The assembly of the three-dimensional(3D) lanthanide complexes,aiming at obtaining large magnetocalo ric effects,encounte rs a substantial challenge.In this study,we successfully isolated a novel series of Lnexclusive...The assembly of the three-dimensional(3D) lanthanide complexes,aiming at obtaining large magnetocalo ric effects,encounte rs a substantial challenge.In this study,we successfully isolated a novel series of Lnexclusive 3D complexes,fo rmulated as {[Ln_(2)(EDTA)(C_(2)O_(4))(H_(2)O)_(2)]}n(abbreviated as Ln_(2),Ln=Gd^(Ⅲ)(1),Eu^(Ⅲ)(2),Sm^(Ⅲ)(3),H_(4)EDTA=ethylene diamine tetraacetic acid;H_(2)C_(2)O_(4)=oxalic acid).Crystallographic study exhibits that complex 1 features a cute snail-shaped Gd_(2) unit.Adjacent Gd_(2) units are aggregated by hexadentate EDTA^(4-) and C_(2)O_(4)^(2-)ligands,further constructing a charming three-dimensional metal-organic framework with interesting parallelogram-shaped layers.Notably,all coordinated EDTA^(4-)ligands and lightweight C_(2)O_(4)^(2-)groups contribute to building a densely packed metal-organic framework,endowing complex 1 with remarkable magnetocaloric effect(-ΔS_(m)^(max)=42.5 J/(kg·K) at 2.5 K and ΔH=7.0 T).Additionally,complexes 2 and 3 exhibit outstanding solid-state luminescent properties with lifetimes of43 8.22 and 4.13 μs,and quantum yields(QY) of 7.03% and 15.46%,respectively.展开更多
There is no safe level of exposure to air pollution,including particulate matter smaller than2.5μm(PM_(2.5)),to human health.Whilst it is well known that exposure to heavily polluted air is associated with several li...There is no safe level of exposure to air pollution,including particulate matter smaller than2.5μm(PM_(2.5)),to human health.Whilst it is well known that exposure to heavily polluted air is associated with several liver disorders,it is unclear how long-term exposure to lowlevel traffic-derived PM_(2.5)affects liver health.BALB/c mice(5 weeks,male)were exposed to traffic-derived PM_(2.5)(10μg/mouse/day,intranasally)daily for 4,8 and 12 weeks.Markers of inflammation and fibrosis were measured at each time point.Changes in liver proteome and lipid profiles were measured using proteomics and lipidomics at 12 weeks.Low-dose PM_(2.5)exposure increased macrophage infiltration,pro-inflammatory cytokine production,and increased collagen deposition at 12 weeks.Despite liver lipid metabolism being increased,the abundance of triglycerides,precursor diacylglycerols,and ceramide was also significantly increased by PM_(2.5)exposure,whereas glycogen content was reduced.Proteomics analysis revealed 64 proteins to be significantly changed in PM_(2.5)-exposed mice,and KEGG pathway enrichment analysis indicated their involvement in lipid metabolism,alcohol-related liver disease,neutrophil extracellular trap formation,and transcriptional dysregulation related to cancer.In conclusion,prolonged exposure to low-dose traffic-derived PM_(2.5)promotes pathological changes in the liver,suggestive of an increased risk of metabolic dysfunctionassociated fatty liver disease.Future studies can enable the identification of the signalling pathways underlying low-dose PM_(2.5)-induced lipid accumulation in the liver.展开更多
