We report an extremely rare case of an unmptured non-communicating rudimentary horn full-term pregnancy. A woman who had a uterine malformation was misdiagnosed as uterus didelphys and gave birth to a live, healthy fe...We report an extremely rare case of an unmptured non-communicating rudimentary horn full-term pregnancy. A woman who had a uterine malformation was misdiagnosed as uterus didelphys and gave birth to a live, healthy fetus. The correct diagnosis was not made until cesarean section at 37 4/7 weeks. The case suggests that women who are pregnant in a rudimentary horn could obtain a full-term delivery and give birth to a live and healthy baby.展开更多
Angiomyolipoma usually present as incidental findings on routine imaging or laparotomy, but rarely they may give rise to massive hemorrhage. If bleeding occurs, the treatment of choice is to save life either by angiog...Angiomyolipoma usually present as incidental findings on routine imaging or laparotomy, but rarely they may give rise to massive hemorrhage. If bleeding occurs, the treatment of choice is to save life either by angiography with selective embolisation or surgery. Herein, we reported a case of a 32-year-old man who came to our hospital complaining of sudden colicky pain in the right hypochondria region, associated with nausea and vomiting. On physical examination, the patient was in a state of shock; blood pressure of 60/36 mmHg, heart rate of 160 beats/min, high abdominal distention, and non-coagulated blood was extracted from abdominal puncture. The abdominal computed tomography (CT) and arteriography showed a 20 × 15 × 15 cm mass suggestive of spontaneous rupture of liver neoplasm and intraperitoneal hemorrhage. On laparotomy, 1500 mL of non-coagulated blood was found, and the tumor located at right upper abdomen, which originated from retroperitoneum. The tumor was resected totally with hematoma and sutured the bleeding vessels. The histological study of the resected mass revealed the presence of angiomyolipoma.展开更多
Introduction:Data on inter-regional transmission clusters of Hepatitis C Virus(HCV)helps optimize targeted preventive strategies.This study aims to detect the national and international dimensions of HCV 1b transmissi...Introduction:Data on inter-regional transmission clusters of Hepatitis C Virus(HCV)helps optimize targeted preventive strategies.This study aims to detect the national and international dimensions of HCV 1b transmission clusters.Methods:Available published HCV 1b nonstructural protein 5B sequences sampled between 1989 and 2021 were collected,including 1,750 sequences from China and 482 comparable sequences from other countries.Network-based and tree-based approaches were introduced to detect transmission clusters and infer their relationships.Results:Three distinct transmission cluster patterns were identified across China:a large cluster with nationwide distribution,two medium clusters predominantly in the Central and Eastern China,and 103 small clusters scattered across 19 provincial-level administrative divisions.No genetic linkages were found between Chinese sequences and those from other countries.The medium clusters exhibited a similar expansion risk compared with the large cluster[adjusted odds ratio(aOR)=1.247,95%confidence interval(CI):0.862,1.804,P=0.241],but showed significantly lower inter-provincial transmission(aOR=0.255,95%CI:0.077,0.798,P=0.019).The small clusters demonstrated faster expansion[adjusted hazard ratio(aHR)=1.327,95%CI:1.050,1.676,P=0.018]and markedly reduced inter-provincial transmission(aOR=0.006,95%CI:0.002,0.014,P<0.001)compared to the large cluster.The Northeast China groups showed significantly higher interprovincial transmission risk compared to the Central China groups(aOR=11.461,95%CI:2.262,87.014,P=0.006).Conclusions:This study emphasizes the urgent need to establish a national molecular epidemiological surveillance network for detecting hidden transmission chains and monitoring the emergence of variants.展开更多
Background:Accurate diagnosis of intrahepatic cholangiocarcinoma(ICC)caused by intrahepatic lithiasis(IHL)is crucial for timely and effective surgical intervention.The aim of the present study was to develop a nomogra...Background:Accurate diagnosis of intrahepatic cholangiocarcinoma(ICC)caused by intrahepatic lithiasis(IHL)is crucial for timely and effective surgical intervention.The aim of the present study was to develop a nomogram to identify ICC associated with IHL(IHL-ICC).Methods:The study included 2,269 patients with IHL,who received pathological diagnosis after hepatectomy or diagnostic biopsy.Machine learning algorithms including Lasso regression and random forest were used to identify important features out of the available features.Univariate and multivariate logistic regression analyses were used to reconfirm the features and develop the nomogram.The nomogram was externally validated in two independent cohorts.Results:The seven potential predictors were revealed for IHL-ICC,including age,abdominal pain,vomiting,comprehensive radiological diagnosis,alkaline phosphatase(ALK),carcinoembryonic antigen(CEA),and cancer antigen(CA)19-9.The optimal cutoff value was 2.05μg/L for serum CEA and 133.65 U/mL for serum CA 19-9.The accuracy of the nomogram in predicting ICC was 82.6%.The area under the curve(AUC)of nomogram in training cohort was 0.867.The AUC for the validation set was 0.881 from The Second Affiliated Hospital of Wenzhou Medical University,and 0.938 from The First Affiliated Hospital of Fujian Medical University.Conclusions:The nomogram holds promise as a novel and accurate tool to predict IHL-ICC,which can identify lesions in IHL in time for hepatectomy or avoid unnecessary surgical resection.展开更多
