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中医药生命观点构思与融通
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作者 木本荣 田杰 +4 位作者 李仁凤 喻湘南 范鑫宇 卢冉 杨静 《哲学进展》 2025年第10期312-319,共8页
现代生命科学逐渐向传统中医药生命观中的部分思维靠拢,具有融合的发展趋势。本文阐释了中医药理论对生命的意义,深入探讨了关于生命构成的基本要素——“形”、“气”、“神”和生命的起源,并着重关注了三大基本要素之一的“气”与现... 现代生命科学逐渐向传统中医药生命观中的部分思维靠拢,具有融合的发展趋势。本文阐释了中医药理论对生命的意义,深入探讨了关于生命构成的基本要素——“形”、“气”、“神”和生命的起源,并着重关注了三大基本要素之一的“气”与现代生物学和现代能量场的相通之处;重点论述了中医药的“整体观”与系统生物学的有机沟通结合,以及推动“辨证论治”在精准医学的结合帮助下实现传承与创新。同时,本文分析了中西医在认识论、实践、临床等方面的差异,发现中医注重整体辩证,西医注重实体微观;还探讨了中西医融合面临的关键科学难题和挑战,如思维方式和表达差异大、视角的不同以及伦理挑战。通过整合相关论述,以“气”为核心,连接“形”和“神”,并对中医药生命观进行现代科学的解读,推进中医药文化在赓续传统的基础上创新发展,实现传承与突破的并进。 展开更多
关键词 中医药生命观 “形” “气” “神” 阴阳之气 精准医学 系统生物学
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LR-Net:Lossless Feature Fusion and Revised SIoU for Small Object Detection
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作者 Gang Li Ru Wang +5 位作者 Yang Zhang Chuanyun Xu xinyu fan Zheng Zhou Pengfei Lv Zihan Ruan 《Computers, Materials & Continua》 2025年第11期3267-3288,共22页
Currently,challenges such as small object size and occlusion lead to a lack of accuracy and robustness in small object detection.Since small objects occupy only a few pixels in an image,the extracted features are limi... Currently,challenges such as small object size and occlusion lead to a lack of accuracy and robustness in small object detection.Since small objects occupy only a few pixels in an image,the extracted features are limited,and mainstream downsampling convolution operations further exacerbate feature loss.Additionally,due to the occlusionprone nature of small objects and their higher sensitivity to localization deviations,conventional Intersection over Union(IoU)loss functions struggle to achieve stable convergence.To address these limitations,LR-Net is proposed for small object detection.Specifically,the proposed Lossless Feature Fusion(LFF)method transfers spatial features into the channel domain while leveraging a hybrid attentionmechanism to focus on critical features,mitigating feature loss caused by downsampling.Furthermore,RSIoU is proposed to enhance the convergence performance of IoU-based losses for small objects.RSIoU corrects the inherent convergence direction issues in SIoU and proposes a penalty term as a Dynamic Focusing Mechanism parameter,enabling it to dynamically emphasize the loss contribution of small object samples.Ultimately,RSIoU significantly improves the convergence performance of the loss function for small objects,particularly under occlusion scenarios.Experiments demonstrate that LR-Net achieves significant improvements across variousmetrics onmultiple datasets compared with YOLOv8n,achieving a 3.7% increase in mean Average Precision(AP)on the VisDrone2019 dataset,along with improvements of 3.3% on the AI-TOD dataset and 1.2% on the COCO dataset. 展开更多
关键词 Small object detection lossless feature fusion attention mechanisms loss function penalty term
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Implicit Feature Contrastive Learning for Few-Shot Object Detection
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作者 Gang Li Zheng Zhou +6 位作者 Yang Zhang Chuanyun Xu Zihan Ruan Pengfei Lv Ru Wang xinyu fan Wei Tan 《Computers, Materials & Continua》 2025年第7期1615-1632,共18页
Although conventional object detection methods achieve high accuracy through extensively annotated datasets,acquiring such large-scale labeled data remains challenging and cost-prohibitive in numerous real-world appli... Although conventional object detection methods achieve high accuracy through extensively annotated datasets,acquiring such large-scale labeled data remains challenging and cost-prohibitive in numerous real-world applications.Few-shot object detection presents a new research idea that aims to localize and classify objects in images using only limited annotated examples.However,the inherent challenge in few-shot object detection lies in the insufficient sample diversity to fully characterize the sample feature distribution,which consequently impacts model performance.Inspired by contrastive learning principles,we propose an Implicit Feature Contrastive Learning(IFCL)module to address this limitation and augment feature diversity for more robust representational learning.This module generates augmented support sample features in a mixed feature space and implicitly contrasts them with query Region of Interest(RoI)features.This approach facilitates more comprehensive learning of both intra-class feature similarity and inter-class feature diversity,thereby enhancing the model’s object classification and localization capabilities.Extensive experiments on PASCAL VOC show that our method achieves a respective improvement of 3.2%,1.8%,and 2.3%on 10-shot of three Novel Sets compared to the baseline model FPD. 展开更多
