Active sulfur dissolution and shuttle effect of lithium polysulfides(LiPSs)are the main obstacles hindering the practical application of lithium-sulfur batteries(LSBs),which is primarily induced by the direct interact...Active sulfur dissolution and shuttle effect of lithium polysulfides(LiPSs)are the main obstacles hindering the practical application of lithium-sulfur batteries(LSBs),which is primarily induced by the direct interaction between sulfur-loading cathode and liquid electrolyte.The introduction of functional interlayer within the separator and cathode is an effective strategy to stabilize the electrode/electrolyte interface reaction and improve the utilization rate of active sulfur.Herein,conductive composite nanofabrics(CCN)with multifunctional groups are employed as the interlayer of sulfur-loading cathode,in which the PMIA/PAN supporting fibers offer robust mechanical strength and high thermostable performance,and gelatin/polypyrrole functional fibers ensure high electrical conductivity and strong chemical interaction for LiPSs.As demonstrated by the experimental data and material characterizations,the presence of CCN interlayer not only blocks the shuttle behavior of LiPSs,but also strengthens the interface stability of both Li anode and sulfur-loading cathode.Interestingly,the assembled LSBs with CCN interlayer can maintain stable capacity of 686 mAh/g after 200 cycles at 0.5 A/g.This work will provide new ideas for the elaborate design of functional in terlayers/se para tors for LSBs and lithium metal batteries.展开更多
The uncontrollable dendrite growth of lithium anode and active material dissolution of transition metal oxides cathodes severely hinder the development of lithium metal batteries.An effective strategy to address these...The uncontrollable dendrite growth of lithium anode and active material dissolution of transition metal oxides cathodes severely hinder the development of lithium metal batteries.An effective strategy to address these issues is optimizing the separator to regulate ion transport and trap the lost active component.Herein,a crosslinked gelatin nonwoven(CGN)separator is elaborately fabricated through electrospinning and in-situ vapor phase crosslinking process to manipulate the dual electrode interface.Benefitting from the characteristic composition of gelatin,and porous structure of electrospun nonwoven,the CGN separator exhibits excellent interface wettability and low interface resistance,featuring a high Li^(+)transference number of 0.70 and high ionic conductivity of 3.75 m S/cm.As expected,the symmetrical Li/Li cells present stable cycling behavior for 1900 h at 0.5 mA/cm^(2)with low overpotential of 20 mV.The optimized LiMn_(2)O_(4)/Li cells deliver high reversible capacity of 103 m Ah/g as well as high capacityretention ratio of 83.7%after 100 cycles at 0.3 C,which can be effectively attributed to the strong interaction between CGN separator and Mn ions to prevent the loss of active Mn component.This study indicates the application potential of protein-based electrospun membrane for high-performance lithium metal batteries.展开更多
The notorious shuttle effect of polyiodides in aqueous Zinc-iodine(Zn-I2)batteries impedes their practical application,which renders it imperative to address this issue.Here,we report natural gelatin as an advanced aq...The notorious shuttle effect of polyiodides in aqueous Zinc-iodine(Zn-I2)batteries impedes their practical application,which renders it imperative to address this issue.Here,we report natural gelatin as an advanced aqueous binder for iodine-loading cathode to enable stable and efficient Zn-I_(2) batteries.The positively charged region in gelatin presents electrostatic attraction to the iodine species,while the electron-rich regions could donate electrons to form physical or even covalent bonds with iodine species,thus inhibiting polyiodides shuttle effect and boosting redox reaction.A high reversible capacity of 138 mAh g^(-1) after 3000 cycles at 2C and an ultra-long cycling stability of 30000 cycles at 25C with 107 mAh g^(-1) capacity was achieved.Gelatin binder also can accommodate high iodine-loading(~10 mg)cathode,punch cells,and severe temperature conditions(-10℃ and 60℃).In-situ UV-vis absorption spectroscopy,in-situ Raman spectra and theoretical calculation revealed the critical role of gelatin binder in suppressing polyiodide shuttling and accelerating reaction kinetics.This work uncovers the potential of natural low-cost binder material in advanced Zn-I_(2) batteries and drives future study of designing functional binders.展开更多
