An efficient synthesis of indazole fused phenanthridinones via Rh(Il)-catalyzed inert C(sp^(2))-H activation/[4+2]annulation of 3-aryl-1H-indazoles with iodonium ylides has been developed,providing a strategy to acces...An efficient synthesis of indazole fused phenanthridinones via Rh(Il)-catalyzed inert C(sp^(2))-H activation/[4+2]annulation of 3-aryl-1H-indazoles with iodonium ylides has been developed,providing a strategy to access multi-conjugated x-system tetracyclic and pentacyclic aza-heterocyclics with the favorable photoluminescence prop-erties.This"one-pot"reaction features high efficiency,excellent regioselectivity,a broad substrate compatibility and could be easily scaled up.Furthermore,the obtained products exhibited low toxicity in MDCK cells as well as selectively labeled the zebrafish larvae,which indicated that the titled products could be potentially utilized as biofluorescent probes or fluorescent dyes.展开更多
基金supported by Fujian Province(No.3502ZCQXT2021006)111 project(No.BC2018061)Open Research Fund of Academy of Advanced Carbon Conversion Technology,HuaqiaoUniversity(No.AACCT0007).
文摘An efficient synthesis of indazole fused phenanthridinones via Rh(Il)-catalyzed inert C(sp^(2))-H activation/[4+2]annulation of 3-aryl-1H-indazoles with iodonium ylides has been developed,providing a strategy to access multi-conjugated x-system tetracyclic and pentacyclic aza-heterocyclics with the favorable photoluminescence prop-erties.This"one-pot"reaction features high efficiency,excellent regioselectivity,a broad substrate compatibility and could be easily scaled up.Furthermore,the obtained products exhibited low toxicity in MDCK cells as well as selectively labeled the zebrafish larvae,which indicated that the titled products could be potentially utilized as biofluorescent probes or fluorescent dyes.