关键词 Few-shot learning object detection implicit contrastive learning feature mixing feature aggregation
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An Efficient Anti-Quantum Blind Signature with Forward Security for Blockchain-Enabled Internet of Medical Things
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作者 Gang Xu xinyu fan +4 位作者 Xiu-Bo Chen Xin Liu Zongpeng Li Yanhui Mao Kejia Zhang 《Computers, Materials & Continua》 2025年第2期2293-2309,共17页
Blockchain-enabled Internet of Medical Things (BIoMT) has attracted significant attention from academia and healthcare organizations. However, the large amount of medical data involved in BIoMT has also raised concern... Blockchain-enabled Internet of Medical Things (BIoMT) has attracted significant attention from academia and healthcare organizations. However, the large amount of medical data involved in BIoMT has also raised concerns about data security and personal privacy protection. To alleviate these concerns, blind signature technology has emerged as an effective method to solve blindness and unforgeability. Unfortunately, most existing blind signature schemes suffer from the security risk of key leakage. In addition, traditional blind signature schemes are also vulnerable to quantum computing attacks. Therefore, it remains a crucial and ongoing challenge to explore the construction of key-secure, quantum-resistant blind signatures. In this paper, we introduce lattice-based forward-secure blind signature (LFSBS), a lattice-based forward-secure blind signature scheme for medical privacy preservation in BIoMT. LFSBS achieves forward security by constructing a key evolution mechanism using a binary tree structure. This mechanism ensures that even if future encryption keys are leaked, past data can still remain secure. Meanwhile, LFSBS realizes post-quantum security based on the hardness assumption of small integer solution (SIS), making it resistant to potential quantum computing attacks. In addition, we formally define and prove the security of LFSBS in a random oracle model, including blindness and forward-secure unforgeability. Comprehensive performance evaluation shows that LFSBS performs well in terms of computational overhead, with a reduction of 22%–73% compared to previous schemes. 展开更多
关键词 Internet of Things blockchain forward-secure blind signature
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Sub-femtometer-resolution absolute spectroscopy with sweeping electro-optic combs 被引量:5
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作者 Bingxin Xu xinyu fan +1 位作者 Shuai Wang Zuyuan He 《Opto-Electronic Advances》 SCIE EI CAS 2022年第12期35-43,共9页
Optical frequency comb with evenly spaced lines over a broad bandwidth has revolutionized the fields of optical metrology and spectroscopy.Here,we propose a fast interleaved dual-comb spectroscopy with sub-femtometer-... Optical frequency comb with evenly spaced lines over a broad bandwidth has revolutionized the fields of optical metrology and spectroscopy.Here,we propose a fast interleaved dual-comb spectroscopy with sub-femtometer-resolution and absolute frequency,in which two electro-optic frequency combs are swept.Electrically-modulated stabilized laser enables ultrahigh resolution of 0.16 fm(or 20 k Hz in optical frequency)and single-shot measurement in 90 ms.Total 20 million points are recorded spanning 3.2 nm(or 400 GHz)bandwidth,corresponding to a spectral sampling rate of 2.5×10^(8)points/s under Nyquist-limitation.Besides,considering the trade-off between the measurement time and spectral resolution,a fast single-shot measurement is also realized in 1.6 ms with 8 fm(or 1 MHz)resolution.We demonstrate the 25-averaged result with 30.6 d B spectral measurement signal-to-noise ratio(SNR)by reducing the filter bandwidth in demodulation.The results show great prospect for precise measurement with flexibly fast refresh time,high spectral resolution,and high SNR. 展开更多