This study investigated the effect of sealing treatment on the corrosion performance of plasma electrolytic oxidation(PEO)coated AZ91D Mg alloy with and without addition of corrosion inhibitor.The microstructure,phase...This study investigated the effect of sealing treatment on the corrosion performance of plasma electrolytic oxidation(PEO)coated AZ91D Mg alloy with and without addition of corrosion inhibitor.The microstructure,phase composition and corrosion property of the sealed and unsealed coatings were evaluated by using scanning electron microscopy(SEM),energy dispersion spectroscopy(EDS),x-ray diffraction(XRD),x-ray photoelectron spectroscopy(XPS),polarization,and electrochemical impedance spectroscopy(EIS)tests.Electrochemical experiments and salt spray tests showed that,after sealing in phosphate solution containing corrosion inhibitor,the corrosion current density of PEO-coated AZ91D decreased more than 10-fold and the anti-corrosion time in a salt spray environment increased more than three-fold.The corrosion rate of the PEO coating slowed down due to the releasing and adsorbing of the corrosion inhibitors in the pores and cracks of the coating during the corrosion process.展开更多
Radiology report generation is of significant importance.Unlike standard image captioning tasks,radiology report generation faces more pronounced visual and textual biases due to constrained data availability,making i...Radiology report generation is of significant importance.Unlike standard image captioning tasks,radiology report generation faces more pronounced visual and textual biases due to constrained data availability,making it increasingly reliant on prior knowledge in this context.In this paper,we introduce a radiology report generation network termed Dynamics Priori Networks(DPN),which leverages a dynamic knowledge graph and prior knowledge.Concretely,we establish an adaptable graph network and harness both medical domain knowledge and expert insights to enhance the model’s intelligence.Notably,we introduce an image-text contrastive module and an image-text matching module to enhance the quality of the generated results.Our method is evaluated on two widely available datasets:X-ray collection from Indiana University(IU X-ray)and Medical Information Mart for Intensive Care,Chest X-Ray(MIMIC-CXR),where it demonstrates superior performance,particularly excelling in critical metrics.展开更多
Fatty acids （FAs） play crucial rules in signal transduction and plant development, however, the regulation of FA metabolism is still poorly understood. To study the relevant regulatory network, fifty-eight FA biosyn...Fatty acids （FAs） play crucial rules in signal transduction and plant development, however, the regulation of FA metabolism is still poorly understood. To study the relevant regulatory network, fifty-eight FA biosynthesis genes including de novo synthases, desaturases and elongases were selected as ＂guide genes＂ to construct the co-expression network. Calculation of the correlation between all Arabidopsis thaliana （L.） genes with each guide gene by Arabidopsis co-expression dating mining tools （ACT） identifies 797 candidate FA-correlated genes. Gene ontology （GO） analysis of these co-expressed genes showed they are tightly correlated to photosynthesis and carbohydrate metabolism, and function in many processes. Interestingly, 63 transcription factors （TFs） were identified as candidate FA biosynthesis regulators and 8 TF families are enriched. Two TF genes, CRC and AP1, both correlating with 8 FA guide genes, were further characterized. Analyses of the ap1 and crc mutant showed the altered total FA composition of mature seeds. The contents of palmitoleic acid, stearic acid, arachidic acid and eicosadienoic acid are decreased, whereas that of oleic acid is increased in apl and crc seeds, which is consistent with the qRT-PCR analysis revealing the suppressed expression of the corresponding guide genes. In addition, yeast one-hybrid analysis and electrophoretic mobility shift assay （EMSA） revealed that CRC can bind to the promoter regions of KCS7 and KCS15, indicating that CRC may directly regulate FA biosynthesis.展开更多
In the last decade,organoid research has entered a golden era,signifying a pivotal shift in the biomedical landscape.The year 2023 marked a milestone with the publication of thousands of papers in this arena,reflectin...In the last decade,organoid research has entered a golden era,signifying a pivotal shift in the biomedical landscape.The year 2023 marked a milestone with the publication of thousands of papers in this arena,reflecting exponential growth.However,amid this burgeoning expansion,a comprehensive and accurate overview of the field has been conspicuously absent.Our review is intended to bridge this gap,providing a panoramic view of the rapidly evolving organoid landscape.We meticulously analyze the organoid field from eight distinctive vantage points,harnessing our rich experience in academic research,industrial application,and clinical practice.We present a deep exploration of the advances in organoid technology,underpinned by our long-standing involvement in this arena.Our narrative traverses the historical genesis of organoids and their transformative impact across various biomedical sectors,including oncology,toxicology,and drug development.We delve into the synergy between organoids and avant-garde technologies such as synthetic biology and single-cell omics and discuss their pivotal role in tailoring personalized medicine,enhancing high-throughput drug screening,and constructing physiologically pertinent disease models.Our comprehensive analysis and reflective discourse provide a deep dive into the existing landscape and emerging trends in