As an innovative physiotherapeutic approach,magnetic hyperthermia therapy(MHT)has unique advantages including minimal invasiveness,precise temperature control,and deep tissue penetration capabilities.It offers unparal...As an innovative physiotherapeutic approach,magnetic hyperthermia therapy(MHT)has unique advantages including minimal invasiveness,precise temperature control,and deep tissue penetration capabilities.It offers unparalleled control over heating areas and temperatures,boasts high efficiency,and results in excellent tissue penetration,while remaining independent of biological tissues.With vast potential in biomedical applications ranging from antitumor therapy to thrombus dissolution,MHT harnesses magnetic nanoparticles(MNPs)to convert magnetic energy into thermal energy under an alternating magnetic field(AMF),thereby achieving therapeutic effects.Advanced magnetic nanocomposite platforms based on magnetic nanoparticles can avoid various risks associated with traditional tools,achieving precise,on-demand,or continuous targeted drug delivery and release through multiple approaches.The potential clinical applications of magnetic hyperthermia therapy are being progressively developed.The present article presents an exhaustive review of the research progress in magnetic hyperthermia therapy.Initially,the overall landscape of MHT was outlined,including physical heat generation mechanisms,types of magnetic nanoparticles and conductive nonmagnetic materials,strategies to increase the thermal efficiency of MNPs,and experimental evidence and research progress on“hotspot”effects.This review has focused on biomedical applications and targeted drug delivery of innovative combination therapy strategies based on MHT.The progress of clinical trials on MNPs-mediated MHT(MNPs-MHT)is summarized below.Furthermore,the limitations,major challenges and prospects in the clinical translation of MHT are discussed.The objective of this work is to provide a panoramic view of biomedical applications and targeted drug delivery of MHT,which can potentially guide researchers and facilitate the successful implementation of advanced MNPs-MHT systems in the future.展开更多
Facial paralysis comorbidities is now understood to include two distinct forms:synkinesis and micro-entrapment syndrome of nerves innervating the face(MESNIF).These disorders manifest as oromandibular synkinesis,stiff...Facial paralysis comorbidities is now understood to include two distinct forms:synkinesis and micro-entrapment syndrome of nerves innervating the face(MESNIF).These disorders manifest as oromandibular synkinesis,stiffness and atrophy of facial muscles on one side,which affect activities of daily living.Acupoint Injection is a treatment for facial paralysis,combining the meridian theory of traditional Chinese medicine,with the injection of specific drugs into acupuncture points of the face.In recent years,the use of acupoint injections has shown in remarkable clinical efficacy and few adverse effects.We report the case to introduce this integrative therapy and outline the key principles of rehabilitation therapy.展开更多
基金supported by the National Natural Science Foundation of China(No.82402780)the China National Postdoctoral Program for Innovative Talents(No.BX20230350)+3 种基金the China Postdoctoral Science Foundation(No.2024M753130)the Scientific Research Project of Anhui Provincial Health Commission(No.AHWJ2024Aa20475)Anhui Postdoctoral Scientific Research Program Foundation(No.2025B1048)the Research Funds of Centre for Leading Medicine and Advanced Technologies of IHM(No.2023IHM02007).
文摘As an innovative physiotherapeutic approach,magnetic hyperthermia therapy(MHT)has unique advantages including minimal invasiveness,precise temperature control,and deep tissue penetration capabilities.It offers unparalleled control over heating areas and temperatures,boasts high efficiency,and results in excellent tissue penetration,while remaining independent of biological tissues.With vast potential in biomedical applications ranging from antitumor therapy to thrombus dissolution,MHT harnesses magnetic nanoparticles(MNPs)to convert magnetic energy into thermal energy under an alternating magnetic field(AMF),thereby achieving therapeutic effects.Advanced magnetic nanocomposite platforms based on magnetic nanoparticles can avoid various risks associated with traditional tools,achieving precise,on-demand,or continuous targeted drug delivery and release through multiple approaches.The potential clinical applications of magnetic hyperthermia therapy are being progressively developed.The present article presents an exhaustive review of the research progress in magnetic hyperthermia therapy.Initially,the overall landscape of MHT was outlined,including physical heat generation mechanisms,types of magnetic nanoparticles and conductive nonmagnetic materials,strategies to increase the thermal efficiency of MNPs,and experimental evidence and research progress on“hotspot”effects.This review has focused on biomedical applications and targeted drug delivery of innovative combination therapy strategies based on MHT.The progress of clinical trials on MNPs-mediated MHT(MNPs-MHT)is summarized below.Furthermore,the limitations,major challenges and prospects in the clinical translation of MHT are discussed.The objective of this work is to provide a panoramic view of biomedical applications and targeted drug delivery of MHT,which can potentially guide researchers and facilitate the successful implementation of advanced MNPs-MHT systems in the future.
基金funded by Beijing Municipal Key Specialty Construction Project of Traditional Chinese Medicine[(1+X+N)2017].
文摘Facial paralysis comorbidities is now understood to include two distinct forms:synkinesis and micro-entrapment syndrome of nerves innervating the face(MESNIF).These disorders manifest as oromandibular synkinesis,stiffness and atrophy of facial muscles on one side,which affect activities of daily living.Acupoint Injection is a treatment for facial paralysis,combining the meridian theory of traditional Chinese medicine,with the injection of specific drugs into acupuncture points of the face.In recent years,the use of acupoint injections has shown in remarkable clinical efficacy and few adverse effects.We report the case to introduce this integrative therapy and outline the key principles of rehabilitation therapy.
