Transcription factors are vital and indispensable for innate lymphoid cell(ILC)subset development and lineage-specific functions as well as the diversity and plasticity of ILCs[1].ILC3s,including lymphoid tissue induc...Transcription factors are vital and indispensable for innate lymphoid cell(ILC)subset development and lineage-specific functions as well as the diversity and plasticity of ILCs[1].ILC3s,including lymphoid tissue inducer(LTi)-like ILC3s and natural cytotoxicity receptor(NCR)+ILC3s,are commonly defined by the expression of the transcription factor retinoic acid receptor-related orphan receptor(ROR)yt[2,3]and coexpress some ILC-associated transcription factors,such as ILC2-expressing RORa and ILC1-defined T-bet.However,the combined role of multiple transcrip-tion factors in ILC diversity and plasticity remains unclear.展开更多
Innate lymphoid cells(ILCs)are the counterpart of T helper cells in the innate immune system and share multiple phenotypes with T helper cells.Inducible T-cell costimulator(ICOS)is recognized on T cells and participat...Innate lymphoid cells(ILCs)are the counterpart of T helper cells in the innate immune system and share multiple phenotypes with T helper cells.Inducible T-cell costimulator(ICOS)is recognized on T cells and participates in T-cell activation and T and B-cell engagement in lymphoid tissues.However,the role of ICOS in ILC3s and ILC3-involved interactions with the immune microenvironment remains unclear.Here,we found that ICOS expression on human ILC3s was correlated with the activated state of ILC3s.ICOS costimulation enhanced the survival,proliferation,and capacity of ILC3s to produce cytokines(IL-22,IL-17A,IFN-γ,TNF,and GM-CSF).Via synergistic effects of ICOS and CD40 signaling,B cells promoted ILC3 functions,and ILC3-induced T-cellindependent B-cell IgA and IgM secretion primarily required CD40 signaling.Hence,ICOS is essential for the nonredundant role of ILC3s and their interaction with adjacent B cells.展开更多
Since the discovery of group 3 innate lymphoid cells(ILC3s),many studies have reported that,in addition to T cells,ILC3s also play an indispensable role in intestinal immune surveillance,host defense,and homeostasis[1...Since the discovery of group 3 innate lymphoid cells(ILC3s),many studies have reported that,in addition to T cells,ILC3s also play an indispensable role in intestinal immune surveillance,host defense,and homeostasis[1].Although both ILC3s and T cells regulate intestinal inflammation through the secretion of interleukin(IL)-22,differences in the behaviors of these two cell types,especially the dynamic shift and mechanism of ILC3 regulation between normal and inflammatory states,remain unclear.A recent paper by Jarade et al.[2]published in Nature Immunology reported that intestinal ILC3s under basal conditions are immotile and arrested in the presence of T cells.Furthermore,the environmental T cells,the microbiota,and the chemokine CCL25 jointly shape ILC3 patrolling behavior and their effector function of maintaining intestinal barrier integrity via IL-22.These findings facilitate the study of ILC biodynamics and ILC immune regulation and the search for therapeutic strategies for gastrointestinal diseases.展开更多
In today’s world,big data permeates every industry,leading to a substantial increase in research data and driving the scientific paradigm towards data-intensive research.With the development of intensive research,the...In today’s world,big data permeates every industry,leading to a substantial increase in research data and driving the scientific paradigm towards data-intensive research.With the development of intensive research,the demand for data processing and analysis is growing,particularly pronounced in the fields of research and management in universities.Currently,education in China is transitioning from informatization to digitization to enhance the quality of education,research by faculty and students,and the overall operational quality of schools,thereby achieving high-quality development in higher education.Digitization has become a crucial innovative path for the modernization of education in China and is an important strategy for building a high-quality education system.However,many university teachers and students still face challenges such as time-consuming and labor-intensive data processing,lack of relevant technical expertise,and difficulty in seeking guidance from professional experts.At the same time,the number of professionals in the big data industry is gradually increasing,and they aspire to enhance their professional skills through practical experience,earn additional income,but lack suitable avenues.To address these market challenges and pain points,fill market gaps,promote the academic and research capabilities of university faculty and students,improve personnel management efficiency,and advance scientific research in China,this survey is conducted to propose practical and feasible suggestions and actively engage in implementation.展开更多
基金supported by grants from the Scientific and Technological Developing Plan of Jilin Province[grant number 20210402009GH].
