The oxygen reduction reaction(ORR)electrocatalytic activity of Pt-based catalysts can be significantly improved by supporting Pt and its alloy nanoparticles(NPs)on a porous carbon support with large surface area.Howev...The oxygen reduction reaction(ORR)electrocatalytic activity of Pt-based catalysts can be significantly improved by supporting Pt and its alloy nanoparticles(NPs)on a porous carbon support with large surface area.However,such catalysts are often obtained by constructing porous carbon support followed by depositing Pt and its alloy NPs inside the pores,in which the migration and agglomeration of Pt NPs are inevitable under harsh operating conditions owing to the relatively weak interaction between NPs and carbon support.Here we develop a facile electrospinning strategy to in-situ prepare small-sized PtZn NPs supported on porous nitrogen-doped carbon nanofibers.Electrochemical results demonstrate that the as-prepared PtZn alloy catalyst exhibits excellent initial ORR activity with a half-wave potential(E_(1/2))of 0.911 V versus reversible hydrogen electrode(vs.RHE)and enhanced durability with only decreasing 11 mV after 30,000 potential cycles,compared to a more significant drop of 24 mV in E_(1/2)of Pt/C catalysts(after 10,000 potential cycling).Such a desirable performance is ascribed to the created triple-phase reaction boundary assisted by the evaporation of Zn and strengthened interaction between nanoparticles and the carbon support,inhibiting the migration and aggregation of NPs during the ORR.展开更多
The cobalt-carbonate(CoCi)/NiFeOOH double-layer co-catalyst was prepared on bismuth vanadate(BiVO_(4)).Compared with the same type of electrode(Co-Pi/NiFeOOH/BiVO_(4)and Co-Sil/NiFeOOH/BiVO_(4)),the photoelectrochemic...The cobalt-carbonate(CoCi)/NiFeOOH double-layer co-catalyst was prepared on bismuth vanadate(BiVO_(4)).Compared with the same type of electrode(Co-Pi/NiFeOOH/BiVO_(4)and Co-Sil/NiFeOOH/BiVO_(4)),the photoelectrochemical(PEC)performance of the composite electrode presents the most excellent performance.The Co-Ci/NiFeOOH/BiVO_(4)electrode prepared by photoelectric deposition(PED)achieves a photocurrent density of 4.1 mA/cm^(2)at 1.23 V vs RHE,and the applied bias photon-current efficiency(ABPE)is up to 0.95%.In addition,with the help of the equivalent circuit fitting in electrochemical impedance spectroscopy(EIS),the charge transfer resistance(R_(ct))of Co-Ci/NiFeOOH/BiVO_(4)is only 108.9Ω,which is 16%that of BiVO_(4).The enhanced PEC performance of Co-Ci/NiFeOOH/BiVO_(4)in the double-layer cocatalyst system is attributed to the outstanding advantages of Co-Ci cocatalyst in oxygen vacancy defects,superior to other cobalt-based catalysts in promoting charge transfer and improving the kinetics of water oxidation.This makes Co-Ci co-catalyst become one of the favorable competitors in the field of photoelectric catalysis.展开更多
Noble metal-based intermetallics are promising electrocatalysts for sustainable energy conversion and consumption processes.High-temperature pyrolysis(>500°C)methods are used to control their crystalline order...Noble metal-based intermetallics are promising electrocatalysts for sustainable energy conversion and consumption processes.High-temperature pyrolysis(>500°C)methods are used to control their crystalline orderings,critical to their electrocatalytic activity and durability.However,the high temperature would cause severe aggregation,resulting in a low catalytic active surface area.Significant research efforts have been devoted to addressing this issue.This short review summarizes recent research progress on synthesizing noble metal-based intermetallic electrocatalysts by space-confined pyrolysis.We focus on three strategies:isolation in pores,coverture by shells,and immobilization by salts.The advantages and existing problems of different methods are highlighted.Last,important issues to be addressed in future research are also discussed.We hope that this article will stimulate future research to develop high-performance intermetallic catalysts for practical applications.展开更多
