Oral submucous fibrosis(OSF),characterized by excessive deposition of extracellular matrix(ECM)that causes oral mucosal tissue sclerosis,and even cancer transformation,is a chronic,progressive fibrosis disease.However...Oral submucous fibrosis(OSF),characterized by excessive deposition of extracellular matrix(ECM)that causes oral mucosal tissue sclerosis,and even cancer transformation,is a chronic,progressive fibrosis disease.However,despite some advancements in recent years,no targeted antifibrotic strategies for OSF have been approved;likely because the complicated mechanisms that initiate and drive fibrosis remain to be determined.In this review,we briefly introduce the epidemiology and etiology of OSF.Then,we highlight how cell-intrinsic changes in significant structural cells can drive fibrotic response by regulating biological behaviors,secretion function,and activation of ECM-producing myofibroblasts.In addition,we also discuss the role of innate and adaptive immune cells and how they contribute to the pathogenesis of OSF.Finally,we summarize strategies to interrupt key mechanisms that cause OSF,including modulation of the ECM,inhibition of inflammation,improvement of vascular disturbance.This review will provide potential routes for developing novel anti-OSF therapeutics.展开更多
Using cinnamon and Litsea cubeba composite essential oils as natural active substances,Gel and Carboxymeth-ylcellulose Sodium(CMC-Na)as sustained-release carriers,and gel as base materials,the antimicrobial activity o...Using cinnamon and Litsea cubeba composite essential oils as natural active substances,Gel and Carboxymeth-ylcellulose Sodium(CMC-Na)as sustained-release carriers,and gel as base materials,the antimicrobial activity of the composite film and its preservation effect on cherry tomatoes were studied.The results showed that the optimal preparation parameters of composite essential oil microcapsule film were 0.75 mL of glycerol,1.00 g of microcapsule,60℃of drying temperature.The antimicrobial film showed excellent comprehensive perfor-mance,with an oxygen permeability of 42.16 cm^(3)/(m^(2)⋅24h⋅0.1 MPa),a moisture permeability of 1181.39 g/(m^(2)⋅day),a transparency of 75.25%,a tensile strength of 35.43 MPa and an elongation at break of 62.20%.The results of scanning electron microscopy and Fourier transform infrared(FTIR)analysis showed that the micro-capsules were uniformly distributed in the film matrix.Thermogravimetric analysis(TGA)confirmed that the film has good thermal stability,thus ensuring its long-term antimicrobial performance in practical applications.The results showed that the weight loss rate of cherry tomatoes after 10 days of storage was only 21.68%,which was significantly lower than that of the blank control group(36.48%).The color brightness and soluble solids content were kept at a high level.The microencapsulation treatment effectively delayed the oxidative degra-dation of phenols and flavonoids,and significantly improved the scavenging ability of tomato fruit extracts against 2,2-Diphenyl-1-picrylhydrazyl(DPPH)and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)[ABTS]free radicals.It indicates that the microencapsulated film has better preservation function than Poly-ethylene Film(PE)film.These findings demonstrate that the microencapsulated films with essential oils represent a promising,biocompatible approach for controlling food related pathogens,and they could be used as active packaging materials to replace food packaging plastics for food preservation.展开更多
基金study was supported by the National Key Research and Development Program of China(2022YFC2402900)National Natural Science Foundation of China(82470989,52103327)+3 种基金The Joint Funds of the Hunan Provincial Natural Science Foundation(2023JJ60509)The Science and Technology Talent Support Project of the Hunan Provincial Science Popularization Special Project(2023TJ-Z08)Hunan Provincial Innovation Foundation for Postgraduate(2023ZZTS0218)The Postgraduate Inde-pendent Exploration Innovation Fund of the Central South University(2023ZZTS0987)。
文摘Oral submucous fibrosis(OSF),characterized by excessive deposition of extracellular matrix(ECM)that causes oral mucosal tissue sclerosis,and even cancer transformation,is a chronic,progressive fibrosis disease.However,despite some advancements in recent years,no targeted antifibrotic strategies for OSF have been approved;likely because the complicated mechanisms that initiate and drive fibrosis remain to be determined.In this review,we briefly introduce the epidemiology and etiology of OSF.Then,we highlight how cell-intrinsic changes in significant structural cells can drive fibrotic response by regulating biological behaviors,secretion function,and activation of ECM-producing myofibroblasts.In addition,we also discuss the role of innate and adaptive immune cells and how they contribute to the pathogenesis of OSF.Finally,we summarize strategies to interrupt key mechanisms that cause OSF,including modulation of the ECM,inhibition of inflammation,improvement of vascular disturbance.This review will provide potential routes for developing novel anti-OSF therapeutics.
基金supported by the National Key Research and Development Program Project(2025YFE0111000).
文摘Using cinnamon and Litsea cubeba composite essential oils as natural active substances,Gel and Carboxymeth-ylcellulose Sodium(CMC-Na)as sustained-release carriers,and gel as base materials,the antimicrobial activity of the composite film and its preservation effect on cherry tomatoes were studied.The results showed that the optimal preparation parameters of composite essential oil microcapsule film were 0.75 mL of glycerol,1.00 g of microcapsule,60℃of drying temperature.The antimicrobial film showed excellent comprehensive perfor-mance,with an oxygen permeability of 42.16 cm^(3)/(m^(2)⋅24h⋅0.1 MPa),a moisture permeability of 1181.39 g/(m^(2)⋅day),a transparency of 75.25%,a tensile strength of 35.43 MPa and an elongation at break of 62.20%.The results of scanning electron microscopy and Fourier transform infrared(FTIR)analysis showed that the micro-capsules were uniformly distributed in the film matrix.Thermogravimetric analysis(TGA)confirmed that the film has good thermal stability,thus ensuring its long-term antimicrobial performance in practical applications.The results showed that the weight loss rate of cherry tomatoes after 10 days of storage was only 21.68%,which was significantly lower than that of the blank control group(36.48%).The color brightness and soluble solids content were kept at a high level.The microencapsulation treatment effectively delayed the oxidative degra-dation of phenols and flavonoids,and significantly improved the scavenging ability of tomato fruit extracts against 2,2-Diphenyl-1-picrylhydrazyl(DPPH)and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)[ABTS]free radicals.It indicates that the microencapsulated film has better preservation function than Poly-ethylene Film(PE)film.These findings demonstrate that the microencapsulated films with essential oils represent a promising,biocompatible approach for controlling food related pathogens,and they could be used as active packaging materials to replace food packaging plastics for food preservation.
