Previous studies on the prenatal organophosphate ester(OPE)exposure's effect on children's neurodevelopment have yielded inconsistent results.In this study,we employed a longitudinal approach,capitalizing on m...Previous studies on the prenatal organophosphate ester(OPE)exposure's effect on children's neurodevelopment have yielded inconsistent results.In this study,we employed a longitudinal approach,capitalizing on multitime-point evaluations of exposure to OPEs and two-stage assessments of children's brain development.The study included 508 mother-child pairs.We measured seven OPEs in maternal serum throughout pregnancy and assessed children's mental health and developmental mile-stones at the age of 2 and 5.The group-based trajectory model identified pregnancy exposure trajectories.Generalized estimated equations and quantile-based g-computation were employed to evaluate the effects of OPEs on children's brain development.Four OPEs,including 2-ethylhexyl diphenyl phosphate(EHDPP),were detected in over 50%of the maternal samples.Each ln-unit increment of EHDPP was associated with an increased peer problem scores(IRR:1.104,95%CI:1.038-1.174)in mental health.Regarding development milestones,EHDPP was related to lower scores in communication,gross motor,personal-social,and total score of the ages and stages questionnaires(ASQ)(IRR:0.963-0.976).Trajectory analysis confirmed these associations.Notably,boys were more affected in terms of mental health,while girls were more vulnerable in terms of developmental milestones.Prenatal exposure to OPEs,particularly EHDPP,is associated with adverse brain development in early childhood with notable sex-specific differences in vulnerability.展开更多
Per-and polyfluoroalkyl substances(PFAS)can pass through the placenta and adversely affect fetal development.However,there is a lack of comparison of legacy and emerging PFAS levels among different biosamples in pregn...Per-and polyfluoroalkyl substances(PFAS)can pass through the placenta and adversely affect fetal development.However,there is a lack of comparison of legacy and emerging PFAS levels among different biosamples in pregnant women and their offspring.This study,based on the Shanghai Maternal–Child Pairs Cohort,analyzed the concentrations of 16 PFAS in the maternal serum,cord serum,and breast milk samples from 1,076 motherchild pairs.The placental and breastfeeding transfer efficiencies of PFAS were determined in maternal-cord and maternal-milk pairs,respectively.The binding affinities of PFAS to five transporters were simulated using molecular docking.The results suggested that PFAS were frequently detected in different biosamples.The median concentration of perfluorooctane sulfonate(PFOS)was the highest at 8.85 ng/mL,followed by perfluorooctanoic acid(PFOA)at 7.13 ng/mL and 6:2 chlorinated polyfluorinated ether sulfonate at 5.59 ng/mL in maternal serum.The median concentrations of PFOA were highest in cord serum(4.23 ng/mL)and breast milk(1.08 ng/mL).PFAS demonstrated higher placental than breastfeeding transfer efficiencies.The transfer efficiencies and the binding affinities of most PFAS to proteins exhibited alkyl chain length-dependent patterns.Furthermore,we comprehensively assessed the estimated daily intakes(EDIs)of PFAS in breastfeeding infants of different age groups and used the hazard quotient(HQ)to characterize the potential health risk.EDIs decreased with infant age,and PFOS had higher HQs than PFOA.These findings highlight the significance of considering PFAS exposure,transfer mechanism,and health risks resulting from breast milk intake in early life.展开更多
Previous research indicated that fine particulate matter(PM_(2.5))exposure affected both offspring neurodevelopment and the colonization of gut microbiota(GM),while the underlying mechanism remained unclear.Our study ...Previous research indicated that fine particulate matter(PM_(2.5))exposure affected both offspring neurodevelopment and the colonization of gut microbiota(GM),while the underlying mechanism remained unclear.Our study aimed to evaluate the impacts of prenatal PM_(2.5) exposure on child cognitive development and investigate the role of neonatal GM colonization in the association.Based on the Shanghai Maternal−Child Pairs Cohort,361 maternal−child pairs were recruited.Prenatal PM_(2.5) exposure concentrations were estimated using a high-spatial-resolution prediction model,and child neurodevelopment was assessed by the Ages and Stages Questionnaire.Multivariable linear regression models,logistic regression models,linear discriminant analysis effect size,and random forest model were applied to explore the associations among PM_(2.5) exposure,GM colonization,and children’s neuro-development.The present study revealed a negative correlation between PM_(2.5) exposure throughout pregnancy and child