关键词 dual-comb spectroscopy optical frequency comb interferometry
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UAV-Aided Data and Energy Integrated Network: System Design and Prototype Development 被引量:2
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作者 xinyu fan Jie Hu Kun Yang 《China Communications》 SCIE CSCD 2023年第7期290-302,共13页
Terminal devices deployed in outdoor environments are facing a thorny problem of power supply.Data and energy integrated network(DEIN)is a promising technology to solve the problem,which simultaneously transfers data ... Terminal devices deployed in outdoor environments are facing a thorny problem of power supply.Data and energy integrated network(DEIN)is a promising technology to solve the problem,which simultaneously transfers data and energy through radio frequency signals.State-of-the-art researches mostly focus on theoretical aspects.By contrast,we provide a complete design and implementation of a fully functioning DEIN system with the support of an unmanned aerial vehicle(UAV).The UAV can be dispatched to areas of interest to remotely recharge batteryless terminals,while collecting essential information from them.Then,the UAV uploads the information to remote base stations.Our system verifies the feasibility of the DEIN in practical applications. 展开更多
关键词 data and energy integrated network(DEIN) internet of things(IoT) simultaneous wire-less information and power transfer(SWIPT) wireless energy transfer(WET) prototype
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Loss Analysis of Electromagnetic Linear Actuator Coupling Control Electromagnetic Mechanical System
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作者 Jiayu Lu Qijing Qin +2 位作者 Cao Tan Bo Li xinyu fan 《Energy Engineering》 EI 2021年第6期1741-1754,共14页
As an energy converter,electromagnetic linear actuators(EMLAs)have been widely used in industries.Multidisciplinary methodology is a preferred tool for the design and optimization of EMLA.In this paper,a multidiscipli... As an energy converter,electromagnetic linear actuators(EMLAs)have been widely used in industries.Multidisciplinary methodology is a preferred tool for the design and optimization of EMLA.In this paper,a multidisciplinary method was proposed for revealing the influence mechanism of load on EMLA’s loss.The motion trajectory of EMLA is planned through tracking differentiator,an adaptive robust control was adopted to compensate the influence of load on motion trajectory.A control-electromagnetic-mechanical coupling model was established and verified experimentally.The influence laws of load change on EMLA’s loss,loss composition and loss distribution were analyzed quantitatively.The results show that the data error of experiment,and simulation result of input energy,mechanical work,and iron loss is less than 3%.The iron loss accounts for less than 54.9%of the total loss under no-load condition,while the iron loss increases with the increase of load.For iron loss distribution,only the percentage of inner yoke keeps increasing with the increase of load.The composition and distribution of loss are the basis of thermal analysis and design. 展开更多
关键词 Multidisciplinary methodology electromagnetic linear actuator loss analysis control method coupling model
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Through-Thickness Thermal Conductivity Prediction Study on Nanocomposites and Multiscale Composites
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作者 Michael Zimmer xinyu fan +4 位作者 Jianwen Bao Richard Liang Ben Wang Chuck Zhang James Brooks 《Materials Sciences and Applications》 2012年第3期131-138,共8页
