups,as well as fluid restriction adherence and fluid restriction non-adherence groups.General patient data were collected,and univariate and logistic regression analyses were conducted to determine the occurrence of depression and anxiety.Logistic regression analysis was used to identify independent factors influencing fluid restriction adherence.RESULTS Statistically significant differences in age,New York Heart Association(NYHA)grading,marital status,educational attainment,and family support were observed between depressed and non-depressed CHF patients(P<0.05).Age,NYHA grading,marital status,educational attainment,and family support were identified as factors influencing the development of depression.The anxiety and non-anxiety groups differed statistically in terms of gender,age,NYHA grading,smoking history,alcohol consumption history,monthly income,educational attainment,and family support(P<0.05).Gender,smoking,alcohol consumption,monthly income,and educational attainment affected anxiety in these patients.The fluid restriction adherence rate was 28.0%,and thirst sensation,anxiety,and depression were identified as independent influencing factors.CONCLUSION CHF patients are susceptible to anxiety and depression,with multiple associated influencing factors.Moreover,anxiety and depression are independent factors that can influence fluid restriction adherence in these patients.
基金the financial support from Shenzhen Science and Technology Program (JCYJ20210324142210027, X.D.)the National Natural Science Foundation of China (52103136, 22275028, U22A20153, 22102017, 22302033, and 52106194)+5 种基金the Sichuan Outstanding Young Scholars Foundation (2021JDJQ0013)Natural Science Foundation of Sichuan Province (2022NSFSC1271)Sichuan Science and Technology Program (2023JDRC0082)“Oncology Medical Engineering Innovation Foundation” project of University of Electronic Science and Technology of China and Sichuan Cancer Hospital (ZYGX2021YGCX009)“Medical and Industrial Cross Foundation” of University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital (ZYGX2021YGLH207)Shandong Key R&D grant (2022CXGC010509)。
文摘Superhydrophobic surface(SHS) has been well developed, as SHS renders the property of minimizing the water/solid contact interface. Water droplets deposited onto SHS with contact angles exceeding 150°, allow them to retain spherical shapes, and the low adhesion of SHS facilitates easy droplet collection when tilting the substrate. These characteristics make SHS suitable for a wide range of applications. One particularly promising application is the fabrication of microsphere and supraparticle materials. SHS offers a distinct advantage as a universal platform capable of providing customized services for a variety of microspheres and supraparticles. In this review, an overview of the strategies for fabricating microspheres and supraparticles with the aid of SHS, including cross-linking process, polymer melting,and droplet template evaporation methods, is first presented. Then, the applications of microspheres and supraparticles formed onto SHS are discussed in detail, for example, fabricating photonic devices with controllable structures and tunable structural colors, acting as catalysts with emerging or synergetic properties, being integrated into the biomedical field to construct the devices with different medicinal purposes, being utilized for inducing protein crystallization and detecting trace amounts of analytes. Finally,the perspective on future developments involved with this research field is given, along with some obstacles and opportunities.
基金supported by the National Natural Science Foundation of China(Nos.52003035,52203135 and 51973023)the CHN Energy Group Project(No.GJNY-21-183).
文摘Passive daytime radiative cooling(PDRC)technology is emerging as one of the most promising solutions to the global problem of spacing cooling,but its practical application is limited due to reduced cooling effectiveness caused by daily wear and tear,as well as dirt contamination.To tackle this problem,we report a novel strategy by introducing a renewable armor structure for prolonging the anti-fouling and cooling effectiveness properties of the PDRC coatings.The armor structure is designed by decorating fluorinated hollow glass microspheres(HGM)inside rigid resin composite matrices.The HGM serve triple purposes,including providing isolated cavities for enhanced solar reflectance,reinforcing the matrices to form robust armored structures,and increasing thermal emittance.When the coatings are worn,the HGM on the surface expose their concave cavities with numerous hydrophobic fragments,generating a highly rough surface that guarantee the superhydrophobic function.The coatings show a high sunlight reflectance(0.93)and thermal emittance(0.94)in the long-wave infrared window,leading to a cooling of 5℃ below ambient temperature under high solar flux(∼900 W/m^(2)).When anti-fouling functions are reduced,they can be regenerated more than 100 cycles without compromising the PDRC function by simple wearing treatment.Furthermore,these coatings can be easily prepared using a one-pot spray method with low-cost materials,exhibit strong adhesion to a variety of substrates,and demonstrate exceptional environmental stability.Therefore,we anticipate their immediate application opportunities for spacing cooling.
基金National Key Research and Development Program of China(Nos.2023YFC2606500 to X.Deng)National Natural Science Foundation of China(Nos.22377151 to X.Deng)+2 种基金the Hunan Provincial Key Research and Development Project(Nos.2021WK2005 to X.Deng)the Hunan Provincial Science Fund for Distinguished Young Scholars(Nos.2023JJ10083 to X.Deng)Huxiang High-Level Talent Gathering Project(Nos.2022RC4029)from the Science and Technology Department of Hunan province for the financial supports.
