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HUNK蛋白抑制细胞货物摄取与运输的新机制
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作者 崔芯蕊 蒋思远 高山 《科学通报》 北大核心 2025年第26期4393-4395,共3页
内吞作用是细胞从胞外获取大分子和颗粒状物质的一种重要方式,涉及将货物包裹在膜结合的囊泡中进行吸收,并通过多种途径将货物运输到细胞的不同亚细胞器^([1]).细胞内膜系统如同一个精密的物流中心,其中的货物可以是传递信息的信号分子... 内吞作用是细胞从胞外获取大分子和颗粒状物质的一种重要方式,涉及将货物包裹在膜结合的囊泡中进行吸收,并通过多种途径将货物运输到细胞的不同亚细胞器^([1]).细胞内膜系统如同一个精密的物流中心,其中的货物可以是传递信息的信号分子,细胞所需的营养物质,也可以是修饰后的药物分子,因此内吞作用在癌症治疗中发挥着相当重要的作用.内吞在机制和形态上可分为多种途径,如能够通过摄取细胞外液和溶质获取营养物质的巨胞饮途径. 展开更多
关键词 细胞货物摄取 癌症治疗 内吞作用 HUNK蛋白
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Pore structure characteristics of low-rank coal reservoirs with different ash yields and their implications for recoverability of coalbed methane—a case study from the Erlian Basin, northeastern China 被引量:2
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作者 Dawei DONG Jiaosheng YANG +4 位作者 Qiujia HU Shitao cui Fenjin SUN Jidong ZHANG xinrui cui 《Frontiers of Earth Science》 SCIE CSCD 2023年第1期18-29,共12页
Pores are the main accumulation sites and migration pathways for coalbed methane(also referred to as CBM).Pore structure restricts the content and recoverability of CBM from coal reservoirs.In this study,12 representa... Pores are the main accumulation sites and migration pathways for coalbed methane(also referred to as CBM).Pore structure restricts the content and recoverability of CBM from coal reservoirs.In this study,12 representative coal samples with different ash yields that have similar tectonic characteristics and burial depths were collected from different mining areas in the Jiergalangtu and Huolinhe depressions in the Erlian Basin.These samples were used to study the restrictions of ash yield on the characteristics of coal pore structures and the recoverability of CBM through macroscopic and microscopic structure observation,scanning electron microscope observations,vitrinite reflectance tests,low-temperature N2 adsorption,nuclear magnetic resonance(NMR),and micro-computed tomography.The results show that coal reservoirs in the study area vary greatly in ash yield,based on which they can be divided into three types,i.e.,low-ash-content,ash-bearing,and high-ash-content coal reservoirs.In addition,the ash yield has a certain impact on the development of coal pores;coal samples with lower ash yields indicate the presence of well-developed medium-large pores and better connectivity.Ash yield also has a certain impact on the brittleness of coal wherein a lower ash yield implies the development of brittle coal that is more liable to fracture as compared to less brittle samples at the same pressure.Absorbed gas content also varies significantly with ash yield;a low ash yield impacts the gas saturation of coal.Overall,for coal reservoirs in the study area,their porosity,pore diameter,movable fluid porosity,adsorbed gas amount,and recoverability decrease as the ash yield increases. 展开更多
关键词 coal reservoir ASH pore structure RECOVERABILITY Erlian Basin
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