In this research, a modeling and experimental study was conducted to explore the effects of nanoparticle type (aluminum nanoparticles and carbon nanotubes), filler concentration and interactions between the nanopartic... In this research, a modeling and experimental study was conducted to explore the effects of nanoparticle type (aluminum nanoparticles and carbon nanotubes), filler concentration and interactions between the nanoparticle and reinforcing fibers on through-thickness conductivity of nanoparticle/epoxy nanocomposites and nanoparticle/fiber-reinforced multiscale composites. Multiple, notable micromechanical models were evaluated to predict through-thickness thermal conductivity of both composite systems, and then compared to the experimental results. The results showed that filler volume fraction ranges and thermal conductivity differences of the constituent materials for the thermal conductivity ratio (km/kf or kf/km) used in the models can affect the resulting predictions. Certain models were found to be suitable for varying conditions on the thermal conductivity ratio. Finite element models (FEM) were developed to reveal heat transport mechanisms of the resultant nanocomposites and multiscale composites. The nanocomposite design for finite element analysis (FEA) provided close predictions and performed better than the micromechanical models. On the multiscale composite system, predictions were concluded to be dependent upon the FEM design where the interactions between nanoparticles and fibers are critical to accurately determine the through-thickness thermal conductivity. 展开更多
关键词 Thermal CONDUCTIVITY MICROMECHANICAL MODELS Finite Element MODELS NANOCOMPOSITES Multiscale COMPOSITES Carbon NANOTUBES
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基于机器学习的电催化剂设计与催化机理研究
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作者 郭柯香 范欣宇 +2 位作者 陈乐添 张旭 周震 《中国科学:化学》 北大核心 2025年第6期1660-1673,共14页
本综述探讨了机器学习在电催化剂设计中的应用,尤其是在筛选高效电催化剂和加速催化过程中的作用.面对气候变化和能源需求的双重挑战,清洁能源技术成为可持续发展的核心,电催化作为关键技术发挥着重要作用.然而,传统的“试错法”存在高... 本综述探讨了机器学习在电催化剂设计中的应用,尤其是在筛选高效电催化剂和加速催化过程中的作用.面对气候变化和能源需求的双重挑战,清洁能源技术成为可持续发展的核心,电催化作为关键技术发挥着重要作用.然而,传统的“试错法”存在高成本和低效率的问题,机器学习通过精确预测电催化性能、加速催化剂筛选与设计,成为解决这一瓶颈的重要工具.描述符能够揭示催化剂的基本特征与性能之间的关系,进而加速筛选过程.本文探讨了描述符如何在电催化剂设计中桥接基本特征与性能之间的关系,并综述了当前机器学习势在催化机制研究中的应用.此外,还介绍了大型语言模型在电催化剂设计中的创新应用.本文展示了机器学习在复杂反应机制探索中的巨大潜力,并展望了未来的发展趋势和挑战. 展开更多
关键词 机器学习 电催化剂 描述符 催化机制
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Novel intelligent adaptive sliding mode control for marine fuel cell system via hybrid algorithm
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作者 Shiyi fang Daifen Chen xinyu fan 《Energy and AI》 2025年第1期96-112,共17页
The transition towards renewable energy in the marine sector has garnered increasing international focus,with PEMFC(Proton Exchange Membrane Fuel Cell)emerging as a viable low-carbon solution for maritime vessels.This... The transition towards renewable energy in the marine sector has garnered increasing international focus,with PEMFC(Proton Exchange Membrane Fuel Cell)emerging as a viable low-carbon solution for maritime vessels.This technology is not only limited to small vessels,but also is applicable to the auxiliary power systems of larger ships.In this paper,a hybrid control scheme based on optimization algorithms and observer are presented.This strategy is designed to enhance the safety and efficiency of stack’s operation during navigation.Within the control system,a sliding mode observer monitors system perturbations,ensuring optimal controller performance.The control strategy employs a non-singular fast terminal sliding surface for the controller,integrating a fuzzy logic and particle swarm optimization to tune the sliding mode gain and dynamically regulate output,thereby enhancing system efficiency and minimizing energy consumption.Results indicate that the newly developed control methodology significantly boosts both the efficiency and dependability of marine PEMFC stack. 展开更多
关键词 Marine PEMFC stack Intelligent controller Decarbonized ship Supply system
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High-resolution mid-infrared dual electro-optic comb interferometer based on spectral interleaving
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作者 Zhengchao Yuan xinyu fan +1 位作者 Bingxin Xu Zuyuan He 《Chinese Optics Letters》 2025年第9期166-170,共5页
