Carotid atherosclerosis is a partial manifestation of arteriosclerosis of organism.In recent years,its incidence rate is increasing year by year.Traditional Chinese medicine(TCM)has a broad prospect in the clinical de...Carotid atherosclerosis is a partial manifestation of arteriosclerosis of organism.In recent years,its incidence rate is increasing year by year.Traditional Chinese medicine(TCM)has a broad prospect in the clinical development of CAS treatment by holism concept and the principle of treatment based on syndrome differentiation.This paper reviews the etiology,pathogenesis,TCM dialectics and TCM treatment of carotid atherosclerosis,in order to provide theoretical guidance for TCM treatment of CAS patients.展开更多
Liver fibrosis is a pathological process resulting from prolonged exposure to various injury factors.It is characterized by the abnormal proliferation and activation of hepatic stellate cells and excessive deposition ...Liver fibrosis is a pathological process resulting from prolonged exposure to various injury factors.It is characterized by the abnormal proliferation and activation of hepatic stellate cells and excessive deposition of extracellular matrix.If left untreated,it can progress to cirrhosis,liver failure,and even liver cancer.There is currently no efficient and accurate clinical diagnostic method for early liver fibrosis.Therefore,there is an urgent need to address the challenge of accurate staging and early diagnosis of liver fibrosis in clinical practice.Recently,nanomaterials have demonstrated significant potential for enhancing the diagnosis of liver fibrosis.Nanomaterials possess the ability to precisely identify and target the microenvironment associated with liver fibrosis.By enhancing their enrichment in the target area,nanomaterials can improve imaging contrast of fibrosis lesions in the liver,thereby enabling accurate diagnosis of liver fibrosis.Accordingly,this review delves into the latest research and advancements concerning nanomaterials in liver fibrosis diagnosis.展开更多
Aims:There are many studies on the incidence of hepatitis B virus(HBV)-associated hepatocellular carcinoma(HCC),but very little is known about the HCC features in different populations.The study aimed to compare chara...Aims:There are many studies on the incidence of hepatitis B virus(HBV)-associated hepatocellular carcinoma(HCC),but very little is known about the HCC features in different populations.The study aimed to compare characteristics in two cohorts of patients with HBV-associated hepatocellular carcinoma from Turkey and China.Methods:Data on patients with HBV-associated HCC diagnosed by imaging or liver biopsy were retrospectively collected from Shandong Provincial Hospital(n=578)and Inonu University Hospital(n=359)between January 2002 and December 2020,and the liver function and HCC characteristics were compared.Continuous variables were compared using Student's t-test or Mann-Whitney U test and categorical variables were compared using the χ^(2) test or Fisher's exact test.Results:The patients in the Turkish cohort had significantly worse Child-Pugh scores(Child-Pugh A:38.3%vs.87.9%;Child-Pugh B:40.3%vs.11.1%;Child-Pugh C:21.4%vs.1.0%;p<0.001)and significantly higher levels of aspartate aminotransferase(66.5[38.0−126.0]vs.36.0[27.0-50.0]IU/L;p<0.001),alanine aminotransferase(47.5[30.0−87.3]vs.33.0[24.0−45.0]IU/L;p<0.001),total bilirubin(20.8[13.7−39.3]vs.17.9[13.8−24.0]mg/dL;p<0.001),and lower albumin levels(32.0[26.0-39.0]vs.40.0[36.1-43.8]g/L;p<0.001)than patients in Chinese cohort.The tumor characteristics showed the Barcelona Clinic Liver Cancer(BCLC)score(BCLC 1:5.1%vs.71.8%;BCLC 2:48.7%vs.24.4%;BCLC 3:24.4%vs.3.8%;BCLC 4:21.8%vs.0;all p<0.001),maximum tumor diameter(5.0[3.0-9.0]vs.3.5[2.5−6.0]cm;p<0.001),alpha-fetoprotein values(27.7 vs.13.2 ng/mL;p<0.001),and percentage of patients with portal vein tumor thrombus(33%vs.6.1%;p<0.001)were all significantly worse in the Turkish cohort compared with Chinese cohort.Conclusions:HBV-associated HCC from the Turkish cohort had worse liver function and more aggressive clinical characteristics than patients from the Chinese cohort.展开更多
