Gastric cancer remains a leading cause of cancer-related mortality worldwide,with its complex tumor microenvironment(TME)playing a crucial role in tumor initiation,progression,and therapeutic response.As key component...Gastric cancer remains a leading cause of cancer-related mortality worldwide,with its complex tumor microenvironment(TME)playing a crucial role in tumor initiation,progression,and therapeutic response.As key components of the TME,mesenchymal stem cells(MSCs)influence tumor cell proliferation,invasion,and treatment resistance through cytokine secretion,exosomal communication,and metabolic regulation.MSCs enhance cancer stemness and therapy resistance by modulating glycolysis and fatty acid oxidation(FAO),while also promoting tumor progression through immune modulation and interactions with surrounding microenvironmental elements.Despite their potential for therapeutic applications,the clinical use of MSCs in gastric cancer is limited by challenges such as functional variability,safety concerns,and their capacity to support tumor growth.Advancing this field requires strategies to optimize MSC-based therapies,including genetic modifications,pharmacological interventions,and cell-free approaches utilizing MSC-derived exosomes.Additionally,metabolic inhibitors targeting pathways such as FAO and glycolysis present promising therapeutic avenues.This review explores the role of MSCs in gastric cancer across three key dimensions-immune suppression,interactions with the tumor microenvironmental,and metabolic modulation-highlighting innovative strategies for therapeutic advancement.These findings highlight the dual role of MSCs in gastric cancer progression and therapy,providing crucial insights for developing targeted strategies to harness their therapeutic potential while mitigating tumor-promoting effects.展开更多
Hydrogenation of CO_(2) to value-added chemicals has attracted much attention all through the world.In2 O_(3) with cubic bixbyite-type(denoted as c-In2O_(3))is well known for its high CO_(2) hydrogenation activity and...Hydrogenation of CO_(2) to value-added chemicals has attracted much attention all through the world.In2 O_(3) with cubic bixbyite-type(denoted as c-In2O_(3))is well known for its high CO_(2) hydrogenation activity and CH3 OH selectivity at high temperature.However,the other structure of In2O_(3) with rhombohedral corundum-type(denoted as rh-In2O_(3))rarely been investigated as catalyst.Herein,c-In2O_(3) and rh-In2O_(3) were prepared and comparatively studied for CO_(2) hydrogenation.The results indicated that c-In2O_(3) showed higher CO_(2) conversion activity than rh-In2O_(3) due to the impressive reducibility and reactivity.Whereas rh-In2O_(3) had higher CH3 OH selectivity due to weaker CH3 OH and stronger CO adsorption on rhIn2O_(3).Although c-In2O_(3) and rh-In2O_(3) catalysts showed different CO_(2) hydrogenation perfo rmance,in-situ diffuse reflectance infrared Fourier transform spectroscopy showed CO_(2) can be reduced to CO through redox cycling and hydrogenation to CH3 OH through formate path.展开更多
The efficient use of water and nitrogen （N） to promote growth and increase yield of fruit trees and crops is well studied.However,little is known about their effects on woody plants growing in arid and semiarid area...The efficient use of water and nitrogen （N） to promote growth and increase yield of fruit trees and crops is well studied.However,little is known about their effects on woody plants growing in arid and semiarid areas with limited water and N availability.To examine the effects of water and N supply on early growth and water use efficiency （WUE） of trees on dry soils,one-year-old seedlings of Robinia pseudoacacia were exposed to three soil water contents （non-limiting,medium drought,and severe drought） as well as to low and high N levels,for four months.Photosynthetic parameters,leaf instantaneous WUE （WUEi） and whole tree WUE （WUEb） were determined.Results showed that,independent of N levels,increasing soil water content enhanced the tree transpiration rate （Tr）,stomatal conductance （Gs）,intercellular CO2 concentration （Ci）,maximum net assimilation rate （Amax）,apparent quantum yield （AQY）,the range of photosynthetically active radiation （PAR） due to both reduced light compensation point and enhanced light saturation point,and dark respiration rate （Rd）,resulting in a higher net photosynthetic rate （Pn） and a significantly increased whole tree biomass.Consequently,WUEi and WUEb were reduced at low N,whereas WUE i was enhanced at high N levels.Irrespective of soil water availability,N supply enhanced Pn in association with an increase of Gs and Ci and a decrease of the stomatal limitation value （Ls）,while Tr remained unchanged.Biomass and WUEi increased under non-limiting water conditions and medium drought,as well as WUEb under all water conditions;but under severe drought,WUEi and biomass were not affected by N application.In conclusion,increasing soil water availability improves photosynthetic capacity and biomass accumulation under low and high N levels,but its effects on WUE vary with soil N levels.N supply increased Pn and WUE,but under severe drought,N supply did not enhance WUEi and biomass.展开更多
