According to the latest data from cancer registration center, there are estimated to be 3,929,000 individuals newly diagnosed with cancer and 2,338,000 deaths from this disease in China in 2015 (1). Among them, colore...According to the latest data from cancer registration center, there are estimated to be 3,929,000 individuals newly diagnosed with cancer and 2,338,000 deaths from this disease in China in 2015 (1). Among them, colorectal cancer (CRC) with 388,000 newly diagnosed cases and 187,000 deaths, stands the third place in incidence and the fifth place in mortality. The Chinese Society of Clinical Oncology (CSCO) has organized an expert committee to write and publish the Guideline for Colorectal Cancer in 2017. And its English version has already been published in March 2019 (2). According to the latest progress, the expert committee updated the guideline to the 2019 version in this April, and the summary of the main updates are as following.展开更多
According to the latest data released by the National Cancer Center,colorectal cancer(CRC)had the third highest incidence and the fifth highest mortality of all malignancies,with 388,000 new cases and 187,000 cancer d...According to the latest data released by the National Cancer Center,colorectal cancer(CRC)had the third highest incidence and the fifth highest mortality of all malignancies,with 388,000 new cases and 187,000 cancer deaths in China(1).The Chinese Society of Clinical Oncology(CSCO)originally published the English version of 2018 guideline concerning CRC and updated them in2019(2,3).According to the latest progress,clinical guidelines have been updated.Here,we present the main updates of the 2020 version compared to 2019 version.展开更多
The neutron capture cross section of ^(232)Th was measured at the neutron time-of-flight facility Back-n of China Spallation Neutron Source(CSNS)for the first time.The measurement was performed with 4 hydrogen-free de...The neutron capture cross section of ^(232)Th was measured at the neutron time-of-flight facility Back-n of China Spallation Neutron Source(CSNS)for the first time.The measurement was performed with 4 hydrogen-free deuterated benzene C6D6 liquid scintillation detectors,in the ES#2 experiment station on the beam line,at a distance of about 76 m from the neutron-production assembly.The total energy detection principle in combination with the pulse height weighting technique(PHWT)was applied to analyze the measured data.Results of the ^(232)Th(n,γ)reaction cross section in the unresolved resonance region from 4 keV to 100 keV were obtained,which shows a good agreement with the existing experimental data from EXFOR,as well as with the evaluated data from the ENDF/B-VIII.0 and CENDL-3.1.In addition,the excitation function of ^(232)Th(n,γ)^(233)Th reaction in the unresolved resonance region was theoretically calculated by using the code TALYS-1.95.By fitting the experimental cross section and theoretical data,the average parameters in the unresolved resonance region were extracted.展开更多
The 2024 updates of the Chinese Society of Clinical Oncology(CSCO)Clinical Guidelines for the diagnosis and treatment of colorectal cancer emphasize standardizing cancer treatment in China,highlighting the latest adva...The 2024 updates of the Chinese Society of Clinical Oncology(CSCO)Clinical Guidelines for the diagnosis and treatment of colorectal cancer emphasize standardizing cancer treatment in China,highlighting the latest advancements in evidence-based medicine,healthcare resource access,and precision medicine in oncology.These updates address disparities in epidemiological trends,clinicopathological characteristics,tumor biology,treatment approaches,and drug selection for colorectal cancer patients across diverse regions and backgrounds.Key revisions include adjustments to evidence levels for intensive treatment strategies,updates to regimens for deficient mismatch repair(dMMR)/microsatellite instability-high(MSI-H)patients,proficient mismatch repair(pMMR)/microsatellite stability(MSS)patients who have failed standard therapies,and rectal cancer patients with low recurrence risk.Additionally,recommendations for digital rectal examination and DNA polymerase epsilon(POLE)/DNA polymerase delta 1(POLD1)gene mutation testing have been strengthened.The 2024CSCOGuidelines are based on both Chinese and international clinical research,aswell as expert consensus,ensuring their relevance and applicability in clinical practice,while maintaining a commitment to scientific rigor,impartiality,and timely updates.展开更多
