[Objectives]To investigate the impact of the compatibility of Bombax malabaricum flowers and Osmanthus fragrans on the analgesic therapeutic effects in mice.[Methods]The analgesic effects of B.malabaricum flowers and ...[Objectives]To investigate the impact of the compatibility of Bombax malabaricum flowers and Osmanthus fragrans on the analgesic therapeutic effects in mice.[Methods]The analgesic effects of B.malabaricum flowers and O.fragrans,as well as their compatibility at a 1:1 ratio,were investigated using the hot plate test and the acetic acid writhing test.Observations were made regarding the reactions of mice,specifically the licking of their forepaws and hindpaws,both prior to and following drug administration.The duration of these reactions was recorded,and the pain threshold of the mice was assessed following drug administration.Additionally,the frequency of writhing responses was documented following the injection of acetic acid into the abdominal cavity of the mice for 20 min.[Results]The pain thresholds observed in the positive control group,the B.malabaricum flowers group,the O.fragrans group,and the compatibility group were significantly elevated compared to those of the blank control group following 14 d of drug administration(P<0.05).This finding indicates that the positive control group,the B.malabaricum flowers group,the O.fragrans group,and the compatibility group of B.malabaricum flowers and O.fragrans at a 1:1 ratio exhibited analgesic efficacy in mice.Furthermore,the pain thresholds of the B.malabaricum flowers and O.fragrans groups were significantly lower than that of the compatibility group(P<0.05),suggesting that the compatibility group demonstrated a significantly superior analgesic effect compared to the B.malabaricum flowers group in mice.A statistically significant difference was observed in the frequency of writhing responses among the five experimental groups:the normal saline group,the positive control group,the B.malabaricum flowers group,the O.fragrans group,and the compatibility group(P=0.01<0.05).Post hoc analyses revealed that the frequency of writhing responses in the O.fragrans group was significantly lower than that observed in both the normal saline group and the compatibility group.Additionally,the frequency of writhing responses in the positive control group was significantly lower than that in the normal saline group.[Conclusions]B.malabaricum flowers and O.fragrans,as well as their compatibility at a 1:1 ratio,exhibits analgesic effects,with the analgesic effect being more pronounced in the compatibility group compared to the B.malabaricum flowers group or the O.fragrans group.展开更多
The fruit and vegetable agricultural products are related to the livelihood of people. With the advance of agricultural informatization, using software to carry out operation, sale, and inventory management on fruit a...The fruit and vegetable agricultural products are related to the livelihood of people. With the advance of agricultural informatization, using software to carry out operation, sale, and inventory management on fruit and vegetable agricultural products is imperative. Through a lot of market surveys and researches combined with data collection and sorting, I develop the distribution management system of fruit and vegetable agricultural products. The system uses the development tools of C++6.0 and SQL Server 2005, to realize system maintenance, data maintenance, purchase control, sales management, inventory management, expense management, container management, statistical reports and other functional modules. The system can meet informatization management of fruit and vegetable agricultural products in Shanghai farmers' market, improve work efficiency, and accelerate the process of agricultural informatization.展开更多
The realization of light-triggered devices where light is used as external stimulus to control the device performances is a long-standing goal in modern opto-electrical interconnection circuits.In this work,it reveals...The realization of light-triggered devices where light is used as external stimulus to control the device performances is a long-standing goal in modern opto-electrical interconnection circuits.In this work,it reveals that light illumination can induce the formation of p-n junctions along two-dimensional conduction channels.The results indicate that the dominant charge carrier type and density in black phosphorus(BP)conduction channel can be effectively modulated by the underlying cadmium sulfide(CdS)photogate layer under light illumination.This enables flexible switching of the working state between BP resistor and BP p-n diode in the designed semi-photo-gate transistor(SPGT)devices when switching the light on and off(ultra-low threshold light power).Simultaneously,the achieved BP p-n junctions also exhibit ultra-high photoresponsivity and evident photovoltaic properties.That is to say,light can be employed as external stimulus to define the BP p-n junctions,and in turn the p-n junctions will further convert the light into electrical power,showing all-in-one opto-electrical interconnection properties.Moreover,the SPGT device architecture is also applicable for construction of other ambipolar semiconductor-based(WSe2-and MoTe2-based)p-n diodes.Such universal all-in-one light-triggered lateral homogeneous pn junctions with ultra-low energy consumption should open a new pathway toward novel optoelectronic devices and deliver various new applications.展开更多
