研究了农业生物质废弃物玉米芯热解产物炭质燃料的理化性能与裂解温度的关系及热解机理,用FT-IR,XRD,SEM对玉米芯炭进行表征,分析了化学组成、官能团分布、芳构化程度与温度的关系.结果表明,随热解温度升高,热解所得焦炭中固定碳和灰分...研究了农业生物质废弃物玉米芯热解产物炭质燃料的理化性能与裂解温度的关系及热解机理,用FT-IR,XRD,SEM对玉米芯炭进行表征,分析了化学组成、官能团分布、芳构化程度与温度的关系.结果表明,随热解温度升高,热解所得焦炭中固定碳和灰分增加,挥发分和水分减小,产率下降,热值先增加后减少,羰基和脂肪族官能团逐渐被破坏,结晶度和芳构化程度不断增强.500℃时,焦炭热值大于32 MJ/kg,产率大于24%,固定碳大于80%,灰分小于4%,且具有发达的孔洞结构,各项指标接近或优于市售燃料炭;233~533℃下玉米芯挥发最剧烈,具有1.5级反应的特征;热解温度从233~353℃上升至353~533℃时,表观活化能从68.15 k J/mol降至37.25 k J/mol.展开更多
Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer cells have a higher dependency on molecular chaperones to maintain pro...Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer cells have a higher dependency on molecular chaperones to maintain proteostasis. The chaperonin T-complex protein ring complex(TRiC) contains eight paralogous subunits(CCT1-8), and assists the folding of as many as 10% of cytosolic proteome.TRiC is essential for the progression of some cancers, but the roles of TRiC subunits in osteosarcoma remain to be explored. Here, we show that CCT4/TRiC is significantly correlated in human osteosarcoma,and plays a critical role in osteosarcoma cell survival. We identify a compound anticarin-β that can specifically bind to and inhibit CCT4. Anticarin-β shows higher selectivity in cancer cells than in normal cells. Mechanistically, anticarin-β potently impedes CCT4-mediated STAT3 maturation. Anticarin-β displays remarkable antitumor efficacy in orthotopic and patient-derived xenograft models of osteosarcoma.Collectively, our data uncover a key role of CCT4 in osteosarcoma, and propose a promising treatment strategy for osteosarcoma by disrupting CCT4 and proteostasis.展开更多
文摘研究了农业生物质废弃物玉米芯热解产物炭质燃料的理化性能与裂解温度的关系及热解机理,用FT-IR,XRD,SEM对玉米芯炭进行表征,分析了化学组成、官能团分布、芳构化程度与温度的关系.结果表明,随热解温度升高,热解所得焦炭中固定碳和灰分增加,挥发分和水分减小,产率下降,热值先增加后减少,羰基和脂肪族官能团逐渐被破坏,结晶度和芳构化程度不断增强.500℃时,焦炭热值大于32 MJ/kg,产率大于24%,固定碳大于80%,灰分小于4%,且具有发达的孔洞结构,各项指标接近或优于市售燃料炭;233~533℃下玉米芯挥发最剧烈,具有1.5级反应的特征;热解温度从233~353℃上升至353~533℃时,表观活化能从68.15 k J/mol降至37.25 k J/mol.
基金the National Natural Science Foundation of China(81903666 and 31930015)the Chinese Academy of Sciences(XDB31000000,KFJ-STS-SCYD-304,and K.C.Wong Education Foundation,China)+4 种基金the Science and Technology Department of Yunnan Province (202101AT070301,2019ZF003,202002AA100007,202003AD150008,and 2019FB103China)Project of Innovative Research Team of Yunnan Province(2019HC005China)the Department of Industry and Information Technology of Yunnan Province (2019-YT-053,China)。
文摘Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer cells have a higher dependency on molecular chaperones to maintain proteostasis. The chaperonin T-complex protein ring complex(TRiC) contains eight paralogous subunits(CCT1-8), and assists the folding of as many as 10% of cytosolic proteome.TRiC is essential for the progression of some cancers, but the roles of TRiC subunits in osteosarcoma remain to be explored. Here, we show that CCT4/TRiC is significantly correlated in human osteosarcoma,and plays a critical role in osteosarcoma cell survival. We identify a compound anticarin-β that can specifically bind to and inhibit CCT4. Anticarin-β shows higher selectivity in cancer cells than in normal cells. Mechanistically, anticarin-β potently impedes CCT4-mediated STAT3 maturation. Anticarin-β displays remarkable antitumor efficacy in orthotopic and patient-derived xenograft models of osteosarcoma.Collectively, our data uncover a key role of CCT4 in osteosarcoma, and propose a promising treatment strategy for osteosarcoma by disrupting CCT4 and proteostasis.