文摘Iminosugars,a class of polyhydroxylated cyclic alkaloids with intriguing properties,hold promising therapeutic potentials against a broad spectrum of enveloped viruses,including DENV,HCV,HIV,and influenza viruses.Mechanistically,iminosugars act as the competitive inhibitors of host endoplasmic reticularα-glucosidases I and II to disrupt the proper folding of viral nascent glycoproteins,which thereby exerts antiviral effects.Remarkably,the glycoproteins of many enveloped viruses are significantly more dependent on the calnexin pathway of the protein folding than most host glycoproteins.Therefore,extensive interests and efforts have been devoted to exploit iminosugars as broad-spectrum antiviral agents.This review provides the summary and insights into the recent advancements in the development of novel iminosugars as effective and selective antiviral agents against a variety of enveloped viruses,as well as the understandings of their antiviral mechanisms.
基金financial support from the National Natural Science Foundation of China(No.32271537 and 22061049)the Science and Technology Department of Guizhou province(QKHJCZK2021-036 and QKHRCPTGCC-2023-003)+1 种基金the Science and Technology Department of Zunyi(ZSKRPT-2020-5,ZSKH-2018-3,ZSKRPT-2021-5)Zunyi Medical University(QKH-2018-5772-014).
文摘Regioselective and enantioselective hydroxylation of propargylic C-H bonds are useful reactions but often lack appropriate catalysts.Here a green and efficient asymmetric hydroxylation of primary and secondary C-H bonds at propargylic positions has been established.A series of optically active propargylic alcohols were prepared with high regio-and enantioselectivity(up to 99%ee)under mild reaction conditions by using P450tol,while the C≡C bonds in the molecule remained unreacted.This protocol provides a green and practical method for constructing enantiomerically chiral propargylic alcohols.In addition,we also demonstrated that the biohydroxylation strategy was able to scaled up to 2.25 mmol scale with the production of chiral propargyl alcohol 2a at a yield of 196 mg with 96%ee,which’s an important synthetic intermediate of antifungal drug Ravuconazole.
文摘设计了一种新型高能量密度化合物2,6-双(二硝基亚甲基)-1,3,4,5,7,8-六硝基十二氢二咪唑[4,5-b:4',5'-e]吡嗪(DNNIP)。首先在B3PW91/6-31G++(d,p)水平下对目标分子进行优化,通过键长和键级的比较分析,判断母环的五元环侧链处N—NO2键为分解引发键,其键解离能是96.40 k J/mol;然后,基于静电势改进的蒙特卡洛法推测出该化合物的理论密度为2.07 g/cm3,采用等键反应计算出生成热为1 907.33 k J/mol,并进一步计算出DNNIP的爆速为10.35 km/s,爆压为51.47 GPa,爆轰性能明显优于现有常见含能材料。DNNIP的撞击感度为12 cm,与CL-20接近;能级差为0.158 78 a.u.(4.32 e V),光热稳定性较高,并且通过态密度分析认为硝基是分子中相对敏感位置。
基金This work was financially supported by the National Basic Research Program of China(973 Program No.2009CB522303 and No.2011CB915503)the NSFC(No.U0932602)+1 种基金the National Natural Science Foundation of China(No.90813004)the State Key Laboratory of Phytochemistry and Plant Resources in West China(No.P2010-ZZ05).
文摘Phytochemical investigation of the aerial parts of the monotypic plant,Musella lasiocarpa,led to the isolation of four rare bicyclic diarylheptanoids,musellarins B-E(2-5),two new phenylphenalenones,2-methoxy-9-(3′,4′-dihydroxyphenyl)-1H-phenalen-1-one(9),2-methoxy-9-(3′-methoxy-4′-hydroxyphenyl)-1H-phenalen-1-one(10),a new acenaphtylene derivative,trans-(1S,2S)-3-(4′-methoxyphenyl)-acenaphthene-1,2-diol(13),and two new sucrose esters,1,2′,3′,4′,6′-O-pentaacetyl-3-O-trans-p-coumaroylsucrose(16),1,2′,3′,4′,6′-O-pentaacetyl-3-O-cis-p-coumaroylsucrose(17),together with nine known compounds.In addition,(4E,6E)-1-(3′,4′-dihydroxyphenyl)-7-(4′′-hydroxyphenyl)-hepta-4,6-dien-3-one(15)was isolated for the first time from a natural source.The structures of new compounds were elucidated by analysis of their spectroscopic data.Compounds 2,6,8-10,12,and 14 were cytotoxic toward several of the human tumor cell lines(HL-60,SMMC-7721,A-549,MCF-7,and SW480).Of these,the new compound 9 was the most potent one,with IC50 values of 5.8,10.3,6.3,3.3,and 2.3μM,respectively.