目的:研究经纳米微针导入0.5%氨甲环酸溶液对中国女性面部皮肤暗沉的疗效及安全性。方法:募集60名无基础病的健康临床受试者,随机分为两组,每组30名。生理盐水组:受试者全面部使用纳米微针导入生理盐水;0.5%氨甲环酸溶液组:受试者全面...目的:研究经纳米微针导入0.5%氨甲环酸溶液对中国女性面部皮肤暗沉的疗效及安全性。方法:募集60名无基础病的健康临床受试者,随机分为两组,每组30名。生理盐水组:受试者全面部使用纳米微针导入生理盐水;0.5%氨甲环酸溶液组:受试者全面部使用纳米微针导入0.5%氨甲环酸溶液。两组受试者均每周接受1次治疗,共治疗2个月,每周两组受试者接受治疗前及治疗后72h都检测经皮水分丢失(trans-epidermal water loss,TEWL)、角质层含水量、红斑量、黑素及皮肤弹性,拍摄每组受试者治疗前后面部照片。通过皮肤状态问卷调查受试者满意度及不良反应,治疗结束后1个月、2个月复测TEWL、角质层含水量、红斑量、黑素及皮肤弹性。结果:生理盐水组治疗后72h经皮水分丢失、角质层含水量、红斑量、皮肤弹性与0.5%氨甲环酸溶液组无显著性差异;生理盐水组治疗后黑素数值显著高于0.5%氨甲环酸溶液组;生理盐水组受试者面部照片治疗前后无显著性差异,0.5%氨甲环酸溶液组治疗后面部照片明显比治疗前肤色白皙;生理盐水组受试者及医生满意度显著低于0.5%氨甲环酸溶液组;生理盐水组及0.5%氨甲环酸溶液组皆无不良反应;0.5%氨甲环酸溶液组治疗后1个月的黑素值与初次治疗前的黑素值有显著性差异(P<0.05),治疗后2个月的黑素值与初次治疗前测得的黑素值无统计学差异。结论:纳米微针导入0.5%氨甲环酸溶液可明显改善中国女性面部皮肤暗沉。展开更多
The stiffened cylindrical shell is commonly used for the pressure hull of submersibles and the legs of offshore platforms. There are various failure modes because of uncertainty with the structural size and material p...The stiffened cylindrical shell is commonly used for the pressure hull of submersibles and the legs of offshore platforms. There are various failure modes because of uncertainty with the structural size and material properties, uncertainty of the calculation model and machining errors. Correlations among failure modes must be considered with the structural reliability of stiffened cylindrical shells. However, the traditional method cannot consider the correlations effectively. The aim of this study is to present a method of reliability analysis for stiffened cylindrical shells which considers the correlations among failure modes. Firstly, the joint failure probability calculation formula of two related failure modes is derived through use of the 2D joint probability density function. Secondly, the full probability formula of the tandem structural system is given with consideration to the correlations among failure modes. At last, the accuracy of the system reliability calculation is verified through use of the Monte Carlo simulation. Result of the analysis shows the failure probability of stiffened cylindrical shells can be gained through adding the failure probability of each mode.展开更多
Objective:To analyze the efficacy and safety o f apatinib in the treatment of stage IV osteogenic sarcoma after chemotherapy failure through a single-arm,prospective,and open clinical phase II study.Methods:Informatio...Objective:To analyze the efficacy and safety o f apatinib in the treatment of stage IV osteogenic sarcoma after chemotherapy failure through a single-arm,prospective,and open clinical phase II study.Methods:Information on 34 patients with stage IV osteogenic sarcoma treated with apatinib after failure o f chemotherapy in Tianjin Medical University Cancer Institute and Hospital between September 2015 and December 2019 was collected and analyzed.The participants included 23 males and 11 females,with an average age of 35.24 years(11-73 years).The objective response rate(ORR),disease control rate(DCR),progression-free survival(PFS),PFS rate(PFR),and overall survival(OS)were evaluated.The treatmentrelated adverse events(AEs)and safety of apatinib were also evaluated.Results:O f the 34 patients,33 were able to be evaluated for efficacy.One patient received apatinib treatment for less than one cycle;therefore,only safety analysis was performed.The 12-week clinical evaluation showed that 2 patients had a partial response(PR),24 patients had stable disease(SD),and 7 patients had progressive disease(PD).The ORR,DCR,and PFR at 12 weeks were 6.06%(2/33),78.79%(26/33),and 82%,respectively.By the end of the follow-up,6 patients had SD(18.18%,6/33),27 patients had PD(81.82%,27/33),and 15 patients died because of disease progression(45.45%,15/33).The ORR was 0(0/33),the DCR was 18.18%(6/33),and the median PFS(mPFS)was 7.89 months(95%Cl:4.56-11.21).The median OS(mOS)was 17.61 months(95%Cl:10.85-24.37).The most common treatment-related AEs were hand-foot syndrome(35.29%,12/34),proteinuria(32.35%,11/34),and hypertension(32.35%,11/34).展开更多
