A series of 3DOM CeMnO3 perovskite catalysts were prepared by poly(methyl methacrylate)hardtemplating-excessive impregnation method at calcination temperature of x℃(x=600,700,800)and the heating rate of y℃/min(y=1,2...A series of 3DOM CeMnO3 perovskite catalysts were prepared by poly(methyl methacrylate)hardtemplating-excessive impregnation method at calcination temperature of x℃(x=600,700,800)and the heating rate of y℃/min(y=1,2,5,10).The samples were characterized by Brunauer-Emmett-Teller method,scanning electron microscopy,transmission electron microscopy,H2-temperature programmed reduction,X-ray photoelectron spectroscopy,X-ray diffraction,moreover,the effect of the calcination process on the catalytic activity of the samples were discussed by the catalytic combustion of toluene.The results show that the 3DOM CeMnO3 catalysts calcined at 600℃promote the formation of a perovskite structure,inhibit the reduction of the Mn4+species in the catalyst with high temperature.The catalyst expresses the complete macroporous structure,large specific surface area(38.8 m^(2)/g),higher adsorption oxygen concentration and Mn4+substance concentration,with a low T90%=172℃.By preparing the catalysts at different calcination heating rates,it can be concluded that the catalyst possesses a high concentration of adsorbed oxygen and a low reduction temperature and a large specific surface area(40.42 m^(2)/g)greatly promotes adsorption stage catalytic oxidation reaction and catalytic combustion of toluene at low temperature under the heating rate of 5℃/min.When the heating rate is 1℃/min,the catalyst has a complete macroporous structure(>250 nm),which is beneficial to the exchange of macromolecular substances during the catalytic reaction and the catalyst has a high concentration of lattice oxygen suitable for the catalysis of toluene in high temperature flue gas combustion.展开更多
Metal-and metal-oxide-based nanoparticles have been widely exploited in cancer photodynamic therapy(PDT).Among these materials,cerium-based nanoparticles have drawn extensive attention due to their superior biosafety ...Metal-and metal-oxide-based nanoparticles have been widely exploited in cancer photodynamic therapy(PDT).Among these materials,cerium-based nanoparticles have drawn extensive attention due to their superior biosafety and distinctive physicochemical properties,especially the reversible transition between the valence states of Ce(Ⅲ)and Ce(Ⅳ).In this review,the recent advances in the use of cerium-based nanoparticles as novel photosensitizers for cancer PDT are discussed,and the activation mechanisms for electron transfer to generate singlet oxygen are presented.In addition,the types of cerium-based nanoparticles used for PDT of cancer are summarized.Finally,the challenges and prospects of clinical translations of cerium-based nanoparticles are briefly addressed.展开更多
Chemodynamic therapy(CDT)utilizes Fenton and/or Fenton-like reactions in the tumor microenvironment(TME)to produce cytotoxic reactive oxygen spe-cies(ROS,mainly hydroxyl radicals,·OH)for inducing cancer cell deat...Chemodynamic therapy(CDT)utilizes Fenton and/or Fenton-like reactions in the tumor microenvironment(TME)to produce cytotoxic reactive oxygen spe-cies(ROS,mainly hydroxyl radicals,·OH)for inducing cancer cell death.Since CDT exhibits minimal invasiveness and high tumor specificity by responding to TME(overexpressed hydrogen peroxide(H_(2)O_(2))and glutathione(GSH)gener-ation),a lot of related research has been conducted recently.Photo-facilitated CDT can further enhance the catalytic activity and controllability of the treat-ment.In addition,other photo-induced therapies,including photodynamic and photothermal therapy(PDT,PTT),may synergize with CDT to obtain boosting treatment efficacy and avoid multidrug resistance.In this minireview,we summarizethe recentadvancesinphoto-assisted CDT,including PTT-facilitated CDT and PDT-facilitated CDT.More importantly,the challenges encountered in the treatment process are discussed and potential development directions are suggested to facilitate the clinicaltranslation of photo-assisted CDT in the future.展开更多
Quasi-two-dimensional perovskite light-emitting diodes (quasi-2D PeLEDs) are emerging as high-potential candidates for new generation of wide-color gamut displays due to their simple, low-cost solution process, and hi...Quasi-two-dimensional perovskite light-emitting diodes (quasi-2D PeLEDs) are emerging as high-potential candidates for new generation of wide-color gamut displays due to their simple, low-cost solution process, and high color purity. However, the luminescence performance of quasi-2D perovskite films is severely limited by dispersed phase distribution and excessive defect density, which are caused by excessive diffusion of nucleation sites during the perovskite growth stage. Here, the benzylphosphonic acid (BPA) molecule, owing