Background:Circular RNAs(circRNAs)generated by back-splicing of precursor mRNAs(pre-mRNAs)are often aberrantly expressed in cancer cells.Accumulating evidence has revealed that circRNAs play a critical role in the pro...Background:Circular RNAs(circRNAs)generated by back-splicing of precursor mRNAs(pre-mRNAs)are often aberrantly expressed in cancer cells.Accumulating evidence has revealed that circRNAs play a critical role in the progression of several cancers,including colorectal cancer(CRC).However,the current understandings of the emerging functions of circRNAs in CRC lipid metabolism and the underlying molecular mechanisms are still limited.Here,we aimed to explore the role of circCAPRIN1 in regulating CRC lipid metabolism and tumorigenesis.Methods:circRNA microarray was performed with three pairs of tumor and non-tumor tissues from CRC patients.The expression of circRNAs were determined by quantitative PCR(qPCR)and in situ hybridization(ISH).The endogenous levels of circRNAs in CRC cells were manipulated by transfection with lentiviruses overexpressing or silencing circRNAs.The regulatory roles of circRNAs in the occurrence of CRC were investigated both in vitro and in vivo using gene expression array,RNA pull-down/mass spectrometry,RNA immunoprecipitation assay,luciferase reporter assay,chromatin immunoprecipitation analysis,and fluorescence in situ hybridization(FISH).Results:Among circRNAs,circCAPRIN1 was most significantly upregulated in CRC tissue specimens.circCAPRIN1 expression was positively correlated with the clinical stage and unfavorable prognosis of CRC patients.Downregulation of circCAPRIN1 suppressed proliferation,migration,and epithelial-mesenchymal transition of CRC cells,while circCAPRIN1 overexpression had opposite effects.RNA sequencing and gene ontology analysis indicated that circCAPRIN1 upregulated the expressions of genes involved in CRC lipid metabolism.Moreover,circCAPRIN1 promoted lipid synthesis by enhancing Acetyl-CoA carboxylase 1(ACC1)expression.Further mechanistic assays demonstrated that circCAPRIN1 directly bound signal transducer and activator of transcription 2(STAT2)to activate ACC1 transcription,thus regulating lipid metabolism and facilitating CRC tumorigenesis.Conclusions:These findings revealed the oncogenic role and mechanism of circCAPRIN1 in CRC.circCAPRIN1 interacted with STAT2 to promote CRC tumor progression and lipid synthesis by enhancing the expression of ACC1.circCAPRIN1 may be considered as a novel potential diagnostic and therapeutic target for CRC patients.展开更多
The presence of malignant ascites in colorectal cancer(CRC)patients is associated with a poor prognosis,a high risk of recurrence,and resistance to chemotherapy and immune therapy[1–3].Understanding the complex inter...The presence of malignant ascites in colorectal cancer(CRC)patients is associated with a poor prognosis,a high risk of recurrence,and resistance to chemotherapy and immune therapy[1–3].Understanding the complex interactions among different kinds of cells and the ecosystem of peritoneal metastasized colorectal cancer(pmCRC)ascites may provide insights into effective treatment strategies.展开更多
The incidence and mortality of colon cancer in China are increasing each year.At present,treatment selection for colon cancer patients mainly depends on imaging results,which require a large number of radiologists to ...The incidence and mortality of colon cancer in China are increasing each year.At present,treatment selection for colon cancer patients mainly depends on imaging results,which require a large number of radiologists to interpret.In China,there is a shortage and uneven distribution of experienced radiologists,which leads to delays and bias in the evaluation of imaging data.Based on these considerations,the Colorectal Surgery Group of the Surgery Branch of the Chinese Medical Association in collaboration with experts at Beihang University has independently developed an artificial intelligence(AI)-based recognition system for the preoperative determination of colon cancer stage to partially replace the work of and relieve the pressure on radiologists.These guidelines aim to standardize the use of AI-based recognition systems in the preoperative staging of colon cancer and guide their clinical application.展开更多
The neutron-induced total cross-section of ^(209)Bi is crucial for the physical design and safety assessment of lead-based fast reactors, and the quality of experimental data should be improved for evaluation and appl...The neutron-induced total cross-section of ^(209)Bi is crucial for the physical design and safety assessment of lead-based fast reactors, and the quality of experimental data should be improved for evaluation and application.A recent experiment was conducted on the back-streaming white neutron beamline(Back-n) at the China Spallation Neutron Source(CSNS) using the neutron total cross-section spectrometer(NTOX). The neutron energy was determined using a fast multi-cell fission chamber and the time-of-flight technique. Two high-purity bismuth samples,6 mm and 20 mm in thickness, were chosen for neutron transmission measurements and comparisons. The neutron total