[Objectives]To explore the molecular mechanism of Zhizi Ganjiang Decoction(ZZGJD)regulating sleep disorders based on the network pharmacology.[Methods]The BATMAN-TCM server was used to predict the potential targets of...[Objectives]To explore the molecular mechanism of Zhizi Ganjiang Decoction(ZZGJD)regulating sleep disorders based on the network pharmacology.[Methods]The BATMAN-TCM server was used to predict the potential targets of ZZGJD and constructed a compound-disease-target network map,and the GeneCards database was used to search for insomnia-related targets;with the aid of Cytoscape 3.5.1 software,the compound-insomnia target interaction network and protein-protein interaction(PPI)network were constructed,and gene ontology(GO)enrichment,Reactome pathway enrichment,and biological pathway enrichment analysis based on KEGG(Kyoto Encyclopedia of Genes and Enomes)was performed.[Results]The constructed PPI network of ZZGJD involves 204 nodes and 645 interaction relationships.Key nodes involve G protein-coupled receptors,rhodopsin-like adrenaline receptor families,zinc finger proteins,nuclear hormone receptor superfamilies,ligand-binding domains of hormone receptors,voltage-gated calcium(Ca^(2+))channel IQ domains,and neuropituitary hormones.The related entries of GO enrichment analysis pathway mainly involve G protein-coupled receptor activity,neurotransmitter receptor activity,adrenergic receptor activity,ammonium ion binding,catecholamine binding,G protein-coupled serotonin receptor activity,serotonin receptor activity,and steroid hormone receptors(SHRs)activity.Reactome pathway mainly involves amine ligand binding receptors,rhodopsin-like receptors,G protein-coupled receptor ligand binding,adrenergic receptors,neuronal systems and signal transduction,etc.KEGG channel analysis mainly involves neural activity ligand-receptor interaction,calcium ion messenger pathway,cAMP signaling pathway,serotonergic synapse,dopaminergic synapse,cGMP-PKG signaling pathway,and cholinergic synapse pathway,etc.[Conclusions]The potential targets of ZZGJD in the treatment of insomnia mainly involve G protein-coupled receptors,and regulate various neural receptor pathways such as calcium ion channels,serotonin,dopamine,and adrenergic receptors.INS,IGF-1,CTNNB1,ESR1,HIF-1A,etc.may be the key targets of ZZGJD in regulating sleep disorders,reflecting the multi-target and overall function characteristics of Chinese herbal compounds.ZZGJD is of great significance in the treatment of sleep disorders caused by blood sugar abnormality in patients with diabetes and perimenopausal hormones in women.This article is expected to It provide new ideas for in-depth study of the molecular mechanism of ZZGJD.展开更多
[Objectives]To observe the clinical analgesic effect of Qianghuo Chushi Decoction(QHCSD)on patients with fasciitis,and explore its possible molecular mechanism based on network pharmacology.[Methods]120 enrolled patie...[Objectives]To observe the clinical analgesic effect of Qianghuo Chushi Decoction(QHCSD)on patients with fasciitis,and explore its possible molecular mechanism based on network pharmacology.[Methods]120 enrolled patients were randomly divided into experimental group and control group,and were separately treated with QHCSD formula granules and Diclofenac Sodium Enteric-coated Tablets for 4 weeks.The patient’s pain visual analogue scale(VAS)was used as the curative effect indicator.The molecular action mechanism of QHCSD was predicted based on network pharmacology,the active components of QHCSD were screened using TCMSP database,potential targets were predicted by PharmMapper server,compound-target network and protein interaction network were constructed,and GO-based enrichment analysis and KEGG-based biological pathway enrichment analysis were performed.[Results]After treatment,the pain scores in each group were significantly lower than those before treatment(P<0.01),the score of the experimental group was significantly lower than that of the control group(P<0.01),and the total effective rate of the experimental group was 83.33%,which was significantly higher than that of the control group(78.33%,P<0.05).Based on 108 active components in QHCSD,a compound-target network was constructed.The PPI network contained 155 nodes and 527 interaction relationships,and key nodes included FOS,ESR1,NCOA1,RELA,EGFR,MAPK8,IL-6,etc.The GO pathway mainly involved steroid hormone and its receptor activity,RNA polymerase II transcriptional regulator binding,nuclear receptor activity,protein heterodimerization activity and other pathways.KEGG metabolic pathways included PI3 K-Akt signaling pathway,Kaposi’s sarcoma-associated herpesvirus(KSHV)infection and other pathways.[Conclusions]QHCSD has a significant analgesic effect on fasciitis,and the PI3 K-Akt signaling pathway may be the key pathway for its analgesic effect.展开更多
