Vitexin is a natural phytofl avonoid glycoside extracted from the leaves of vitexin,a plant of the Verbenaceae family,which is an active ingredient in many traditional Chinese medicines and is present in a wide range ...Vitexin is a natural phytofl avonoid glycoside extracted from the leaves of vitexin,a plant of the Verbenaceae family,which is an active ingredient in many traditional Chinese medicines and is present in a wide range of medicinal plants.In this review,pharmacological eff ects including anti-infl ammatory,diabetes mellitus are described.The novel formulation of vitexin of nano delivery and hybrid micelles are elucidated.展开更多
Duplex stainless steels(DSSs)are suffering from various localized corrosion attacks such as pitting,selective dissolution,crevice corrosion during their service period.It is of great value to quantitatively analyze an...Duplex stainless steels(DSSs)are suffering from various localized corrosion attacks such as pitting,selective dissolution,crevice corrosion during their service period.It is of great value to quantitatively analyze and grasp the micro-electrochemical corrosion behavior and related mechanism for DSSs on the micrometer or even smaller scales.In this work,scanning Kelvin probe force microscopy(SKPFM)and energy dispersive spectroscopy(EDS)measurements were performed to reveal the difference between the austenite phase and ferrite phase in microregion of DSS 2205.Then traditional electrochemical impedance spectroscopy(EIS)and potentiodynamic polarization(PDP)tests were employed for micro-electrochemical characterization of DSS 2205 with different proportion phases inϕ40 andϕ10μm micro holes.Both of them can only be utilized for qualitative or semi-quantitative micro-electrochemical characterization of DSS 2205.Coulostatic perturbation method was employed for quantitative micro-electrochemical characterization of DSS 2205.What is more,the applicable conditions of coulostatic perturbation were analyzed in depth by establishing a detailed electrochemical interface circuit.A series of microregion coulostatic perturbations for DSS 2205 with different proportion phases inϕ10μm micro holes showed that as the austenite proportion increases,the corresponding polarization resistance of microregion increases linearly.展开更多
Paeonol is a bioactive phenol present in Dioscorea japonica,Paeonia suff ruticosa and Paeonia lactiflora.It is the main active ingredient in the traditional Chinese medicines Mudanpi and Xu Changqing.Clinical applicat...Paeonol is a bioactive phenol present in Dioscorea japonica,Paeonia suff ruticosa and Paeonia lactiflora.It is the main active ingredient in the traditional Chinese medicines Mudanpi and Xu Changqing.Clinical applications of paeonol are mainly focused on anti-inflammatory effects due to its ability to act as an antioxidant,a regulator of inflammatory enzyme activities,a modulator of inflammatory signaling pathways and a regulator of adhesion molecules to modulate inflammation through molecular mechanisms of action.In addition,paeonol also regulates inflammation by regulating the metabolism of gut microbes.In this review,we searched PubMed,Web of Science,ESI and other websites using“paeonol”“inflammation”“oxidative stress”“signaling pathways”and“gut microbiota”as keywords.We mainly referred to the relevant literature in the last decade and systematically summarized the studies on the anti-inflammatory effects of paeonol to provide a reference for new drug development and clinical application of paeonol.展开更多
Minerals are essential components of terrestrial surface soils,forming the basis for soil formation,development,and functionality.They play a vital role in the ecological functions of soils,which has long been a focus...Minerals are essential components of terrestrial surface soils,forming the basis for soil formation,development,and functionality.They play a vital role in the ecological functions of soils,which has long been a focus of soil science research.Minerals significantly affect the physicochemical properties of soils and,as a result,regulate the biogeochemical cycles of nutrients and organic/inorganic pollutants.The early concept of the“Mineralosphere”highlights the influence of minerals on the spatial distribution and functional activity of soil microorganisms.More recently,the concept of the soil mineral carbon pump has gained attention for its emphasis on the role of minerals in preserving soil organic carbon.This paper reviews the development of the Mineralosphere,expanding its conceptual framework by exploring the interactions between soil minerals,microorganisms,pollutants,and nutrients,and by elucidating the mechanisms by which minerals stabilize organic carbon.Finally,we propose future research directions for the Mineralosphere,aiming to further clarify the biogeochemical cycles involved and contribute to sustainable agricultural development and the achievement of dual carbon goals.展开更多
Bibenzyls,a kind of important plant polyphenols,have attracted growing attention for their broad and remarkable pharmacological activities.However,due to the low abundance in nature,uncontrollable and environmentally ...Bibenzyls,a kind of important plant polyphenols,have attracted growing attention for their broad and remarkable pharmacological activities.However,due to the low abundance in nature,uncontrollable and environmentally unfriendly chemical synthesis processes,these compounds are not readily accessible.Herein,one high-yield bibenzyl backbone-producing Escherichia coli strain was constructed by using a highly active and substrate-promiscuous bibenzyl synthase identified from Dendrobium officinale in combination with starter and extender biosynthetic enzymes.Three types of efficiently postmodifying modular strains were engineered by employing methyltransferases,prenyltransferase,and glycosyltransferase with high activity and substrate tolerance together with their corresponding donor biosynthetic modules.Structurally different bibenzyl derivatives were tandemly and/or divergently synthesized by co-culture engineering in various combination modes.Especially,a prenylated bibenzyl derivative(12)was found to be an antioxidant that exhibited potent neuroprotective activity in the cellular and rat models of ischemia stroke.RNA-seq,quantitative RT-PCR,and Western-blot analysis demonstrated that 12 could up-regulate the expression level of an apoptosis-inducing factor,mitochondria associated 3(Aifm3),suggesting that Aifm3 might be a new target in ischemic stroke therapy.This study provides a flexible plug-and-play strategy for the easy-to-implement synthesis of structurally diverse bibenzyls through a modular co-culture engineering pipeline for drug discovery.展开更多
文摘Vitexin is a natural phytofl avonoid glycoside extracted from the leaves of vitexin,a plant of the Verbenaceae family,which is an active ingredient in many traditional Chinese medicines and is present in a wide range of medicinal plants.In this review,pharmacological eff ects including anti-infl ammatory,diabetes mellitus are described.The novel formulation of vitexin of nano delivery and hybrid micelles are elucidated.