Portal hypertension is the primary cause of severe complications associated with cirrhosis,such as hepatic encephalopathy,ascites,and gastroesophageal variceal bleeding.Measurement of hepatic venous pressure gradient(...Portal hypertension is the primary cause of severe complications associated with cirrhosis,such as hepatic encephalopathy,ascites,and gastroesophageal variceal bleeding.Measurement of hepatic venous pressure gradient(HVPG)derived by subtracting the free hepatic venous pressure from the wedged hepatic venous pressure via catheterization of the right hepatic vein stands as a well-established technique for assessing portal venous pressure[1].An HVPG equal to or exceeding 10 mm Hg denotes clinically significant portal hypertension(CSPH),serving as a pivotal parameter for prognostication and treatment response evaluation among patients with portal hypertension[2–4].But it is limited in availability due to invasive examination,cost implications and perceived risks.Currently,several techniques such as transient ultrasound elastography and two-dimensional phase-contrast MRI are available noninvasive imaging methods for detecting CSPH,but the results are still unsatisfactory[5–7].Thus,it is urgent to explore a new alternative noninvasive method for CSPH diagnosis.展开更多
Wearable electronics are advancing towards miniaturization and flexibility.However,traditional energy supply methods have largely hindered their development.An effective solution to this problem is to convert human me...Wearable electronics are advancing towards miniaturization and flexibility.However,traditional energy supply methods have largely hindered their development.An effective solution to this problem is to convert human mechanical energy into electricity to power wearable electronic devices.Therefore,it is greatly attractive to design flexible,foldable and even stretchable energy harvesting devices.Herein,we use the electrospinning and kirigami approach to develop a type of highly stretchable kirigami-patterned nanofiber-based triboelectric nanogenerator(K-TENG).Due to its innovative structural design,the K-TENG can achieve a tensile strain of 220%,independent of the tensile properties of the material itself.When a person swings their arms,the K-TENG fixed to the clothing can convert mechanical energy from human movement into electrical energy.The produced electricity can directly drive 50 LED lights and a digital watch,or be stored in a lithium battery to charge the smartwatch and smartphone,respectively.This study employs a new method to fabricate a stretchable triboelectric nanogenerator and demonstrates its promising applications in wearable power technology.展开更多
文摘Carotid atherosclerosis is a partial manifestation of arteriosclerosis of organism.In recent years,its incidence rate is increasing year by year.Traditional Chinese medicine(TCM)has a broad prospect in the clinical development of CAS treatment by holism concept and the principle of treatment based on syndrome differentiation.This paper reviews the etiology,pathogenesis,TCM dialectics and TCM treatment of carotid atherosclerosis,in order to provide theoretical guidance for TCM treatment of CAS patients.
基金National Natural Science Foundation of China,Grant/Award Number:82372031,22104073,82371916Natural Science Foundation of Shandong Province,Grant/Award Number:2022HWYQ-079,ZR2021QB119,ZR2021QA100+1 种基金Taishan Scholar Foundation of Shandong Province,Grant/Award Numbers:tsqn202312352,tsqn202408248the Youth Innovation Science and Technology Program of Shandong Provincial Universities,Grant/Award Number:2021KJ100。
文摘Liver fibrosis is a pathological process resulting from prolonged exposure to various injury factors.It is characterized by the abnormal proliferation and activation of hepatic stellate cells and excessive deposition of extracellular matrix.If left untreated,it can progress to cirrhosis,liver failure,and even liver cancer.There is currently no efficient and accurate clinical diagnostic method for early liver fibrosis.Therefore,there is an urgent need to address the challenge of accurate staging and early diagnosis of liver fibrosis in clinical practice.Recently,nanomaterials have demonstrated significant potential for enhancing the diagnosis of liver fibrosis.Nanomaterials possess the ability to precisely identify and target the microenvironment associated with liver fibrosis.By enhancing their enrichment in the target area,nanomaterials can improve imaging contrast of fibrosis lesions in the liver,thereby enabling accurate diagnosis of liver fibrosis.Accordingly,this review delves into the latest research and advancements concerning nanomaterials in liver fibrosis diagnosis.