to its strong P-O-Pb bond energy sites and strong electronegativity to PEA+, can aggregate lead-halide octahedron to grow high-dimensional phases, avoiding scattered low-dimensional phases (n = 1). The continuous gradient phase distribution will be beneficial to smooth carrier injection and effectively suppress the leakage current in PeLEDs. Meanwhile, the introduction of phosphonic acid groups will fill the vacancies of Pb ions and reduce non-radiative recombination. As a result, the maximum external quantum efficiency (EQE) of PeLEDs can be increased from 8% to 20.6% with a 514 nm light emission and a 21 nm full-width half maximum, and the device lifetime (T 50) is nearly 6-fold of the pristine sample. In addition, this strategy is also suitable for other wavelength. For example, in blue light, performance improvement is also realized that the maximum EQE of 8% and the luminance increased from 1045 to 5264 cd/m2. These results provide a feasible strategy to regulate the phase distribution and passivate the defects of quasi-2D perovskites.展开更多
Main text Cerebral small vessel disease(CSVD)is a prevalent cer-ebrovascular disease characterized by chronic vascular dysfunction[1],primarily diagnosed using MRI-based markers such as white matter hyperintensities(W...Main text Cerebral small vessel disease(CSVD)is a prevalent cer-ebrovascular disease characterized by chronic vascular dysfunction[1],primarily diagnosed using MRI-based markers such as white matter hyperintensities(WMHs),cerebral microbleeds,perivascular spaces,and lacunes[2].CSVD also involves blood-brain barrier(BBB)dis-ruption,evident with an elevated cerebrospinal fluid(CSF)/serum albumin ratio(also called Albumin Quo-tient,QAlb)[3].Despite these markers reflecting dif-ferent aspects of cerebrovascular disease,its underlying causes are not fully understood.Interestingly,CSVD often coincides with Alzheimer’s disease(AD)pathol-ogy[4].展开更多
基金Project supported by Natural Science Foundation of Shandong Province(ZR2019MEE112)。
文摘A series of 3DOM CeMnO3 perovskite catalysts were prepared by poly(methyl methacrylate)hardtemplating-excessive impregnation method at calcination temperature of x℃(x=600,700,800)and the heating rate of y℃/min(y=1,2,5,10).The samples were characterized by Brunauer-Emmett-Teller method,scanning electron microscopy,transmission electron microscopy,H2-temperature programmed reduction,X-ray photoelectron spectroscopy,X-ray diffraction,moreover,the effect of the calcination process on the catalytic activity of the samples were discussed by the catalytic combustion of toluene.The results show that the 3DOM CeMnO3 catalysts calcined at 600℃promote the formation of a perovskite structure,inhibit the reduction of the Mn4+species in the catalyst with high temperature.The catalyst expresses the complete macroporous structure,large specific surface area(38.8 m^(2)/g),higher adsorption oxygen concentration and Mn4+substance concentration,with a low T90%=172℃.By preparing the catalysts at different calcination heating rates,it can be concluded that the catalyst possesses a high concentration of adsorbed oxygen and a low reduction temperature and a large specific surface area(40.42 m^(2)/g)greatly promotes adsorption stage catalytic oxidation reaction and catalytic combustion of toluene at low temperature under the heating rate of 5℃/min.When the heating rate is 1℃/min,the catalyst has a complete macroporous structure(>250 nm),which is beneficial to the exchange of macromolecular substances during the catalytic reaction and the catalyst has a high concentration of lattice oxygen suitable for the catalysis of toluene in high temperature flue gas combustion.
基金supported by the National Natural Science Foundation(NNSF)of China(52103166 and 61935004)the Natural Science Foundation(NSF)of Jiangsu Province(BK20200710)+3 种基金Jiangsu Postdoctoral Science Foundation(51204087)NSF of Shandong Province(ZR2020KB018)Taishan Scholars"Construction Special Fund of Shandong Province,the Natural Science Foundation of Ningbo(202003N40448)the Open Project Program of Wuhan National Laboratory for Optoelectronics No.2020WNLOKF022.
文摘Metal-and metal-oxide-based nanoparticles have been widely exploited in cancer photodynamic therapy(PDT).Among these materials,cerium-based nanoparticles have drawn extensive attention due to their superior biosafety and distinctive physicochemical properties,especially the reversible transition between the valence states of Ce(Ⅲ)and Ce(Ⅳ).In this review,the recent advances in the use of cerium-based nanoparticles as novel photosensitizers for cancer PDT are discussed,and the activation mechanisms for electron transfer to generate singlet oxygen are presented.In addition,the types of cerium-based nanoparticles used for PDT of cancer are summarized.Finally,the challenges and prospects of clinical translations of cerium-based nanoparticles are briefly addressed.