We demonstrate a high-resolution mid-infrared(MIR)dual-comb interferometer(DCI)using spectral interleaving.By generating electro-optic frequency combs(EOFCs)at 1550 nm via a dual-drive Mach-Zehnder modulator(DD-MZM)an... We demonstrate a high-resolution mid-infrared(MIR)dual-comb interferometer(DCI)using spectral interleaving.By generating electro-optic frequency combs(EOFCs)at 1550 nm via a dual-drive Mach-Zehnder modulator(DD-MZM)and employing injection locking to create a linearly swept lightwave spanning 18 GHz,we achieve gapless spectral interleaving.This swept lightwave serves as the seed for dual EOFCs with a 1 MHz repetition rate difference,which are subsequently converted to the MIR region(3.3μm)via difference frequency generation(DFG).Experimental results demonstrate a dual-comb spectrum spanning 486 GHz with a 100 MHz resolution,validated by direct detection and demodulation. 展开更多
关键词 mid-infrared region electro-optic comb spectral interleaving
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High-accuracy distributed forward state-of-polarization reconstruction in optical fibers enabled by polarization-sensitive optical frequency domain reflectometry
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作者 Yidai Zhu xinyu fan +1 位作者 Yangyang Wan Zuyuan He 《Chinese Optics Letters》 2025年第9期55-60,共6页
We propose a method for reconstructing the distributed forward state of polarization(SOP)in single-mode fibers(SMFs)to solve the problem of an unpredictable blind box of SOP evolution in many applications such as fibe... We propose a method for reconstructing the distributed forward state of polarization(SOP)in single-mode fibers(SMFs)to solve the problem of an unpredictable blind box of SOP evolution in many applications such as fiber-optic parametric amplification systems.Using polarization-sensitive optical frequency domain reflectometry(POFDR)and a quaternion-based model to describe polarization changes,our approach achieves high spatial resolution and precision.By an improved iterative fitting algorithm,the mean square error(MSE)of forward SOP reconstruction for approximately 100 consecutive measurement points was reduced to below 0.1%.This method enables visualization of SOP dynamics along the fiber,offering critical insights for polarization-dependent systems. 展开更多
关键词 state of polarization reconstruction polarization-sensitive optical frequency domain reflectometry QUATERNION
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Integrated sensing and communication in an optical fibre 被引量:18
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作者 Haijun He Lin Jiang +7 位作者 Yan Pan Anlin Yi Xihua Zou Wei Pan Alan E.Willner xinyu fan Zuyuan He Lianshan Yan 《Light(Science & Applications)》 SCIE EI CSCD 2023年第5期729-742,共14页
The integration of high-speed optical communication and distributed sensing could bring intelligent functionalities to ubiquitous optical fibre networks,such as urban structure imaging,ocean seismic detection,and safe... The integration of high-speed optical communication and distributed sensing could bring intelligent functionalities to ubiquitous optical fibre networks,such as urban structure imaging,ocean seismic detection,and safety monitoring of underground embedded pipelines.This work demonstrates a scheme of integrated sensing and communication in an optical fibre(ISAC-OF)using the same wavelength channel for simultaneous data transmission and distributed vibration sensing.The scheme not only extends the intelligent functionality for optical fibre communication system,but also improves its transmission performance.A periodic linear frequency modulation(LFM)light is generated to act as the optical carrier and sensing probe in PAM4 signal transmission and phase-sensitive optical time-domain reflectometry(Φ-OTDR),respectively.After a 24.5 km fibre transmission,the forward PAM4 signal and the carriercorrespondence Rayleigh backscattering signal are detected and demodulated.Experimental results show that the integrated solution achieves better transmission performance(~1.3 dB improvement)and a larger launching power(7 dB enhancement)at a 56 Gbit/s bit rate compared to a conventional PAM4 signal transmission.Meanwhile,a 4m spatial resolution,4.32-nε/√Hz strain resolution,and over 21 kHz frequency response for the vibration sensing are obtained.The proposed solution offers a new path to further explore the potential of existing or future fibre-optic networks by the convergence of data transmission and status sensing.In addition,such a scheme of using shared spectrum in communication and distributed optical fibre sensing may be used to measure non-linear parameters in coherent optical communications,offering possible benefits for data transmission. 展开更多