organoid technology.We spotlight technological innovations,methodological evolution,and the broadening spectrum of applications,emphasizing the revolutionary influence of organoids in personalized medicine,oncology,drug discovery,and other fields.Looking ahead,we cautiously anticipate future developments in the field of organoid research,especially its potential implications for personalized patient care,new avenues of drug discovery,and clinical research.We trust that our comprehensive review will be an asset for researchers,clinicians,and patients with keen interest in personalized medical strategies.We offer a broad view of the present and prospective capabilities of organoid technology,encompassing a wide range of current and future applications.In summary,in this review we attempt a comprehensive exploration of the organoid field.We offer reflections,summaries,and projections that might be useful for current researchers and clinicians,and we hope to contribute to shaping the evolving trajectory of this dynamic and rapidly advancing field.展开更多
An efficient trifluoromethylation reaction of vinyldiazoacetates under mild reaction conditions was depicted.Pre-generated CuCF_(3) was used as a trifluoromethylation reagent and water acted as both a promoter and pro...An efficient trifluoromethylation reaction of vinyldiazoacetates under mild reaction conditions was depicted.Pre-generated CuCF_(3) was used as a trifluoromethylation reagent and water acted as both a promoter and proton source.The reaction is compatible with a broad scope of functional groups and easy to scale-up.The wide functional group tolerance of the reaction enables further synthetic manipulation of the products.展开更多
Electrochromic(EC)devices have been regarded as promising candidates for energy-saving smart windows,next-generation displays,and wearable electronics.Monovalent ions such as H^(+)-and Li^(+)-based electrolytes are th...Electrochromic(EC)devices have been regarded as promising candidates for energy-saving smart windows,next-generation displays,and wearable electronics.Monovalent ions such as H^(+)-and Li^(+)-based electrolytes are the benchmark insertion ions for EC devices but have serious limitations such as high cost,instability,and difficulty to handle.Seeking multivalent electrolytes is an effective alternative way to prepare high-performance EC devices;unfortunately,the related reports are currently limited to tungsten oxide EC materials.Herein,for the first time,we investigate the EC properties driven by different valence cationic(i.e.,Li^(+),Zn^(2+),and Al^(3+))electrolytes in the titanium dioxide system.It is found that the initial optical modulation ranges of TiO_(2)nanocrystal(NC)films in Li^(+),Zn^(2+),and Al^(3+)electrolytes are 76.8%,77.4%,and 77.3%,respectively.After 250 cycles,the optical contrast of these films in Zn^(2+)electrolyte decreased by only 2.3%,much lower than that in benchmark Li^(+)electrolyte of 10.1%and Al^(3+)electrolyte of 59.1%.Density functional theory calculation indicates that the potential barriers of Li^(+),Zn^(2+),and Al^(3+)in TiO_(2)are 0.59,0.55,and 0.74 eV,respectively,which makes TiO_(2)NCs show good EC properties in Zn^(2+)electrolytes.This work unravels the effect of different valence cations on the electrochromic properties of titanium dioxide NCs,which may provide some new directions for the development of excellent EC devices with long-term stability and durability.展开更多
基金supported by National Natural Science Foundation of China(No.22309029)Guangdong Basic and Applied Basic Research Foundation(No.2021A1515110089)+2 种基金Dongguan Social Development Technology Foundation(No.20231800907933)Collaborative Innovation Center of Marine Science and Technology of Hainan University(No.XTCX2022HYC14)Start-up Research Foundation of Hainan University(No.KYQD(ZR)-23069)。
文摘Active sulfur dissolution and shuttle effect of lithium polysulfides(LiPSs)are the main obstacles hindering the practical application of lithium-sulfur batteries(LSBs),which is primarily induced by the direct interaction between sulfur-loading cathode and liquid electrolyte.The introduction of functional interlayer within the separator and cathode is an effective strategy to stabilize the electrode/electrolyte interface reaction and improve the utilization rate of active sulfur.Herein,conductive composite nanofabrics(CCN)with multifunctional groups are employed as the interlayer of sulfur-loading cathode,in which the PMIA/PAN supporting fibers offer robust mechanical strength and high thermostable performance,and gelatin/polypyrrole functional fibers ensure high electrical conductivity and strong chemical interaction for LiPSs.As demonstrated by the experimental data and material characterizations,the presence of CCN interlayer not only blocks the shuttle behavior of LiPSs,but also strengthens the interface stability of both Li anode and sulfur-loading cathode.Interestingly,the assembled LSBs with CCN interlayer can maintain stable capacity of 686 mAh/g after 200 cycles at 0.5 A/g.This work will provide new ideas for the elaborate design of functional in terlayers/se para tors for LSBs and lithium metal batteries.