Summary What is already known about this topic?Migration has a significant impact on the transmission of human immunodeficiency virus(HIV).To date,there have been few studies examining the characteristics of migration...Summary What is already known about this topic?Migration has a significant impact on the transmission of human immunodeficiency virus(HIV).To date,there have been few studies examining the characteristics of migration among HIV-positive men who have sex with men(MSM).What is added by this report?The prevalence of migrants among newly reported HIV-positive MSM in Guangxi Zhuang Autonomous Region increased from 2005 to 2021.Yulin Prefecture had the highest proportion of out-migrant MSM(12.6%),while Nanning Prefecture had the highest proportion of in-migrant MSM(55.9%).Risk factors associated with migration among MSM included being in the 18–24 age range,having a college education or higher,and being a student.展开更多
There has been a long history of interest on how(if)the absorption coefficient of“pure”fresh water(a_(fw)(λ))and“pure”seawater(a_(sw)(λ))changes with temperature(T),yet the impact of T reported in the literature...There has been a long history of interest on how(if)the absorption coefficient of“pure”fresh water(a_(fw)(λ))and“pure”seawater(a_(sw)(λ))changes with temperature(T),yet the impact of T reported in the literature differs significantly in the blue domain.Unlike the previous studies based on laboratory measurements,we took an approach based on~18 years(2002–2020)of MODIS ocean color and temperature measurements in the oligotrophic oceans,along with field measured chlorophyll concentration and phytoplankton absorption coefficient,to examine the relationship between T and the total absorption coefficient(a(λ))at 412 and 443 nm.We found that the values of a(412)and a(443)in the summer are nearly flat(slightly decreasing)for the observed T range of~19–27℃.Since there are no detectable changes of chlorophyll during this period,the results suggest that T has a negligible impact on a_(sw)(412) and a_(sw)(443)in this T range.As a complement,the impact of salinity on a_(fw)(λ) was also evaluated using three independent determinations of a_(sw)(λ) and a_(fw)(λ),where good agreements were found from these observations.展开更多
Summary What is already known about this topic?The effects of concurrent human immunodeficiency virus(HIV)/hepatitis C virus(HCV)infection on mortality and patient attrition in those undergoing antiretroviral therapy ...Summary What is already known about this topic?The effects of concurrent human immunodeficiency virus(HIV)/hepatitis C virus(HCV)infection on mortality and patient attrition in those undergoing antiretroviral therapy continue to be a contested area of research.展开更多
文摘We report an extremely rare case of an unmptured non-communicating rudimentary horn full-term pregnancy. A woman who had a uterine malformation was misdiagnosed as uterus didelphys and gave birth to a live, healthy fetus. The correct diagnosis was not made until cesarean section at 37 4/7 weeks. The case suggests that women who are pregnant in a rudimentary horn could obtain a full-term delivery and give birth to a live and healthy baby.
文摘Angiomyolipoma usually present as incidental findings on routine imaging or laparotomy, but rarely they may give rise to massive hemorrhage. If bleeding occurs, the treatment of choice is to save life either by angiography with selective embolisation or surgery. Herein, we reported a case of a 32-year-old man who came to our hospital complaining of sudden colicky pain in the right hypochondria region, associated with nausea and vomiting. On physical examination, the patient was in a state of shock; blood pressure of 60/36 mmHg, heart rate of 160 beats/min, high abdominal distention, and non-coagulated blood was extracted from abdominal puncture. The abdominal computed tomography (CT) and arteriography showed a 20 × 15 × 15 cm mass suggestive of spontaneous rupture of liver neoplasm and intraperitoneal hemorrhage. On laparotomy, 1500 mL of non-coagulated blood was found, and the tumor located at right upper abdomen, which originated from retroperitoneum. The tumor was resected totally with hematoma and sutured the bleeding vessels. The histological study of the resected mass revealed the presence of angiomyolipoma.
基金Supported by the National Natural Science Foundation of China(12071366)the project of the Disease Control and Prevention Administration of Guangxi Zhuang Autonomous Region(GXJKKJ24C002).