关键词 COMMUNICATION OPTICAL FIBRE
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Review on Speckle-Based Spectrum Analyzer 被引量:7
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作者 Yangyang WAN xinyu fan Zuyuan HE 《Photonic Sensors》 SCIE EI CSCD 2021年第2期187-202,共16页
Accurate spectral measurement and wavelength determination are fundamental and vital for many fields.A compact spectrum analyzer with high performance is expected to meet the growing requirements,and speckle-based spe... Accurate spectral measurement and wavelength determination are fundamental and vital for many fields.A compact spectrum analyzer with high performance is expected to meet the growing requirements,and speckle-based spectrum analyzer is a potential solution.The basic principle is based on using the random medium to establish a speckle-to-wavelength mapping relationship for spectrum reconstruction.This article introduces current speckle-based spectrum analyzers with different schemes and reviews recent advances in this field.Besides,some applications by using speckle-based spectrum analyzers are also introduced.Finally,the existing challenges and the future prospects of using speckle for spectrum recovery are discussed. 展开更多
关键词 SPECKLE spectrum analyzer random medium SPECTROSCOPY
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Single-end hybrid Rayleigh Brillouin and Raman distributed fibre-optic sensing system 被引量:6
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作者 Linjing Huang xinyu fan +2 位作者 Haijun He Lianshan Yan Zuyuan He 《Light(Advanced Manufacturing)》 2023年第3期171-180,共10页
Backscattered lightwaves from an optical fibre are used to realise distributed fibre optic sensing(DFOS)systems for measuring various parameters.Rayleigh,Brillouin,and Raman backscattering provide different sensitivit... Backscattered lightwaves from an optical fibre are used to realise distributed fibre optic sensing(DFOS)systems for measuring various parameters.Rayleigh,Brillouin,and Raman backscattering provide different sensitivities to different measurands and have garnered the attention of researchers.A system combining the three principles above can effectively separate the measured strain and temperature completely as well as provide measurements of both dynamic and static parameters.However,the combined system is extremely complicated if the three systems are independent of each other.Hence,we propose a single-end hybrid DFOS system that uses two successive pulses to realise the Brillouin amplification of Rayleigh backscattering lightwaves for combining Rayleigh and Brillouin systems.A 3-bit pulse-coding method is employed to demodulate the Raman scattering of the two pulses to integrate Raman optical time-domain reflectometry into the hybrid system.Using this hybrid scheme,a simultaneous measurement of multiple parameters is realised,and a favourable measurement accuracy is achieved. 展开更多
关键词 Rayleigh backscattering Brillouin backscattering Raman backscattering Distributed fiber-optic sensing system
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Single-element amorphous palladium nanoparticles formed via phase separation 被引量:1
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作者 Dong Sheng He Yi Huang +13 位作者 Benjamin D.Myers Dieter Isheim xinyu fan Guang-Jie Xia Yunsheng Deng Lin Xie Shaobo Han Yang Qiu Yang-Gang Wang Junhua Luan Zengbao Jiao Li Huang Vinayak P.Dravid Jiaqing He 《Nano Research》 SCIE EI CSCD 2022年第6期5575-5580,共6页
Physically vitrifying amorphous single-element metal requires ultrahigh cooling rates,which are still unachievable for most of the closest-packed metals.Here,we report a facile chemical synthetic strategy for single-e... Physically vitrifying amorphous single-element metal requires ultrahigh cooling rates,which are still unachievable for most of the closest-packed metals.Here,we report a facile chemical synthetic strategy for single-element amorphous palladium nanoparticles with a purity of 99.35 at.%±0.23 at.%from palladium–silicon liquid droplets.In-situ transmission electron microscopy directly detected the solidification of palladium and the separation of silicon.Further hydrogen absorption experiment showed that the amorphous palladium expanded little upon hydrogen uptake,exhibiting a great potential application for hydrogen separation.Our results provide insight into the formation of amorphous metal at nanoscale. 展开更多
