Micellar nanostructures formed by amphiphilic polymers are prone to dissociation when the in vivo environment changes.Polyprodrug micelles can cross-link with other hydrophobic drugs through noncovalent bonds,which ha...Micellar nanostructures formed by amphiphilic polymers are prone to dissociation when the in vivo environment changes.Polyprodrug micelles can cross-link with other hydrophobic drugs through noncovalent bonds,which has the advantage of fixed structure and avoids the use of chemical cross-linking agents.In this study,we prepared a polyprodrug with hydrophobic curcumin(CUR)and hydrophilic poly(ethylene glycol)(PEG)in the main chain through a click reaction between CUR derivatives containing azide groups and di-alkynly-capped PEG.Due to the presence of benzene rings in the structure of CUR,the polyprodrug can form non-covalent cross-linked nanoparticles(NCCL-CUR NPs)through hydrophobic andπ-πstacking interaction.The structure,molecular weight,and self-assembly properties of the polyprodrug were characterized.The anti-cancer drug camptothecin(CPT)was encapsulated in the polyprodrug nanoparticles,producing dual-drug-loaded nanoparticles(abbreviated as CPT@NCCL-CUR NPs).The test results indicate that the NPs have reductive responsiveness and can release the original drugs CUR and CPT in phosphate buffer(PB)solution containing glutathione(GSH),while remaining stability in physiological environment.Cell and in vivo experiments further demonstrate that the dualdrug-loaded CPT@NCCL-CUR NPs can inhibit the growth of tumor through synergistic effects.This work provides a valuable approach for the preparation of amphiphilic polyprodrug with anti-tumor CUR as the backbone,and the stable dual-drug-loaded NPs containing both CUR and CPT through non-covalent cross-linking for synergistic therapy.展开更多
Objective:To investigate the safety of relieving bed restriction in hepatic arterial infusion chemotherapy(HAIC)and its effects on patient comfort.Methods:A prospective study was conducted.Patients with malignant live...Objective:To investigate the safety of relieving bed restriction in hepatic arterial infusion chemotherapy(HAIC)and its effects on patient comfort.Methods:A prospective study was conducted.Patients with malignant liver tumors,who met the enrollment criteria,were randomly divided into experimental and control groups.During HAIC treatment,the patients in the experimental group,who were not confined to bed and could get out of bed,used electronic injection pumps to infuse chemotherapy drugs.The patients in the control group,who were strictly confined to bed and prohibited from getting out of bed,used infusion pumps to infuse chemotherapy drugs.The complications of the two groups were observed.The Christenson standard improved method was used to evaluate the bleeding and hematoma of limbs on the operation side.The Kolcaba General Comfort Questionnaire(GCQ)and Barthel Index(BI)were used to evaluate the two groups.Results:Ninety patients with malignant liver tumors were enrolled,including 53 with primary liver cancer and 37 with colorectal liver metastasis.There were 70 males and 20 females,aged 41-81 years old,with an average age of 61.6±9.248 years old.There were 60 patients in the experimental group and 30 patients in the control group.All patients underwent HAIC.The study showed that,during the treatment period,there were 3 cases of postoperative puncture point hematoma formation in the two groups,including 2 cases in the experimental group(2/60,3.3%)and 1 case in the control group(1/30,3.3%).The difference was not statistically significant(p>0.05).There were 5 cases of postoperative puncture point bleeding,including 4 cases in the experimental group(4/60,6.7%)and 1 case in the control group(1/30,3.3%),and the difference was not statistically significant(p>0.05).A total of 23 cases,with 6 cases in the experimental group(6/60,10%)and 17 cases in the control group(17/30,56.7%),complained of back pain after the operation,and the difference was statistically significant(p<0.05).Twenty-one cases complained of poor defecation after the operation,including 10 cases in the experimental group(10/60,16.7%)and 11 cases in the control group(11/30,36.7%).The difference was statistically significant(p<0.05).During the period of infusion chemotherapy,the two groups of patients had there was a significant difference between the two groups in terms of comfort status(GCQ)(88.78±6.705,78.47±9.519,p<0.001)and self-care ability(BI)(74.25±9.152,66.83±6.628,p<0.001).Conclusion:During HAIC treatment,getting out of bed is safe and reliable and can increase the patients’comfort and self-care ability.Hence,it merits clinical application.展开更多
Due to the influence of magnetic hysteresis and energy loss inherent in giant magnetostrictive materials （GMM）, output displacement accuracy of giant magnetostrictive actuator （GMA） can not meet the precision and ...Due to the influence of magnetic hysteresis and energy loss inherent in giant magnetostrictive materials （GMM）, output displacement accuracy of giant magnetostrictive actuator （GMA） can not meet the precision and ultra precision machining. Using a GMM rod as the core driving element, a GMA which may be used in the field of precision and ultra precision drive engineering is designed through modular design method. Based on the Armstrong theory and elastic Gibbs free energy theory, a nonlinear magnetostriction model which considers magnetic hysteresis and energy loss characteristics is established. Moreover, the mechanical system differential equation model for GMA is established by utilizing D＇Alembert＇s principle. Experimental results show that the model can preferably predict magnetization property, magnetic potential orientation, energy loss for GMM. It is also able to describe magnetostrictive elongation and output displacement of GMA. Research results will provide a theoretical basis for solving the dynamic magnetic hysteresis, energy loss and working precision for GMA fundamentally.展开更多
基金supported by the National Natural Science Foundation of China(No.21975169)the Project Fund of the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions+2 种基金the Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function of Soochow Universitythe Research project of China Baoyuan Investment Co.,Ltd.Suzhou Science and Technology Plan Project(No.SKY2023051)。
文摘Micellar nanostructures formed by amphiphilic polymers are prone to dissociation when the in vivo environment changes.Polyprodrug micelles can cross-link with other hydrophobic drugs through noncovalent bonds,which has the advantage of fixed structure and avoids the use of chemical cross-linking agents.In this study,we prepared a polyprodrug with hydrophobic curcumin(CUR)and hydrophilic poly(ethylene glycol)(PEG)in the main chain through a click reaction between CUR derivatives containing azide groups and di-alkynly-capped PEG.Due to the presence of benzene rings in the structure of CUR,the polyprodrug can form non-covalent cross-linked nanoparticles(NCCL-CUR NPs)through hydrophobic andπ-πstacking interaction.The structure,molecular weight,and self-assembly properties of the polyprodrug were characterized.The anti-cancer drug camptothecin(CPT)was encapsulated in the polyprodrug nanoparticles,producing dual-drug-loaded nanoparticles(abbreviated as CPT@NCCL-CUR NPs).The test results indicate that the NPs have reductive responsiveness and can release the original drugs CUR and CPT in phosphate buffer(PB)solution containing glutathione(GSH),while remaining stability in physiological environment.Cell and in vivo experiments further demonstrate that the dualdrug-loaded CPT@NCCL-CUR NPs can inhibit the growth of tumor through synergistic effects.This work provides a valuable approach for the preparation of amphiphilic polyprodrug with anti-tumor CUR as the backbone,and the stable dual-drug-loaded NPs containing both CUR and CPT through non-covalent cross-linking for synergistic therapy.