Electrochemical CO_(2) reduction reaction (CO_(2) RR) offers a practical solution to current global greenhouse effect by converting excessive CO_(2) into value-added chemicals or fuels. Noble metal-based nanomaterials...Electrochemical CO_(2) reduction reaction (CO_(2) RR) offers a practical solution to current global greenhouse effect by converting excessive CO_(2) into value-added chemicals or fuels. Noble metal-based nanomaterials have been considered as efficient catalysts for the CO_(2) RR owing to their high catalytic activity, long-term stability and superior selectivity to targeted products. On the other hand, they are usually loaded on different support materials in order to minimize their usage and maximize the utilization because of high price and limited reserve. The strong metal-support interaction (MSI) between the metal and substrate plays an important role in affecting the CO_(2) RR performance. In this review, we mainly focus on different types of support materials (e.g., oxides, carbons, ligands, alloys and metal carbides) interacting with noble metal as electrocatalysts for CO_(2) RR. Moreover, the positive effects about MSI for boosting the CO_(2) RR performance via regulating the adsorption strength, electronic structure, coordination environment and binding energy are presented. Lastly, emerging challenges and future opportunities on noble metal electrocatalysts with strong MSI are discussed.展开更多
Objective:To ensure the quality of Perilla frutescens(L.)Britt.and improve the associated benefits for stakeholders,this study analyzed the influences of different circulation channels and stakeholders on the quality,...Objective:To ensure the quality of Perilla frutescens(L.)Britt.and improve the associated benefits for stakeholders,this study analyzed the influences of different circulation channels and stakeholders on the quality,price,and other factors of P.frutescens with consideration to P.frutescens distribution.Method:We interviewed the local stakeholders and e-commerce platforms in Oroqen Autonomous Banner and Morin Dawa Daur Autonomous Banner regarding the origin,circulation,distribution,and prices of different medicinal parts of P.frutescens.In addition,the maximumentropymodel was used to predict the potential distribution of P.frutescens in the study area.According to the Chinese Pharmacopeia(2020 edition),we measured the content of index components in the collected Perillae Folium,Perillae Caulis,and Perillae Fructus samples and evaluated the quality of the samples by quantitative and cluster analyses.Remote sensing was employed to distinguish and calculate the P.frutescens area in highly suitable regions.The autoregressive integrated moving average model was adopted to analyze the Perillae Fructus price in the study area.Result:The results showed 8 value chains for P.frutescens.The cooperation chain between farmers and enterprises in the study area could maximize the benefits for all stakeholders and guarantee the quality of the medicinal materials.The results of the regionalization analysis showed that themost suitable area for planting P.frutescens was the junction between Oroqen Autonomous Banner and Morin Dawa Daur Autonomous Banner.Chemical results showed that Perillae Fructus and Perillae Caulis samples were unqualified andmostly purchased from e-commerce platforms.We identified 5 land types,among which the cultivated land area was 3247.7501 km2.The price of Perillae Fructus in the study area showed a rising trend,although this trend slowed down.Conclusion:This study involved various links in the production and circulation of medicinal materials from planting to consumption by consumers,which can help to facilitate the future research on any link.The findings help to guarantee the quality of medicinal materials and benefits of all stakeholders and promote the development of the P.frutescens industry in the study area.展开更多
基金This work was financially supported by National Key Research and Development Program(2018YFB1502503).