cross-sections of ^(209)Bi, ranging from 0.3 e V to 20 Me V, were derived considering neutron flight time determination, flight path calibration, and background subtraction. A comparison of the experimental results with the data in the ENDF/B-VⅢ.0 library showed fair agreement, and the point-wise cross-sections were found to be consistent with existing experimental data. Special attention was given to the determination of resonance parameters, which were analyzed using the R-matrix code SAMMY and Bayesian method in the 0.5 ke V to 20 ke V energy range. The extracted resonance parameters were compared to previously reported results and evaluated data. This study is recognized as the first one where the neutron total cross-section of bismuth across such a broad energy spectrum is measured in a single measurement or experiment, and it provides valuable data for the assessment of related reaction information for evaluated libraries and the advancement of lead-bismuth-based nuclear systems.展开更多
The neutron total cross-section of ^(nat)Cr plays a crucial role in new nuclear engineering design and fundamental science.A new measurement of the neutron-induced total cross-sections of ^(nat)Cr was performed using ...The neutron total cross-section of ^(nat)Cr plays a crucial role in new nuclear engineering design and fundamental science.A new measurement of the neutron-induced total cross-sections of ^(nat)Cr was performed using the transmission method on the back-streaming white neutron beamline(Back-n)at the China Spallation Neutron Source(CSNS).The neutron energy was determined using the time-of-flight technique.The neutron total cross-sections of ^(nat)Cr were obtained across a broad energy range(0.3 eV−20 MeV)in one experiment for the first time.The resulting effective total cross-sections were compared with the existing experimental data in different energy ranges,which revealed good agreement with the evaluated libraries.Theoretical calculation of the total cross-section in the energy range of 1.5 to 20 MeV was then conducted using TALYS-1.96 and compared with the present results.The measurement provides a high-quality total cross-section of ^(nat)Cr,including detailed uncertainty data across a wide energy range,offering a valuable reference for nuclear data re-evaluation and nuclear engineering design.展开更多
文摘According to the latest data from cancer registration center, there are estimated to be 3,929,000 individuals newly diagnosed with cancer and 2,338,000 deaths from this disease in China in 2015 (1). Among them, colorectal cancer (CRC) with 388,000 newly diagnosed cases and 187,000 deaths, stands the third place in incidence and the fifth place in mortality. The Chinese Society of Clinical Oncology (CSCO) has organized an expert committee to write and publish the Guideline for Colorectal Cancer in 2017. And its English version has already been published in March 2019 (2). According to the latest progress, the expert committee updated the guideline to the 2019 version in this April, and the summary of the main updates are as following.
文摘According to the latest data released by the National Cancer Center,colorectal cancer(CRC)had the third highest incidence and the fifth highest mortality of all malignancies,with 388,000 new cases and 187,000 cancer deaths in China(1).The Chinese Society of Clinical Oncology(CSCO)originally published the English version of 2018 guideline concerning CRC and updated them in2019(2,3).According to the latest progress,clinical guidelines have been updated.Here,we present the main updates of the 2020 version compared to 2019 version.
基金supported by the Chinese TMSR Strategic Pioneer Science and Technology Project(Grant No.XDA02010000)the National Natural Science Foundation of China(Grant No.11790321).
文摘The neutron capture cross section of ^(232)Th was measured at the neutron time-of-flight facility Back-n of China Spallation Neutron Source(CSNS)for the first time.The measurement was performed with 4 hydrogen-free deuterated benzene C6D6 liquid scintillation detectors,in the ES#2 experiment station on the beam line,at a distance of about 76 m from the neutron-production assembly.The total energy detection principle in combination with the pulse height weighting technique(PHWT)was applied to analyze the measured data.Results of the ^(232)Th(n,γ)reaction cross section in the unresolved resonance region from 4 keV to 100 keV were obtained,which shows a good agreement with the existing experimental data from EXFOR,as well as with the evaluated data from the ENDF/B-VIII.0 and CENDL-3.1.In addition,the excitation function of ^(232)Th(n,γ)^(233)Th reaction in the unresolved resonance region was theoretically calculated by using the code TALYS-1.95.By fitting the experimental cross section and theoretical data,the average parameters in the unresolved resonance region were extracted.