文摘Introduction:Data on inter-regional transmission clusters of Hepatitis C Virus(HCV)helps optimize targeted preventive strategies.This study aims to detect the national and international dimensions of HCV 1b transmission clusters.Methods:Available published HCV 1b nonstructural protein 5B sequences sampled between 1989 and 2021 were collected,including 1,750 sequences from China and 482 comparable sequences from other countries.Network-based and tree-based approaches were introduced to detect transmission clusters and infer their relationships.Results:Three distinct transmission cluster patterns were identified across China:a large cluster with nationwide distribution,two medium clusters predominantly in the Central and Eastern China,and 103 small clusters scattered across 19 provincial-level administrative divisions.No genetic linkages were found between Chinese sequences and those from other countries.The medium clusters exhibited a similar expansion risk compared with the large cluster[adjusted odds ratio(aOR)=1.247,95%confidence interval(CI):0.862,1.804,P=0.241],but showed significantly lower inter-provincial transmission(aOR=0.255,95%CI:0.077,0.798,P=0.019).The small clusters demonstrated faster expansion[adjusted hazard ratio(aHR)=1.327,95%CI:1.050,1.676,P=0.018]and markedly reduced inter-provincial transmission(aOR=0.006,95%CI:0.002,0.014,P<0.001)compared to the large cluster.The Northeast China groups showed significantly higher interprovincial transmission risk compared to the Central China groups(aOR=11.461,95%CI:2.262,87.014,P=0.006).Conclusions:This study emphasizes the urgent need to establish a national molecular epidemiological surveillance network for detecting hidden transmission chains and monitoring the emergence of variants.
文摘Background:Accurate diagnosis of intrahepatic cholangiocarcinoma(ICC)caused by intrahepatic lithiasis(IHL)is crucial for timely and effective surgical intervention.The aim of the present study was to develop a nomogram to identify ICC associated with IHL(IHL-ICC).Methods:The study included 2,269 patients with IHL,who received pathological diagnosis after hepatectomy or diagnostic biopsy.Machine learning algorithms including Lasso regression and random forest were used to identify important features out of the available features.Univariate and multivariate logistic regression analyses were used to reconfirm the features and develop the nomogram.The nomogram was externally validated in two independent cohorts.Results:The seven potential predictors were revealed for IHL-ICC,including age,abdominal pain,vomiting,comprehensive radiological diagnosis,alkaline phosphatase(ALK),carcinoembryonic antigen(CEA),and cancer antigen(CA)19-9.The optimal cutoff value was 2.05μg/L for serum CEA and 133.65 U/mL for serum CA 19-9.The accuracy of the nomogram in predicting ICC was 82.6%.The area under the curve(AUC)of nomogram in training cohort was 0.867.The AUC for the validation set was 0.881 from The Second Affiliated Hospital of Wenzhou Medical University,and 0.938 from The First Affiliated Hospital of Fujian Medical University.Conclusions:The nomogram holds promise as a novel and accurate tool to predict IHL-ICC,which can identify lesions in IHL in time for hepatectomy or avoid unnecessary surgical resection.
基金The National Natural Science Foundation of China(82160636).
文摘Summary What is already known about this topic?Migration has a significant impact on the transmission of human immunodeficiency virus(HIV).To date,there have been few studies examining the characteristics of migration among HIV-positive men who have sex with men(MSM).What is added by this report?The prevalence of migrants among newly reported HIV-positive MSM in Guangxi Zhuang Autonomous Region increased from 2005 to 2021.Yulin Prefecture had the highest proportion of out-migrant MSM(12.6%),while Nanning Prefecture had the highest proportion of in-migrant MSM(55.9%).Risk factors associated with migration among MSM included being in the 18–24 age range,having a college education or higher,and being a student.
基金support provided by the National Natural Science Foundation of China(#41890803,#41941008,and#41830102)the Joint Polar Satellite System(JPSS)funding for the NOAA ocean color calibration and validation(Cal/Val)project(SA18-UMB01)+1 种基金the University of Massachusetts Boston is greatly appreciatedNASA OBPG for processing and providing global MODIS ocean color data and the Hawaii Ocean Time-series HOT-DOGS application(University of Hawai’i at Mānoa,National Science Foundation Award#1756517)for data collection and sharing。
文摘There has been a long history of interest on how(if)the absorption coefficient of“pure”fresh water(a_(fw)(λ))and“pure”seawater(a_(sw)(λ))changes with temperature(T),yet the impact of T reported in the literature differs significantly in the blue domain.Unlike the previous studies based on laboratory measurements,we took an approach based on~18 years(2002–2020)of MODIS ocean color and temperature measurements in the oligotrophic oceans,along with field measured chlorophyll concentration and phytoplankton absorption coefficient,to examine the relationship between T and the total absorption coefficient(a(λ))at 412 and 443 nm.We found that the values of a(412)and a(443)in the summer are nearly flat(slightly decreasing)for the observed T range of~19–27℃.Since there are no detectable changes of chlorophyll during this period,the results suggest that T has a negligible impact on a_(sw)(412) and a_(sw)(443)in this T range.As a complement,the impact of salinity on a_(fw)(λ) was also evaluated using three independent determinations of a_(sw)(λ) and a_(fw)(λ),where good agreements were found from these observations.
基金Laboratory of AIDS Prevention Control and Translation of Guangxi Zhuang Autonomous Region(ZZH2020010)the Guangxi Bagui Scholars Program of Key Technical Position for HIV/AIDS Prevention and Control.
文摘Summary What is already known about this topic?The effects of concurrent human immunodeficiency virus(HIV)/hepatitis C virus(HCV)infection on mortality and patient attrition in those undergoing antiretroviral therapy continue to be a contested area of research.