In this paper,a controllable leakage flux reverse salient permanent magnet synchronous motor(CLF-RSPMSM)is designed,which has the advantages of wide speed range and low irreversible demagnetization risk.Firstly,the pr...In this paper,a controllable leakage flux reverse salient permanent magnet synchronous motor(CLF-RSPMSM)is designed,which has the advantages of wide speed range and low irreversible demagnetization risk.Firstly,the principle of controllable leakage flux and reverse saliency effect is introduced,and the design of the rotor flux barrier is emphatically discussed.Secondly,multiple design variables are stratified by the comprehensive sensitivity method,and the main variables are screened out.Then the relationship between the main variables and the optimization goal is discussed according to the response surface diagram.Thirdly,a sequential nonlinear programming algorithm(SNP)is used to optimize the three optimization objectives comprehensively.Finally,the electromagnetic performance of the proposed motor is compared with the initial IPM motor,the mechanical strength of the proposed rotor is analyzed,and the results verify the effectiveness of the design and optimization method of the proposed motor.展开更多
In this paper, we study the multiple positive solutions of integral boundary value problems for a class of p-Laplacian differential equations involving the Caputo fractional derivative. Using a fixed point theorem due...In this paper, we study the multiple positive solutions of integral boundary value problems for a class of p-Laplacian differential equations involving the Caputo fractional derivative. Using a fixed point theorem due to Avery and Peterson, we obtain the existence of at least three positive decreasing solutions of the nonlocal boundary value problems. We give an example to illustrate our results.展开更多
A novel mechanical variable-leakage-flux interior permanent magnet machine(MVLF-IPMM)is proposed for electric vehicles(EVs)in this paper,which employs a mechanical flux-regulating device and auxiliary rotatable magnet...A novel mechanical variable-leakage-flux interior permanent magnet machine(MVLF-IPMM)is proposed for electric vehicles(EVs)in this paper,which employs a mechanical flux-regulating device and auxiliary rotatable magnetic poles.The magnetic poles acting as the flux adjustors can be rotated by the additional device to vary the leakage flux in magnetic circuit and realize the adjustment of the PM flux linkage.Due to the flux-regulating effect,the flux distribution in this machine is complex and changeable.Therefore,the working principle is illustrated in detail.To obtain the perfect coordination between the dominant magnetic poles and auxiliary magnetic poles,a multi-objective optimization method is presented based on the parameter sensitivity analysis combining with the Coefficient of Prognosis(CoP).Then,some design parameters with strong sensitive are selected by the sensitivity analysis and the initial model of the proposed motor is optimized by utilizing the multi-objective genetic algorithm(MOGA).According to the result of the optimization,the machine performances of the initial and the optimal design under the different flux states are compared and analyzed to verify the validity of the new variable-flux motor and the optimization method.展开更多
In this paper, we study the multiplicity of positive solutions for multi-point boundary value problem of Riemann-Liouville fractional differential equation with multi-terms fractional derivative in the boundary condit...In this paper, we study the multiplicity of positive solutions for multi-point boundary value problem of Riemann-Liouville fractional differential equation with multi-terms fractional derivative in the boundary conditions. By using the properties of the Green function and a generalization of the Leggett-Williams fixed point theorem due to the work of Bai and Ge, the sufficient conditions to guarantee the existence of at least three positive solutions are established. In the end of this paper, we have also given out the example to illustrate the wide range of potential application of our main results.展开更多
In this paper,a novel intensifying-flux variable flux-leakage interior permanent magnet(IFVF-IPM)machine is proposed,in which flux barriers were designed deliberately between the adjacent poles to obtain intensifying-...In this paper,a novel intensifying-flux variable flux-leakage interior permanent magnet(IFVF-IPM)machine is proposed,in which flux barriers were designed deliberately between the adjacent poles to obtain intensifying-flux effect and variable flux-leakage property.The rotor topology and design principles of the proposed machine are also introduced.Then,a multi-objective optimization method is adopted based on the sensitivity analysis,and some design variables of IFVF-IPM machine with strong sensitivity are selected to optimization progress by using the non-dominated sorting genetic algorithm-Ⅱ(NSGA-Ⅱ).Moreover,the electromagnetic characteristics of conventional IPM machine,conventional IFVF-IPM machine(CIFVF-IPM)and the novel IFVF-IPM machine are compared based on the finite element analysis(FEA)method which includes flux linkage,inductances characteristic,torque-speed envelops and power characteristic,as well as evaluation of the risk of irreversible demagnetization.Finally,the experiment results show that the IFVF-IPM machine has a better performance in flux weakening capability for wide speed range and a lower risk of irreversible demagnetization,which indicates the validity and feasibility of the proposed machine.展开更多