基金supported by National Natural Science Foundation of China(No.22309029)Guangdong Basic and Applied Basic Research Foundation(No.2024A1515140011)+1 种基金Dongguan Social Development Technology Foundation(No.20231800907933)Collaborative Innovation Center of Marine Science and Technology of Hainan University(No.XTCX2022HYC14)。
文摘The uncontrollable dendrite growth of lithium anode and active material dissolution of transition metal oxides cathodes severely hinder the development of lithium metal batteries.An effective strategy to address these issues is optimizing the separator to regulate ion transport and trap the lost active component.Herein,a crosslinked gelatin nonwoven(CGN)separator is elaborately fabricated through electrospinning and in-situ vapor phase crosslinking process to manipulate the dual electrode interface.Benefitting from the characteristic composition of gelatin,and porous structure of electrospun nonwoven,the CGN separator exhibits excellent interface wettability and low interface resistance,featuring a high Li^(+)transference number of 0.70 and high ionic conductivity of 3.75 m S/cm.As expected,the symmetrical Li/Li cells present stable cycling behavior for 1900 h at 0.5 mA/cm^(2)with low overpotential of 20 mV.The optimized LiMn_(2)O_(4)/Li cells deliver high reversible capacity of 103 m Ah/g as well as high capacityretention ratio of 83.7%after 100 cycles at 0.3 C,which can be effectively attributed to the strong interaction between CGN separator and Mn ions to prevent the loss of active Mn component.This study indicates the application potential of protein-based electrospun membrane for high-performance lithium metal batteries.
基金supported by National Natural Science Foundation of China(22309029,52404316)Guangdong Basic and Applied Basic Research Foundation(Nos.2024A1515140011,and 2024A1515110010)+2 种基金Dongguan Social Development Technology Foundation(Nos.20231800907933,and 20221800905122)Collaborative Innovation Center of Marine Science and Technology of Hainan University(No.XTCX2022HYC14)Start-up Research Foundation of Hainan University(No.KYQD(ZR)-23069).
文摘The notorious shuttle effect of polyiodides in aqueous Zinc-iodine(Zn-I2)batteries impedes their practical application,which renders it imperative to address this issue.Here,we report natural gelatin as an advanced aqueous binder for iodine-loading cathode to enable stable and efficient Zn-I_(2) batteries.The positively charged region in gelatin presents electrostatic attraction to the iodine species,while the electron-rich regions could donate electrons to form physical or even covalent bonds with iodine species,thus inhibiting polyiodides shuttle effect and boosting redox reaction.A high reversible capacity of 138 mAh g^(-1) after 3000 cycles at 2C and an ultra-long cycling stability of 30000 cycles at 25C with 107 mAh g^(-1) capacity was achieved.Gelatin binder also can accommodate high iodine-loading(~10 mg)cathode,punch cells,and severe temperature conditions(-10℃ and 60℃).In-situ UV-vis absorption spectroscopy,in-situ Raman spectra and theoretical calculation revealed the critical role of gelatin binder in suppressing polyiodide shuttling and accelerating reaction kinetics.This work uncovers the potential of natural low-cost binder material in advanced Zn-I_(2) batteries and drives future study of designing functional binders.