文摘The oxygen reduction reaction(ORR)electrocatalytic activity of Pt-based catalysts can be significantly improved by supporting Pt and its alloy nanoparticles(NPs)on a porous carbon support with large surface area.However,such catalysts are often obtained by constructing porous carbon support followed by depositing Pt and its alloy NPs inside the pores,in which the migration and agglomeration of Pt NPs are inevitable under harsh operating conditions owing to the relatively weak interaction between NPs and carbon support.Here we develop a facile electrospinning strategy to in-situ prepare small-sized PtZn NPs supported on porous nitrogen-doped carbon nanofibers.Electrochemical results demonstrate that the as-prepared PtZn alloy catalyst exhibits excellent initial ORR activity with a half-wave potential(E_(1/2))of 0.911 V versus reversible hydrogen electrode(vs.RHE)and enhanced durability with only decreasing 11 mV after 30,000 potential cycles,compared to a more significant drop of 24 mV in E_(1/2)of Pt/C catalysts(after 10,000 potential cycling).Such a desirable performance is ascribed to the created triple-phase reaction boundary assisted by the evaporation of Zn and strengthened interaction between nanoparticles and the carbon support,inhibiting the migration and aggregation of NPs during the ORR.
基金financially supported by the National Natural Science Foundation of China(Nos.52173277 and 21808189)the Key Science and Technology Foundation of Gansu Province,China(No.20YF3GA021)the Natural Science Foundation of Gansu Province,China(No.20JR5RA523).
文摘The cobalt-carbonate(CoCi)/NiFeOOH double-layer co-catalyst was prepared on bismuth vanadate(BiVO_(4)).Compared with the same type of electrode(Co-Pi/NiFeOOH/BiVO_(4)and Co-Sil/NiFeOOH/BiVO_(4)),the photoelectrochemical(PEC)performance of the composite electrode presents the most excellent performance.The Co-Ci/NiFeOOH/BiVO_(4)electrode prepared by photoelectric deposition(PED)achieves a photocurrent density of 4.1 mA/cm^(2)at 1.23 V vs RHE,and the applied bias photon-current efficiency(ABPE)is up to 0.95%.In addition,with the help of the equivalent circuit fitting in electrochemical impedance spectroscopy(EIS),the charge transfer resistance(R_(ct))of Co-Ci/NiFeOOH/BiVO_(4)is only 108.9Ω,which is 16%that of BiVO_(4).The enhanced PEC performance of Co-Ci/NiFeOOH/BiVO_(4)in the double-layer cocatalyst system is attributed to the outstanding advantages of Co-Ci cocatalyst in oxygen vacancy defects,superior to other cobalt-based catalysts in promoting charge transfer and improving the kinetics of water oxidation.This makes Co-Ci co-catalyst become one of the favorable competitors in the field of photoelectric catalysis.
基金financially supported by the National Key Research and Development Program(2018YFB1502503)the Sichuan Science and Technology Program(2020YJ0299)financial supports from the Australian Research Council under the future fellowship scheme(FT160100107)。
文摘Noble metal-based intermetallics are promising electrocatalysts for sustainable energy conversion and consumption processes.High-temperature pyrolysis(>500°C)methods are used to control their crystalline orderings,critical to their electrocatalytic activity and durability.However,the high temperature would cause severe aggregation,resulting in a low catalytic active surface area.Significant research efforts have been devoted to addressing this issue.This short review summarizes recent research progress on synthesizing noble metal-based intermetallic electrocatalysts by space-confined pyrolysis.We focus on three strategies:isolation in pores,coverture by shells,and immobilization by salts.The advantages and existing problems of different methods are highlighted.Last,important issues to be addressed in future research are also discussed.We hope that this article will stimulate future research to develop high-performance intermetallic catalysts for practical applications.