文摘The 2024 updates of the Chinese Society of Clinical Oncology(CSCO)Clinical Guidelines for the diagnosis and treatment of colorectal cancer emphasize standardizing cancer treatment in China,highlighting the latest advancements in evidence-based medicine,healthcare resource access,and precision medicine in oncology.These updates address disparities in epidemiological trends,clinicopathological characteristics,tumor biology,treatment approaches,and drug selection for colorectal cancer patients across diverse regions and backgrounds.Key revisions include adjustments to evidence levels for intensive treatment strategies,updates to regimens for deficient mismatch repair(dMMR)/microsatellite instability-high(MSI-H)patients,proficient mismatch repair(pMMR)/microsatellite stability(MSS)patients who have failed standard therapies,and rectal cancer patients with low recurrence risk.Additionally,recommendations for digital rectal examination and DNA polymerase epsilon(POLE)/DNA polymerase delta 1(POLD1)gene mutation testing have been strengthened.The 2024CSCOGuidelines are based on both Chinese and international clinical research,aswell as expert consensus,ensuring their relevance and applicability in clinical practice,while maintaining a commitment to scientific rigor,impartiality,and timely updates.
基金National Natural Science Foundation of China,Grant/Award Numbers:81972260,82103259Shanghai Municipal Natural Science Foundation,Grant/Award Number:21ZR1414400Shanghai Medical Innovation Research Project,Grant/Award Number:22Y11907600。
文摘Background:Circular RNAs(circRNAs)generated by back-splicing of precursor mRNAs(pre-mRNAs)are often aberrantly expressed in cancer cells.Accumulating evidence has revealed that circRNAs play a critical role in the progression of several cancers,including colorectal cancer(CRC).However,the current understandings of the emerging functions of circRNAs in CRC lipid metabolism and the underlying molecular mechanisms are still limited.Here,we aimed to explore the role of circCAPRIN1 in regulating CRC lipid metabolism and tumorigenesis.Methods:circRNA microarray was performed with three pairs of tumor and non-tumor tissues from CRC patients.The expression of circRNAs were determined by quantitative PCR(qPCR)and in situ hybridization(ISH).The endogenous levels of circRNAs in CRC cells were manipulated by transfection with lentiviruses overexpressing or silencing circRNAs.The regulatory roles of circRNAs in the occurrence of CRC were investigated both in vitro and in vivo using gene expression array,RNA pull-down/mass spectrometry,RNA immunoprecipitation assay,luciferase reporter assay,chromatin immunoprecipitation analysis,and fluorescence in situ hybridization(FISH).Results:Among circRNAs,circCAPRIN1 was most significantly upregulated in CRC tissue specimens.circCAPRIN1 expression was positively correlated with the clinical stage and unfavorable prognosis of CRC patients.Downregulation of circCAPRIN1 suppressed proliferation,migration,and epithelial-mesenchymal transition of CRC cells,while circCAPRIN1 overexpression had opposite effects.RNA sequencing and gene ontology analysis indicated that circCAPRIN1 upregulated the expressions of genes involved in CRC lipid metabolism.Moreover,circCAPRIN1 promoted lipid synthesis by enhancing Acetyl-CoA carboxylase 1(ACC1)expression.Further mechanistic assays demonstrated that circCAPRIN1 directly bound signal transducer and activator of transcription 2(STAT2)to activate ACC1 transcription,thus regulating lipid metabolism and facilitating CRC tumorigenesis.Conclusions:These findings revealed the oncogenic role and mechanism of circCAPRIN1 in CRC.circCAPRIN1 interacted with STAT2 to promote CRC tumor progression and lipid synthesis by enhancing the expression of ACC1.circCAPRIN1 may be considered as a novel potential diagnostic and therapeutic target for CRC patients.
基金financial support from the National Key R&D Program of China(No.2019YFA0110601)National Natural Science Foundation of China(No.81571827)+5 种基金Natural Science Foundation Project of Shanghai Science and Technology Commission(SKW2030)Excellent Discipline Reserve Talent Plan of Tongji Hospital Affiliated to Tongji University(HBRC2014)Clinical research Project of Tongji Hospital Affiliated to Tongji University(ITJ-ZD-2104)Key talent introduction project of Tongji Hospital Affiliated to Tongji University(RCQD2102)Talent project of Tongji Hospital Affiliated to Tongji University(GJPY2111)Shanghai Tongji Hospital special disease database construction project(TJ-DB-2105).