In order to meet the requirement of reliably running which is by Electric Vehicle for motor controller, the paper is focused on a sensorless brushless DC motor controller design and a commutation point method. By util...In order to meet the requirement of reliably running which is by Electric Vehicle for motor controller, the paper is focused on a sensorless brushless DC motor controller design and a commutation point method. By utilizing the saturation effect of stator iron core, six short voltage pulses are employed to estimate the initial rotor position. After that a series of voltage pulses are used to accelerate the motor. When the motor reaches a certain speed at which the back-electromotive force (EMF) method can be applied, the running state of the motor is smoothly switched at the moment determined by the relationship between the terminal voltage waveform and the commutation phases. “Lagging 90?-α commutation” is bring forward to overcome the shortages existing in the traditional method. The experimental results verify the feasibility and validity of the proposed method.展开更多
In this article, a new variable leakage flux reverse salient-pole motor(VLF-RSPM) is raised to widen the speed range. The innovation is to realize both reverse salient-pole characteristics and variable leakage flux ch...In this article, a new variable leakage flux reverse salient-pole motor(VLF-RSPM) is raised to widen the speed range. The innovation is to realize both reverse salient-pole characteristics and variable leakage flux characteristics by using a method of adding magnetic bridges and magnetic barriers. Firstly, the evolution of the topological structure and working principle of the motor are introduced. Secondly, based on 2D Finite Element Analysis(FEA), the electromagnetic properties and noise of the motor are analyzed in detail, and the electromagnetic properties are contrasted with that of the conventional V-type synchronous motor(CVTSM). The results show that VLF-RSPM has the advantages of small torque ripple, strong magnetic weakening ability, low noise, high efficiency, and low risk of permanent magnet demagnetization under different conditions. In addition, it is verified that the proposed motor extends the speed range.展开更多
基金supported by the National Natural Science Foundation of China(No.82260895).
文摘Gastric cancer remains a leading cause of cancer-related mortality worldwide,with its complex tumor microenvironment(TME)playing a crucial role in tumor initiation,progression,and therapeutic response.As key components of the TME,mesenchymal stem cells(MSCs)influence tumor cell proliferation,invasion,and treatment resistance through cytokine secretion,exosomal communication,and metabolic regulation.MSCs enhance cancer stemness and therapy resistance by modulating glycolysis and fatty acid oxidation(FAO),while also promoting tumor progression through immune modulation and interactions with surrounding microenvironmental elements.Despite their potential for therapeutic applications,the clinical use of MSCs in gastric cancer is limited by challenges such as functional variability,safety concerns,and their capacity to support tumor growth.Advancing this field requires strategies to optimize MSC-based therapies,including genetic modifications,pharmacological interventions,and cell-free approaches utilizing MSC-derived exosomes.Additionally,metabolic inhibitors targeting pathways such as FAO and glycolysis present promising therapeutic avenues.This review explores the role of MSCs in gastric cancer across three key dimensions-immune suppression,interactions with the tumor microenvironmental,and metabolic modulation-highlighting innovative strategies for therapeutic advancement.These findings highlight the dual role of MSCs in gastric cancer progression and therapy,providing crucial insights for developing targeted strategies to harness their therapeutic potential while mitigating tumor-promoting effects.
基金the National Natural Science Foundation of China(No.21878116)Natural Science Foundation of Hubei Province(No.2019CFA070)。
文摘Hydrogenation of CO_(2) to value-added chemicals has attracted much attention all through the world.In2 O_(3) with cubic bixbyite-type(denoted as c-In2O_(3))is well known for its high CO_(2) hydrogenation activity and CH3 OH selectivity at high temperature.However,the other structure of In2O_(3) with rhombohedral corundum-type(denoted as rh-In2O_(3))rarely been investigated as catalyst.Herein,c-In2O_(3) and rh-In2O_(3) were prepared and comparatively studied for CO_(2) hydrogenation.The results indicated that c-In2O_(3) showed higher CO_(2) conversion activity than rh-In2O_(3) due to the impressive reducibility and reactivity.Whereas rh-In2O_(3) had higher CH3 OH selectivity due to weaker CH3 OH and stronger CO adsorption on rhIn2O_(3).Although c-In2O_(3) and rh-In2O_(3) catalysts showed different CO_(2) hydrogenation perfo rmance,in-situ diffuse reflectance infrared Fourier transform spectroscopy showed CO_(2) can be reduced to CO through redox cycling and hydrogenation to CH3 OH through formate path.