文摘[Objectives]To explore the molecular mechanism of Zhizi Ganjiang Decoction(ZZGJD)regulating sleep disorders based on the network pharmacology.[Methods]The BATMAN-TCM server was used to predict the potential targets of ZZGJD and constructed a compound-disease-target network map,and the GeneCards database was used to search for insomnia-related targets;with the aid of Cytoscape 3.5.1 software,the compound-insomnia target interaction network and protein-protein interaction(PPI)network were constructed,and gene ontology(GO)enrichment,Reactome pathway enrichment,and biological pathway enrichment analysis based on KEGG(Kyoto Encyclopedia of Genes and Enomes)was performed.[Results]The constructed PPI network of ZZGJD involves 204 nodes and 645 interaction relationships.Key nodes involve G protein-coupled receptors,rhodopsin-like adrenaline receptor families,zinc finger proteins,nuclear hormone receptor superfamilies,ligand-binding domains of hormone receptors,voltage-gated calcium(Ca^(2+))channel IQ domains,and neuropituitary hormones.The related entries of GO enrichment analysis pathway mainly involve G protein-coupled receptor activity,neurotransmitter receptor activity,adrenergic receptor activity,ammonium ion binding,catecholamine binding,G protein-coupled serotonin receptor activity,serotonin receptor activity,and steroid hormone receptors(SHRs)activity.Reactome pathway mainly involves amine ligand binding receptors,rhodopsin-like receptors,G protein-coupled receptor ligand binding,adrenergic receptors,neuronal systems and signal transduction,etc.KEGG channel analysis mainly involves neural activity ligand-receptor interaction,calcium ion messenger pathway,cAMP signaling pathway,serotonergic synapse,dopaminergic synapse,cGMP-PKG signaling pathway,and cholinergic synapse pathway,etc.[Conclusions]The potential targets of ZZGJD in the treatment of insomnia mainly involve G protein-coupled receptors,and regulate various neural receptor pathways such as calcium ion channels,serotonin,dopamine,and adrenergic receptors.INS,IGF-1,CTNNB1,ESR1,HIF-1A,etc.may be the key targets of ZZGJD in regulating sleep disorders,reflecting the multi-target and overall function characteristics of Chinese herbal compounds.ZZGJD is of great significance in the treatment of sleep disorders caused by blood sugar abnormality in patients with diabetes and perimenopausal hormones in women.This article is expected to It provide new ideas for in-depth study of the molecular mechanism of ZZGJD.
文摘[Objectives]To observe the clinical analgesic effect of Qianghuo Chushi Decoction(QHCSD)on patients with fasciitis,and explore its possible molecular mechanism based on network pharmacology.[Methods]120 enrolled patients were randomly divided into experimental group and control group,and were separately treated with QHCSD formula granules and Diclofenac Sodium Enteric-coated Tablets for 4 weeks.The patient’s pain visual analogue scale(VAS)was used as the curative effect indicator.The molecular action mechanism of QHCSD was predicted based on network pharmacology,the active components of QHCSD were screened using TCMSP database,potential targets were predicted by PharmMapper server,compound-target network and protein interaction network were constructed,and GO-based enrichment analysis and KEGG-based biological pathway enrichment analysis were performed.[Results]After treatment,the pain scores in each group were significantly lower than those before treatment(P<0.01),the score of the experimental group was significantly lower than that of the control group(P<0.01),and the total effective rate of the experimental group was 83.33%,which was significantly higher than that of the control group(78.33%,P<0.05).Based on 108 active components in QHCSD,a compound-target network was constructed.The PPI network contained 155 nodes and 527 interaction relationships,and key nodes included FOS,ESR1,NCOA1,RELA,EGFR,MAPK8,IL-6,etc.The GO pathway mainly involved steroid hormone and its receptor activity,RNA polymerase II transcriptional regulator binding,nuclear receptor activity,protein heterodimerization activity and other pathways.KEGG metabolic pathways included PI3 K-Akt signaling pathway,Kaposi’s sarcoma-associated herpesvirus(KSHV)infection and other pathways.[Conclusions]QHCSD has a significant analgesic effect on fasciitis,and the PI3 K-Akt signaling pathway may be the key pathway for its analgesic effect.
