BACKGROUND:Ischemic stroke refers to a disorder in the blood supply to a local area of brain tissue for various reasons and is characterized by high morbidity,mortality,and disability.Early reperfusion of brain tissue...BACKGROUND:Ischemic stroke refers to a disorder in the blood supply to a local area of brain tissue for various reasons and is characterized by high morbidity,mortality,and disability.Early reperfusion of brain tissue at risk of injury is crucial for the treatment of acute ischemic stroke.The purpose of this study was to evaluate comfort levels in managing acute stroke patients with hypoxemia who required endotracheal intubation after multidisciplinary in situ simulation training and to shorten the door-to-image time.METHODS:This quality improvement project utilized a comprehensive multidisciplinary in situ simulation exercise.A total of 53 participants completed the two-day in situ simulation training.The main outcome was the self-reported comfort levels of participants in managing acute stroke patients with hypoxemia requiring endotracheal intubation before and after simulation training.A 5-point Likert scale was used to measure participant comfort.A paired-sample t-test was used to compare the mean self-reported comfort scores of participants,as well as the endotracheal intubation time and door-to-image time on the fi rst and second days of in situ simulation training.The door-to-image time before and after the training was also recorded.RESULTS:The findings indicated that in situ simulation training could enhance participant comfort when managing acute stroke patients with hypoxemia who required endotracheal intubation and shorten door-to-image time.For the emergency management of hypoxemia or tracheal intubation,the mean post-training self-reported comfort score was signifi cantly higher than the mean pre-training comfort score(hypoxemia:4.53±0.64 vs.3.62±0.69,t=-11.046,P<0.001;tracheal intubation:3.98±0.72 vs.3.43±0.72,t=-6.940,P<0.001).We also observed a decrease in the tracheal intubation and door-to-image time and a decreasing trend in the door-to-image time,which continued after the training.CONCLUSION:Our study demonstrates that the implementation of in situ simulation training in a clinical environment with a multidisciplinary approach may improve the ability and confi dence of stroke team members,optimize the fi rst-aid process,and eff ectively shorten the door-to-image time of stroke patients with emergency complications.展开更多
In recent years,there are some problems in science and technology management,such as untimely task supervision and independent information system,which makes it difficult to achieve accurate,quantitative and standardi...In recent years,there are some problems in science and technology management,such as untimely task supervision and independent information system,which makes it difficult to achieve accurate,quantitative and standardized management.The storage of scientific research test data is scattered,and there are many deficiencies in the management,promotion and use of existing intellectual property.In this paper,on the basis of the knowledge economy,intelligence economy under the conditions of knowledge management concept and cutting-edge technology,technology management and service management related data,information,knowledge,method of blend together.Based on science and technology management,knowledge management as the core of management and service platform of science and technology technical route,main function,construction principles and standards.In order to realize the management systematization of science and technology,intelligent,better educated,multi-level and multi-angle application services.展开更多
Intelligent decision-making(IDM)is a cornerstone of artificial intelligence(AI)designed to automate or augment decision processes.Modern IDM paradigms integrate advanced frameworks to enable intelligent agents to make...Intelligent decision-making(IDM)is a cornerstone of artificial intelligence(AI)designed to automate or augment decision processes.Modern IDM paradigms integrate advanced frameworks to enable intelligent agents to make effective and adaptive choices and decompose complex tasks into manageable steps,such as AI agents and high-level reinforcement learning.Recent advances in multimodal foundation-based approaches unify diverse input modalities—such as vision,language,and sensory data—into a cohesive decision-making process.Foundation models(FMs)have become pivotal in science and industry,transforming decision-making and research capabilities.Their large-scale,multimodal data-processing abilities foster adaptability and interdisciplinary breakthroughs across fields such as healthcare,life sciences,and education.This survey examines IDM’s evolution,advanced paradigms with FMs and their transformative impact on decision-making across diverse scientific and industrial domains,highlighting the challenges and opportunities in building efficient,adaptive,and ethical decision systems.展开更多
