Within the prefrontal-cingulate cortex,abnormalities in coupling between neuronal networks can disturb the emotion-cognition interactions,contributing to the development of mental disorders such as depression.Despite ...Within the prefrontal-cingulate cortex,abnormalities in coupling between neuronal networks can disturb the emotion-cognition interactions,contributing to the development of mental disorders such as depression.Despite this understanding,the neural circuit mechanisms underlying this phenomenon remain elusive.In this study,we present a biophysical computational model encompassing three crucial regions,including the dorsolateral prefrontal cortex,subgenual anterior cingulate cortex,and ventromedial prefrontal cortex.The objective is to investigate the role of coupling relationships within the prefrontal-cingulate cortex networks in balancing emotions and cognitive processes.The numerical results confirm that coupled weights play a crucial role in the balance of emotional cognitive networks.Furthermore,our model predicts the pathogenic mechanism of depression resulting from abnormalities in the subgenual cortex,and network functionality was restored through intervention in the dorsolateral prefrontal cortex.This study utilizes computational modeling techniques to provide an insight explanation for the diagnosis and treatment of depression.展开更多
Dear Editor,alLuitol,Stress contributes significantly to many diseases in modern society.Numerous studies have revealed that exposure to stress leads to increased vulnerability to anxiety,depression,and other mood dis...Dear Editor,alLuitol,Stress contributes significantly to many diseases in modern society.Numerous studies have revealed that exposure to stress leads to increased vulnerability to anxiety,depression,and other mood disorders,which are often accompanied by conditions such as cardiovascular disease and cognitive impairments[1,2].展开更多
Nanocatalytic therapy shows great potential for therapeutic interventions.However,therapeutic efficiency is often limited by unsatisfactory enzyme activity and lack of the coordination of immune system.Therefore,engin...Nanocatalytic therapy shows great potential for therapeutic interventions.However,therapeutic efficiency is often limited by unsatisfactory enzyme activity and lack of the coordination of immune system.Therefore,engineering nanozymes activity enhancement while activating immune system will be an effective strategy to achieve efficient tumor therapy.Herein,we synthesize a DSPE-PEG-FA modified manganese dioxide-based dual-atom nanozyme(MDF),on which iridium and platinum atoms are anchored.The obtained MDF can simultaneously mimic four enzyme activities of catalase,oxidase,peroxidase,and glutathione oxidase,set off a reactive oxygen species(ROS)storm,cause tumor cell death.The enzyme activity of MDF can be enhanced by its own photothermal effect.Meanwhile,MDF can consume intracellular glutathione and release Mn^(2+),which can prevent generated ROS from consumption and further activate cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes(cGAS-STING)pathway and promote the secretion of type I interferon,which will help promote dendritic cells maturation,present antigens to T lymphocytes to help kill tumor cells.Ultimately,MDF shows excellent tumor suppressive effects.This work provides a new paradigm for the field of nanozymes and offers a new reference for involvement of cGAS-STING pathway activation in tumor catalytic therapy.展开更多
To further improve the quantum efficiency of atomically thin transition metal dichalcogenides (TMDs) is crucial for the realization of high-performance optoelectronic applications. To this regard, a few chemical or ph...To further improve the quantum efficiency of atomically thin transition metal dichalcogenides (TMDs) is crucial for the realization of high-performance optoelectronic applications. To this regard, a few chemical or physical approaches such as superacid treatment, electrical gating, dielectric screening, and laser irradiation have been developed. In particular, the laser irradiation appears to be a more efficient way with good processability and spatial selectivity. However, the underlying mechanism especially about whether chemisorption or physisorption plays a more important role is still debatable. Here, we unravel the mystery of laser irradiation induced photoluminescence enhancement in monolayer WS_(2) by precisely controlling irradiation time and environment. It is found that the synergetic effect of physisorption and chemisorption is responsible for the photoluminescence enhancement, where the physisorption dominates with more than 74% contribution. The comprehensive understanding of the adsorption mechanism in laser-irradiated TMDs may trigger the potential applications for patterned light source, effective photosensor and ultrathin optical memory.展开更多
Proxy records from the North Atlantic realm reveal that large and rapid cooling known as the Bond events continued into the Holocene [1],repeatedly punctuating what is conventionally thought to have been a relatively ...Proxy records from the North Atlantic realm reveal that large and rapid cooling known as the Bond events continued into the Holocene [1],repeatedly punctuating what is conventionally thought to have been a relatively stable climate.Given that the Holocene is the most recent interglacial period that has spurred the development of modern societies,scrutinizing climate variabil- ity during this period is important not only for predicting the trend of future climate changes,but also for better understanding the driving forces behind the rise and fall of ancient civilizations.展开更多
基金supported by the Major Research Instrument Development Project of the National Natural Science Foundation of China(82327810)the Foundation of the President of Hebei University(XZJJ202202)the Hebei Province“333 talent project”(A202101058).