The combinational density of immobilized functional molecules on biomaterial surfaces directs cell behaviors. However, limited by the low efficiency of traditional low-throughput experimental methods, investigation an...The combinational density of immobilized functional molecules on biomaterial surfaces directs cell behaviors. However, limited by the low efficiency of traditional low-throughput experimental methods, investigation and optimization of the combinational density remain daunting challenges. Herein, we report a high-throughput screening set-up to study biomaterial surface functionalization by integrating photo-controlled thiol-ene surface chemistry and machine learning-based label-free cell identification and statistics. Through such a strategy, a specific surface combinational density of polyethylene glycol (PEG) and arginine-glutamic acid-aspartic acid-valine peptide (REDV) leads to high endothelial cell (EC) selectivity against smooth muscle cell (SMC) was identified. The composition was translated as a coating formula to modify medical nickel-titanium alloy surfaces, which was then proved to improve EC competitiveness and induce endothelialization. This work provided a high-throughput method to investigate behaviors of co-cultured cells on biomaterial surfaces modified with combinatorial functional molecules.展开更多
The newly emerged two-dimensional(2D) semiconducting materials, owning to the atomic thick nature and excellent optical and electrical properties, are considered as potential candidates to solve the bottlenecks of tra...The newly emerged two-dimensional(2D) semiconducting materials, owning to the atomic thick nature and excellent optical and electrical properties, are considered as potential candidates to solve the bottlenecks of traditional semiconductors. However, the realization of high performance 2D semiconductorbased field-effect transistors(FETs) has been a longstanding challenge in 2D electronics, which is mainly ascribing to the presence of significant Schottky barrier(SB) at metal-semiconductor interfaces. Here, an additional contact gate is induced in 2D ambipolar FET to realize near ideal reconfigurable FET(RFET)devices without restrictions of SB. Benefitting from the consistently high doping of contact region, the effective SB height can be maintained at ultra-small value during all operation conditions, resulting in the near ideal subthreshold swing(SS) values(132 mV/decade for MoTe2 RFET and 67 mV/decade for WSe2 RFET) and the relatively high mobility(28.6 cm2/(Vs) for MoTe2 RFET and 89.8 cm2/(V s) for WSe2 RFET). Moreover, the flexible control on the doping polarity of contact region enables the remodeling and switching of the achieved unipolar FETs between p-type mode and n-type mode. Based on such reconfigurable behaviors, high gain complementary MoTe2 inverters are further realized. The findings in this work push forward the development of high-performance 2D semiconductor integrated devices and circuits.展开更多
Intramuscular fat(IMF) is a major meat-quality trait in pigs. The content of IMF is directly associated with the taste and flavor of pork. As a complex trait, there could be multiple genes affecting IMF content in por...Intramuscular fat(IMF) is a major meat-quality trait in pigs. The content of IMF is directly associated with the taste and flavor of pork. As a complex trait, there could be multiple genes affecting IMF content in pork. Genomewide association study is a powerful tool to detect genomic regions associated with phenotypic variations. The objectives of the present study were to identify or refine the positions of genomic regions affecting IMF, and to characterize candidate genes and pathways that may influence this trait. Of note, we identified a significant region in longissium dorsi muscle in a Duroc pig population for IMF content with Porcine SNP60 v2 Bead Chip. This region spans 1.24 Mb on chromosome 8 and had been identified as a quantitative trait locus for IMF in Pietrain, Large White, Landrace, and Leicoma pigs. In this region, eight SNPs were significantly associated with IMF content. Three genes proximal to these significant SNPs were considered candidate genes, including ZDHHC16, LOC102162218 and PCDH7. Our results confirm several previous findings and highlight several genes that may contribute to IMF variation in Duroc pigs.展开更多