文摘The presence of malignant ascites in colorectal cancer(CRC)patients is associated with a poor prognosis,a high risk of recurrence,and resistance to chemotherapy and immune therapy[1–3].Understanding the complex interactions among different kinds of cells and the ecosystem of peritoneal metastasized colorectal cancer(pmCRC)ascites may provide insights into effective treatment strategies.
文摘The incidence and mortality of colon cancer in China are increasing each year.At present,treatment selection for colon cancer patients mainly depends on imaging results,which require a large number of radiologists to interpret.In China,there is a shortage and uneven distribution of experienced radiologists,which leads to delays and bias in the evaluation of imaging data.Based on these considerations,the Colorectal Surgery Group of the Surgery Branch of the Chinese Medical Association in collaboration with experts at Beihang University has independently developed an artificial intelligence(AI)-based recognition system for the preoperative determination of colon cancer stage to partially replace the work of and relieve the pressure on radiologists.These guidelines aim to standardize the use of AI-based recognition systems in the preoperative staging of colon cancer and guide their clinical application.
基金the National Natural Science Foundation of China(12375296)the Key Laboratory of Nuclear Data Foundation(JCKY2022201C153)+1 种基金the National Key Research and Development Plan(2022YFA1603303)the Natural Science Foundation of Hunan Province of China(2021JJ40444,2020RC3054)。
文摘The neutron-induced total cross-section of ^(209)Bi is crucial for the physical design and safety assessment of lead-based fast reactors, and the quality of experimental data should be improved for evaluation and application.A recent experiment was conducted on the back-streaming white neutron beamline(Back-n) at the China Spallation Neutron Source(CSNS) using the neutron total cross-section spectrometer(NTOX). The neutron energy was determined using a fast multi-cell fission chamber and the time-of-flight technique. Two high-purity bismuth samples,6 mm and 20 mm in thickness, were chosen for neutron transmission measurements and comparisons. The neutron total cross-sections of ^(209)Bi, ranging from 0.3 e V to 20 Me V, were derived considering neutron flight time determination, flight path calibration, and background subtraction. A comparison of the experimental results with the data in the ENDF/B-VⅢ.0 library showed fair agreement, and the point-wise cross-sections were found to be consistent with existing experimental data. Special attention was given to the determination of resonance parameters, which were analyzed using the R-matrix code SAMMY and Bayesian method in the 0.5 ke V to 20 ke V energy range. The extracted resonance parameters were compared to previously reported results and evaluated data. This study is recognized as the first one where the neutron total cross-section of bismuth across such a broad energy spectrum is measured in a single measurement or experiment, and it provides valuable data for the assessment of related reaction information for evaluated libraries and the advancement of lead-bismuth-based nuclear systems.
基金Supported by the National Natural Science Foundation of China(12375296)the Educational Commission of Hunan Province,China(21A0281)+2 种基金the Youth Innovation Promotion Association CAS(2023014)the Key Laboratory of Nuclear Data Foundation(JCKY2022201C153)the Natural Science Foundation of Hunan Province,China(2024RC3205,2024JJ2044)。
文摘The neutron total cross-section of ^(nat)Cr plays a crucial role in new nuclear engineering design and fundamental science.A new measurement of the neutron-induced total cross-sections of ^(nat)Cr was performed using the transmission method on the back-streaming white neutron beamline(Back-n)at the China Spallation Neutron Source(CSNS).The neutron energy was determined using the time-of-flight technique.The neutron total cross-sections of ^(nat)Cr were obtained across a broad energy range(0.3 eV−20 MeV)in one experiment for the first time.The resulting effective total cross-sections were compared with the existing experimental data in different energy ranges,which revealed good agreement with the evaluated libraries.Theoretical calculation of the total cross-section in the energy range of 1.5 to 20 MeV was then conducted using TALYS-1.96 and compared with the present results.The measurement provides a high-quality total cross-section of ^(nat)Cr,including detailed uncertainty data across a wide energy range,offering a valuable reference for nuclear data re-evaluation and nuclear engineering design.