文摘Within the prefrontal-cingulate cortex,abnormalities in coupling between neuronal networks can disturb the emotion-cognition interactions,contributing to the development of mental disorders such as depression.Despite this understanding,the neural circuit mechanisms underlying this phenomenon remain elusive.In this study,we present a biophysical computational model encompassing three crucial regions,including the dorsolateral prefrontal cortex,subgenual anterior cingulate cortex,and ventromedial prefrontal cortex.The objective is to investigate the role of coupling relationships within the prefrontal-cingulate cortex networks in balancing emotions and cognitive processes.The numerical results confirm that coupled weights play a crucial role in the balance of emotional cognitive networks.Furthermore,our model predicts the pathogenic mechanism of depression resulting from abnormalities in the subgenual cortex,and network functionality was restored through intervention in the dorsolateral prefrontal cortex.This study utilizes computational modeling techniques to provide an insight explanation for the diagnosis and treatment of depression.
基金supported by grants from the National Natural Science Foundation of China(32200826,32230042,and U20A20224)the Shenzhen Medical Research Fund(B2302004)+1 种基金the Shenzhen Science and Technology Program(JCYJ20220530154412028)the Financial Support for Outstanding Talents Training Fund in Shenzhen,and the Natural Science Foundation of Hebei Province(F2022201037).
文摘Dear Editor,alLuitol,Stress contributes significantly to many diseases in modern society.Numerous studies have revealed that exposure to stress leads to increased vulnerability to anxiety,depression,and other mood disorders,which are often accompanied by conditions such as cardiovascular disease and cognitive impairments[1,2].
基金supported by the National Natural Science Foundation of China(52371254,22020102003)the Jilin Province Youth Science and Technology Talent Support Project(QT202229)+1 种基金the Program of Science and Technology Development Plan of Jilin Province of China(YDZJ202302CXJD065)the Natural Science Foundation of Chongqing of China(cstc2021jcyj-msxmX0936)。
文摘Nanocatalytic therapy shows great potential for therapeutic interventions.However,therapeutic efficiency is often limited by unsatisfactory enzyme activity and lack of the coordination of immune system.Therefore,engineering nanozymes activity enhancement while activating immune system will be an effective strategy to achieve efficient tumor therapy.Herein,we synthesize a DSPE-PEG-FA modified manganese dioxide-based dual-atom nanozyme(MDF),on which iridium and platinum atoms are anchored.The obtained MDF can simultaneously mimic four enzyme activities of catalase,oxidase,peroxidase,and glutathione oxidase,set off a reactive oxygen species(ROS)storm,cause tumor cell death.The enzyme activity of MDF can be enhanced by its own photothermal effect.Meanwhile,MDF can consume intracellular glutathione and release Mn^(2+),which can prevent generated ROS from consumption and further activate cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes(cGAS-STING)pathway and promote the secretion of type I interferon,which will help promote dendritic cells maturation,present antigens to T lymphocytes to help kill tumor cells.Ultimately,MDF shows excellent tumor suppressive effects.This work provides a new paradigm for the field of nanozymes and offers a new reference for involvement of cGAS-STING pathway activation in tumor catalytic therapy.
基金Y. Li and J. Yan contributed equally to this work. This work was supported by the Program of National Natural Science Foundation of China (Nos. 51732003, 51872043, 61604037, 11874104, 12074060, and 12004069)the National Science Fund for Distinguished Young Scholars (No. 52025022)+7 种基金the “111” Project (No. B13013)the National Key Research and Development Program of China (Nos. 2016YFA0201902 and 2019YFB2205100)Fund from Ministry of Education (No. 6141A02033414)Shenzhen Nanshan District Pilotage Team Program (No. LHTD20170006)the China Postdoctoral Science Foundation funded project (Nos. 2020M681025, 2021T140109, and 2021M693905)the Fundamental Research Funds for the Central Universities (Nos. 2412020QD015, 2412019BJ006, 2412021ZD007, 2412021ZD012, and 2412019FZ034)Postdoctoral Science Foundation funded project from Jilin Province (No. 111865005)the Fund from Jilin Province (Nos. YDZJ202101ZYTS049, YDZJ202101ZYTS041, YDZJ202101ZYTS133, JJKH20211273KJ, JJKH20211274KJ, and 20190103007JH).
文摘To further improve the quantum efficiency of atomically thin transition metal dichalcogenides (TMDs) is crucial for the realization of high-performance optoelectronic applications. To this regard, a few chemical or physical approaches such as superacid treatment, electrical gating, dielectric screening, and laser irradiation have been developed. In particular, the laser irradiation appears to be a more efficient way with good processability and spatial selectivity. However, the underlying mechanism especially about whether chemisorption or physisorption plays a more important role is still debatable. Here, we unravel the mystery of laser irradiation induced photoluminescence enhancement in monolayer WS_(2) by precisely controlling irradiation time and environment. It is found that the synergetic effect of physisorption and chemisorption is responsible for the photoluminescence enhancement, where the physisorption dominates with more than 74% contribution. The comprehensive understanding of the adsorption mechanism in laser-irradiated TMDs may trigger the potential applications for patterned light source, effective photosensor and ultrathin optical memory.
基金supported by the start-up grant of Jiangsu Normal Universitythe Chinese Program to Introduce Disciplinary Talents to Universities (111-2-09)
文摘Proxy records from the North Atlantic realm reveal that large and rapid cooling known as the Bond events continued into the Holocene [1],repeatedly punctuating what is conventionally thought to have been a relatively stable climate.Given that the Holocene is the most recent interglacial period that has spurred the development of modern societies,scrutinizing climate variabil- ity during this period is important not only for predicting the trend of future climate changes,but also for better understanding the driving forces behind the rise and fall of ancient civilizations.