基金supported by the National Key Plan for Scientific Research and Development of China(2020YFA0509304 and 2021YFA0805300)the Chinese Academy of Sciences(XDB39000000)+3 种基金the National Natural Science Foundation of China(82030034,32121002,and 81971123)CAMS Innovation Fund for Medical Sciences(2021-I2M-C&T-B-012)the Fundamental Research Funds for the Central Universities(YD9110002027)the Guangzhou Key Research Program on Brain Science(202007030008)。
基金Jiangsu Provincial Key Research and Development Plan,Grant/Award Number:BE2021711NNSF of China,Grant/Award Numbers:62120106002,22175089,61935004+2 种基金‘Taishan scholars’construction special fund of Shandong ProvinceNSF of Shandong Province,Grant/Award Number:ZR2020KB018Jiangsu Province Postgraduate Scientific Research Innovation Program Project,Grant/Award Number:KYCX22_1336。
文摘Chemodynamic therapy(CDT)utilizes Fenton and/or Fenton-like reactions in the tumor microenvironment(TME)to produce cytotoxic reactive oxygen spe-cies(ROS,mainly hydroxyl radicals,·OH)for inducing cancer cell death.Since CDT exhibits minimal invasiveness and high tumor specificity by responding to TME(overexpressed hydrogen peroxide(H_(2)O_(2))and glutathione(GSH)gener-ation),a lot of related research has been conducted recently.Photo-facilitated CDT can further enhance the catalytic activity and controllability of the treat-ment.In addition,other photo-induced therapies,including photodynamic and photothermal therapy(PDT,PTT),may synergize with CDT to obtain boosting treatment efficacy and avoid multidrug resistance.In this minireview,we summarizethe recentadvancesinphoto-assisted CDT,including PTT-facilitated CDT and PDT-facilitated CDT.More importantly,the challenges encountered in the treatment process are discussed and potential development directions are suggested to facilitate the clinicaltranslation of photo-assisted CDT in the future.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39000000)the Fundamental Research Funds for the Central Universities(YD9100002033)+1 种基金the Hefei Comprehensive National Science Center Hefei Brain Projectthe Natural Science Foundation of Anhui Province(2308085QH265)。
基金financially supported by the National Key Research and Development Program of China(No.2022YFB3606502)the National Natural Science Foundation of China(Nos.52131304 and 62004101).
文摘Quasi-two-dimensional perovskite light-emitting diodes (quasi-2D PeLEDs) are emerging as high-potential candidates for new generation of wide-color gamut displays due to their simple, low-cost solution process, and high color purity. However, the luminescence performance of quasi-2D perovskite films is severely limited by dispersed phase distribution and excessive defect density, which are caused by excessive diffusion of nucleation sites during the perovskite growth stage. Here, the benzylphosphonic acid (BPA) molecule, owing to its strong P-O-Pb bond energy sites and strong electronegativity to PEA+, can aggregate lead-halide octahedron to grow high-dimensional phases, avoiding scattered low-dimensional phases (n = 1). The continuous gradient phase distribution will be beneficial to smooth carrier injection and effectively suppress the leakage current in PeLEDs. Meanwhile, the introduction of phosphonic acid groups will fill the vacancies of Pb ions and reduce non-radiative recombination. As a result, the maximum external quantum efficiency (EQE) of PeLEDs can be increased from 8% to 20.6% with a 514 nm light emission and a 21 nm full-width half maximum, and the device lifetime (T 50) is nearly 6-fold of the pristine sample. In addition, this strategy is also suitable for other wavelength. For example, in blue light, performance improvement is also realized that the maximum EQE of 8% and the luminance increased from 1045 to 5264 cd/m2. These results provide a feasible strategy to regulate the phase distribution and passivate the defects of quasi-2D perovskites.
基金supported by the National Key Plan for Scientific Research and Development of China(2020YFA0509304 and 2021YFA0805300)the Chinese Academy of Sciences(XDB39000000)+2 种基金the National Natural Sciences Foundation of China(82371418,82030034 and U23A20422)the Fundamental Research Funds for the Central Universities(YD9110002027 and WK9100000057)Postdoctoral Science Foundation of Anhui Province(2023B723).
文摘Main text Cerebral small vessel disease(CSVD)is a prevalent cer-ebrovascular disease characterized by chronic vascular dysfunction[1],primarily diagnosed using MRI-based markers such as white matter hyperintensities(WMHs),cerebral microbleeds,perivascular spaces,and lacunes[2].CSVD also involves blood-brain barrier(BBB)dis-ruption,evident with an elevated cerebrospinal fluid(CSF)/serum albumin ratio(also called Albumin Quo-tient,QAlb)[3].Despite these markers reflecting dif-ferent aspects of cerebrovascular disease,its underlying causes are not fully understood.Interestingly,CSVD often coincides with Alzheimer’s disease(AD)pathol-ogy[4].