基金the National Natural Science Foundation of China(No.U1737102,51531007,51371059)Young Elite Scientists Sponsorship Program by CAST(2017QNRC001)+3 种基金Guangxi Natural Science Foundation of China(Nos.2016GXNSFDA380022)Major Science and Technology Projects in Guangxi(No.AA18118030 and AA17204100)Project of Development of Science and Technology of Nanning(No.20181191-2)the Fundamental Research Funds for the Central Universities(N170203006).
文摘This study investigated the effect of sealing treatment on the corrosion performance of plasma electrolytic oxidation(PEO)coated AZ91D Mg alloy with and without addition of corrosion inhibitor.The microstructure,phase composition and corrosion property of the sealed and unsealed coatings were evaluated by using scanning electron microscopy(SEM),energy dispersion spectroscopy(EDS),x-ray diffraction(XRD),x-ray photoelectron spectroscopy(XPS),polarization,and electrochemical impedance spectroscopy(EIS)tests.Electrochemical experiments and salt spray tests showed that,after sealing in phosphate solution containing corrosion inhibitor,the corrosion current density of PEO-coated AZ91D decreased more than 10-fold and the anti-corrosion time in a salt spray environment increased more than three-fold.The corrosion rate of the PEO coating slowed down due to the releasing and adsorbing of the corrosion inhibitors in the pores and cracks of the coating during the corrosion process.
基金supported by the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB38050100)the Shenzhen Science and Technology Program(No.SGDX20201103095603009)the Shenzhen Polytechnic Research Fund(No.6023310009K).
文摘Radiology report generation is of significant importance.Unlike standard image captioning tasks,radiology report generation faces more pronounced visual and textual biases due to constrained data availability,making it increasingly reliant on prior knowledge in this context.In this paper,we introduce a radiology report generation network termed Dynamics Priori Networks(DPN),which leverages a dynamic knowledge graph and prior knowledge.Concretely,we establish an adaptable graph network and harness both medical domain knowledge and expert insights to enhance the model’s intelligence.Notably,we introduce an image-text contrastive module and an image-text matching module to enhance the quality of the generated results.Our method is evaluated on two widely available datasets:X-ray collection from Indiana University(IU X-ray)and Medical Information Mart for Intensive Care,Chest X-Ray(MIMIC-CXR),where it demonstrates superior performance,particularly excelling in critical metrics.
基金supported by the National High-tech R&D Program (863 Program, 2007AA02Z128)
文摘Fatty acids （FAs） play crucial rules in signal transduction and plant development, however, the regulation of FA metabolism is still poorly understood. To study the relevant regulatory network, fifty-eight FA biosynthesis genes including de novo synthases, desaturases and elongases were selected as ＂guide genes＂ to construct the co-expression network. Calculation of the correlation between all Arabidopsis thaliana （L.） genes with each guide gene by Arabidopsis co-expression dating mining tools （ACT） identifies 797 candidate FA-correlated genes. Gene ontology （GO） analysis of these co-expressed genes showed they are tightly correlated to photosynthesis and carbohydrate metabolism, and function in many processes. Interestingly, 63 transcription factors （TFs） were identified as candidate FA biosynthesis regulators and 8 TF families are enriched. Two TF genes, CRC and AP1, both correlating with 8 FA guide genes, were further characterized. Analyses of the ap1 and crc mutant showed the altered total FA composition of mature seeds. The contents of palmitoleic acid, stearic acid, arachidic acid and eicosadienoic acid are decreased, whereas that of oleic acid is increased in apl and crc seeds, which is consistent with the qRT-PCR analysis revealing the suppressed expression of the corresponding guide genes. In addition, yeast one-hybrid analysis and electrophoretic mobility shift assay （EMSA） revealed that CRC can bind to the promoter regions of KCS7 and KCS15, indicating that CRC may directly regulate FA biosynthesis.
基金National Natural Science Foundation of China(82373719,82173662,and 32200581)National Key R&D Program of China(2023YFC3605702 and 2023YFC2308002)Extraordinary 2025 Elite Project of Fudan University.