基金supported by the National Natural Science Foundation of China(No.30972335)the International Science & Technology Cooperation Program of China(No.2010DFA34380)+1 种基金the International Cooperation Project(No.TS2010XBNL063)the "111" Project of the Education Ministry of China(No.B12007)
文摘The efficient use of water and nitrogen （N） to promote growth and increase yield of fruit trees and crops is well studied.However,little is known about their effects on woody plants growing in arid and semiarid areas with limited water and N availability.To examine the effects of water and N supply on early growth and water use efficiency （WUE） of trees on dry soils,one-year-old seedlings of Robinia pseudoacacia were exposed to three soil water contents （non-limiting,medium drought,and severe drought） as well as to low and high N levels,for four months.Photosynthetic parameters,leaf instantaneous WUE （WUEi） and whole tree WUE （WUEb） were determined.Results showed that,independent of N levels,increasing soil water content enhanced the tree transpiration rate （Tr）,stomatal conductance （Gs）,intercellular CO2 concentration （Ci）,maximum net assimilation rate （Amax）,apparent quantum yield （AQY）,the range of photosynthetically active radiation （PAR） due to both reduced light compensation point and enhanced light saturation point,and dark respiration rate （Rd）,resulting in a higher net photosynthetic rate （Pn） and a significantly increased whole tree biomass.Consequently,WUEi and WUEb were reduced at low N,whereas WUE i was enhanced at high N levels.Irrespective of soil water availability,N supply enhanced Pn in association with an increase of Gs and Ci and a decrease of the stomatal limitation value （Ls）,while Tr remained unchanged.Biomass and WUEi increased under non-limiting water conditions and medium drought,as well as WUEb under all water conditions;but under severe drought,WUEi and biomass were not affected by N application.In conclusion,increasing soil water availability improves photosynthetic capacity and biomass accumulation under low and high N levels,but its effects on WUE vary with soil N levels.N supply increased Pn and WUE,but under severe drought,N supply did not enhance WUEi and biomass.
基金This work was supported by the National Natural Science Foundation of China under Grant no.52067008in part by the Plan Project of Jiangxi Province of P.R.China under grant no.GJJ160598 and 20181BAB206035,and in part by the Program of Qingjiang Excellent Young Talents.
文摘In this paper,a controllable leakage flux reverse salient permanent magnet synchronous motor(CLF-RSPMSM)is designed,which has the advantages of wide speed range and low irreversible demagnetization risk.Firstly,the principle of controllable leakage flux and reverse saliency effect is introduced,and the design of the rotor flux barrier is emphatically discussed.Secondly,multiple design variables are stratified by the comprehensive sensitivity method,and the main variables are screened out.Then the relationship between the main variables and the optimization goal is discussed according to the response surface diagram.Thirdly,a sequential nonlinear programming algorithm(SNP)is used to optimize the three optimization objectives comprehensively.Finally,the electromagnetic performance of the proposed motor is compared with the initial IPM motor,the mechanical strength of the proposed rotor is analyzed,and the results verify the effectiveness of the design and optimization method of the proposed motor.
基金Supported by the National Natural Science Foundation of China(Grant No.11171220)the Innovation Program of Shanghai Municipal Education Commission(Grant No.10ZZ93)
文摘In this paper, we study the multiple positive solutions of integral boundary value problems for a class of p-Laplacian differential equations involving the Caputo fractional derivative. Using a fixed point theorem due to Avery and Peterson, we obtain the existence of at least three positive decreasing solutions of the nonlocal boundary value problems. We give an example to illustrate our results.