Chiral molecules containing sulfonyl and 1,5-diol moieties are useful synthetic blocks for various asymmetric transformations.A protocol has been developed for the enantioselective synthesis of optically active bis(β...Chiral molecules containing sulfonyl and 1,5-diol moieties are useful synthetic blocks for various asymmetric transformations.A protocol has been developed for the enantioselective synthesis of optically active bis(β-hydroxy)sulfones catalyzed by a chiral cationic ruthenium diamine catalyst.A series of bis(β-hydroxy)sulfones have been obtained in excellent yields(up to 99%)with excellent enantioselectivities(up to 99%)as well as good diastereoselectivities(up to 99∶1).展开更多
Robust, accurate, and fast monitoring of residual plastic film (RPF) pollution in farmlands has great significance. Based on CBAM-DBNet, this study proposed a threshold-adaptive joint framework for identifying the RPF...Robust, accurate, and fast monitoring of residual plastic film (RPF) pollution in farmlands has great significance. Based on CBAM-DBNet, this study proposed a threshold-adaptive joint framework for identifying the RPF on farmland surfaces and estimating its coverage rate. UAV imaging was used to gather images of the RPF from several locations with various soil backgrounds. RPFs were manually labeled, and the degree of RPF pollution was defined based on the RPF coverage rate. Combining differentiable binarization network (DBNet) with the convolutional block attention module (CBAM), whose feature extraction module was improved. A dynamic adaptive binarization threshold formula was defined for segmenting the RPF’s approximate binary map. Regarding the RPF image detection branch, the CBAM-DBNet exhibited a precision (P) value of 85.81%, a recall (R) value of 82.69%, and an F1-score (F1) value of 84.22%, which was 1.09 percentage points higher than the DBNet in the comprehensive index F1 value. For the RPF image segmentation branch, using CBAM-DBNet to segment the RPF image combined with an adaptive binarization threshold formula. Subsequently, the mean absolute percentage error (MAPE), root mean square error (RMSE), and mean absolute error (MAE) of the prediction of RPF’s coverage rate were 0.276, 0.366, and 0.605, respectively, outperforming the DBNet and the Iterative Threshold method. This study provides a theoretical reference for the further development of evaluation technology for RPF pollution based on UAV imaging.展开更多
基金Supported by Undergraduate Innovation and Entrepreneurship Training Program of Guangxi Zhuang Autonomous Region(S202310599060).
文摘[Objectives]To investigate the impact of the compatibility of Bombax malabaricum flowers and Osmanthus fragrans on the analgesic therapeutic effects in mice.[Methods]The analgesic effects of B.malabaricum flowers and O.fragrans,as well as their compatibility at a 1:1 ratio,were investigated using the hot plate test and the acetic acid writhing test.Observations were made regarding the reactions of mice,specifically the licking of their forepaws and hindpaws,both prior to and following drug administration.The duration of these reactions was recorded,and the pain threshold of the mice was assessed following drug administration.Additionally,the frequency of writhing responses was documented following the injection of acetic acid into the abdominal cavity of the mice for 20 min.[Results]The pain thresholds observed in the positive control group,the B.malabaricum flowers group,the O.fragrans group,and the compatibility group were significantly elevated compared to those of the blank control group following 14 d of drug administration(P<0.05).This finding indicates that the positive control group,the B.malabaricum flowers group,the O.fragrans group,and the compatibility group of B.malabaricum flowers and O.fragrans at a 1:1 ratio exhibited analgesic efficacy in mice.Furthermore,the pain thresholds of the B.malabaricum flowers and O.fragrans groups were significantly lower than that of the compatibility group(P<0.05),suggesting that the compatibility group demonstrated a significantly superior analgesic effect compared to the B.malabaricum flowers group in mice.A statistically significant difference was observed in the frequency of writhing responses among the five experimental groups:the normal saline group,the positive control group,the B.malabaricum flowers group,the O.fragrans group,and the compatibility group(P=0.01<0.05).Post hoc analyses revealed that the frequency of writhing responses in the O.fragrans group was significantly lower than that observed in both the normal saline group and the compatibility group.Additionally,the frequency of writhing responses in the positive control group was significantly lower than that in the normal saline group.[Conclusions]B.malabaricum flowers and O.fragrans,as well as their compatibility at a 1:1 ratio,exhibits analgesic effects,with the analgesic effect being more pronounced in the compatibility group compared to the B.malabaricum flowers group or the O.fragrans group.