Hydrophobicity enhancement of metal-free leather,which is crucial for improving its comprehensive performance,can be achieved by using amphiphilic copolymer retanning agents.However,the relationship between the sequen...Hydrophobicity enhancement of metal-free leather,which is crucial for improving its comprehensive performance,can be achieved by using amphiphilic copolymer retanning agents.However,the relationship between the sequential structure and the hydrophobic modification effect of amphiphilic copolymers remains unclear.Herein,an amphiphilic block copolymer was synthesized using stearyl methacrylate and 2-(dimethylamino)ethyl methacrylate via atom transfer radical polymerization,and the corresponding random copolymer with similar monomer compositions and molecular weights was prepared for comparison.The aggregation behavior of block and random copolymers was investigated.DLS and TEM results indicate that the block copolymer exhibits a larger aggregate size than the corresponding random copolymer.Molecular dynamics simulations suggest that the block copolymer aggregate exhibit a thicker hydrophilic shell and more concentrated distribution of cationic DMA block than the random copolymer aggregate.Subsequently,the block and random copolymers were used for the hydrophobic modification of metal-free tanned collagen fibers(CFs).The block copolymer shows superior binding capacity to CFs than the random one because of its larger size and more concentrated charge distribution.Hence,the block copolymer can form a dense and uniform hydrophobic film on the surface of collagen fibrils and endow CFs with higher hydrophobicity than the random one.This work provides theoretical guidance for modulating the hydrophobicity of CFs by tailoring the sequential structure of amphiphilic copolymers,which is expected to inspire the manufacturing of high-perfor-mance metal-free leather.展开更多
基金supported by Hangzhou Construction Fund of Key Medical Disciplines(OO20200265)Zhejiang Medical and Health Science and Technology Plan Project(2020KY687)+1 种基金Hangzhou Science and Technology Development Project(20200401B04)Hangzhou Biomedical and Health Industry Development Supporting Technology Projects(2021WJCY256).
文摘BACKGROUND:Ischemic stroke refers to a disorder in the blood supply to a local area of brain tissue for various reasons and is characterized by high morbidity,mortality,and disability.Early reperfusion of brain tissue at risk of injury is crucial for the treatment of acute ischemic stroke.The purpose of this study was to evaluate comfort levels in managing acute stroke patients with hypoxemia who required endotracheal intubation after multidisciplinary in situ simulation training and to shorten the door-to-image time.METHODS:This quality improvement project utilized a comprehensive multidisciplinary in situ simulation exercise.A total of 53 participants completed the two-day in situ simulation training.The main outcome was the self-reported comfort levels of participants in managing acute stroke patients with hypoxemia requiring endotracheal intubation before and after simulation training.A 5-point Likert scale was used to measure participant comfort.A paired-sample t-test was used to compare the mean self-reported comfort scores of participants,as well as the endotracheal intubation time and door-to-image time on the fi rst and second days of in situ simulation training.The door-to-image time before and after the training was also recorded.RESULTS:The findings indicated that in situ simulation training could enhance participant comfort when managing acute stroke patients with hypoxemia who required endotracheal intubation and shorten door-to-image time.For the emergency management of hypoxemia or tracheal intubation,the mean post-training self-reported comfort score was signifi cantly higher than the mean pre-training comfort score(hypoxemia:4.53±0.64 vs.3.62±0.69,t=-11.046,P<0.001;tracheal intubation:3.98±0.72 vs.3.43±0.72,t=-6.940,P<0.001).We also observed a decrease in the tracheal intubation and door-to-image time and a decreasing trend in the door-to-image time,which continued after the training.CONCLUSION:Our study demonstrates that the implementation of in situ simulation training in a clinical environment with a multidisciplinary approach may improve the ability and confi dence of stroke team members,optimize the fi rst-aid process,and eff ectively shorten the door-to-image time of stroke patients with emergency complications.
基金supported by Research on Construction of Green Building Material Information Management Platform(Grant 2016024).