文摘Transcription factors are vital and indispensable for innate lymphoid cell(ILC)subset development and lineage-specific functions as well as the diversity and plasticity of ILCs[1].ILC3s,including lymphoid tissue inducer(LTi)-like ILC3s and natural cytotoxicity receptor(NCR)+ILC3s,are commonly defined by the expression of the transcription factor retinoic acid receptor-related orphan receptor(ROR)yt[2,3]and coexpress some ILC-associated transcription factors,such as ILC2-expressing RORa and ILC1-defined T-bet.However,the combined role of multiple transcrip-tion factors in ILC diversity and plasticity remains unclear.
基金the National Key Research and Development Program(Grant 2021YFF0704800)the Science and Technology Development Program of Jilin Province(Grant 20210402009GH)+1 种基金the Science and Technology Development Program of Jilin Province(Grant YDZJ202201ZYTS098)the Norman Bethune Program of Jilin University(Grant No.2022B34).
文摘Innate lymphoid cells(ILCs)are the counterpart of T helper cells in the innate immune system and share multiple phenotypes with T helper cells.Inducible T-cell costimulator(ICOS)is recognized on T cells and participates in T-cell activation and T and B-cell engagement in lymphoid tissues.However,the role of ICOS in ILC3s and ILC3-involved interactions with the immune microenvironment remains unclear.Here,we found that ICOS expression on human ILC3s was correlated with the activated state of ILC3s.ICOS costimulation enhanced the survival,proliferation,and capacity of ILC3s to produce cytokines(IL-22,IL-17A,IFN-γ,TNF,and GM-CSF).Via synergistic effects of ICOS and CD40 signaling,B cells promoted ILC3 functions,and ILC3-induced T-cellindependent B-cell IgA and IgM secretion primarily required CD40 signaling.Hence,ICOS is essential for the nonredundant role of ILC3s and their interaction with adjacent B cells.
基金supported by the grants from the National Key Research and Development Program[grant number 2021YFF0704805]the Scientific and Technological Development Plan of Jilin Province[grant number 20210402009GH].
文摘Since the discovery of group 3 innate lymphoid cells(ILC3s),many studies have reported that,in addition to T cells,ILC3s also play an indispensable role in intestinal immune surveillance,host defense,and homeostasis[1].Although both ILC3s and T cells regulate intestinal inflammation through the secretion of interleukin(IL)-22,differences in the behaviors of these two cell types,especially the dynamic shift and mechanism of ILC3 regulation between normal and inflammatory states,remain unclear.A recent paper by Jarade et al.[2]published in Nature Immunology reported that intestinal ILC3s under basal conditions are immotile and arrested in the presence of T cells.Furthermore,the environmental T cells,the microbiota,and the chemokine CCL25 jointly shape ILC3 patrolling behavior and their effector function of maintaining intestinal barrier integrity via IL-22.These findings facilitate the study of ILC biodynamics and ILC immune regulation and the search for therapeutic strategies for gastrointestinal diseases.
文摘In today’s world,big data permeates every industry,leading to a substantial increase in research data and driving the scientific paradigm towards data-intensive research.With the development of intensive research,the demand for data processing and analysis is growing,particularly pronounced in the fields of research and management in universities.Currently,education in China is transitioning from informatization to digitization to enhance the quality of education,research by faculty and students,and the overall operational quality of schools,thereby achieving high-quality development in higher education.Digitization has become a crucial innovative path for the modernization of education in China and is an important strategy for building a high-quality education system.However,many university teachers and students still face challenges such as time-consuming and labor-intensive data processing,lack of relevant technical expertise,and difficulty in seeking guidance from professional experts.At the same time,the number of professionals in the big data industry is gradually increasing,and they aspire to enhance their professional skills through practical experience,earn additional income,but lack suitable avenues.To address these market challenges and pain points,fill market gaps,promote the academic and research capabilities of university faculty and students,improve personnel management efficiency,and advance scientific research in China,this survey is conducted to propose practical and feasible suggestions and actively engage in implementation.