基金NIH,Grant/Award Number:CA 82723National Natural Science Fund,Grant/Award Numbers:81970545,82170609+2 种基金Natural Science Foundation of Shandong Province,Grant/Award Number:ZR2020KH006Nanjing Medical Science and Technique Development Foundation,Grant/Award Number:YKK20058Natural Science Foundation of Jiangsu Province,Grant/Award Number:BK20231118。
文摘Aims:There are many studies on the incidence of hepatitis B virus(HBV)-associated hepatocellular carcinoma(HCC),but very little is known about the HCC features in different populations.The study aimed to compare characteristics in two cohorts of patients with HBV-associated hepatocellular carcinoma from Turkey and China.Methods:Data on patients with HBV-associated HCC diagnosed by imaging or liver biopsy were retrospectively collected from Shandong Provincial Hospital(n=578)and Inonu University Hospital(n=359)between January 2002 and December 2020,and the liver function and HCC characteristics were compared.Continuous variables were compared using Student's t-test or Mann-Whitney U test and categorical variables were compared using the χ^(2) test or Fisher's exact test.Results:The patients in the Turkish cohort had significantly worse Child-Pugh scores(Child-Pugh A:38.3%vs.87.9%;Child-Pugh B:40.3%vs.11.1%;Child-Pugh C:21.4%vs.1.0%;p<0.001)and significantly higher levels of aspartate aminotransferase(66.5[38.0−126.0]vs.36.0[27.0-50.0]IU/L;p<0.001),alanine aminotransferase(47.5[30.0−87.3]vs.33.0[24.0−45.0]IU/L;p<0.001),total bilirubin(20.8[13.7−39.3]vs.17.9[13.8−24.0]mg/dL;p<0.001),and lower albumin levels(32.0[26.0-39.0]vs.40.0[36.1-43.8]g/L;p<0.001)than patients in Chinese cohort.The tumor characteristics showed the Barcelona Clinic Liver Cancer(BCLC)score(BCLC 1:5.1%vs.71.8%;BCLC 2:48.7%vs.24.4%;BCLC 3:24.4%vs.3.8%;BCLC 4:21.8%vs.0;all p<0.001),maximum tumor diameter(5.0[3.0-9.0]vs.3.5[2.5−6.0]cm;p<0.001),alpha-fetoprotein values(27.7 vs.13.2 ng/mL;p<0.001),and percentage of patients with portal vein tumor thrombus(33%vs.6.1%;p<0.001)were all significantly worse in the Turkish cohort compared with Chinese cohort.Conclusions:HBV-associated HCC from the Turkish cohort had worse liver function and more aggressive clinical characteristics than patients from the Chinese cohort.
文摘Portal hypertension is the primary cause of severe complications associated with cirrhosis,such as hepatic encephalopathy,ascites,and gastroesophageal variceal bleeding.Measurement of hepatic venous pressure gradient(HVPG)derived by subtracting the free hepatic venous pressure from the wedged hepatic venous pressure via catheterization of the right hepatic vein stands as a well-established technique for assessing portal venous pressure[1].An HVPG equal to or exceeding 10 mm Hg denotes clinically significant portal hypertension(CSPH),serving as a pivotal parameter for prognostication and treatment response evaluation among patients with portal hypertension[2–4].But it is limited in availability due to invasive examination,cost implications and perceived risks.Currently,several techniques such as transient ultrasound elastography and two-dimensional phase-contrast MRI are available noninvasive imaging methods for detecting CSPH,but the results are still unsatisfactory[5–7].Thus,it is urgent to explore a new alternative noninvasive method for CSPH diagnosis.
基金the China Postdoctoral Science Foundation(Grant No.2023TQ0316)the National Natural Science Foundation of China(Grant No.52273046).
文摘Wearable electronics are advancing towards miniaturization and flexibility.However,traditional energy supply methods have largely hindered their development.An effective solution to this problem is to convert human mechanical energy into electricity to power wearable electronic devices.Therefore,it is greatly attractive to design flexible,foldable and even stretchable energy harvesting devices.Herein,we use the electrospinning and kirigami approach to develop a type of highly stretchable kirigami-patterned nanofiber-based triboelectric nanogenerator(K-TENG).Due to its innovative structural design,the K-TENG can achieve a tensile strain of 220%,independent of the tensile properties of the material itself.When a person swings their arms,the K-TENG fixed to the clothing can convert mechanical energy from human movement into electrical energy.The produced electricity can directly drive 50 LED lights and a digital watch,or be stored in a lithium battery to charge the smartwatch and smartphone,respectively.This study employs a new method to fabricate a stretchable triboelectric nanogenerator and demonstrates its promising applications in wearable power technology.