neurodevelopment.Prenatal PM_(2.5) exposure was associated with an increased risk of suspected developmental delay(SDD)(OR=1.683,95%CI:1.138,2.489)in infants aged 2 months.Additionally,potential operational taxonomic unit markers were identified for PM_(2.5)-related neurotoxicity,demonstrating promising classification potential for early SDD screening(AUC=71.27%).Prenatal PM_(2.5) exposure might disrupt the composition,richness,and evenness of meconium GM,thereby influencing cognitive development and the occurrence of SDD in offspring.Seven PM_(2.5)-related genera,Ruminococcus gnavus group,Romboutsia,Burkholderiaceae Caballeronia Paraburkholderia,Blautia,Alistipes,Parabacteroides,and Bacteroides,were validated as correlated with prenatal PM_(2.5) exposure and the occurrence of SDD.Moreover,alterations of GM related to PM_(2.5) exposure and SDD might be accompanied by changes in functional pathways of amino acid,lipid,and vitamin metabolism as indicated by differentially enriched species in the Kyoto Encyclopedia of Genes and Genomes.展开更多
The connections between urinary organophosphate ester(OPE)metabolites and child growth have been identified in prior research,but there is currently a dearth of epidemiological evidence regarding the sex-specific impa...The connections between urinary organophosphate ester(OPE)metabolites and child growth have been identified in prior research,but there is currently a dearth of epidemiological evidence regarding the sex-specific impact of OPEs on child growth trajectories.This study enrolled 804 maternal-child pairs,and five OPE congeners were quantified in maternal serum during pregnancy.In this study,the impact of prenatal OPE exposure on child growth trajectories was assessed using linear mixed-effect models and a group-based trajectory model(GBTM),with consideration given to sex-specific effects.Fetuses were frequently exposed to OPEs in utero,and tris(2-butoxyethel)phosphate(TBEP)exhibited the highest concentration levels in maternal serum.Among male children,an increase of 2.72 ng/g lipid in TBEP concentration was associated with a 0.11-unit increase in head circumference-for-age z-score(HCAZ),and the effect was mainly concentrated at 1 and 2 months of age.Among female children,an increase of 2.72 ng/g lipid in tris(2-chloro-1-(chloromethyl)ethyl)phosphate(TDCPP)concentration was associated with a 0.15-unit increase in length-for-age z-score(LAZ)and a 0.14-unit increase in weight-for-age z-score(WAZ),and the effects were mainly concentrated at 9 months of age.For HCAZ trajectories,higher prenatal TBEP exposure was associated with higher odds for the fast growth group in male children.For the LAZ and WAZ trajectories,higher prenatal TDCPP exposure was associated with higher odds for the fast growth group in female children.The trajectory analysis approach provided insight into the complex associations between OPE exposure and child growth.展开更多
Prenatal ozone(O3)exposure may disrupt normal offspring growth.However,epidemiological evidence that prenatal O3 exposure affects the physical development of offspring early in life is far from adequate.A total of 490...Prenatal ozone(O3)exposure may disrupt normal offspring growth.However,epidemiological evidence that prenatal O3 exposure affects the physical development of offspring early in life is far from adequate.A total of 4909 maternal-child pairs from the Shanghai Maternal-Child Pairs Cohort were included.A high-resolution random forest model was utilized to evaluate prenatal exposure levels of O3 based on the home addresses of pregnant women.Group-based trajectory and mixed-effects models were used to assess associations between prenatal Os exposure and physical parameters.Each 10μg/m increase in O3 concentration was associated with 0.084,0.048,and 0.082-unit increases in body mass index(BMI)for age Z score(BAZ),weight for age Z score(WAZ),and weight for length Z score(WLZ),respectively.Specifically,a 10μg/m^(3) increase in O3 concentration was linked to a 1.208-fold and 1.209-fold increase in the elevated-increasing group for the BAZ and WLZ trajectories,respectively.Moreover,each 10μg/m^(3) increases in prenatal O3 was associated with a 1.396-fold and 0.786-fold increase in the risk of BAZ and length for age Z score(LAZ)accelerated growth,respectively.Furthermore,a 10μg/m^(3) increase in prenatal Og was linked to a 1.355-fold increase in the risk of overweight and obesity(OAO).Our study revealed that prenatal O3 exposure is associated with accelerated BMI gain or decelerated body length gain in the early life of children.Prenatal Os may also increase the risk of OAO in children for the first two years.展开更多
基金supported by the National Natural Science Foundation of China[Grant numbers:82273585,81872581]the Shanghai 3-year Public Health Action Plan(Grant number:GWVI-11.1-39).