关键词 Pd single-element metallic glass nanoparticle phase separation UNDERCOOLING
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Study on frictional behavior of SiC_(f)/SiC composite clad tube clamping condition under nuclear irradiation 被引量:1
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作者 Chenglong XIAO Liangliang SHEN +5 位作者 Tianqi ZHU Jianbo TANG Ximing XIE xinyu fan Jian XU Zhiying REN 《Friction》 SCIE EI CAS CSCD 2024年第5期919-938,共20页
Silicon carbide fiber reinforced silicon carbide matrix(SiC_(f)/SiC)composite is the key cladding material of nuclear fuel,which determines the safety and reliability of nuclear fuel storage and transportation.The rep... Silicon carbide fiber reinforced silicon carbide matrix(SiC_(f)/SiC)composite is the key cladding material of nuclear fuel,which determines the safety and reliability of nuclear fuel storage and transportation.The replacement of its storage and transportation scenario needs to be completed by the manipulator,but the application of SiC_(f)/SiC wear,fracture,and nuclear leakage in the snatching process of brittle-flexible-rigid contact in the irradiation environment has been seriously restricted due to unclear understanding of the damage mechanism.Therefore,the effects of irradiation dose and clamping load on the friction characteristics of the contact interface between SiC_(f)/SiC clad tube are studied in this paper,and the effects of irradiation parameters and clamping force on the static friction coefficient of the contact interface between the clad tube and flexible nitrile are obtained.Based on the Greenwood-Williamson tribological model,a numerical model of the shape and structure of the contact micro-convex at the micro-scale of the clamping interface is constructed by introducing the multi-surface integral,and finally verified by experiments.The research results show that there is a unique“Irradiation suppression zone”under the clamping condition of SiC_(f)/SiC cladding tube under the nuclear irradiation environment,and the growth of static friction coefficient slows down until stagnates after irradiation reaches a certain extent(600 kGy),and there will be a decline when the irradiation dose continues to increase,among which the clamping force of 15.2 N within the irradiation interval of 1,000 kGy can meet the safety of nuclear environment operation.The results of this paper can provide an important theoretical basis and application guidance for the safe operation of SiC_(f)/SiC cladding tubes in the storage and transportation clamping process. 展开更多
关键词 SiC_(f)/SiC Clad tube nuclear irradiation conditions Greenwood-Williamson tribological model multi-surface integral
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2D4,a humanized monoclonal antibody targeting CD132,is a promising treatment for systemic lupus erythematosus 被引量:3
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作者 Huiqi Yin Liming Li +9 位作者 Xiwei Feng Zijun Wang Meiling Zheng Junpeng Zhao xinyu fan Wei Wu Lingyu Gao Yijing Zhan Ming Zhao Qianjin Lu 《Signal Transduction and Targeted Therapy》 CSCD 2024年第12期5693-5707,共15页
Current therapies for systemic lupus erythematosus that target a particular factor or cell type exhibit limited effectiveness.To address this limitation,our focus was on CD132,a subunit common to six inflammatory fact... Current therapies for systemic lupus erythematosus that target a particular factor or cell type exhibit limited effectiveness.To address this limitation,our focus was on CD132,a subunit common to six inflammatory factor receptors implicated in SLE.Our study revealed heightened CD132 expression in SLE patients’lymphocytes,contributing to the production of pro-inflammatory cytokines and immunoglobulins.We developed a novel humanized anti-CD132 monoclonal antibody,named as 2D4.2D4 efficiently blocked IL-21 and IL-15,with limited effectiveness against IL-2,thereby suppressing T and B cells without disrupting immune tolerance.In the mouse immunization model,2D4 virtually inhibited T cell-dependent,antigen-specific B-cell response.In lupus murine models,2D4 mitigated inflammation by suppressing multiple pro-inflammatory cytokines and anti-dsDNA antibody titers,also diminishing proteinuria and glomerulonephritis.Compared to Belimumab,2D4 exhibited superior efficacy in ameliorating the inflammatory state and preserving renal function.Moreover,2D4 exhibited the ability to inhibit the production of pro-inflammatory factors and autoantibodies in PBMCs from individuals with SLE,highlighting its therapeutic potential for SLE individuals.Potent,2D4 has the potential to significantly improve clinical outcomes in SLE and other complex autoimmune disorders. 