Liposome has the ability to co-encapsulate hydrophobic and hydrophilic bioactive compounds due to its unique structure consisting of both aqueous core and lipid bilayer.The simultaneous delivery of bioactive compounds...Liposome has the ability to co-encapsulate hydrophobic and hydrophilic bioactive compounds due to its unique structure consisting of both aqueous core and lipid bilayer.The simultaneous delivery of bioactive compounds often brings synergistic effects and more health benefits.This article discusses the recent progress on the liposomal co-delivery systems for various combinations of bioactive compounds,including two hydrophobic bioactives,two hydrophilic bioactives,and hydrophobic/hydrophilic bioactives,as well as to combine biopolymer modification.The co-encapsulation mechanisms,influencing factors,and functional food applications are illustrated.The liposomal co-encapsulation has shown the synergistic effects on the stability,antioxidant activity,anti-inflammatory activity,and controlled release of bioactive compounds.The advantages and limitations associated with the co-delivery efficiency of liposomes are also highlighted.展开更多
基金supported by the National Key Research and Development Program of China(2023YFF1103601)National Natural Sci-ence Foundation of China for Young Scholars(32101879).
文摘Liposome has the ability to co-encapsulate hydrophobic and hydrophilic bioactive compounds due to its unique structure consisting of both aqueous core and lipid bilayer.The simultaneous delivery of bioactive compounds often brings synergistic effects and more health benefits.This article discusses the recent progress on the liposomal co-delivery systems for various combinations of bioactive compounds,including two hydrophobic bioactives,two hydrophilic bioactives,and hydrophobic/hydrophilic bioactives,as well as to combine biopolymer modification.The co-encapsulation mechanisms,influencing factors,and functional food applications are illustrated.The liposomal co-encapsulation has shown the synergistic effects on the stability,antioxidant activity,anti-inflammatory activity,and controlled release of bioactive compounds.The advantages and limitations associated with the co-delivery efficiency of liposomes are also highlighted.