文摘The fruit and vegetable agricultural products are related to the livelihood of people. With the advance of agricultural informatization, using software to carry out operation, sale, and inventory management on fruit and vegetable agricultural products is imperative. Through a lot of market surveys and researches combined with data collection and sorting, I develop the distribution management system of fruit and vegetable agricultural products. The system uses the development tools of C++6.0 and SQL Server 2005, to realize system maintenance, data maintenance, purchase control, sales management, inventory management, expense management, container management, statistical reports and other functional modules. The system can meet informatization management of fruit and vegetable agricultural products in Shanghai farmers' market, improve work efficiency, and accelerate the process of agricultural informatization.
基金supported by the National Natural Science Foundation of China (51902098, 51972105, 51525202, and 61574054)the Hunan Provincial Natural Science Foundation (2018RS3051).
文摘The realization of light-triggered devices where light is used as external stimulus to control the device performances is a long-standing goal in modern opto-electrical interconnection circuits.In this work,it reveals that light illumination can induce the formation of p-n junctions along two-dimensional conduction channels.The results indicate that the dominant charge carrier type and density in black phosphorus(BP)conduction channel can be effectively modulated by the underlying cadmium sulfide(CdS)photogate layer under light illumination.This enables flexible switching of the working state between BP resistor and BP p-n diode in the designed semi-photo-gate transistor(SPGT)devices when switching the light on and off(ultra-low threshold light power).Simultaneously,the achieved BP p-n junctions also exhibit ultra-high photoresponsivity and evident photovoltaic properties.That is to say,light can be employed as external stimulus to define the BP p-n junctions,and in turn the p-n junctions will further convert the light into electrical power,showing all-in-one opto-electrical interconnection properties.Moreover,the SPGT device architecture is also applicable for construction of other ambipolar semiconductor-based(WSe2-and MoTe2-based)p-n diodes.Such universal all-in-one light-triggered lateral homogeneous pn junctions with ultra-low energy consumption should open a new pathway toward novel optoelectronic devices and deliver various new applications.
基金supported by the National Key R&D Program of China(2022YFB3807300)the National Natural Science Foundation of China(52293381,22175152,52103188)+2 种基金the Joint Funds of the Zhejiang Provincial Natural Science Foundation of China and Huadong Medicine(LHDMZ22H300011)the Fundamental Research Funds for the Central Universities(226-2022-00146)the International Research Center for X Polymers,Zhejiang University(130000-171207723/001/010).
文摘The combinational density of immobilized functional molecules on biomaterial surfaces directs cell behaviors. However, limited by the low efficiency of traditional low-throughput experimental methods, investigation and optimization of the combinational density remain daunting challenges. Herein, we report a high-throughput screening set-up to study biomaterial surface functionalization by integrating photo-controlled thiol-ene surface chemistry and machine learning-based label-free cell identification and statistics. Through such a strategy, a specific surface combinational density of polyethylene glycol (PEG) and arginine-glutamic acid-aspartic acid-valine peptide (REDV) leads to high endothelial cell (EC) selectivity against smooth muscle cell (SMC) was identified. The composition was translated as a coating formula to modify medical nickel-titanium alloy surfaces, which was then proved to improve EC competitiveness and induce endothelialization. This work provided a high-throughput method to investigate behaviors of co-cultured cells on biomaterial surfaces modified with combinatorial functional molecules.
基金supported by the National Natural Science Foundation of China (U19A2090, 51902098, 51972105, 51525202, and 61574054)the Hunan Provincial Natural Science Foundation (2018RS3051)。
文摘The newly emerged two-dimensional(2D) semiconducting materials, owning to the atomic thick nature and excellent optical and electrical properties, are considered as potential candidates to solve the bottlenecks of traditional semiconductors. However, the realization of high performance 2D semiconductorbased field-effect transistors(FETs) has been a longstanding challenge in 2D electronics, which is mainly ascribing to the presence of significant Schottky barrier(SB) at metal-semiconductor interfaces. Here, an additional contact gate is induced in 2D ambipolar FET to realize near ideal reconfigurable FET(RFET)devices without restrictions of SB. Benefitting from the consistently high doping of contact region, the effective SB height can be maintained at ultra-small value during all operation conditions, resulting in the near ideal subthreshold swing(SS) values(132 mV/decade for MoTe2 RFET and 67 mV/decade for WSe2 RFET) and the relatively high mobility(28.6 cm2/(Vs) for MoTe2 RFET and 89.8 cm2/(V s) for WSe2 RFET). Moreover, the flexible control on the doping polarity of contact region enables the remodeling and switching of the achieved unipolar FETs between p-type mode and n-type mode. Based on such reconfigurable behaviors, high gain complementary MoTe2 inverters are further realized. The findings in this work push forward the development of high-performance 2D semiconductor integrated devices and circuits.