文摘Objective:To investigate the safety of relieving bed restriction in hepatic arterial infusion chemotherapy(HAIC)and its effects on patient comfort.Methods:A prospective study was conducted.Patients with malignant liver tumors,who met the enrollment criteria,were randomly divided into experimental and control groups.During HAIC treatment,the patients in the experimental group,who were not confined to bed and could get out of bed,used electronic injection pumps to infuse chemotherapy drugs.The patients in the control group,who were strictly confined to bed and prohibited from getting out of bed,used infusion pumps to infuse chemotherapy drugs.The complications of the two groups were observed.The Christenson standard improved method was used to evaluate the bleeding and hematoma of limbs on the operation side.The Kolcaba General Comfort Questionnaire(GCQ)and Barthel Index(BI)were used to evaluate the two groups.Results:Ninety patients with malignant liver tumors were enrolled,including 53 with primary liver cancer and 37 with colorectal liver metastasis.There were 70 males and 20 females,aged 41-81 years old,with an average age of 61.6±9.248 years old.There were 60 patients in the experimental group and 30 patients in the control group.All patients underwent HAIC.The study showed that,during the treatment period,there were 3 cases of postoperative puncture point hematoma formation in the two groups,including 2 cases in the experimental group(2/60,3.3%)and 1 case in the control group(1/30,3.3%).The difference was not statistically significant(p>0.05).There were 5 cases of postoperative puncture point bleeding,including 4 cases in the experimental group(4/60,6.7%)and 1 case in the control group(1/30,3.3%),and the difference was not statistically significant(p>0.05).A total of 23 cases,with 6 cases in the experimental group(6/60,10%)and 17 cases in the control group(17/30,56.7%),complained of back pain after the operation,and the difference was statistically significant(p<0.05).Twenty-one cases complained of poor defecation after the operation,including 10 cases in the experimental group(10/60,16.7%)and 11 cases in the control group(11/30,36.7%).The difference was statistically significant(p<0.05).During the period of infusion chemotherapy,the two groups of patients had there was a significant difference between the two groups in terms of comfort status(GCQ)(88.78±6.705,78.47±9.519,p<0.001)and self-care ability(BI)(74.25±9.152,66.83±6.628,p<0.001).Conclusion:During HAIC treatment,getting out of bed is safe and reliable and can increase the patients’comfort and self-care ability.Hence,it merits clinical application.
基金Supported by National Natural Science Foundation of China(Grant No.51305277)Doctoral Program of Higher Education China(Grant No.20132102120007)+1 种基金Shenyang Science and Technology Plan Project(Grant No.F15-199-1-14)China Postdoctoral Science Foundation(Grant No.2014T70261)
文摘Due to the influence of magnetic hysteresis and energy loss inherent in giant magnetostrictive materials （GMM）, output displacement accuracy of giant magnetostrictive actuator （GMA） can not meet the precision and ultra precision machining. Using a GMM rod as the core driving element, a GMA which may be used in the field of precision and ultra precision drive engineering is designed through modular design method. Based on the Armstrong theory and elastic Gibbs free energy theory, a nonlinear magnetostriction model which considers magnetic hysteresis and energy loss characteristics is established. Moreover, the mechanical system differential equation model for GMA is established by utilizing D＇Alembert＇s principle. Experimental results show that the model can preferably predict magnetization property, magnetic potential orientation, energy loss for GMM. It is also able to describe magnetostrictive elongation and output displacement of GMA. Research results will provide a theoretical basis for solving the dynamic magnetic hysteresis, energy loss and working precision for GMA fundamentally.
基金partially supported by the National Key Research and Development Program of China(2022YFB3804600 and 2021YFF0701800)the National Natural Science Foundation of China(U20A20254 and 52072253)+7 种基金Collaborative Innovation Center of Suzhou Nano Science and TechnologySuzhou Key Laboratory of Nanotechnology and Biomedicinethe Jiangsu Natural Science Fund for Distinguished Young Scholars(BK20211544)the 111 ProjectJoint International Research Laboratory of Carbon-Based Functional Materials and DevicesMedical Research Project of Jiangsu Province(ZD2022024)New Cornerstone Science Foundation through the XPLORER PRIZEKey Laboratory of Structural Deformities in Children of Suzhou(SZS2022018)。