文摘Previous studies on the prenatal organophosphate ester(OPE)exposure's effect on children's neurodevelopment have yielded inconsistent results.In this study,we employed a longitudinal approach,capitalizing on multitime-point evaluations of exposure to OPEs and two-stage assessments of children's brain development.The study included 508 mother-child pairs.We measured seven OPEs in maternal serum throughout pregnancy and assessed children's mental health and developmental mile-stones at the age of 2 and 5.The group-based trajectory model identified pregnancy exposure trajectories.Generalized estimated equations and quantile-based g-computation were employed to evaluate the effects of OPEs on children's brain development.Four OPEs,including 2-ethylhexyl diphenyl phosphate(EHDPP),were detected in over 50%of the maternal samples.Each ln-unit increment of EHDPP was associated with an increased peer problem scores(IRR:1.104,95%CI:1.038-1.174)in mental health.Regarding development milestones,EHDPP was related to lower scores in communication,gross motor,personal-social,and total score of the ages and stages questionnaires(ASQ)(IRR:0.963-0.976).Trajectory analysis confirmed these associations.Notably,boys were more affected in terms of mental health,while girls were more vulnerable in terms of developmental milestones.Prenatal exposure to OPEs,particularly EHDPP,is associated with adverse brain development in early childhood with notable sex-specific differences in vulnerability.
基金supported by the National Natural Science Foundation of China(Grant No.82273585)the National Key Research and Development Program of China(Grant No.2022YFC2705004,2019YFE0114500).
文摘Per-and polyfluoroalkyl substances(PFAS)can pass through the placenta and adversely affect fetal development.However,there is a lack of comparison of legacy and emerging PFAS levels among different biosamples in pregnant women and their offspring.This study,based on the Shanghai Maternal–Child Pairs Cohort,analyzed the concentrations of 16 PFAS in the maternal serum,cord serum,and breast milk samples from 1,076 motherchild pairs.The placental and breastfeeding transfer efficiencies of PFAS were determined in maternal-cord and maternal-milk pairs,respectively.The binding affinities of PFAS to five transporters were simulated using molecular docking.The results suggested that PFAS were frequently detected in different biosamples.The median concentration of perfluorooctane sulfonate(PFOS)was the highest at 8.85 ng/mL,followed by perfluorooctanoic acid(PFOA)at 7.13 ng/mL and 6:2 chlorinated polyfluorinated ether sulfonate at 5.59 ng/mL in maternal serum.The median concentrations of PFOA were highest in cord serum(4.23 ng/mL)and breast milk(1.08 ng/mL).PFAS demonstrated higher placental than breastfeeding transfer efficiencies.The transfer efficiencies and the binding affinities of most PFAS to proteins exhibited alkyl chain length-dependent patterns.Furthermore,we comprehensively assessed the estimated daily intakes(EDIs)of PFAS in breastfeeding infants of different age groups and used the hazard quotient(HQ)to characterize the potential health risk.EDIs decreased with infant age,and PFOS had higher HQs than PFOA.These findings highlight the significance of considering PFAS exposure,transfer mechanism,and health risks resulting from breast milk intake in early life.
基金supported by the National Natural Science Foundation of China(Grant No.82273585,81872581)the National Key Research and Development Program of China(Grant No.2019YFE0114500,2022YFC2705004)the China Postdoctoral Science Foundation(Grant No.2022T150127,2021M700797).