基金financial support from the National Natural Science Foundation of China (31601912)the Natural Science Foundation of Guangdong Province (2016A030310447)the Applied Science and Technology Research and Development of Special Funds of Guangdong Province (2015B020231010)
文摘Intramuscular fat(IMF) is a major meat-quality trait in pigs. The content of IMF is directly associated with the taste and flavor of pork. As a complex trait, there could be multiple genes affecting IMF content in pork. Genomewide association study is a powerful tool to detect genomic regions associated with phenotypic variations. The objectives of the present study were to identify or refine the positions of genomic regions affecting IMF, and to characterize candidate genes and pathways that may influence this trait. Of note, we identified a significant region in longissium dorsi muscle in a Duroc pig population for IMF content with Porcine SNP60 v2 Bead Chip. This region spans 1.24 Mb on chromosome 8 and had been identified as a quantitative trait locus for IMF in Pietrain, Large White, Landrace, and Leicoma pigs. In this region, eight SNPs were significantly associated with IMF content. Three genes proximal to these significant SNPs were considered candidate genes, including ZDHHC16, LOC102162218 and PCDH7. Our results confirm several previous findings and highlight several genes that may contribute to IMF variation in Duroc pigs.
基金the National Natural Science Foundation of China(No.21272166)the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions(No.13KJA150004)the Program for New Century Excellent Talents in University(No.NCET-12-0743).
文摘Chiral molecules containing sulfonyl and 1,5-diol moieties are useful synthetic blocks for various asymmetric transformations.A protocol has been developed for the enantioselective synthesis of optically active bis(β-hydroxy)sulfones catalyzed by a chiral cationic ruthenium diamine catalyst.A series of bis(β-hydroxy)sulfones have been obtained in excellent yields(up to 99%)with excellent enantioselectivities(up to 99%)as well as good diastereoselectivities(up to 99∶1).
基金supported by the National Natural Science Foundation of China(Grant No.32060288)the National Natural Science Foundation of China(Grant No.32160300)+1 种基金the Bingtuan Science and Technology Program(Grant No.2019AB007)the Science and Technology Planning Project of the first division of Alaer city(Grant No.2022XX06).
文摘Robust, accurate, and fast monitoring of residual plastic film (RPF) pollution in farmlands has great significance. Based on CBAM-DBNet, this study proposed a threshold-adaptive joint framework for identifying the RPF on farmland surfaces and estimating its coverage rate. UAV imaging was used to gather images of the RPF from several locations with various soil backgrounds. RPFs were manually labeled, and the degree of RPF pollution was defined based on the RPF coverage rate. Combining differentiable binarization network (DBNet) with the convolutional block attention module (CBAM), whose feature extraction module was improved. A dynamic adaptive binarization threshold formula was defined for segmenting the RPF’s approximate binary map. Regarding the RPF image detection branch, the CBAM-DBNet exhibited a precision (P) value of 85.81%, a recall (R) value of 82.69%, and an F1-score (F1) value of 84.22%, which was 1.09 percentage points higher than the DBNet in the comprehensive index F1 value. For the RPF image segmentation branch, using CBAM-DBNet to segment the RPF image combined with an adaptive binarization threshold formula. Subsequently, the mean absolute percentage error (MAPE), root mean square error (RMSE), and mean absolute error (MAE) of the prediction of RPF’s coverage rate were 0.276, 0.366, and 0.605, respectively, outperforming the DBNet and the Iterative Threshold method. This study provides a theoretical reference for the further development of evaluation technology for RPF pollution based on UAV imaging.