基金Project supported by the National Natural Science Foundation of China (92161109)the Postgraduate Research&Practice Innovation Program of Jiangsu Province (KYCX24_1566)。
文摘The assembly of the three-dimensional(3D) lanthanide complexes,aiming at obtaining large magnetocalo ric effects,encounte rs a substantial challenge.In this study,we successfully isolated a novel series of Lnexclusive 3D complexes,fo rmulated as {[Ln_(2)(EDTA)(C_(2)O_(4))(H_(2)O)_(2)]}n(abbreviated as Ln_(2),Ln=Gd^(Ⅲ)(1),Eu^(Ⅲ)(2),Sm^(Ⅲ)(3),H_(4)EDTA=ethylene diamine tetraacetic acid;H_(2)C_(2)O_(4)=oxalic acid).Crystallographic study exhibits that complex 1 features a cute snail-shaped Gd_(2) unit.Adjacent Gd_(2) units are aggregated by hexadentate EDTA^(4-) and C_(2)O_(4)^(2-)ligands,further constructing a charming three-dimensional metal-organic framework with interesting parallelogram-shaped layers.Notably,all coordinated EDTA^(4-)ligands and lightweight C_(2)O_(4)^(2-)groups contribute to building a densely packed metal-organic framework,endowing complex 1 with remarkable magnetocaloric effect(-ΔS_(m)^(max)=42.5 J/(kg·K) at 2.5 K and ΔH=7.0 T).Additionally,complexes 2 and 3 exhibit outstanding solid-state luminescent properties with lifetimes of43 8.22 and 4.13 μs,and quantum yields(QY) of 7.03% and 15.46%,respectively.
基金supported by a project grant awarded to Hui Chen and Brian G.Oliver by the Australian National Health&Medical Research Council(No.APP1158186)supported by scholarships from the Chinese Scholarship Councilsupported by scholarships from the Australian Government Research Training Program。
文摘There is no safe level of exposure to air pollution,including particulate matter smaller than2.5μm(PM_(2.5)),to human health.Whilst it is well known that exposure to heavily polluted air is associated with several liver disorders,it is unclear how long-term exposure to lowlevel traffic-derived PM_(2.5)affects liver health.BALB/c mice(5 weeks,male)were exposed to traffic-derived PM_(2.5)(10μg/mouse/day,intranasally)daily for 4,8 and 12 weeks.Markers of inflammation and fibrosis were measured at each time point.Changes in liver proteome and lipid profiles were measured using proteomics and lipidomics at 12 weeks.Low-dose PM_(2.5)exposure increased macrophage infiltration,pro-inflammatory cytokine production,and increased collagen deposition at 12 weeks.Despite liver lipid metabolism being increased,the abundance of triglycerides,precursor diacylglycerols,and ceramide was also significantly increased by PM_(2.5)exposure,whereas glycogen content was reduced.Proteomics analysis revealed 64 proteins to be significantly changed in PM_(2.5)-exposed mice,and KEGG pathway enrichment analysis indicated their involvement in lipid metabolism,alcohol-related liver disease,neutrophil extracellular trap formation,and transcriptional dysregulation related to cancer.In conclusion,prolonged exposure to low-dose traffic-derived PM_(2.5)promotes pathological changes in the liver,suggestive of an increased risk of metabolic dysfunctionassociated fatty liver disease.Future studies can enable the identification of the signalling pathways underlying low-dose PM_(2.5)-induced lipid accumulation in the liver.
