Hydrogels emerge as a promising electrode material for scalp electroencephalogram monitoring,which stands as a pivotal technique in neuroscience,enabling real-time monitoring of brain activity.However,conventional hyd...Hydrogels emerge as a promising electrode material for scalp electroencephalogram monitoring,which stands as a pivotal technique in neuroscience,enabling real-time monitoring of brain activity.However,conventional hydrogel-enabled electrodes suffer from low scalp compliance,high scalpelectrode impedance,and inferior interfacial stability.Here,we propose an injectable eutectogelenabled electrode for high-quality,long-term scalp electroencephalogram monitoring.This gelatinbased eutectogel exhibits temperature-controlled reversible phase transitions,enabling rapid in-situ gelation on the scalp and forming a robust self-adhesive interface.It demonstrates exceptional mechanical durability(1000 cycles at 100%strain),robust adhesion(0.7 N cm^(-1)on human epidermis and 1.7 N cm^(-1)on Ag/AgCl electrode),and outstanding anti-drying properties(negligible water loss after 7 days).Additionally,the eutectogel shows superior healing properties,antibacterial properties,and recyclability.Furthermore,it exhibits remarkably low scalp-electrode contact impedance(<20 kΩat 16 Hz).The eutectogel is injected on the human scalp with dense hair for high-fidelity electroencephalogram recording,enabling long-term monitoring.Its practical applications include monitoring visual evoked potentials,steady-state visual evoked potentials,somatosensory evoked potentials,slow vertex response,auditory brainstem response,multi-channel cognitive electroencephalogram during various daily activities,and event-related potentials P300 signals.The eutectogel-enabled electrode provides a versatile and reliable solution for long-term electroencephalogram monitoring in diverse clinical and research settings.展开更多
The development of adaptable hydrogel bioelectronics capable of sustaining long-term,continuous operation is essential for advancing early disease diagnosis and enabling personalized healthcare solutions.However,chall...The development of adaptable hydrogel bioelectronics capable of sustaining long-term,continuous operation is essential for advancing early disease diagnosis and enabling personalized healthcare solutions.However,challenges such as hydrogel dehydration,poor temperature adaptability,and weak mechanical strength hinder the engineering of ultrathin,gas-permeable organohydrogel epidermal electrodes for long-term use in complex environments.Here,we report an ultrathin,robust,gas-permeable,and freeze-resistant organohydrogel epidermal electrode for high-quality electrophysiological monitoring.The 17μm-thick reinforced structure is readily achieved by dipping coating polyurethane nanomeshes into a high-temperature(55℃−75℃)gelatin-deep eutectic solvent solution and gelling at room temperature.The introduction of deep eutectic solvents significantly enhances the anti-freezing and anti-drying properties of the organohydrogel.The resulting organohydrogels exhibit superior mechanical robustness(1000 cycles at 100%strain),excellent adhesion performance(135.9μJ·cm^(-2)),high gas permeance(2.1×10^(-2)cm^(3)·cm^(-2)·s^(-1)·cmHg^(-1)),great water vapor transmission rate(1130.5 g·m^(-2)·day^(-1)),exceptional anti-freezing(−25℃),and anti-drying(98.6%weight retention after 7 days)properties.Herein,we validate the utility of these gas-permeable organohydrogel epidermal electronics for continuous,high-precision bio-signal acquisition,ensuring robust performance even within dynamic ambulatory settings.展开更多
基金support from the National Natural Science Foundation of China(grant Nos.:52303371,W2521021)Guangdong Science and Technology Department(grant Nos.:STKJ2023075,2022A1515110209,2021B0301030005)Education foundation of Guangdong Technion-Israel institute of Technology,and the Key Discipline(KD)Fund,the Technion,and the Start-Up Fund from Guangdong Technion.
文摘Hydrogels emerge as a promising electrode material for scalp electroencephalogram monitoring,which stands as a pivotal technique in neuroscience,enabling real-time monitoring of brain activity.However,conventional hydrogel-enabled electrodes suffer from low scalp compliance,high scalpelectrode impedance,and inferior interfacial stability.Here,we propose an injectable eutectogelenabled electrode for high-quality,long-term scalp electroencephalogram monitoring.This gelatinbased eutectogel exhibits temperature-controlled reversible phase transitions,enabling rapid in-situ gelation on the scalp and forming a robust self-adhesive interface.It demonstrates exceptional mechanical durability(1000 cycles at 100%strain),robust adhesion(0.7 N cm^(-1)on human epidermis and 1.7 N cm^(-1)on Ag/AgCl electrode),and outstanding anti-drying properties(negligible water loss after 7 days).Additionally,the eutectogel shows superior healing properties,antibacterial properties,and recyclability.Furthermore,it exhibits remarkably low scalp-electrode contact impedance(<20 kΩat 16 Hz).The eutectogel is injected on the human scalp with dense hair for high-fidelity electroencephalogram recording,enabling long-term monitoring.Its practical applications include monitoring visual evoked potentials,steady-state visual evoked potentials,somatosensory evoked potentials,slow vertex response,auditory brainstem response,multi-channel cognitive electroencephalogram during various daily activities,and event-related potentials P300 signals.The eutectogel-enabled electrode provides a versatile and reliable solution for long-term electroencephalogram monitoring in diverse clinical and research settings.
基金support from the Natural Science Foundation of China(Grant Nos.52303371,W2521021)Guangdong Science and Technology Department(Grant Nos.STKJ2023075,2022A1515110209,2021B0301030005)+1 种基金Education Foundation of Guangdong Technion-Israel Institute of Technology,seed fund(GCIISeed-202406)from GTIIT Changzhou Innovation Institutethe Start-Up Fund from Guangdong Technion.
文摘The development of adaptable hydrogel bioelectronics capable of sustaining long-term,continuous operation is essential for advancing early disease diagnosis and enabling personalized healthcare solutions.However,challenges such as hydrogel dehydration,poor temperature adaptability,and weak mechanical strength hinder the engineering of ultrathin,gas-permeable organohydrogel epidermal electrodes for long-term use in complex environments.Here,we report an ultrathin,robust,gas-permeable,and freeze-resistant organohydrogel epidermal electrode for high-quality electrophysiological monitoring.The 17μm-thick reinforced structure is readily achieved by dipping coating polyurethane nanomeshes into a high-temperature(55℃−75℃)gelatin-deep eutectic solvent solution and gelling at room temperature.The introduction of deep eutectic solvents significantly enhances the anti-freezing and anti-drying properties of the organohydrogel.The resulting organohydrogels exhibit superior mechanical robustness(1000 cycles at 100%strain),excellent adhesion performance(135.9μJ·cm^(-2)),high gas permeance(2.1×10^(-2)cm^(3)·cm^(-2)·s^(-1)·cmHg^(-1)),great water vapor transmission rate(1130.5 g·m^(-2)·day^(-1)),exceptional anti-freezing(−25℃),and anti-drying(98.6%weight retention after 7 days)properties.Herein,we validate the utility of these gas-permeable organohydrogel epidermal electronics for continuous,high-precision bio-signal acquisition,ensuring robust performance even within dynamic ambulatory settings.
