The impaired differentiation ability of resident cells and disordered immune microenvironment in periodontitis pose a huge challenge for bone regeneration.Herein,we construct a piezoelectric hydrogel to rescue the imp...The impaired differentiation ability of resident cells and disordered immune microenvironment in periodontitis pose a huge challenge for bone regeneration.Herein,we construct a piezoelectric hydrogel to rescue the impaired osteogenic capability and rebuild the regenerative immune microenvironment through bioenergetic activation.Under local mechanical stress,the piezoelectric hydrogel generated piezopotential that initiates osteogenic differentiation of inflammatory periodontal ligament stem cells(PDLSCs)via modulating energy metabolism and promoting adenosine triphosphate(ATP)synthesis.Moreover,it also reshapes an anti-inflammatory and pro-regenerative niche through switching M1 macrophages to the M2 phenotype.The synergy of tilapia gelatin and piezoelectric stimulation enhances in situ regeneration in periodontal inflammatory defects of rats.These findings pave a new pathway for treating periodontitis and other immune-related bone defects through piezoelectric stimulation-enabled energy metabolism modulation and immunomodulation.展开更多
Electrochemical system with electro-Fenton reaction is an effective pathway for oxidative degradation of refractory organic pollutants for water treatment.However,the method is limited by the low catalytic efficiency ...Electrochemical system with electro-Fenton reaction is an effective pathway for oxidative degradation of refractory organic pollutants for water treatment.However,the method is limited by the low catalytic efficiency and high electrical cost in practical applications.This work presents a self-powered and high-efficient electrochemical system for water treatment including pollutant degradation and bacterial inactivation,which is composed of a self-powered triboelectric nanogenerator(TENG)converting mechanical energy into electrical energy,a power management circuit integrated with a supercapacitor to store the harvesting electrical energy temporarily,and an electrochemical setup integrated with two-dimentional Co(OH)_(2)/Pt nanosheet as electrocatalyst.The nanocatalyst,ultrafine Pt nanoparticles(Pt NPs)loaded on Co(OH)_(2) nanosheet(Co(OH)_(2)/Pt),is synthesized by a facile one step hydrothermal reaction without any surfactant,which can improve H_(2)O_(2)and hydroxyl radical production via redox reaction.This self-powered electrocatalytic system is able to degrade nearly 100%of organic pollutant within 100 min,and efficiently kill bacteria.This work shows great potential to develop high-efficient and self-powered electrochemical water treatment system through integrating TENG and nanocatalyst.展开更多
基金grants from the National Natural Science Foundation of China(82271024,82072065,82202333)National Clinical Key Specialty(Z155080000004)+5 种基金Science and Technology Commission of Shanghai Municipality(22DZ2201300)Shanghai Pujiang Programme(23PJD050)Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZLCX20212400)Research Discipline fund(KQXJXK2023)from Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,and College of Stomatology,Shanghai Jiao Tong University,the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA16021103)the Fundamental Research Funds for the Central Universities(E2EG6802X2,E2E46801)the National Youth Talent Support Program.
文摘The impaired differentiation ability of resident cells and disordered immune microenvironment in periodontitis pose a huge challenge for bone regeneration.Herein,we construct a piezoelectric hydrogel to rescue the impaired osteogenic capability and rebuild the regenerative immune microenvironment through bioenergetic activation.Under local mechanical stress,the piezoelectric hydrogel generated piezopotential that initiates osteogenic differentiation of inflammatory periodontal ligament stem cells(PDLSCs)via modulating energy metabolism and promoting adenosine triphosphate(ATP)synthesis.Moreover,it also reshapes an anti-inflammatory and pro-regenerative niche through switching M1 macrophages to the M2 phenotype.The synergy of tilapia gelatin and piezoelectric stimulation enhances in situ regeneration in periodontal inflammatory defects of rats.These findings pave a new pathway for treating periodontitis and other immune-related bone defects through piezoelectric stimulation-enabled energy metabolism modulation and immunomodulation.
基金supported by the National Natural Science Foundation of China(82072065 and 81471784)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16021103)+1 种基金the Fundamental Research Funds for the Central Universities(E2EG6802X2 and E2E46801)the National Youth Talent Support Program.
基金supported by the Strategic Priority Research Program of The Chinese Academy of Sciences(No.XDA16021103)National Natural Science Foundation(Nos.82072065 and 81471784)+1 种基金the National Youth Talent Support Program and the China Postdoctoral Science Foundation(Nos.BX2021299 and 2021M703166)the Fundamental Research Funds for the Central Universities.
文摘Electrochemical system with electro-Fenton reaction is an effective pathway for oxidative degradation of refractory organic pollutants for water treatment.However,the method is limited by the low catalytic efficiency and high electrical cost in practical applications.This work presents a self-powered and high-efficient electrochemical system for water treatment including pollutant degradation and bacterial inactivation,which is composed of a self-powered triboelectric nanogenerator(TENG)converting mechanical energy into electrical energy,a power management circuit integrated with a supercapacitor to store the harvesting electrical energy temporarily,and an electrochemical setup integrated with two-dimentional Co(OH)_(2)/Pt nanosheet as electrocatalyst.The nanocatalyst,ultrafine Pt nanoparticles(Pt NPs)loaded on Co(OH)_(2) nanosheet(Co(OH)_(2)/Pt),is synthesized by a facile one step hydrothermal reaction without any surfactant,which can improve H_(2)O_(2)and hydroxyl radical production via redox reaction.This self-powered electrocatalytic system is able to degrade nearly 100%of organic pollutant within 100 min,and efficiently kill bacteria.This work shows great potential to develop high-efficient and self-powered electrochemical water treatment system through integrating TENG and nanocatalyst.