文摘目的:研究经纳米微针导入0.5%氨甲环酸溶液对中国女性面部皮肤暗沉的疗效及安全性。方法:募集60名无基础病的健康临床受试者,随机分为两组,每组30名。生理盐水组:受试者全面部使用纳米微针导入生理盐水;0.5%氨甲环酸溶液组:受试者全面部使用纳米微针导入0.5%氨甲环酸溶液。两组受试者均每周接受1次治疗,共治疗2个月,每周两组受试者接受治疗前及治疗后72h都检测经皮水分丢失(trans-epidermal water loss,TEWL)、角质层含水量、红斑量、黑素及皮肤弹性,拍摄每组受试者治疗前后面部照片。通过皮肤状态问卷调查受试者满意度及不良反应,治疗结束后1个月、2个月复测TEWL、角质层含水量、红斑量、黑素及皮肤弹性。结果:生理盐水组治疗后72h经皮水分丢失、角质层含水量、红斑量、皮肤弹性与0.5%氨甲环酸溶液组无显著性差异;生理盐水组治疗后黑素数值显著高于0.5%氨甲环酸溶液组;生理盐水组受试者面部照片治疗前后无显著性差异,0.5%氨甲环酸溶液组治疗后面部照片明显比治疗前肤色白皙;生理盐水组受试者及医生满意度显著低于0.5%氨甲环酸溶液组;生理盐水组及0.5%氨甲环酸溶液组皆无不良反应;0.5%氨甲环酸溶液组治疗后1个月的黑素值与初次治疗前的黑素值有显著性差异(P<0.05),治疗后2个月的黑素值与初次治疗前测得的黑素值无统计学差异。结论:纳米微针导入0.5%氨甲环酸溶液可明显改善中国女性面部皮肤暗沉。
基金The Defence Advance Research Program of Science and Technology of Ship Industry(Grant No.11J1.3.1)
文摘The stiffened cylindrical shell is commonly used for the pressure hull of submersibles and the legs of offshore platforms. There are various failure modes because of uncertainty with the structural size and material properties, uncertainty of the calculation model and machining errors. Correlations among failure modes must be considered with the structural reliability of stiffened cylindrical shells. However, the traditional method cannot consider the correlations effectively. The aim of this study is to present a method of reliability analysis for stiffened cylindrical shells which considers the correlations among failure modes. Firstly, the joint failure probability calculation formula of two related failure modes is derived through use of the 2D joint probability density function. Secondly, the full probability formula of the tandem structural system is given with consideration to the correlations among failure modes. At last, the accuracy of the system reliability calculation is verified through use of the Monte Carlo simulation. Result of the analysis shows the failure probability of stiffened cylindrical shells can be gained through adding the failure probability of each mode.
基金partly supported by the Natural Science Foundation of Tianjin(Grant Nos.16JCYBJC24100 and 18YFZCSY00550).
文摘Objective:To analyze the efficacy and safety o f apatinib in the treatment of stage IV osteogenic sarcoma after chemotherapy failure through a single-arm,prospective,and open clinical phase II study.Methods:Information on 34 patients with stage IV osteogenic sarcoma treated with apatinib after failure o f chemotherapy in Tianjin Medical University Cancer Institute and Hospital between September 2015 and December 2019 was collected and analyzed.The participants included 23 males and 11 females,with an average age of 35.24 years(11-73 years).The objective response rate(ORR),disease control rate(DCR),progression-free survival(PFS),PFS rate(PFR),and overall survival(OS)were evaluated.The treatmentrelated adverse events(AEs)and safety of apatinib were also evaluated.Results:O f the 34 patients,33 were able to be evaluated for efficacy.One patient received apatinib treatment for less than one cycle;therefore,only safety analysis was performed.The 12-week clinical evaluation showed that 2 patients had a partial response(PR),24 patients had stable disease(SD),and 7 patients had progressive disease(PD).The ORR,DCR,and PFR at 12 weeks were 6.06%(2/33),78.79%(26/33),and 82%,respectively.By the end of the follow-up,6 patients had SD(18.18%,6/33),27 patients had PD(81.82%,27/33),and 15 patients died because of disease progression(45.45%,15/33).The ORR was 0(0/33),the DCR was 18.18%(6/33),and the median PFS(mPFS)was 7.89 months(95%Cl:4.56-11.21).The median OS(mOS)was 17.61 months(95%Cl:10.85-24.37).The most common treatment-related AEs were hand-foot syndrome(35.29%,12/34),proteinuria(32.35%,11/34),and hypertension(32.35%,11/34).