基金financial support from the Ministry of Science and Technology, China for the national key research and development plan (No. 2017YFB0701904)China Nuclear Power Engineering Co., Ltd. (No. KY1672)the 111 Project (No. B12012)
文摘Duplex stainless steels(DSSs)are suffering from various localized corrosion attacks such as pitting,selective dissolution,crevice corrosion during their service period.It is of great value to quantitatively analyze and grasp the micro-electrochemical corrosion behavior and related mechanism for DSSs on the micrometer or even smaller scales.In this work,scanning Kelvin probe force microscopy(SKPFM)and energy dispersive spectroscopy(EDS)measurements were performed to reveal the difference between the austenite phase and ferrite phase in microregion of DSS 2205.Then traditional electrochemical impedance spectroscopy(EIS)and potentiodynamic polarization(PDP)tests were employed for micro-electrochemical characterization of DSS 2205 with different proportion phases inϕ40 andϕ10μm micro holes.Both of them can only be utilized for qualitative or semi-quantitative micro-electrochemical characterization of DSS 2205.Coulostatic perturbation method was employed for quantitative micro-electrochemical characterization of DSS 2205.What is more,the applicable conditions of coulostatic perturbation were analyzed in depth by establishing a detailed electrochemical interface circuit.A series of microregion coulostatic perturbations for DSS 2205 with different proportion phases inϕ10μm micro holes showed that as the austenite proportion increases,the corresponding polarization resistance of microregion increases linearly.
文摘Paeonol is a bioactive phenol present in Dioscorea japonica,Paeonia suff ruticosa and Paeonia lactiflora.It is the main active ingredient in the traditional Chinese medicines Mudanpi and Xu Changqing.Clinical applications of paeonol are mainly focused on anti-inflammatory effects due to its ability to act as an antioxidant,a regulator of inflammatory enzyme activities,a modulator of inflammatory signaling pathways and a regulator of adhesion molecules to modulate inflammation through molecular mechanisms of action.In addition,paeonol also regulates inflammation by regulating the metabolism of gut microbes.In this review,we searched PubMed,Web of Science,ESI and other websites using“paeonol”“inflammation”“oxidative stress”“signaling pathways”and“gut microbiota”as keywords.We mainly referred to the relevant literature in the last decade and systematically summarized the studies on the anti-inflammatory effects of paeonol to provide a reference for new drug development and clinical application of paeonol.
基金supported by the CAS Youth Interdisciplinary Team and Program of the Chinese Academy of Sciencesthe National Natural Science Fund for Young Scientists Fund Program(Grant No.42407434)。
文摘Minerals are essential components of terrestrial surface soils,forming the basis for soil formation,development,and functionality.They play a vital role in the ecological functions of soils,which has long been a focus of soil science research.Minerals significantly affect the physicochemical properties of soils and,as a result,regulate the biogeochemical cycles of nutrients and organic/inorganic pollutants.The early concept of the“Mineralosphere”highlights the influence of minerals on the spatial distribution and functional activity of soil microorganisms.More recently,the concept of the soil mineral carbon pump has gained attention for its emphasis on the role of minerals in preserving soil organic carbon.This paper reviews the development of the Mineralosphere,expanding its conceptual framework by exploring the interactions between soil minerals,microorganisms,pollutants,and nutrients,and by elucidating the mechanisms by which minerals stabilize organic carbon.Finally,we propose future research directions for the Mineralosphere,aiming to further clarify the biogeochemical cycles involved and contribute to sustainable agricultural development and the achievement of dual carbon goals.
基金supported by the National Key Research and Development Program of China(2020YFA0908000)CAMS Innovation fund for Medical Sciences(CIFMS-2021-I2M1-028 and CIFMS-2021-I2M-1-029,China)Beijing Key Laboratory of non-Clinical Drug Metabolism and PK/PD Study(Z141102004414062,China)。
文摘Bibenzyls,a kind of important plant polyphenols,have attracted growing attention for their broad and remarkable pharmacological activities.However,due to the low abundance in nature,uncontrollable and environmentally unfriendly chemical synthesis processes,these compounds are not readily accessible.Herein,one high-yield bibenzyl backbone-producing Escherichia coli strain was constructed by using a highly active and substrate-promiscuous bibenzyl synthase identified from Dendrobium officinale in combination with starter and extender biosynthetic enzymes.Three types of efficiently postmodifying modular strains were engineered by employing methyltransferases,prenyltransferase,and glycosyltransferase with high activity and substrate tolerance together with their corresponding donor biosynthetic modules.Structurally different bibenzyl derivatives were tandemly and/or divergently synthesized by co-culture engineering in various combination modes.Especially,a prenylated bibenzyl derivative(12)was found to be an antioxidant that exhibited potent neuroprotective activity in the cellular and rat models of ischemia stroke.RNA-seq,quantitative RT-PCR,and Western-blot analysis demonstrated that 12 could up-regulate the expression level of an apoptosis-inducing factor,mitochondria associated 3(Aifm3),suggesting that Aifm3 might be a new target in ischemic stroke therapy.This study provides a flexible plug-and-play strategy for the easy-to-implement synthesis of structurally diverse bibenzyls through a modular co-culture engineering pipeline for drug discovery.