文摘Previous research indicated that fine particulate matter(PM_(2.5))exposure affected both offspring neurodevelopment and the colonization of gut microbiota(GM),while the underlying mechanism remained unclear.Our study aimed to evaluate the impacts of prenatal PM_(2.5) exposure on child cognitive development and investigate the role of neonatal GM colonization in the association.Based on the Shanghai Maternal−Child Pairs Cohort,361 maternal−child pairs were recruited.Prenatal PM_(2.5) exposure concentrations were estimated using a high-spatial-resolution prediction model,and child neurodevelopment was assessed by the Ages and Stages Questionnaire.Multivariable linear regression models,logistic regression models,linear discriminant analysis effect size,and random forest model were applied to explore the associations among PM_(2.5) exposure,GM colonization,and children’s neuro-development.The present study revealed a negative correlation between PM_(2.5) exposure throughout pregnancy and child neurodevelopment.Prenatal PM_(2.5) exposure was associated with an increased risk of suspected developmental delay(SDD)(OR=1.683,95%CI:1.138,2.489)in infants aged 2 months.Additionally,potential operational taxonomic unit markers were identified for PM_(2.5)-related neurotoxicity,demonstrating promising classification potential for early SDD screening(AUC=71.27%).Prenatal PM_(2.5) exposure might disrupt the composition,richness,and evenness of meconium GM,thereby influencing cognitive development and the occurrence of SDD in offspring.Seven PM_(2.5)-related genera,Ruminococcus gnavus group,Romboutsia,Burkholderiaceae Caballeronia Paraburkholderia,Blautia,Alistipes,Parabacteroides,and Bacteroides,were validated as correlated with prenatal PM_(2.5) exposure and the occurrence of SDD.Moreover,alterations of GM related to PM_(2.5) exposure and SDD might be accompanied by changes in functional pathways of amino acid,lipid,and vitamin metabolism as indicated by differentially enriched species in the Kyoto Encyclopedia of Genes and Genomes.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFC2705004)the National Natural Science Foundation of China(Grant No.82273585)Key Project on Science and Technology Program of Fujian Health Commission(Gran No.2021ZD01002).
文摘The connections between urinary organophosphate ester(OPE)metabolites and child growth have been identified in prior research,but there is currently a dearth of epidemiological evidence regarding the sex-specific impact of OPEs on child growth trajectories.This study enrolled 804 maternal-child pairs,and five OPE congeners were quantified in maternal serum during pregnancy.In this study,the impact of prenatal OPE exposure on child growth trajectories was assessed using linear mixed-effect models and a group-based trajectory model(GBTM),with consideration given to sex-specific effects.Fetuses were frequently exposed to OPEs in utero,and tris(2-butoxyethel)phosphate(TBEP)exhibited the highest concentration levels in maternal serum.Among male children,an increase of 2.72 ng/g lipid in TBEP concentration was associated with a 0.11-unit increase in head circumference-for-age z-score(HCAZ),and the effect was mainly concentrated at 1 and 2 months of age.Among female children,an increase of 2.72 ng/g lipid in tris(2-chloro-1-(chloromethyl)ethyl)phosphate(TDCPP)concentration was associated with a 0.15-unit increase in length-for-age z-score(LAZ)and a 0.14-unit increase in weight-for-age z-score(WAZ),and the effects were mainly concentrated at 9 months of age.For HCAZ trajectories,higher prenatal TBEP exposure was associated with higher odds for the fast growth group in male children.For the LAZ and WAZ trajectories,higher prenatal TDCPP exposure was associated with higher odds for the fast growth group in female children.The trajectory analysis approach provided insight into the complex associations between OPE exposure and child growth.
基金supported by the National Key Research and Development Program of China (Grant 2022YFC2705004)the National Natural Science Foundation of China (Grant 82273585)Fudan University&Minhang Health Joint Venture Cooperation Project (2022FM11).
文摘Prenatal ozone(O3)exposure may disrupt normal offspring growth.However,epidemiological evidence that prenatal O3 exposure affects the physical development of offspring early in life is far from adequate.A total of 4909 maternal-child pairs from the Shanghai Maternal-Child Pairs Cohort were included.A high-resolution random forest model was utilized to evaluate prenatal exposure levels of O3 based on the home addresses of pregnant women.Group-based trajectory and mixed-effects models were used to assess associations between prenatal Os exposure and physical parameters.Each 10μg/m increase in O3 concentration was associated with 0.084,0.048,and 0.082-unit increases in body mass index(BMI)for age Z score(BAZ),weight for age Z score(WAZ),and weight for length Z score(WLZ),respectively.Specifically,a 10μg/m^(3) increase in O3 concentration was linked to a 1.208-fold and 1.209-fold increase in the elevated-increasing group for the BAZ and WLZ trajectories,respectively.Moreover,each 10μg/m^(3) increases in prenatal O3 was associated with a 1.396-fold and 0.786-fold increase in the risk of BAZ and length for age Z score(LAZ)accelerated growth,respectively.Furthermore,a 10μg/m^(3) increase in prenatal Og was linked to a 1.355-fold increase in the risk of overweight and obesity(OAO).Our study revealed that prenatal O3 exposure is associated with accelerated BMI gain or decelerated body length gain in the early life of children.Prenatal Os may also increase the risk of OAO in children for the first two years.