基金the National Natural Science Foundation of China under grant no.51767009in part by the Plan Project of Jiangxi Province of P.R.China under grant no.GJJ160598 and 20181BAB206035in part by the Program of Qingjiang Excellent Young Talents,Jiangxi University of Science and Technology(JXUST)。
文摘A novel mechanical variable-leakage-flux interior permanent magnet machine(MVLF-IPMM)is proposed for electric vehicles(EVs)in this paper,which employs a mechanical flux-regulating device and auxiliary rotatable magnetic poles.The magnetic poles acting as the flux adjustors can be rotated by the additional device to vary the leakage flux in magnetic circuit and realize the adjustment of the PM flux linkage.Due to the flux-regulating effect,the flux distribution in this machine is complex and changeable.Therefore,the working principle is illustrated in detail.To obtain the perfect coordination between the dominant magnetic poles and auxiliary magnetic poles,a multi-objective optimization method is presented based on the parameter sensitivity analysis combining with the Coefficient of Prognosis(CoP).Then,some design parameters with strong sensitive are selected by the sensitivity analysis and the initial model of the proposed motor is optimized by utilizing the multi-objective genetic algorithm(MOGA).According to the result of the optimization,the machine performances of the initial and the optimal design under the different flux states are compared and analyzed to verify the validity of the new variable-flux motor and the optimization method.
基金Supported by the National Natural Science Foundation of China(Grant No.11171220)the Hujiang Foundation of China(Grant No.B14005)
文摘In this paper, we study the multiplicity of positive solutions for multi-point boundary value problem of Riemann-Liouville fractional differential equation with multi-terms fractional derivative in the boundary conditions. By using the properties of the Green function and a generalization of the Leggett-Williams fixed point theorem due to the work of Bai and Ge, the sufficient conditions to guarantee the existence of at least three positive solutions are established. In the end of this paper, we have also given out the example to illustrate the wide range of potential application of our main results.
基金This work was supported in part by the National Natural Science Foundation of China under grant no.52067008.
文摘In this paper,a novel intensifying-flux variable flux-leakage interior permanent magnet(IFVF-IPM)machine is proposed,in which flux barriers were designed deliberately between the adjacent poles to obtain intensifying-flux effect and variable flux-leakage property.The rotor topology and design principles of the proposed machine are also introduced.Then,a multi-objective optimization method is adopted based on the sensitivity analysis,and some design variables of IFVF-IPM machine with strong sensitivity are selected to optimization progress by using the non-dominated sorting genetic algorithm-Ⅱ(NSGA-Ⅱ).Moreover,the electromagnetic characteristics of conventional IPM machine,conventional IFVF-IPM machine(CIFVF-IPM)and the novel IFVF-IPM machine are compared based on the finite element analysis(FEA)method which includes flux linkage,inductances characteristic,torque-speed envelops and power characteristic,as well as evaluation of the risk of irreversible demagnetization.Finally,the experiment results show that the IFVF-IPM machine has a better performance in flux weakening capability for wide speed range and a lower risk of irreversible demagnetization,which indicates the validity and feasibility of the proposed machine.
文摘In order to meet the requirement of reliably running which is by Electric Vehicle for motor controller, the paper is focused on a sensorless brushless DC motor controller design and a commutation point method. By utilizing the saturation effect of stator iron core, six short voltage pulses are employed to estimate the initial rotor position. After that a series of voltage pulses are used to accelerate the motor. When the motor reaches a certain speed at which the back-electromotive force (EMF) method can be applied, the running state of the motor is smoothly switched at the moment determined by the relationship between the terminal voltage waveform and the commutation phases. “Lagging 90?-α commutation” is bring forward to overcome the shortages existing in the traditional method. The experimental results verify the feasibility and validity of the proposed method.
基金supported by National Natural Science Foundation of China Grant No. 52067008China Jiangxi Provincial Planning Project Grant No. 20181BAB206035Qingjiang Excellent Young Talents Program,Jiangxi University of Science and Technology (JXUST)。
文摘In this article, a new variable leakage flux reverse salient-pole motor(VLF-RSPM) is raised to widen the speed range. The innovation is to realize both reverse salient-pole characteristics and variable leakage flux characteristics by using a method of adding magnetic bridges and magnetic barriers. Firstly, the evolution of the topological structure and working principle of the motor are introduced. Secondly, based on 2D Finite Element Analysis(FEA), the electromagnetic properties and noise of the motor are analyzed in detail, and the electromagnetic properties are contrasted with that of the conventional V-type synchronous motor(CVTSM). The results show that VLF-RSPM has the advantages of small torque ripple, strong magnetic weakening ability, low noise, high efficiency, and low risk of permanent magnet demagnetization under different conditions. In addition, it is verified that the proposed motor extends the speed range.