基金This work was financially supported by National Key Research and Development Program(No.2018YFB1502503)and Sichuan Science and Technology Program(No.2020YJ0299).
文摘Electrochemical CO_(2) reduction reaction (CO_(2) RR) offers a practical solution to current global greenhouse effect by converting excessive CO_(2) into value-added chemicals or fuels. Noble metal-based nanomaterials have been considered as efficient catalysts for the CO_(2) RR owing to their high catalytic activity, long-term stability and superior selectivity to targeted products. On the other hand, they are usually loaded on different support materials in order to minimize their usage and maximize the utilization because of high price and limited reserve. The strong metal-support interaction (MSI) between the metal and substrate plays an important role in affecting the CO_(2) RR performance. In this review, we mainly focus on different types of support materials (e.g., oxides, carbons, ligands, alloys and metal carbides) interacting with noble metal as electrocatalysts for CO_(2) RR. Moreover, the positive effects about MSI for boosting the CO_(2) RR performance via regulating the adsorption strength, electronic structure, coordination environment and binding energy are presented. Lastly, emerging challenges and future opportunities on noble metal electrocatalysts with strong MSI are discussed.
基金supported by the China Agriculture Research SystemofMOF andMARA(NO.CARS-21)the College Students Innovation and Entrepreneurship Training Project of Inner MongoliaMedical University(202310132039).
文摘Objective:To ensure the quality of Perilla frutescens(L.)Britt.and improve the associated benefits for stakeholders,this study analyzed the influences of different circulation channels and stakeholders on the quality,price,and other factors of P.frutescens with consideration to P.frutescens distribution.Method:We interviewed the local stakeholders and e-commerce platforms in Oroqen Autonomous Banner and Morin Dawa Daur Autonomous Banner regarding the origin,circulation,distribution,and prices of different medicinal parts of P.frutescens.In addition,the maximumentropymodel was used to predict the potential distribution of P.frutescens in the study area.According to the Chinese Pharmacopeia(2020 edition),we measured the content of index components in the collected Perillae Folium,Perillae Caulis,and Perillae Fructus samples and evaluated the quality of the samples by quantitative and cluster analyses.Remote sensing was employed to distinguish and calculate the P.frutescens area in highly suitable regions.The autoregressive integrated moving average model was adopted to analyze the Perillae Fructus price in the study area.Result:The results showed 8 value chains for P.frutescens.The cooperation chain between farmers and enterprises in the study area could maximize the benefits for all stakeholders and guarantee the quality of the medicinal materials.The results of the regionalization analysis showed that themost suitable area for planting P.frutescens was the junction between Oroqen Autonomous Banner and Morin Dawa Daur Autonomous Banner.Chemical results showed that Perillae Fructus and Perillae Caulis samples were unqualified andmostly purchased from e-commerce platforms.We identified 5 land types,among which the cultivated land area was 3247.7501 km2.The price of Perillae Fructus in the study area showed a rising trend,although this trend slowed down.Conclusion:This study involved various links in the production and circulation of medicinal materials from planting to consumption by consumers,which can help to facilitate the future research on any link.The findings help to guarantee the quality of medicinal materials and benefits of all stakeholders and promote the development of the P.frutescens industry in the study area.