文摘In the last decade,organoid research has entered a golden era,signifying a pivotal shift in the biomedical landscape.The year 2023 marked a milestone with the publication of thousands of papers in this arena,reflecting exponential growth.However,amid this burgeoning expansion,a comprehensive and accurate overview of the field has been conspicuously absent.Our review is intended to bridge this gap,providing a panoramic view of the rapidly evolving organoid landscape.We meticulously analyze the organoid field from eight distinctive vantage points,harnessing our rich experience in academic research,industrial application,and clinical practice.We present a deep exploration of the advances in organoid technology,underpinned by our long-standing involvement in this arena.Our narrative traverses the historical genesis of organoids and their transformative impact across various biomedical sectors,including oncology,toxicology,and drug development.We delve into the synergy between organoids and avant-garde technologies such as synthetic biology and single-cell omics and discuss their pivotal role in tailoring personalized medicine,enhancing high-throughput drug screening,and constructing physiologically pertinent disease models.Our comprehensive analysis and reflective discourse provide a deep dive into the existing landscape and emerging trends in organoid technology.We spotlight technological innovations,methodological evolution,and the broadening spectrum of applications,emphasizing the revolutionary influence of organoids in personalized medicine,oncology,drug discovery,and other fields.Looking ahead,we cautiously anticipate future developments in the field of organoid research,especially its potential implications for personalized patient care,new avenues of drug discovery,and clinical research.We trust that our comprehensive review will be an asset for researchers,clinicians,and patients with keen interest in personalized medical strategies.We offer a broad view of the present and prospective capabilities of organoid technology,encompassing a wide range of current and future applications.In summary,in this review we attempt a comprehensive exploration of the organoid field.We offer reflections,summaries,and projections that might be useful for current researchers and clinicians,and we hope to contribute to shaping the evolving trajectory of this dynamic and rapidly advancing field.
基金the National Natural Science Foundation of China(21901196)the Natural Science Basic Research Plan in Shaanxi Province of China(2020JQ-016)Xi’an Jiaotong University(71211920000001)for financial support.
文摘An efficient trifluoromethylation reaction of vinyldiazoacetates under mild reaction conditions was depicted.Pre-generated CuCF_(3) was used as a trifluoromethylation reagent and water acted as both a promoter and proton source.The reaction is compatible with a broad scope of functional groups and easy to scale-up.The wide functional group tolerance of the reaction enables further synthetic manipulation of the products.
基金This work was supported by the National Natural Science Foundation of China(51902064)the Scientific and Technological Bases and Talents of Guangxi(Guike AD20159073)the Natural Science Foundation of Guangxi Province(2022GXNSFFA0350325),the“Guangxi Hundred-Talent Program”,and the special fund for“Guangxi Bagui Scholars.”。
文摘Electrochromic(EC)devices have been regarded as promising candidates for energy-saving smart windows,next-generation displays,and wearable electronics.Monovalent ions such as H^(+)-and Li^(+)-based electrolytes are the benchmark insertion ions for EC devices but have serious limitations such as high cost,instability,and difficulty to handle.Seeking multivalent electrolytes is an effective alternative way to prepare high-performance EC devices;unfortunately,the related reports are currently limited to tungsten oxide EC materials.Herein,for the first time,we investigate the EC properties driven by different valence cationic(i.e.,Li^(+),Zn^(2+),and Al^(3+))electrolytes in the titanium dioxide system.It is found that the initial optical modulation ranges of TiO_(2)nanocrystal(NC)films in Li^(+),Zn^(2+),and Al^(3+)electrolytes are 76.8%,77.4%,and 77.3%,respectively.After 250 cycles,the optical contrast of these films in Zn^(2+)electrolyte decreased by only 2.3%,much lower than that in benchmark Li^(+)electrolyte of 10.1%and Al^(3+)electrolyte of 59.1%.Density functional theory calculation indicates that the potential barriers of Li^(+),Zn^(2+),and Al^(3+)in TiO_(2)are 0.59,0.55,and 0.74 eV,respectively,which makes TiO_(2)NCs show good EC properties in Zn^(2+)electrolytes.This work unravels the effect of different valence cations on the electrochromic properties of titanium dioxide NCs,which may provide some new directions for the development of excellent EC devices with long-term stability and durability.