文摘In recent years,there are some problems in science and technology management,such as untimely task supervision and independent information system,which makes it difficult to achieve accurate,quantitative and standardized management.The storage of scientific research test data is scattered,and there are many deficiencies in the management,promotion and use of existing intellectual property.In this paper,on the basis of the knowledge economy,intelligence economy under the conditions of knowledge management concept and cutting-edge technology,technology management and service management related data,information,knowledge,method of blend together.Based on science and technology management,knowledge management as the core of management and service platform of science and technology technical route,main function,construction principles and standards.In order to realize the management systematization of science and technology,intelligent,better educated,multi-level and multi-angle application services.
基金supported by the National Natural Science Foundation of China under grant nos.62372470,72225011,62402414,U23B2059,62173034,32222070,62402017,72421002,62206303,62476264,62406312,62102266,52173241,and U23A20468the National Key Research and Development Program of China(2023YFD1900604)+8 种基金the Strategic Priority Research Program of the Chinese Academy of Science(XDB0680301)the Youth Innovation Promotion Association CAS(2023112)the National High Level Hospital Clinical Research funding(2022-PUMCH-A-014),the Beijing Natural Science Foundation(4244098)the Science and Technology Innovation Program of Hunan Province(2023RC3009)the Key Research and Development Program of Yunnan Province(202202AE090034)the MNR Key Laboratory for Geo-Environmental Monitoring of Greater Bay Area(GEMLab-2023001)the Science and Technology Innovation Key R&D Program of Chongqing(CSTB2024TIAD-STX0024)the China National Postdoctoral Program for Innovative Talents(BX20240385)the River Talent Recruitment Program of Guangdong Province(2019ZT08X603).
文摘Intelligent decision-making(IDM)is a cornerstone of artificial intelligence(AI)designed to automate or augment decision processes.Modern IDM paradigms integrate advanced frameworks to enable intelligent agents to make effective and adaptive choices and decompose complex tasks into manageable steps,such as AI agents and high-level reinforcement learning.Recent advances in multimodal foundation-based approaches unify diverse input modalities—such as vision,language,and sensory data—into a cohesive decision-making process.Foundation models(FMs)have become pivotal in science and industry,transforming decision-making and research capabilities.Their large-scale,multimodal data-processing abilities foster adaptability and interdisciplinary breakthroughs across fields such as healthcare,life sciences,and education.This survey examines IDM’s evolution,advanced paradigms with FMs and their transformative impact on decision-making across diverse scientific and industrial domains,highlighting the challenges and opportunities in building efficient,adaptive,and ethical decision systems.
基金financially supported by the National Natural Science Foundation of China (22278280)
文摘Hydrophobicity enhancement of metal-free leather,which is crucial for improving its comprehensive performance,can be achieved by using amphiphilic copolymer retanning agents.However,the relationship between the sequential structure and the hydrophobic modification effect of amphiphilic copolymers remains unclear.Herein,an amphiphilic block copolymer was synthesized using stearyl methacrylate and 2-(dimethylamino)ethyl methacrylate via atom transfer radical polymerization,and the corresponding random copolymer with similar monomer compositions and molecular weights was prepared for comparison.The aggregation behavior of block and random copolymers was investigated.DLS and TEM results indicate that the block copolymer exhibits a larger aggregate size than the corresponding random copolymer.Molecular dynamics simulations suggest that the block copolymer aggregate exhibit a thicker hydrophilic shell and more concentrated distribution of cationic DMA block than the random copolymer aggregate.Subsequently,the block and random copolymers were used for the hydrophobic modification of metal-free tanned collagen fibers(CFs).The block copolymer shows superior binding capacity to CFs than the random one because of its larger size and more concentrated charge distribution.Hence,the block copolymer can form a dense and uniform hydrophobic film on the surface of collagen fibrils and endow CFs with higher hydrophobicity than the random one.This work provides theoretical guidance for modulating the hydrophobicity of CFs by tailoring the sequential structure of amphiphilic copolymers,which is expected to inspire the manufacturing of high-perfor-mance metal-free leather.