展开更多
关键词 CD13 LUPUS ERYTHEMATOSUS
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Whispering-gallery-mode barcode-based broadband sub-femtometer-resolution spectroscopy with an electro-optic frequency comb 被引量:1
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作者 Bingxin Xu Yangyang Wan +1 位作者 xinyu fan Zuyuan He 《Advanced Photonics》 SCIE EI CAS CSCD 2024年第1期115-125,共11页
Spectroscopy is the basic tool for studying molecular physics and realizing biochemical sensing.However,it is challenging to realize sub-femtometer resolution spectroscopy over broad bandwidth.Broadband and high-resol... Spectroscopy is the basic tool for studying molecular physics and realizing biochemical sensing.However,it is challenging to realize sub-femtometer resolution spectroscopy over broad bandwidth.Broadband and high-resolution spectroscopy with calibrated optical frequency is demonstrated by bridging the fields of speckle pattern and electro-optic frequency comb.A wavemeter based on a whispering-gallery-mode barcode is proposed to link the frequencies of a probe continuous-wave laser and an ultrastable laser.The ultrafine electro-optic comb lines are generated from the probe laser to record spectrum of sample with sub-femtometer resolution.Measurement bandwidth is a thousandfold broader than comb bandwidth,by sequentially tuning the probe laser while its wavelength is determined.This approach fully exploits the advantages of two fields to realize 0.8-fm resolution with a fiber laser and 80-nm bandwidth with an external cavity diode laser.The spectroscopic measurements of an ultrahigh Q-factor cavity and gas molecular absorption are experimentally demonstrated.The compact system,predominantly constituted by few-gigahertz electronics and telecommunication components,shows enormous potential for practical spectroscopic applications. 展开更多
关键词 frequency comb reconstructive wavemeter SPECTROSCOPY
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Machine learning guided discovery of ternary compounds involving La and immiscible Co and Pb elements
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作者 Renhai Wang Weiyi Xia +5 位作者 Tyler JSlade xinyu fan Huafeng Dong Kai-Ming Ho Paul C.Canfield Cai-Zhuang Wang 《npj Computational Materials》 SCIE EI CSCD 2022年第1期2462-2470,共9页
Ternary compounds with an immiscible pair of elements are relatively unexplored but promising for novel quantum materials discovery.Exploring what third element and its ratio that can be added to make stable ternary c... Ternary compounds with an immiscible pair of elements are relatively unexplored but promising for novel quantum materials discovery.Exploring what third element and its ratio that can be added to make stable ternary compounds out of an immiscible pair of elements remains a great challenge.In this work,we combine a machine learning(ML)method with ab initio calculations to efficiently search for the energetically favorable ternary La-Co-Pb compounds containing immiscible elements Co and Pb.Three previously reported structures are correctly captured by our approach.Moreover,we predict a ground state La_(3)CoPb compound and 57 low-energy La-Co-Pb ternary compounds.Attempts to synthesize La_(3)CoPb via multiple techniques produce mixed or multi-phases samples with,at best,ambiguous signals of the predicted lowest-energy La_(3)CoPb and the second lowest-energy La_(18)Co_(28)Pb_(3)phases.The calculated results of Gibbs free energy are consistent with experiments,and will provide very useful guidance for further experimental synthesis. 展开更多
关键词 ELEMENTS IMMISCIBLE TERNARY
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